Effect of Vitamin C Supplementation on Oxidative Stress and Lipid Profiles in Hemodialysis Patients

2009 ◽  
Vol 79 (56) ◽  
pp. 281-287 ◽  
Author(s):  
Hadi Abdollahzad ◽  
Shahriar Eghtesadi ◽  
Issa Nourmohammadi ◽  
Mohammadhasan Khadem-Ansari ◽  
Hossein Nejad-Gashti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Serum Vitamin ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hemodialysis Patients ◽  
Lipid Profiles ◽  
Significant Difference ◽  
Vitamin C Supplementation

Background and aims: The increase in oxidative stress is the main factor in acceleration of atherosclerosis, leading to death in hemodialysis patients. Vitamin C is one of the most important antioxidants that inhibits lipid peroxidation and improves endothelial function. This study aims to assess the effects of vitamin C supplementation on lipid profiles as well as markers of lipid peroxidation among hemodialysis patients. Materials and methods: In this double-blind, randomized, controlled clinical trial, a total of 42 patients were randomly assigned to vitamin C (n=21) or placebo groups (n=21). Patients in the vitamin C group consumed 250 mg vitamin C and those in the placebo group were given placebo every other day for 12 weeks. Fasting blood samples were collected at baseline and at the end of the study to measure serum concentrations of lipid profiles, as well as malondialdehyde (MDA) and vitamin C. Results: After supplementation with vitamin C, serum vitamin C levels increased significantly in the vitamin C group as compared to baseline (p=0.033). There was also a significant difference in serum vitamin C levels between vitamin C and placebo groups (p=0.001). Serum MDA concentrations were marginally decreased in the vitamin C group after taking supplements (p=0.057). A significant difference was also seen in mean MDA changes between vitamin C and placebo groups (p=0.002). There was a significant difference in serum levels of total cholesterol (p=0.005), low-density lipoprotein (LDL-C) (p=0.012), and LDL-C/high-density lipoprotein (HDL-C) ratio (p=0.018) between the two groups; however, serum triglyceride and HDL-C levels were not significantly different between groups. Conclusion: Every other day supplementation with 250 mg vitamin C for 12 weeks increases serum vitamin C, decreases MDA levels, and improves lipid profiles in hemodialysis patients.

scholarly journals Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ljiljana M. Popovic ◽  
Nebojsa R. Mitic ◽  
Dijana Miric ◽  
Boban Bisevac ◽  
Mirjana Miric ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Vitamin C ◽  
Inflammatory Response ◽  
Acute Exercise ◽  
Exercise Group ◽  
Vitamin Supplementation ◽  
Regular Exercise ◽  
Biological Macromolecules ◽  
Vitamin C Supplementation

Exercise induces a multitude of physiological and biochemical changes in blood affecting its redox status. Tissue damage resulting from exercise induces activation of inflammatory cells followed by the increased activity of myeloperoxidase (MPO) in circulation. Vitamin C readily scavenges free radicals and may thereby prevent oxidative damage of important biological macromolecules. The aim of this study was to examine the effect of vitamin C supplementation on oxidative stress and neutrophil inflammatory response induced by acute and regular exercise. Experiment was conducted on acute exercise group (performing Bruce Treadmill Protocol (BTP)) and regular training group. Markers of lipid peroxidation, malondialdehyde (MDA), MPO activity, and vitamin C status were estimated at rest and after BTP (acute exercise group) and before and after vitamin C supplementation in both groups. Our results showed increased postexercise Asc in serum independently of vitamin supplementation. They also showed that vitamin C can significantly decrease postexercise MDA level in both experimental groups. Increased postexercise MPO activity has been found in both groups and was not affected by vitamin C supplementation. We concluded that vitamin C supplementation can suppress lipid peroxidation process during exercise but cannot affect neutrophil inflammatory response in either exercise group.

Lipid peroxidation in hemodialysis patients: Effect of vitamin C supplementation

2008 ◽  
Vol 41 (6) ◽  
pp. 381-386 ◽  
Author(s):  
Gianna Ferretti ◽  
Tiziana Bacchetti ◽  
Simona Masciangelo ◽  
Giosafatte Pallotta
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin C ◽  
Hemodialysis Patients ◽  
Vitamin C Supplementation

scholarly journals Effects of pomegranate juice on cardiometabolic risk factors and biomarkers of oxidative stress and inflammation in hemodialysis patients, a crossover controlled trial

2019 ◽  
Author(s):  
Reza Barati Boldaji ◽  
Masoumeh Akhlaghi ◽  
Mohammad Mehdi Sagheb ◽  
Zahra Esmaeilinezhad
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Hemodialysis Patients ◽  
Pomegranate Juice ◽  
Inflammatory Biomarkers ◽  
Dialysis Session ◽  
Significant Difference

