Seasonal variation in consumption and plasma concentrations of fatty acids in Japanese female dietitians

The questioned reliability of 15:0, 17:0, and trans9-16:1 acids as biomarkers of dairy fat intake also questions the relationship between the intake of these products and their health effects. Two studies were conducted in the same geographical region. In an intervention study, volunteers followed a diet rich in dairy products followed by a diet without dairy products. Plasma and erythrocyte fatty acids (FA) were analyzed, and their correlations with dairy product intakes were tested. The FA biomarkers selected were validated in the Gipuzkoa cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC) observational study. The correlation coefficients between plasma concentrations of iso16:0, iso17:0, trans11-18:1, cis9, trans11-18:2, and cis6-18:1 and the dairy fat ingested are similar in both studies, indicating that their concentration increases by 0.8 µmol/L per gram of dairy fat ingested. The biomarkers are positively related to plasma triglycerides (r = 0.324 and 0.204 in the intervention and observational studies, respectively) and total cholesterol (r = 0.459 and 0.382), but no correlation was found between the biomarkers and atherogenicity indexes. In conclusion, the sum of the plasma concentration of the selected FAs can be used as biomarkers of dairy product consumption. A linear relationship exists between their plasma concentrations and ruminant product intake. These biomarkers allow for obtaining consistent relationships between dairy intake and plasma biochemical parameters.

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Plasma glycerophospholipid profile, erythrocyte n–3 PUFAs, and metabolic syndrome incidence: a prospective study in Chinese men and women

American Journal of Clinical Nutrition ◽

10.1093/ajcn/nqab050 ◽

2021 ◽

Author(s):

Shuangshuang Chen ◽

Qingqing Wu ◽

Li Zhu ◽

Geng Zong ◽

Huaixing Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Fatty Acids ◽

Polyunsaturated Fatty Acids ◽

Animal Studies ◽

Plasma Concentrations ◽

Positive Association ◽

Community Dwelling ◽

P Value ◽

Total N ◽

Long Chain

ABSTRACT Background Animal studies have highlighted critical roles of glycerophospholipid (GP) metabolism in various metabolic syndrome (MetS)-related features such as dyslipidemia, obesity, and insulin resistance. However, human prospective studies of associations between circulating GPs and risks of MetS are scarce. Objectives We aimed to investigate whether GPs are associated with incidence of MetS in a well-established cohort. Methods A total of 1243 community-dwelling Chinese aged 50–70 y without MetS at baseline and followed up for 6 y were included in current analyses. A total of 145 plasma GPs were quantified by high-throughput targeted lipidomics. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Results After 6 y, 429 participants developed MetS. Eleven GPs, especially those with long-chain polyunsaturated fatty acids (LCPUFAs) or very-long-chain polyunsaturated fatty acids (VLCPUFAs) at the sn-2 position, including 1 phosphatidylcholine (PC) [PC(18:0/22:6)], 9 phosphatidylethanolamines (PEs) [PE(16:0/22:6), PE(18:0/14:0), PE(18:0/18:1), PE(18:0/18:2), PE(18:0/20:3), PE(18:0/22:5), PE(18:0/22:6), PE(18:1/22:6), and PE(18:2/22:6)], and 1 phosphatidylserine (PS) [PS(18:0/18:0)], were positively associated with incident MetS (RRs: 1.16–1.30 per SD change; Bonferroni-corrected P < 0.05). In network analysis, the strongest positive association for MetS incidence was evidenced in a module mainly composed of PEs containing C22:6 and PSs [RR: 1.21; 95% CI: 1.12, 1.31 per SD change; Bonferroni-corrected P < 0.05]. This association was more pronounced in participants with lower erythrocyte total n–3 PUFA concentrations [Bonferroni-corrected Pinter(P value for the interaction)< 0.05]. Conclusions Elevated plasma concentrations of GPs, especially PEs with LCPUFAs or VLCPUFAs at the sn-2 position, are associated with higher risk of incident MetS. Future studies are merited to confirm our findings.

