Metalloproteinase-sensitive peptide linkers for cell-surface modification of macrophages toward use in cell-based drug delivery

Background: Blood-brain barrier (BBB) plays a most hindering role in drug delivery to the brain. Recent research comes out with the nanoparticles approach, is continuously working towards improving the delivery to the brain. Currently, polymeric nanoparticle is extensively involved in many therapies for spatial and temporal targeted areas delivery. Methods: We did a non-systematic review, and the literature was searched in Google, Science Direct and PubMed. An overview is provided for the formulation of polymeric nanoparticles using different methods, effect of surface modification on the nanoparticle properties with types of polymeric nanoparticles and preparation methods. An account of different nanomedicine employed with therapeutic agent to cross the BBB alone with biodistribution of the drugs. Results: We found that various types of polymeric nanoparticle systems are available and they prosper in delivering the therapeutic amount of the drug to the targeted area. The effect of physicochemical properties on nanoformulation includes change in their size, shape, elasticity, surface charge and hydrophobicity. Surface modification of polymers or nanocarriers is also vital in the formulation of nanoparticles to enhance targeting efficiency to the brain. Conclusion: More standardized methods for the preparation of nanoparticles and to assess the relationship of surface modification on drug delivery. While the preparation and its output like drug loading, particle size, and charge, permeation is always conflicted, so it requires more attention for the acceptance of nanoparticles for brain delivery.

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Direct surface modification of mesoporous silica nanoparticles by DBD plasma as a green approach to prepare dual-responsive drug delivery system

Journal of the Taiwan Institute of Chemical Engineers ◽

10.1016/j.jtice.2021.05.024 ◽

2021 ◽

Author(s):

Sahar Porrang ◽

Nader Rahemi ◽

Soodabeh Davaran ◽

Majid Mahdavi ◽

Belal Hassanzadeh ◽

...

Keyword(s):

Drug Delivery ◽

Surface Modification ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Delivery System ◽

Mesoporous Silica Nanoparticles ◽

Dbd Plasma ◽

Dual Responsive ◽

Green Approach

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Effects of surface modification and size on oral drug delivery of mesoporous silica formulation

Journal of Colloid and Interface Science ◽

10.1016/j.jcis.2017.11.065 ◽

2018 ◽

Vol 513 ◽

pp. 736-747 ◽

Cited By ~ 25

Author(s):

Ying Wang ◽

Yu Cui ◽

Yating Zhao ◽

Qinfu Zhao ◽

Bing He ◽

...

Keyword(s):

Drug Delivery ◽

Surface Modification ◽

Mesoporous Silica ◽

Oral Drug Delivery ◽

Oral Drug

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Direct Cell Surface Modification with DNA for the Capture of Primary Cells and the Investigation of Myotube Formation on Defined Patterns

Langmuir ◽

10.1021/la900150n ◽

2009 ◽

Vol 25 (12) ◽

pp. 6985-6991 ◽

Cited By ~ 97

Author(s):

Sonny C. Hsiao ◽

Betty J. Shum ◽

Hiroaki Onoe ◽

Erik S. Douglas ◽

Zev J. Gartner ◽

...

Keyword(s):

Surface Modification ◽

Cell Surface ◽

Primary Cells ◽

Myotube Formation ◽

Direct Cell

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Cell-surface remodelling during mammalian erythropoiesis

Biochemical Journal ◽

10.1042/bj2080239 ◽

1982 ◽

Vol 208 (1) ◽

pp. 239-242 ◽

Cited By ~ 9

Author(s):

D C Wraith ◽

C J Chesterton

Keyword(s):

Surface Modification ◽

Membrane Proteins ◽

Cell Surface ◽

Protein Composition ◽

Surface Protein ◽

Current Evidence ◽

Cell Surface Protein ◽

Erythroid Cells ◽

Selective Loss ◽

Before And After

Current evidence suggests that the major cell-surface modification occurring during mammalian erythropoiesis could be generated by two separate mechanisms: either selective loss of membrane proteins during enucleation or endocytosis at the subsequent reticulocyte and erythrocyte stages. The former idea was tested by collecting developing rabbit erythroid cells before and after the enucleation step and comparing their cell-surface protein composition via radiolabelling and electrophoresis. Few changes were observed. Our data thus lend support to the endocytosis mechanism.

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Metabolic Delivery of Methacryloyl Groups on Living Cells and Cell Surface Modification via Thiol-Ene “Click” Reaction

Macromolecular Bioscience ◽

10.1002/mabi.201100242 ◽

2011 ◽

pp. n/a-n/a ◽

Cited By ~ 3

Author(s):

Yasuhiko Iwasaki ◽

Hiroshi Matsuno

Keyword(s):

Surface Modification ◽

Cell Surface ◽

Click Reaction ◽

Living Cells

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Surface Modification of Bacterial Cellulose for Biomedical Applications

International Journal of Molecular Sciences ◽

10.3390/ijms23020610 ◽

2022 ◽

Vol 23 (2) ◽

pp. 610

Author(s):

Teresa Aditya ◽

Jean Paul Allain ◽

Camilo Jaramillo ◽

Andrea Mesa Restrepo

Keyword(s):

Mechanical Properties ◽

Drug Delivery ◽

Tissue Engineering ◽

Surface Modification ◽

Bacterial Cellulose ◽

Biomedical Applications ◽

Human Tissues ◽

Naturally Occurring ◽

Microstructure And Mechanical Properties

Bacterial cellulose is a naturally occurring polysaccharide with numerous biomedical applications that range from drug delivery platforms to tissue engineering strategies. BC possesses remarkable biocompatibility, microstructure, and mechanical properties that resemble native human tissues, making it suitable for the replacement of damaged or injured tissues. In this review, we will discuss the structure and mechanical properties of the BC and summarize the techniques used to characterize these properties. We will also discuss the functionalization of BC to yield nanocomposites and the surface modification of BC by plasma and irradiation-based methods to fabricate materials with improved functionalities such as bactericidal capabilities.

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