Secoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling

The effects of a Chinese herb, Cornus officinalis, on the motility of human sperm was studied. An aqueous extract was prepared from the dried fruits of the herb and used in this study. The crude extract at a final concentration of 0.5 μg/μl in phosphate buffered saline (pH 7.4) increased sperm motility from 25.8 ± 7.7% to 42.8 ± 10.3% (i.e. 68% increase, n = 7), as determined by the computer-aided-sperm-analysis (CASA) method. The crude extract was fractionated by high-performance liquid chromatography (HPLC) into four fractions: Cl , C2, C3 and C4. Their effects on sperm motility were further studied by CASA. Only the C4 fraction showed substantial stimulatory effects on sperm motility. At a concentration of 5 ng/μl, C4 increased the sperm motility from 15.7 ± 3.8% to 34.5 ± 6.4% (i.e. 120% increase, n = 6) by CASA and from 14.9 ± 4.3 to 28.5 ± 8.1 (i.e. 91% increase, n = 8) by transmembrane migration ratio (TMMR) method. This result suggests that C4 is the active component in Cornus officinalis that enhances sperm motility.

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Morphological, anatomical and genetic differentiation of Cornus mas, Cornus officinalis and their interspecific hybrid

Dendrobiology ◽

10.12657/denbio.070.005 ◽

2013 ◽

Vol 70 ◽

pp. 45-57 ◽

Cited By ~ 8

Author(s):

Maria Morozowska ◽

Barbara Gawrońska ◽

Agata Woźnicka

Keyword(s):

Genetic Differentiation ◽

Interspecific Hybrid ◽

Cornus Officinalis ◽

Cornus Mas

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Investigation of the Effect of Rice Wine on the Metabolites of the Main Components of Herbal Medicine in Rat Urine by Ultrahigh-Performance Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry: A Case Study onCornus officinalis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2013/306712 ◽

2013 ◽

Vol 2013 ◽

pp. 1-10

Author(s):

Gang Cao ◽

Hao Cai ◽

Xianke Yue ◽

Sicong Tu ◽

Baochang Cai ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Herbal Medicine ◽

Rice Wine ◽

Rat Urine ◽

Flight Mass Spectrometry ◽

Cornus Officinalis ◽

Ultrahigh Performance Liquid Chromatography ◽

Main Components

Ultrahigh-performance liquid chromatography-quadrupole/time-of-flight mass spectrometry (UPLC-QTOF/MS) was developed for rapid and sensitive analysis of the effect of rice wine on the metabolites of the main components of herbal medicine in rat urine. UsingCornus officinalisas a model of herbal medicine, the metabolite profiles of crude and processed (steaming the crude drug presteeped in rice wine)Cornus officinalisextracts in rat urine were investigated. The metabolites ofCornus officinaliswere identified by using dynamic adjustment of the fragmentor voltage to produce structure-relevant fragment ions. In this work, we identified the parent compounds and metabolites of crude and processedCornus officinalisin rats. In total, three parent compounds and seventeen new metabolites ofCornus officinaliswere found in rats. The contents of the parent compounds and metabolitesin vivovaried significantly after intragastric (i.g.) administration of aqueous extracts of crude and processedCornus officinalis. Data from this study suggests that UPLC-QTOF/MS could be used as a potential tool for uncovering the effects of excipients found in the metabolites of the main components of herbal medicine,in vivo, to predict and discover the processing mechanisms of herbal medicine.

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Synthesis, characterization and evaluation cytotoxic activity of silver nanoparticles synthesized by Chinese herbal Cornus officinalis via environment friendly approach

Environmental Toxicology and Pharmacology ◽

10.1016/j.etap.2017.08.035 ◽

2017 ◽

Vol 56 ◽

pp. 56-60 ◽

Cited By ~ 16

Author(s):

Yangqing He ◽

Xing Li ◽

Ju Wang ◽

Qian Yang ◽

Binghua Yao ◽

...

Keyword(s):

Silver Nanoparticles ◽

Cytotoxic Activity ◽

Environment Friendly ◽

Chinese Herbal ◽

Cornus Officinalis

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Anti-Obesity Effects of Combined Cornus officinalis and Ribes fasciculatum Extract in High-Fat Diet-Induced Obese Male Mice

Animals ◽

10.3390/ani11113187 ◽

2021 ◽

Vol 11 (11) ◽

pp. 3187

Author(s):

Eunkuk Park ◽

Chang-Gun Lee ◽

Hyoju Jeon ◽

Hyesoo Jeong ◽

Subin Yeo ◽

...