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Effect of time of supplementary feeding on intake, apparent digestibility and rumen fermentation of grass hay by sheep

Animal Science ◽

10.1017/s0003356100007704 ◽

1994 ◽

Vol 59 (2) ◽

pp. 217-222 ◽

Cited By ~ 2

Author(s):

M. D. Carro ◽

A. R. Mantecón ◽

I. A. Wright ◽

I. J. Gordon

Keyword(s):

Fatty Acids ◽

Volatile Fatty Acids ◽

Plasma Concentrations ◽

Rumen Fermentation ◽

Apparent Digestibility ◽

Nonesterified Fatty Acids ◽

Rumen Ph ◽

Grass Hay ◽

Forage Intake ◽

Male Sheep

AbstractEffects of time of supplementation on forage intake, nutrient apparent digestibility and rumen fermentation were studied with 12 mature castrated male sheep (wethers) offered grass hay from 16.30 h to 09.30 h and supplemented with a cereal-based concentrate given at either 09.30 or 16.00 h. Voluntary intake of hay organic matter (OM) was decreased by feeding the concentrate (P< 0·01). Offering concentrate at 09.30 h after hay was available, increased intake of hay and total OM compared with offering it at 16.00 h before hay was available (P< 0·05). Daily pattern of hay intake was not changed when concentrate was offered at 09.30 h compared with feeding hay alone, but concentrate given at 16.00 h resulted in a lower hay intake between 16.30 and 18.00 h. Sheep offered concentrate at 09.30 h had higher rumen ammonia levels than those offered concentrate at 16.00 h, but there were no differences in the apparent digestibility of the nutrients, rumen pH and molar proportions of the main volatile fatty acids. There were also no differences between groups in the blood plasma concentrations of 3-hydroxybutyrate (30HB), nonesterified fatty acids (NEFA) and glucose. It is concluded that feeding supplement after rather than before a period of intake of forage or a bout of grazing may offer a means of minimizing reduction of forage intake as a consequence of feeding concentrate.

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Plasma concentrations of trans fatty acids in persons with type 2 diabetes between September 2002 and April 2004

American Journal of Clinical Nutrition ◽

10.3945/ajcn.112.046508 ◽

2013 ◽

Vol 97 (4) ◽

pp. 862-871 ◽

Cited By ~ 9

Author(s):

Dawn C Schwenke ◽

John P Foreyt ◽

Edgar R Miller ◽

Rebecca S Reeves ◽

Mara Z Vitolins ◽

...

Keyword(s):

Type 2 Diabetes ◽

Fatty Acids ◽

Trans Fatty Acids ◽

Plasma Concentrations

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Seasonal Variation of Fatty Acids and Stable Carbon Isotopes in Sponges as Indicators for Nutrition: Biomarkers in Sponges Identified

Marine Biotechnology ◽

10.1007/s10126-014-9594-8 ◽

2014 ◽

Vol 17 (1) ◽

pp. 43-54 ◽

Cited By ~ 8

Author(s):

Marieke Koopmans ◽

Pieter van Rijswijk ◽

Henricus T. S. Boschker ◽

Houtekamer Marco ◽

Dirk Martens ◽

...

Keyword(s):

Fatty Acids ◽

Seasonal Variation ◽

Carbon Isotopes ◽

Stable Carbon Isotopes ◽

Stable Carbon

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Effects of Dietary Supplementation with Different Polyunsaturated Fatty Acids on Expression of Genes Related to Somatotropic Axis Function in the Liver, Selected Blood Indicators, Milk Yield and Milk Fatty Acids Profile in Dairy Cows

Annals of Animal Science ◽

10.1515/aoas-2016-0019 ◽

2016 ◽

Vol 16 (4) ◽

pp. 1045-1058 ◽

Cited By ~ 9

Author(s):

Essa Dirandeh ◽

Armin Towhidi ◽

Zarbakht Ansari ◽

Saeeid Zeinoaldini ◽

Mehdi Ganjkhanlou

Keyword(s):

