Complementary Effects of Multivitamin and Omega-3 Fatty Acid Supplementation on Indices of Cardiovascular Health in Individuals with Elevated Homocysteine

2012 ◽  
Vol 82 (1) ◽  
pp. 41-52 ◽  
Author(s):  
P. Earnest ◽  
S. Kupper ◽  
M. Thompson ◽  
Guo ◽  
S. Church
Keyword(s):  
Risk Factors ◽  
Cardiovascular Health ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Fatty Acid Supplementation ◽  
Omega 3 Fatty Acid ◽  
Reactive Protein ◽  
Daily Ingestion

Homocysteine (HCY), C-reactive protein (hsCRP), and triglycerides (TG) are risk factors for cardiovascular disease (CVD). While multivitamins (MVit) may reduce HCY and hsCRP, omega-3 fatty acids (N3) reduce TG; yet, they are seldom studied simultaneously. We randomly assigned 100 participants with baseline HCY (> 8.0 umol/L) to the daily ingestion of: (1) placebo, (2) MVit (VitC: 200 mg; VitE: 400 IU; VitB6: 25 mg; Folic Acid: 400 ug; VitB12: 400 ug) + placebo, (3) N3 (2 g N3, 760 mg EPA, 440 mg DHA)+placebo, or (4) MVit + N3 for 12 weeks. At follow-up, we observed significant reductions in HCY (umol/L) for the MVit (- 1.43, 95 %CI, - 2.39, - 0.47) and MVit + N3 groups (- 1.01, 95 %CI, - 1.98, - 0.04) groups, both being significant (p < 0.05) vs. placebo (- 0.57, 95 %CI, - 1.49, 0.35) and N3 (1.11, 95 % CI, 0.07, 2.17). hsCRP (nmol/L) was significantly reduced in the MVit (- 6.00, 95 %CI, - 1.04, - 0.15) and MVit + N3 (- 0.98, 95 %CI, - 1.51, - 0.46) groups, but not vs. placebo (- 0.15, 95 %CI, - 0.74, 0.43) or N3 (- 0.53, 95 %CI, - 1.18, 0.12). Lastly, we observed significant reductions in TG for the N3 (- 0.41, 95 %CI, - 0.69, - 0.13) and MVit + N3 (- 0.71, 95 %CI, - 0.93, - 0.46) groups, both significant vs. placebo (- 0.10, 95 %CI, - 0.36, 0.17) and MVit groups (0.15, 95 %CI, - 12, 0.42). The co-ingestion of MVit + N3 provides synergistic affects on HCY, hsCRP, and plasma TG.

scholarly journals Regular consumption of cod liver oil is associated with reduced basal and exercise-induced C-reactive protein levels; a prospective observational trial

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Mette Wærstad Hansen ◽  
Stein Ørn ◽  
Christine B. Erevik ◽  
Magnus Friestad Bjørkavoll-Bergseth ◽  
Øyvind Skadberg ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Strenuous Exercise ◽  
Cod Liver Oil ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Omega 3 Fatty Acid ◽  
Recreational Athletes ◽  
Reactive Protein ◽  
Supplement Use ◽  
Exercise Induced

Abstract Background Dietary supplement use among recreational athletes is common, with the intention of reducing inflammation and improving recovery. We aimed to describe the relationship between omega-3 fatty acid supplement use and inflammation induced by strenuous exercise. Methods C-reactive protein (CRP) concentrations were measured in 1002 healthy recreational athletes before and 24 h after a 91-km bicycle race. The use of omega-3 fatty acid supplements was reported in 856 out of 1002 recreational athletes, and the association between supplement use and the exercise-induced CRP response was assessed. Results Two hundred seventy-four subjects reported regular use of omega-3 fatty acid supplements. One hundred seventy-three of these used cod liver oil (CLO). Regular users of omega-3 fatty acid supplements had significantly lower basal and exercise-induced CRP levels as compared to non-users (n = 348, p < 0.001). Compared to non-users, regular users had a 27% (95% confidence interval (CI): 14–40) reduction in Ln CRP response (unadjusted model, p < 0.001) and 16% (95% CI: 5–28, p = 0.006) reduction after adjusting for age, sex, race duration, body mass index, delta creatine kinase, MET hours per week, resting heart rate and higher education. CLO was the primary driver of this response with a 34% (95% CI: 19–49) reduction (unadjusted model, p < 0.001) compared to non-users. Corresponding numbers in the adjusted model were 24% (95% CI: 11–38, p < 0.001). Conclusion Basal CRP levels were reduced, and the exercise-induced CRP response was attenuated in healthy recreational cyclists who used omega-3 fatty acid supplements regularly. This effect was only present in regular users of CLO. Trial registration NCT02166216, registered June 18, 2014 – Retrospectively registered.

scholarly journals Does omega-3 fatty acids supplementation affect C-Reactive protein and Nitric oxide in pediatric patients undergoing hemodialysis?

