scholarly journals α,β-Unsaturated Carbonyl System of Chalcone-Based Derivatives Is Responsible for Broad Inhibition of Proteasomal Activity and Preferential Killing of Human Papilloma Virus (HPV) Positive Cervical Cancer Cells

2011 ◽  
Vol 54 (2) ◽  
pp. 449-456 ◽  
Author(s):  
Martina Bazzaro ◽  
Ravi K. Anchoori ◽  
Mohana Krishna R. Mudiam ◽  
Olga Issaenko ◽  
Srinivas Kumar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Cancer Cells ◽  
Papilloma Virus ◽  
Proteasomal Activity ◽  
Cervical Cancer Cells

scholarly journals Extracellular Vesicles from Human Papilloma Virus-Infected Cervical Cancer Cells Enhance HIV-1 Replication in Differentiated U1 Cell Line

Viruses ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 239 ◽  
Author(s):  
Sabina Ranjit ◽  
Sunitha Kodidela ◽  
Namita Sinha ◽  
Subhash Chauhan ◽  
Santosh Kumar
Keyword(s):  
Oxidative Stress ◽  
Cervical Cancer ◽  
Human Papilloma Virus ◽  
Cancer Cells ◽  
Cell Line ◽  
Extracellular Vesicles ◽  
Papilloma Virus ◽  
Cervical Cancer Cells ◽  
Hpv Oncoproteins ◽  
Hiv 1

In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an oxidative stress pathway. To test the hypothesis, we treated an HIV-1-infected macrophage cell line (U1) with HPV-infected Caski cell culture supernatant (CCS). We observed a significant increase in HIV-1 replication, which was associated with an increase in the expression of cytochrome P450 (CYPs 1A1 and 2A6) in the CCS-treated U1 cells. Furthermore, we isolated EVs from CCS (CCS-EVs), which showed the presence of CYPs (1A1, 2A6), superoxide dismutase 1 (SOD1), and HPV oncoproteins HPV16 E6. CCS-EVs when exposed to the U1 cells also significantly increased HIV-1 replication. Treatment of antioxidant, CYP1A1 and CYP2A6 inhibitors, and chemodietary agents with antioxidant properties significantly reduced the CCS and CCS-EVs mediated HIV-1 replication in U1 cells. Altogether, we demonstrate that cervical cancer cells exacerbate HIV-1 replication in differentiated U1 cell line via transferring CYPs and HPV oncoproteins through EVs. We also show that the viral replication occurs via CYP and oxidative stress pathways, and the viral replication is also reduced by chemodietary agents. This study provides important information regarding biological interactions between HPV and HIV-1 via EVs leading to enhanced HIV-1 replication.

scholarly journals A BRIEF REVIEW ON CRYOGUN MACHINE FOR PRE-CERVIX CANCER HEALING

2021 ◽  
Vol 3 (1) ◽  
pp. 32
Author(s):  
Aji Bagaskara ◽  
Rita Sundari ◽  
Rini Anggraini
Keyword(s):  
Cervical Cancer ◽  
Virus Infection ◽  
Human Papilloma Virus ◽  
Cancer Cells ◽  
Cervix Cancer ◽  
Papilloma Virus ◽  
Ablation Therapy ◽  
Cone Biopsy ◽  
Cancer Diseases

 Cervical cancer is generally found in women of all ages due to  virus infection on epithelial cells of female cervix. It is known that a certain type of Human Papilloma Virus (HPV) is suspected to cause cervix cancer in women from various ethnics.   Several therapies have been used to cure cancer diseases like cone biopsy, laser treatment, electrosurgical excision, thermocoagulation, ablation therapy, and cryotherapy. This paper has highlighted on the role of cryogun machine applied in cryotherapy for pre-cervical cancer treatment in relation to freezing technique using liquid nitrogen to kill cancer cells on infectious area.   

scholarly journals Biologi Molekuler Human Papilloma Virus

2018 ◽  
Vol 11 (1) ◽  
pp. 1
Author(s):  
Maya Savira
Keyword(s):  
Cervical Cancer ◽  
High Risk ◽  
Human Papilloma Virus ◽  
Cancer Cells ◽  
Persistent Infection ◽  
Malignant Disease ◽  
Risk Group ◽  
High Risk Group ◽  
Papilloma Virus ◽  
Carcinogenic Process

Persistent infection of the high-risk group Human Papilloma Virus (hrHPV) has been known to cause cervical cancer.Currently cervical cancer still ranks as the number two of most malignant disease in women. The infection of HPVthat lead to cancer cells to form can be known through the structure of the HPV virus itself and what particles in thevirus play a role in initiating the carcinogenic process of its host cell.

Water-soluble amphiphilic ruthenium(ii) polypyridyl complexes as potential light-activated therapeutic agents

2020 ◽  
Vol 56 (65) ◽  
pp. 9332-9335
Author(s):  
Sandra Estalayo-Adrián ◽  
Salvador Blasco ◽  
Sandra A. Bright ◽  
Gavin J. McManus ◽  
Guillermo Orellana ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Cellular Uptake ◽  
Therapeutic Agents ◽  
Water Soluble ◽  
Polypyridyl Complexes ◽  
Cervical Cancer Cells

Two new water-soluble amphiphilic Ru(ii) polypyridyl complexes were synthesised and their photophysical and photobiological properties evaluated; both complexes showed a rapid cellular uptake and phototoxicity against HeLa cervical cancer cells.

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