Keyword(s):

High Fat Diet ◽

Insulin Action ◽

Normal Diet ◽

Male Mice ◽

Impaired Glucose Metabolism ◽

High Fat ◽

Beneficial Effects ◽

Cornus Officinalis ◽

Treatment And Prevention ◽

Obese Male

Medicinal plants are widely used as supplements for the treatment of various diseases because of their few side-effects. Here, we examined the anti-obesity effects of a mixture extract of Cornus officinalis and Ribes fasciculatum (CR) in high-fat diet (HFD)-induced obese male mice. Four week old male C57BL/6J mice were fed a normal diet (ND) or 60% high-fat diet (HFD) with different concentrations of CR extracts (75, 150, and 300 mg/kg/day) by oral administration for 12 weeks. CR extract administration prevented HFD-induced weight gain, hepatic steatosis, and adipocyte enlargement through the downregulation of adipogenesis-associated genes in obese male mice. In addition, CR administration improved the impaired glucose metabolism, insulin action, biochemical obesity parameters, and metabolic profiles in HFD-induced male mice. Consequently, the CR extract exhibited beneficial effects on HFD-induced systemic metabolic challenges. Taken together, our findings suggest that CR extract may be a potent therapeutic supplement for the treatment and prevention of obesity.

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Molecules and Functions of Cornus officinalis Bark Volatiles

Emirates Journal of Food and Agriculture ◽

10.9755/ejfa.2018.v30.i10.1826 ◽

2018 ◽

pp. 828

Author(s):

Wanxi Peng

Keyword(s):

Amino Acids ◽

Weight Loss ◽

Human Body ◽

Essential Elements ◽

Pharmacological Effects ◽

Bioactive Components ◽

Medicinal Material ◽

Cornus Officinalis ◽

Analysis Methods ◽

Made In

Cornus officinalis Sieb. et Zucc is a traditional Chinese valuable medicinal material. Clinically, it is customary to use ripe fruits from which seeds have been removed for medicinal purposes. The pulp contains 16 amino acids and a large number of essential elements for the human body. In recent years, with the expansion of the application of cornus officinalis, its pharmacological and pharmacological effects have been increasingly studied. At present, significant achievements have been made in the study of the bioactive components of cornus officinalis. The research of these achievements has been based on the research of the fruit of cornus officinalis. The study of branches or bark of cornus officinalis is very rare. With the fruit of cornus officinalis getting more and more attention, in order to solve the problem of the shortage of cornus officinalis fruit in the market, in this paper, starting from the study of bark of cornus officinalis, TGA-DTG and PY-GC-MS analysis methods were used to study the weight loss and pyrolysis of cornus officinalis bark, providing a basis for more fully utilizing cornus officinalis resources. With reference.

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Microglial M2 Polarization Mediated the Neuroprotective Effect of Morroniside in Transient MCAO-Induced Mice

Frontiers in Pharmacology ◽

10.3389/fphar.2021.784329 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hao Liu ◽

Mei-Xian Ou ◽

Qiao-Qiao Han

Keyword(s):

Neuroprotective Effect ◽

Interleukin 10 ◽

Artery Occlusion ◽

Inflammatory Factor ◽

Cornus Officinalis ◽

M2 Polarization ◽

Mitogen Activated Protein ◽

Enhanced Expression ◽

Glucagon Like Peptide 1 ◽

Cerebral Artery Occlusion

Morroniside, a secoiridoid glycoside from Cornus officinalis, is a class of small molecule non-peptide glucagon-like peptide-1 receptor (GLP-1R) agonists and possess many important biomedical functions. Our previous studies reported that GLP-1R agonist exenatide promoted M2 polarization and the expression of cell-specific anti-inflammatory factor interleukin-10 in neuropathological pain model. In this study, we proved that morroniside not only induced M2 polarization and stimulated interleukin-10 expression specifically in cortical primary microglia by p38β mitogen-activated protein kinases pathway but also protected nerve cells against H2O2-induced cell oxidative damage and prohibited ischemic injury by reducing infarct size, which is at least in part mediated by enhanced expression of microglial interleukin-10. In the cortical penumbra area in middle cerebral artery occlusion (MCAO) mice. In general, our results indicated that GLP-1R agonist morroniside might play a neuroprotective effect by inducing M2 polarization, and cyclic-AMP/protein kinase A/p38β pathway might mediate morroniside-induced expression of interleukin-10 protein in M2 microglia.

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