2016 ◽  
Vol 5 (5) ◽  
Author(s):  
Areej Mohamed Ateya ◽  
Dr. Nagwa Ali Sabri ◽  
Dr. Ihab El Hakim ◽  
Dr. Sara M Shaheen
Keyword(s):  
Nitric Oxide ◽  
Fatty Acids ◽  
Endothelial Dysfunction ◽  
Pediatric Patients ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Once Daily ◽  
Reactive Protein ◽  
Traditional Risk Factors

<italic>Background:</italic>Chronic kidney disease (CKD) is a worldwide public health problem in the pediatric population. Patients with CKD die of cardiovascular causes rather than from renal disease. There are several traditional and non-traditional risk factors for cardiovascular disease (CVD) in these patients. Endothelial dysfunction is one of the non-traditional risk factors for CVD. Many studies have shown the ability of omega-3 fatty acids to improve the endothelial function and reduce the cardiovascular events in the general population. Thus, the aim of this study was to evaluate the effect of omega-3 fatty acids supplementation on markers of endothelial dysfunction in children with CKD on regular hemodialysis (HD). <italic>Methods and procedures:</italic> This double-blinded randomized placebo-controlled trial included 49 pediatric patients on maintenance HD. Group 1 (n=25) received 1 g omega-3 capsule once daily and group 2 (n=24) received 1 g matched placebo capsule once daily. Both groups were treated for four months. Blood samples were taken from patients of both groups at baseline and after 4 months of supplementation. Serum samples were examined for C-reactive protein (CRP) and nitric oxide (NO) levels as markers of endothelial dysfunction. <italic>Results:</italic> Our results showed that CRP was reduced insignificantly in omega-3 group. NO levels showed no significant differences between groups at the end of the study. <italic>Conclusion:</italic> The administration of 1 g omega-3 capsule once daily for 4 months had no beneficial effects neither on CRP nor NO but should evaluate more.

scholarly journals Effect of omega 3 fatty acids on C-reactive protein and interleukin-6 in patients with advanced nonsmall cell lung cancer

Medicine ◽  
2018 ◽  
Vol 97 (37) ◽  
pp. e11971 ◽  
Author(s):  
Yan Lu ◽  
Ren-gang Chen ◽  
San-zou Wei ◽  
Han-guo Hu ◽  
Fei Sun ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Fatty Acids ◽  
Cell Lung Cancer ◽  
Interleukin 6 ◽  
Nonsmall Cell Lung Cancer ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Reactive Protein

From Homicide to Happiness – A Commentary on Omega-3 Fatty Acids in Human Society

2007 ◽  
Vol 19 (1-2) ◽  
pp. 9-19 ◽  
Author(s):  
Joseph R. Hibbeln
Keyword(s):  
Risk Factors ◽  
Fatty Acids ◽  
Fatty Acid ◽  
American Psychiatric Association ◽  
Human Society ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Omega 3 Fatty Acid ◽  
Increased Risk ◽  
Omega 6

The field of omega-3 fatty acid deficiencies as reversible risk factors in major psychiatric disorders has flourished in the last decade. Treatment recommendations of the American Psychiatric Association may be considered for application to more normative states of psychiatric health. Considered here is the proposition that an increased risk of personality disorders, and an increased sense of despair in normative populations, might be considered as symptoms of deficiencies of omega-3 fatty acids. The major changes in the essential fatty acid composition of the food supply, including increased availability of the omega-6 linoleic acid, may be correlated not only with increased risks of homicide, but also increased risks of suicide and suboptimal social cohesion.

Effects of Selective Cyclooxygenase-2 Inhibitor and Omega-3 Fatty Acid on Serum Interleukin-1β, Osteocalcin, and C-Reactive Protein Levels in Rats

2006 ◽  
Vol 77 (4) ◽  
pp. 657-663 ◽  
Author(s):  
Saynur Vardar-Şengül ◽  
Nurcan Buduneli ◽  
Eralp Buduneli ◽  
Haluk Baylas ◽  
Gül Atilla ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cyclooxygenase 2 ◽  
Interleukin 1Β ◽  
Omega 3 ◽  
C Reactive Protein ◽  
Omega 3 Fatty Acid ◽  
Protein Levels ◽  
Reactive Protein
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