Depressed and normal individuals differ both in selection and in perceived tonal quality of positive-negative messages.

1995 ◽  
Vol 104 (2) ◽  
pp. 305-311 ◽  
Author(s):  
J. Jeffrey Crowson ◽  
Rue L. Cromwell
Keyword(s):  
Normal Individuals ◽  
Negative Messages

scholarly journals The ulcerative colitis associated gene FUT8 regulates the quantity and quality of secreted mucins

2021 ◽  
Author(s):  
Gerard Cantero ◽  
Carla Burballa ◽  
Yuki Ohkawa ◽  
Tomohiko Fukuda ◽  
Yoichiro Harada ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Shear Stress ◽  
Stress Resistance ◽  
Viscoelastic Properties ◽  
Distal Part ◽  
Proximal Colon ◽  
Mucus Layer ◽  
Intracellular Accumulation ◽  
Normal Individuals

Fucosylation of mucins, the main macrocomponents of the mucus layer that protects the digestive tract from pathogens, increases their viscoelasticity and shear stress resistance. These properties are altered in patients with ulcerative colitis (UC), which is marked by a chronic inflammation of the distal part of the colon. Here we show that the levels of Fucosyltransferase 8 (FUT8) and specific mucins are increased in the distal inflamed colon of UC patients compared to normal individuals. Overexpressing FUT8, as observed in UC, in mucin-producing HT29-18N2 colonic cell line increases trafficking of MUC1 to plasma membrane and secretion of MUC2/MUC5AC. FUT8 depletion (FUT8 KD), instead, causes intracellular accumulation of MUC1 and alters the ratio of secreted MUC2 to MUC5AC. Mucins secreted by FUT8 overexpressing cells are more resistant to shear stress compared to mucins secreted by FUT8 KD cells. These data fit well with the Fut8-/- mice phenotype, which are protected against UC. Fut8-/- mice exhibit a thinner proximal colon mucus layer with an altered ratio of neutral to acidic mucins compared to Fut8+/+ mice. Together, these data reveal that FUT8 optimizes the viscoelastic properties of the extracellular mucous by controlling the quantities of mucins secreted.

scholarly journals EFFECT OF NEURAL MOBILIZATION ON BALANCE, FLEXIBILITY, STRENGTH AND GAIT IN STROKE PATIENTS

2020 ◽  
pp. 1-5
Author(s):  
Rosimere de Lima Souza ◽  
Karine Rocha Moriz ◽  
Francisca Deyze Reis Teixiera ◽  
Adriano Araújo Fernandes ◽  
Sinval Souza da Costa Neto ◽  
...  
Keyword(s):  
Muscular Strength ◽  
Hemorrhagic Stroke ◽  
Muscular Endurance ◽  
Stroke Patients ◽  
Homogeneous Sample ◽  
Neurological Sequelae ◽  
Positive Effects ◽  
Normal Individuals ◽  
Neurological Patients

Background: Neural mobilization is characterized by the neurodynamics of the nervous system with the objectives of: reducing musculoskeletal tension and pain and increasing muscular endurance and strength. Stroke is a worldwide health problem due to the impacts on quality of life, and makes the physical capacity of individuals after stroke about 40% lower of normal individuals of the same age. Objective: To verify the efficacy of neural mobilization in patients with stroke. Methods: This is a blinded randomized clinical trial performed in 12 volunteers, aged between 20 and 80 years, with a diagnosis of ischemic or hemorrhagic stroke. It was performed five mobilizations of 60 seconds in the bilateral sciatic nerve. The degree of balance and gait of the volunteers was verified, as well as the muscular strength and flexibility of the quadriceps and hamstrings muscles pre-mobilization, immediately after and after 10 sessions performed three times a week. Results: Neural mobilization on neurological patients showed positive effects in relation to flexibility, lower limb muscle strength, gait and balance. Conclusion: The present study demonstrated that the technique of neural mobilization can present good results in neurological patients with stroke sequelae. However, it is suggested that more studies be done with a larger number of volunteers and with a homogeneous sample on the approach of this technique in patients with neurological sequelae.