Abstract Background: Pomegranate has antioxidant, cardioprotective, and anti-inflammatory properties. We questioned if pomegranate juice (PJ) benefits lipid profile and oxidative and inflammatory biomarkers of hemodialysis patients. Methods: The study had a crossover design. Hemodialysis patients (n=41) were divided into two groups: PJ-treated group who received 100 ml natural PJ immediately after their dialysis session three times a week and the control group who received the usual care. After 8 weeks, a 4-week washout period was established and afterwards the role of the groups was exchanged. Lipid profile, blood pressure, and oxidative and inflammatory biomarkers were measured before and after each sequence. Comparisons between the two conditions were performed by ANCOVA with adjustments for potential confounders. Results: Based on results of intention-to-treat analysis, triglycerides were decreased in PJ condition and increased in the control. Conversely, high-density lipoprotein (HDL)-cholesterol was increased in PJ and decreased in control. There was a significant between-condition difference for both triglycerides and HDL-cholesterol (P<0.001). Total and low-density lipoprotein (LDL)-cholesterol did not significantly change in either condition. Systolic and diastolic blood pressure significantly decreased in PJ condition and caused a significant difference between two conditions (P<0.001). Total antioxidant capacity increased in PJ condition (P<0.001) and decreased in control (P<0.001). Conversely, malondialdehyde and interleukin-6 decreased in PJ (P<0.001) and increased in the control (P≤0.001). The changes of these biomarkers were significantly different between two conditions. Conclusions: In conclusion, 8-week PJ consumption showed beneficial effects on blood pressure, serum triglycerides, HDL cholesterol, oxidative stress, and inflammation in hemodialysis patients. The trial was registered at Iranian Registry of Clinical Trials (ID number: IRCT 2016070428797N1). Keywords: Pomegranate, hemodialysis, hypertension, oxidative stress, inflammation, lipid profile.

scholarly journals The Influence of Oral Multivitamins Supplementation on Selected Oxidative Stress Parameters and Lipid Profiles among Sudanese Patients with Type-2 Diabetes

2019 ◽  
Vol 7 (5) ◽  
pp. 775-778 ◽  
Author(s):  
Abd Elgadir A. Altoum ◽  
Mohammed Y. Abbas ◽  
Ahmed L. Osman ◽  
Sharique Ahmed ◽  
Asaad MA Babker
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Vitamin A ◽  
Serum Vitamin ◽  
Lipid Profiles ◽  
P Value ◽  
Oxidative Stress Parameters ◽  
Significant Difference ◽  
Stress Parameters

AIM: The objective of the current study was to assess the influence of oral multivitamins supplementation on some oxidative stress parameters (serum Vitamin A, C, E, Zinc, Malondialdehyde (MDA)) and lipid profile among Sudanese patients with type- 2 diabetes mellitus (T2DM). MATERIAL AND METHOD: Three hundred Sudanese patients with T2DM and Hundred healthy subjects (control group) were enrolled in this cross-sectional study. Blood was collected after overnight fasting for 10-12 hrs. Fasting plasma glucose (FBG), lipid profiles, Glycosylated haemoglobin (HbA1c%), Serum zinc, Malondialdehyde (MDA), Vitamins A, E, and C levels were measured using standardised laboratory techniques. Data was collected with the help of a structured questionnaire and direct interview. RESULTS: Biochemical parameters of the study population were shown a highly significant difference (P value < 0.05), between the means of serum vitamin A, C, E, Zinc, MDA, HbA1c, triglycerides, HDL, FBG, total cholesterol and LDL. Significant differences in serum vitamin A, C, E, Zinc, MDA, triglycerides, HDL and FBG between people with diabetes who used multivitamins and diabetics who did not use it (P-value < 0.05). CONCLUSION: The study observed a significant increase in serum levels of vitamin A, C & E and other biomarkers parameters in patients with T2DM who take oral multivitamins supplements; such improvement may lead to minimising the diabetic complications. Further studies are needed to explore the possible therapeutic role of multivitamins supplements for T2DM patients.

scholarly journals Effect Of Vêo® Premium and Vitamin C Supplementation on Lipid Profile Before and During Pregnancy in Some Local Iraqi Ewes During Heat Stress

2021 ◽  
pp. 2122-2130
Author(s):  
Othman Ghazi Najeeb Alani ◽  
Yassen Taha Abdul-Rahaman ◽  
Thafer Thabit Mohammed
Keyword(s):  
Heat Stress ◽  
Vitamin C ◽  
Lipid Profile ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Control Group ◽  
Low Density ◽  
Significant Difference ◽  
Vitamin C Supplementation ◽  
Vit C

