scholarly journals Hb and dyslipidaemia as predicting markers of serum alanine aminotransferase elevation in Chinese adolescents

2015 ◽  
Vol 19 (6) ◽  
pp. 1067-1073 ◽  
Author(s):  
Kuo-Ching Chao ◽  
Chun-Chao Chang ◽  
Eddy Owaga ◽  
Chyi-Huey Bai ◽  
Tzu-chieh Huang ◽  
...  

AbstractObjectiveFe is an essential element for erythropoiesis and Hb synthesis. High Hb levels affect the blood’s viscosity and are associated with cardiovascular dysfunction. The aim of the present study was to examine relationships of Hb and cardiometabolic abnormalities with the risk of alanine aminotransferase (ALT) elevation in adolescents.DesignA population-based, cross-sectional study.SettingNational Nutrition and Health Survey in Taiwan (2010–2011, adolescents).SubjectsHealthy adolescents aged 13–18 years.ResultsIn total, 1941 adolescents (963 boys and 978 girls) were entered in the study. The mean age was 15·3 (sd 0·1) years (boys, 15·3 (sd 0·1) years; girls, 15·2 (sd 0·1) years). ALT tertile cut-off points for boys were 11 and 16 U/l, and for girls were 9 and 12 U/l. Girls without dyslipidaemia and presenting in the highest quartile (Q1) of Hb (>13·6 g/dl) were 1·89 and 3·76 times more likely to have raised serum ALT (9 and >12 U/l, respectively) than the reference (lowest quartile of Hb (Q1), <12·4 g/dl). Moreover, for those girls with dyslipidaemia, serum ALT seemed to increase with an increase in Hb levels. Specifically, girls with dyslipidaemia and Hb levels of 12·4, 13·1 and 13·6 g/dl were, respectively, 2·86, 3·53 and 5·64 times more likely to have elevated serum ALT levels (>12 U/l) than the reference (Q1 of Hb, <12·4 g/dl). The only effect found in boys was for those who had dyslipidaemia and presenting in Q4 of Hb (>15·4 g/dl), who were 7·40 times more likely to have elevated serum ALT of >16 U/l than the reference (Q1 of Hb, <14·1 g/dl).ConclusionsOur findings suggest that an increased Hb level is a predictor of elevated serum ALT in adolescent girls with dyslipidaemia. Our study also highlights the importance of further research to establish cut-off points for Hb and its utility in diagnosing and preventing the onset of dyslipidaemia in adolescents.

2021 ◽  
Vol 10 ◽  
Author(s):  
Rachel M. Harris ◽  
Angela M. C. Rose ◽  
Suzanne Soares-Wynter ◽  
Nigel Unwin

Abstract Our objective was to describe, for the first time in an English-speaking Caribbean country, the contribution of ultra-processed foods (UPFs) to nutrients linked to non-communicable disease. Using a cross-sectional study design, dietary data were collected from two non-consecutive 24-h dietary recalls. Recorded food items were then classified according to their degree of processing by the NOVA system. The present study took place in Barbados (2012–13). A representative population-based sample of 364 adult Barbadians (161 males and 203 females) aged 25–64 years participated in the study. UPFs represented 40⋅5 % (838 kcal/d; 95 % CI 791, 885) of mean energy intake. Sugar-sweetened beverages made the largest contribution to energy within the UPF category. Younger persons (25–44 years) consumed a significantly higher proportion of calories from UPF (NOVA group 4) compared with older persons (45–64 years). The mean energy shares of UPF ranged from 22⋅0 to 58⋅9 % for those in the lowest tertile to highest tertile. Within each tertile, the energy contribution was significantly higher in the younger age group (25–44 years) compared with the older (45–64 years). One-quarter of persons consume ≥50 % of their daily calories from UPF, this being significantly higher in younger persons. The ultra-processed diet fraction contained about six times the mean of free sugars and about 0⋅8 times the dietary fibre of the non-ultra-processed fraction (NOVA groups 1–3). Targeted interventions to decrease the consumption of UPF especially in younger persons is thus of high priority to improve the diet quality of Barbadians.


2011 ◽  
Vol 14 (11) ◽  
pp. 2055-2064 ◽  
Author(s):  
Anna Floegel ◽  
Sang-Jin Chung ◽  
Anne von Ruesten ◽  
Meng Yang ◽  
Chin E Chung ◽  
...  