Personality pattern and quality of life among neurotic patients: A comparative study

2018 ◽  
Vol 9 (01) ◽  
Author(s):  
Anjana Bhattacharjee ◽  
Nabarupa Bhattacharya ◽  
Rebeka Debbarma
Keyword(s):  
Quality Of Life ◽  
Medical College ◽  
Normal Individuals ◽  
Significant Difference ◽  
Quality Of Life Scale ◽  
Life Scale ◽  
Personality Pattern ◽  
Insignificant Difference ◽  
Psychiatric Department

The present study attempted to compare neurotic patients and normal (non-neurotic) individuals with respect to their personality pattern and quality of life. For the said purpose a group of 50 neurotic patients were purposively selected from the OPD of Psychiatric department of Tripura Medical College, Hapania. Another matched group of normal persons was also purposively selected from West District. Data were collected by using NEO-Five Factor Personality Inventory developed Paul and McCrae (2008) and Quality of Life Scale-WHOQOL-BREF (1991). Data analysis revealed significant difference between neurotic and normal individuals with respect to their personality pattern and quality of life. However, insignificant difference was observed between them with respect to openness to experience dimension of their personality.

scholarly journals A Novel DNA Extraction Protocol from Frozen Blood of Normal Individuals and Patients Who Received Systemic Chemotherapy

2020 ◽  
Author(s):  
Hayder O. Hashim ◽  
Mohammed Baqur S. Al-Shuhaib
Keyword(s):  
Molecular Biology ◽  
Chemotherapeutic Drugs ◽  
Chain Reaction ◽  
Novel Approach ◽  
Normal Individuals ◽  
Negative Effect ◽  
Polymerase Chain ◽  
Positive Results ◽  
Validation Experiments

Herein, we describe a highly efficient, non-complicated, and non-organic procedure to overcome the negative effect of chemotherapeutic drugs on the quality of the extracted DNA by applying several modulations in cell washing, suspension, and lysis of cells treated with these drugs. In this protocol, 500µl were extracted from patients who received systemic sessions of chemotherapy. The validity of this protocol for digestion with restriction endonucleases and both conventional and real-time polymerase chain reaction were tested. This protocol proved obvious purity (1.8±0.02 and 2.1±1.2, for A260/280 and A260/230, respectively) and adequate yields (10±2.24) µg/100 ml. The positive results of validation experiments proved the validity of the extracted DNA for downstream applications of molecular biology. In addition to the proven efficiency of this protocol to extract DNA from normal samples, its validity was also confirmed from patients who were exposed to chemotherapy. This entails a novel approach to extract a molecular biology grade DNA without having inhibitors against enzymes used in digestion, amplification, and subsequent sequencing even after the systemic sessions with several doses of chemotherapy.

scholarly journals THE USE OF EXCHANGE TRANSFUSION FOR THE TREATMENT OF SEVERE ERYTHROBLASTOSIS DUE TO A-B SENSITIZATION, WITH OBSERVATIONS ON THE PATHOGENESIS OF THE DISEASE

Blood ◽  
1949 ◽  
Vol 4 (9) ◽  
pp. 1014-1032 ◽  
Author(s):  
A. S. WIENER ◽  
I. B. WEXLER ◽  
J. G. HURST
Keyword(s):  
Immune Globulin ◽  
Exchange Transfusion ◽  
Blood Groups ◽  
Maternal Serum ◽  
Normal Individuals ◽  
Rh Incompatibility ◽  
Antibody Titers ◽  
Per Se ◽  
In Pregnancy

Abstract Two unusual cases of severe erythroblastosis due to A and B sensitization have been presented. When injections of A and B group substances failed to arrest the disease, exchange transfusions were carried out, using 900 to 1,000 cc. of fresh group O blood. In each case the response was prompt and dramatic, although the convalescence in one was prolonged by an intercurrent diarrhea. Both infants have made complete recoveries and have developed normally both physically and mentally. Observations have been presented regarding the pathogenesis of erythroblastosis and icterus precox due to A-B sensitization. The following conclusions seem to be warranted on the basis of the evidence presented: 1. The greatest majority of cases of jaundice and anemia of the newborn that cannot be explained on the basis of Rh incompatibility are caused by incompatibility of the major blood groups. 2. High maternal alpha and beta antibody titers per se are not necessarily correlated with disease in the infant. 3. Univalent alpha and beta antibodies present in the maternal serum traverse the placenta and are the cause of the disease in the infant. Bivalent antibodies are held back by the intact placenta and play no or hardly any role in the causation of the disease. Univalent alpha and beta antibodies are demonstrable in the sera of a large proportion of "normal" individuals. 4. A-B sensitization in pregnancy occurs mainly when the infant belongs to the secretor type. 5. A theory is suggested that the quality of the alpha and beta antibodies, namely, whether they are homospecific or heterospecific, may affect the severity of the manifestations in the infant. Technics of titrating alpha and beta and Rh antibodies are described and discussed. A table has been prepared which converts antibody titers into concentrations of immune globulin in the serum, and demonstrates the impossibility of certain extravagantly high titers claimed in the literature.