The present study was designed to investigate the effects of VêO® premium and vitamin C (Vit. C) supplementation on lipid profile before and during pregnancy in local Iraqi ewes during heat stress. The study was conducted in a private field in Fallujah city, west Iraq, during the period from 6/8/2019 to 8/2/2020. Twenty local Iraqi ewes were divided randomly into four equal groups (5 for each group) The first group (T1) was given VêO® premium (4 g/ ewe/ day), the second group (T2) was given VêO® premium (2 g/ ewe/ day), and the third group (T3) was given Vit. C (40 mg/ ewe/ day), and the fourth group (T4) was left without treatment, as a control group. After 14 days of treatment, vaginal sponges were inserted for 14 days and, after their withdrawal, the rams were introduced for 6 days. Blood samples were collected from the jugular vein into vacutainer tubes (10 ml) at 4 periods (periods 1 and 2 before pregnancy; periods 3 and 4 during pregnancy). Lipid profile parameters were also estimated, which includes cholesterol, triglyceride, high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and malondialdehyde (MDA). There were no significant difference in the serum levels of cholesterol, triglyceride, HDL, and LDL among the various treatments before and during pregnancy. The level of VLDL was significantly higher in T2 group as compared to the other treatments (P≤0.05) at the fourth periods. There was a significant difference in the level of MDA (P≤0.05) in treatment T3 in the first period compared with the treatments T1, T2, and T4, whereas treatment T4 showed significantly higher level (P≤0.05) in the second, third, and fourth periods as compared to treatments T1, T2, and T3. In conclusion, different effects of VêO® premium and Vitamin C supplementation were noticed on the lipid profile before and during pregnancy in local Iraqi ewes during heat stress.

Effect of High Dose Vitamin C Supplementation on Muscle Soreness, Damage, Function, and Oxidative Stress to Eccentric Exercise

2006 ◽  
Vol 16 (3) ◽  
pp. 270-280 ◽  
Author(s):  
S.C. Bryer ◽  
A.H. Goldfarb
Keyword(s):  
Oxidative Stress ◽  
Vitamin C ◽  
Eccentric Exercise ◽  
Muscle Function ◽  
Muscle Soreness ◽  
Damage Function ◽  
High Dose ◽  
Before And After ◽  
Vitamin C Supplementation ◽  
Glutathione Oxidation

This study investigated if vitamin C supplementation before and after eccentric exercise could reduce muscle soreness (MS), oxidative stress, and muscle function. Eighteen healthy men randomly assigned to either a placebo (P) or vitamin C (VC) (3 g/d) treatment group took pills for 2 wk prior and 4 d after performing 70 eccentric elbow extensions with their non-dominant arm. MS increased in both groups with significantly reduced MS for the first 24 h with VC. Range of motion was reduced equally in both groups after the exercise (P ≥ 0.05). Muscle force declined equally and was unaffected by treatment. VC attenuated the creatine kinase (CK) increase at 48 h after exercise with similar CK after this time. Gluta-thione ratio (oxidized glutathione/total glutathione) was significantly increased at 4 and 24 h with P but VC prevented this change. These data suggest that vitamin C pretreatment can reduce MS, delay CK increase, and prevent blood glutathione oxidation with little influence on muscle function loss.

scholarly journals In Vivo Protective Effects of Gallic Acid Isolated from Peltiphyllum Peltatum Against Sodium Fluoride-Induced Oxidative Stress in Rat Erythrocytes

2013 ◽  
Vol 64 (4) ◽  
pp. 553-559 ◽  
Author(s):  
Seyed Fazel Nabavi ◽  
Solomon Habtemariam ◽  
Antoni Sureda ◽  
Akbar Hajizadeh Moghaddam ◽  
Maria Daglia ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Superoxide Dismutase ◽  
Vitamin C ◽  
Gallic Acid ◽  
Sodium Fluoride ◽  
Enzyme Activities ◽  
Control Group ◽  
Rat Erythrocytes ◽  
Pre Treatment

Abstract Gallic acid has been identified as an antioxidant component of the edible and medicinal plant Peltiphyllum peltatum. The present study examined its potential protective role against sodium fluoride (NaF)-induced oxidative stress in rat erythrocytes. Oxidative stress was induced by NaF administration through drinking water (1030.675 mg m-3 for one week). Gallic acid at 10 mg kg-1 and 20 mg kg-1 and vitamin C for positive controls (10 mg kg-1) were administered daily intraperitoneally for one week prior to NaF administration. Thiobarbituric acid reactive substances, antioxidant enzyme activities (superoxide dismutase and catalase), and the level of reduced glutathione were evaluated in rat erythrocytes. Lipid peroxidation in NaF-exposed rats significantly increased (by 88.8 %) when compared to the control group (p<0.05). Pre-treatment with gallic acid suppressed lipid peroxidation in erythrocytes in a dose-dependent manner. Catalase and superoxide dismutase enzyme activities and glutathione levels were reduced by NaF intoxication by 54.4 %, 63.69 %, and 42 % (p<0.001; vs. untreated control group), respectively. Pre-treatment with gallic acid or vitamin C significantly attenuated the deleterious effects. Gallic acid isolated from Peltiphyllum peltatum and vitamin C mitigated the NaF-induced oxidative stress in rat erythrocytes.

Sign in / Sign up

Export Citation Format

Share Document