Fatty Acids ◽

Plasma Concentrations ◽

Dietary Supplementation ◽

Omega 3 ◽

Milk Fatty Acids ◽

Somatotropic Axis ◽

Fatty Acids Profile ◽

Expression Of Genes ◽

Omega 6 ◽

And Control

Abstract The objective of this study was to investigate whether dietary supplementation with different polyunsaturated fatty acids (PUFA s) affects expression of genes related to somatotropic axis and the plasma concentrations of insulin, glucose, non-esterified fatty acids (NEFA), beta hydroxyl butyrate acids (BHBA) and insulin-like growth factor 1 (IGF1) and milk fatty acids profile. Right after calving, Holstein cows (n=45) were randomly assigned to one of three diets supplemented with roasted whole soybean as a source of omega-6 PUFA (omega-6, n=15), linseed as a source of omega-3 PUFA (omega-3, n=15) or palm oil (control, n=15). Each cow was in the study over a period of 70 days. Blood samples were collected every two weeks from day 1 to 70 of lactation and plasma concentrations of insulin, glucose, NEFA, BHBA and IGF1 were determined. Liver samples were taken from a subset of 18 cows (6 per diet) at day 70 postpartum and hepatic mRNA level of total growth hormone-receptor 1A (GHR1A), insulin receptor (INSR), IGF1 and insulinlike growth factor binding protein (IGFBP2) was assessed. Experimental diets did not affect milk yield. Plasma glucose and insulin concentrations were greater for omega-3 treatment compared to omega-6 and control treatments. Cows fed diets enriched in omega-3 exhibited greater INSR and GHR1A mRNA expression, and a tendency for greater IGF1 mRNA expression in the liver compared to omega-6 and control cows. Plasma IGF1 concentration was significantly higher in omega-3 treatment compared with omega-6 and control treatments. Results of this study suggest that feeding omega-3 PUFA s during early postpartum couples with the somatotropic axis, leading to an increase in plasma IGF1 concentration in dairy cows.

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Influence of High Plasma Concentrations of Free Fatty Acids on Heart Rhythm in Healthy Fasting Men

Acta Medica Scandinavica ◽

10.1111/j.0954-6820.1979.tb06051.x ◽

2009 ◽

Vol 205 (1-6) ◽

pp. 299-301 ◽

Cited By ~ 3

Author(s):

Harald Wang ◽

Knut Rasmussen ◽

Harald Vik-Mo ◽

Ole D. Mjøs ◽

Helge Grendahl

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Plasma Concentrations ◽

Heart Rhythm ◽

High Plasma

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The response of plasma minerals, free fatty acids and glucose to adrenaline and cortisol infusion in sheep

The Journal of Agricultural Science ◽

10.1017/s0021859600063784 ◽

1986 ◽

Vol 106 (2) ◽

pp. 209-217 ◽

Cited By ~ 2

Author(s):

Sarah C. Bolton ◽

T. E. C. Weekes

Keyword(s):

Fatty Acids ◽

Free Fatty Acids ◽

Marked Decrease ◽

Plasma Concentrations ◽

Sodium Concentration ◽

Plasma Calcium ◽

Plasma Sodium ◽

Plasma Phosphate ◽

Plasma Sodium Concentration ◽

Plasma Magnesium

SUMMARYAdrenaline was infused at three rates, 40, 15 or 3 μ/kg/h, in normal sheep and in sheep rendered hypercortisolaemic by infusion of cortisol at 150 μg/kg/h. In both normal and hypercortisolaemic animals, plasma concentrations of glucose and free fatty acids were increased by adrenaline treatment; plasma phosphate decreased with all treatments; plasma magnesium and potassium decreased on infusion of adrenaline at 40 or 15, but not at 3 μg/kg/h; plasma calcium decreased only on infusion of adrenaline in hypercortisolaemic animals, and plasma sodium concentration was unaffected by treatment.Induction of a degree of lipolysis likely to occur in the field was not associated with a marked decrease in plasma magnesium.

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