AbstractObjectiveTo investigate the association of antioxidant intakes from diet and supplements with elevated blood C-reactive protein (CRP) and homocysteine (Hcy) concentrations.DesignA cross-sectional study. The main exposures were vitamins C and E, carotene, flavonoid and Se intakes from diet and supplements. Elevated blood CRP and Hcy concentrations were the outcome measures.SettingThe US population and its subgroups.SubjectsWe included 8335 US adults aged ≥19 years from the National Health and Nutrition Examination Survey 1999–2002.ResultsIn this US population, the mean serum CRP concentration was 4·14 (95 % CI 3·91, 4·37) mg/l. Intakes of vitamins C and E and carotene were inversely associated with the probability of having serum CRP concentrations >3 mg/l in multivariate logistic regression models. Flavonoid and Se intakes were not associated with the odds of elevated serum CRP concentrations. The mean plasma Hcy concentration was 8·61 (95 % CI 8·48, 8·74) μmol/l. Intakes of vitamins C, E, carotenes and Se were inversely associated with the odds of plasma Hcy concentrations >13 μmol/l after adjusting for covariates. Flavonoid intake was not associated with the chance of elevated plasma Hcy concentrations.ConclusionsThese results suggest that high antioxidant intake is associated with lower blood concentrations of CRP and Hcy. These inverse associations may be among the potential mechanisms for the beneficial effect of antioxidant intake on CVD risk mediators in observational studies.


Author(s):  
Shantanu Sharma ◽  
Devika Mehra ◽  
Charu Kohli ◽  
M. M. Singh

Background: Menarche is an important milestone in the life of a girl which signifies the onset of fertility in a woman. To understand the health consequences and importance of menstrual hygiene practices among adolescent girls, it is important to study the current practices about the same so that future interventions can be planned accordingly.Methods: This study adopted a cross-sectional study design. A total of 85 adolescent girls (10-19 years old) were interviewed by the investigator over a period of 3 months (Jan-Mar 2015). Data were analyzed using the software SPSS version 17.Results: Out of 85 adolescent girls studied, the majority was between 15 to 19 years. In our study 71(83.5%) out of 85 adolescent girls had already started their menstruation. The mean (±SD) age of menarche in the study subjects was 11.4±5.3 years. Around 33 out of 71 (46.4%) girls practiced different restrictions during menstruation. Out of 71 (85.9%) girls used sanitary pads during menstruation. In cases of reused cloth, the place of its drying was observed, responses stated were; outside the house in sunlight in 1 (5.8%) girl, 14 (82.2%) dried them inside the house, and 2 (11.7%) girls dried them outside in a dark place.Conclusions: It is imperative to strengthen the menstrual hygiene management (MHM) programs of the country and have a greater outreach. Multiple strategies need to be used to address this such as education on reproductive health and menstruation provided in schools, media campaign’s and improving water and sanitation for improving school retention of adolescent girls and their overall health.


2017 ◽  
Vol 102 (6) ◽  
pp. 761-766 ◽  
Author(s):  
Sandra Guimaraes ◽  
Tiago Fernandes ◽  
Patrício Costa ◽  
Eduardo Silva

AimsTo determine a normative of tumbling E optotype and its feasibility for visual acuity (VA) assessment in children aged 3-4 years.MethodsA cross-sectional study of 1756 children who were invited to participate in a comprehensive non-invasive eye exam. Uncorrected monocular VA with crowded tumbling E with a comprehensive ophthalmological examination were assessed. Testability rates of the whole population and VA of the healthy children for different age subgroups, gender, school type and the order of testing in which the ophthalmological examination was performed were evaluated.ResultsThe overall testability rate was 95% (92% and 98% for children aged 3 and 4 years, respectively). The mean VA of the first-day assessment (first-VA) and best-VA over 2 days’ assessments was 0.14 logMAR (95% CI 0.14 to 0.15) (decimal=0.72, 95% CI 0.71 to 0.73) and 0.13 logMAR (95% CI 0.13 to 0.14) (decimal=0.74, 95% CI 0.73 to 0.74). Analysis with age showed differences between groups in first-VA (F(3,1146)=10.0; p<0.001; η2=0.026) and best-VA (F(3,1155)=8.8; p<0.001; η2=0.022). Our normative was very highly correlated with previous reported HOTV-Amblyopia-Treatment-Study (HOTV-ATS) (first-VA, r=0.97; best-VA, r=0.99), with 0.8 to 0.7 lines consistent overestimation for HOTV-ATS as described in literature. Overall false-positive referral was 1.3%, being specially low regarding anisometropias of ≥2 logMAR lines (0.17%). Interocular difference ≥1 line VA logMAR was not associated with age (p=0.195).ConclusionsThis is the first normative for European Caucasian children with single crowded tumbling E in healthy eyes and the largest study comparing 3 and 4 years old testability. Testability rates are higher than found in literature with other optotypes, especially in children aged 3 years, where we found 5%–11% better testability rates.


Author(s):  
Mahshid Mahdavi ◽  
Mansour Ghafourifard ◽  
Azad Rahmani

Background & Aim: Nursing presence is an essential element of nursing care. Since the perception of nursing presence is influenced by different factors depending on the culture within which patients receive nursing care, this study aimed to investigate Iranian patients' nursing presence with cancer. Methods & Materials: In this cross-sectional study, 130 cancer patients were selected by random sampling from an oncology teaching hospital. Data was collected by the Presence of Nursing Scale and analyzed by SPSS software. Results: The results showed that the mean score of nursing presence (in a range of 0 to 125) was 101.91±16.19. According to the results, the highest and lowest scores belonged to the items "I trusted in these nurses" and "These nurses met my spiritual needs" with a mean score of 4.38±0.81 and 3.68±1.16, respectively. Data analysis by Pearson correlation coefficient showed no significant correlation between the mean score of nursing presence and quantitative variables such as patients' age, length of stay in the hospital, and the number of hospitalization (p>0.05). Conclusion: Although the total score of nursing presence was high, improvements in some items such as fulfilling the spiritual needs of cancer patients seem necessary. Evaluation of nursing presence by valid measures, encouraging nurses to spend more time and interacting with their patients, and providing special courses on nursing presence could help nurses improve and implement oncology nursing.  


Author(s):  
Puja Dudeja ◽  
Apoorva Sindhu ◽  
Pooja Shankar ◽  
Tukaram Gadekar

Abstract Introduction: Reproductive health of adolescent girls is crucial as it determines the health of future generations. School girls when experiencing menarche find themselves in a setting without water, toilets or a supportive female teacher to explain the changes happening in their body. An important concern for adolescent girls is to have adequate, correct knowledge along with facilities and the cultural environment to manage menstruation hygienically and with dignity. Hence, the present study was done to assess knowledge and practices about menstruation in adolescent school girls of an urban slum. Methodology: This was a descriptive cross-sectional study conducted among girls of a Government School located in an urban slum of western Maharashtra. A total of 250 girls participated. Data collection was through a pilot-tested questionnaire. The data thus collected were entered into Microsoft Excel and analyzed using the SPSS 20 software. All girls were educated about menstrual hygiene after the study. Results: The mean age of the students was 14.9±1.75 years. The mean age at menarche was 11.97 (95% CI: 11.94–11.99). It was observed that only half (56.4%) had acquired prior knowledge about attaining menarche. Out of these in a large proportion, the knowledge was imparted to them by their mothers (60.7%), followed by friends (31.8%). There was no significant association between educational status of mother and awareness in respondent about menstruation. Regarding the organ of menstrual blood flow, half (50.7%) knew the correct answer (i.e. uterus); whereas the rest believed that it was stomach/kidney, etc. Most of the school girls (90.5%) used sanitary pads. Almost 90% of the young women faced physical complaints or health problems during menstruation. Most of the participants had some kind of restrictions on them during the menstruation and most of these were religious restrictions (69.7%) followed by physical (41.2%) and social restrictions (22.3%). All of them were unsatisfied with the toilets and hand washing facilities available inside the school premises. Conclusion: Correct knowledge in adolescent young girls regarding menstruation is lacking. Lack of awareness is a roadblock in adopting safe and hygienic menstrual practices. It also hinders them from overcoming traditional beliefs, misconceptions and restrictions regarding menstruation. This will empower them as they transition into womanhood.


Author(s):  
Alireza Janbakhsh ◽  
Zahra Naghibifar ◽  
Sodabeh Eskandari ◽  
Zeinab Mohseniafshar ◽  
Maria Shirvani ◽  
...  

Background: Although coronavirus disease 2019 (COVID-19) is a respiratory disease, it seems that liver abnormalities are also prevalent in the patients. Objectives: The present study aimed to evaluate liver enzymes in COVID-19 patients. Methods: This descriptive, cross-sectional study was conducted on 111 COVID-19 patients admitted to Imam Reza Hospital in Kermanshah during September-November 2020. The required data were extracted from the hospital files, and data analysis was performed in the Excel software and SPSS version 21. Results: The mean age of the patients was 60.87 ± 15.85 years. 50.5% of patients were female. Among the patients, 38.7% had hypertension, 19.8% had diabetes, and 7.2% had cardiovascular diseases. Moreover, 34.2% of the patients had abnormal aspartate aminotransferase (AST), 17.1% had abnormal alanine aminotransferase (ALT), and 100% had abnormal lactate dehydrogenase (LDH). Conclusions: According to the results, hypertension, diabetes, and cardiovascular diseases were the most common comorbidities among the COVID-19 patients. AST, ALT, and LDH are important indicators of hepatic disorders, which were abnormal in these patients as well. Moreover, the patients aged less than 60 years, male patients, and those with renal disorders had a higher mean ALT.


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