Chronic Spontaneous Urticaria and Gut Flora (Lactobacilli)

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
M M Refaat ◽  
S T Kamal ◽  
A M M Elgendy ◽  
D H Ismail
Keyword(s):  
Gut Microbiota ◽  
Chronic Urticaria ◽  
Bacterial Load ◽  
Chronic Spontaneous Urticaria ◽  
Healthy Controls ◽  
Gut Flora ◽  
University Hospitals ◽  
Normal Individuals ◽  
Stool Samples

Abstract Background and Aims Chronic Urticaria is a common disorder which is defined by recurrent occurrence of wheals and sometimes angioedema. It has a notable influence on the patient’s quality of life. Regulation of the immune system is one of the important roles of the gut microbiota. Objective Comparing the frequency and bacterial load of Lactobacillus between patients with chronic urticaria and healthy controls. Methods Forty patients with chronic urticaria were recruited from the outpatient clinic of Allergy and Clinical Immunology at Ain Shams University Hospitals and 40 age and sex matched healthy individuals were included in the present study. Stool samples were analyzed for determining the frequency and bacterial load of Lactobacillus. Results There was a difference among the frequency of detectable Lactobacillus in stool samples of patients with chronic urticaria and healthy controls. The relative amounts of Lactobacillus were significantly higher in fecal samples from controls compared to patients with chronic urticaria (P < 0.001). Conclusion Our study showed that some types of gut microbiota are found in normal individuals in a higher amounts than patients with chronic spontaneous urticaria.

scholarly journals Reading eye movements performance on iPad vs print using a visagraph

2021 ◽  
Vol 14 (2) ◽  
Author(s):  
Alicia Feis ◽  
Amanda Lallensack ◽  
Elizabeth Pallante ◽  
Melanie Nielsen ◽  
Nicole Demarco ◽  
...  
Keyword(s):  
Eye Movements ◽  
Fixation Duration ◽  
Reading Speed ◽  
Normal Subjects ◽  
Reading Performance ◽  
Movement Characteristics ◽  
Normal Individuals ◽  
The Mean ◽  
Printed Text

This study investigated reading comprehension, reading speed, and the quality of eye movements while reading on an iPad, as compared to printed text. 31 visually-normal subjects were enrolled. Two of the passages were read from the Visagraph standardized text on iPad and Print. Eye movement characteristics and comprehension were evaluated. Mean (SD) fixation duration was significantly longer with the iPad at 270 ms (40) compared to the printed text (p=0.04) at 260 ms (40). Subjects’ mean reading rates were significantly lower on the iPad at 294 words per minute (wpm) than the printed text at 318 wpm (p=0.03). The mean (SD) overall reading duration was significantly (p=0.02) slower on the iPad that took 31 s (9.3) than the printed text at 28 s (8.0). Overall reading performance is lower with an iPad than printed text in normal individuals. These findings might be more consequential in children and adult slower readers when they read using iPads.  

scholarly journals GCT-57. ARE MELATONIN LEVELS A RELIABLE MARKER FOR INTRACRANIAL GERM CELL TUMORS POST TREATMENT DEFICIENCY?

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii339-iii339
Author(s):  
Andréa M Cappellano ◽  
Alex M M Fujita ◽  
Nasjla S Silva ◽  
Daniela B Almeida ◽  
Fernanda G Amaral
Keyword(s):  
Germ Cell ◽  
Mature Teratoma ◽  
Germ Cell Tumors ◽  
Pineal Tumors ◽  
Clinically Normal ◽  
Normal Individuals ◽  
Intracranial Germ Cell Tumors ◽  
Reliable Marker

Abstract BACKGROUND Pineal is the melatonin-producing gland, with this hormone importantly acting as a central and peripheral chronobiotic, antioxidant and in energy metabolism. The urinary dosage of 6-sulfatoxymelatonin (aMT6s), a melatonin metabolite, is an indirect marker to estimate the total melatonin nocturnal production, ranging in clinically normal individuals from 10–50 micrograms(ug). The purpose of this study was to evaluate aMT6s in patients with diagnosis of intracranial germ cell tumors (iGCT) treated at IOP/GRAACC/UNIFESP. METHODS After an interview to collect data about therapies employed and medications, night urine samples (from 8:00pm to first void in the morning) were collected and analyzed by ELISA. RESULTS Twenty patients between 5–42 years old (mean 20.9 years), all male, were analyzed. Thirteen patients had diagnosis of Germinoma, 1 with Imature Teratoma, 5 NGGCT and 2 Mature Teratoma. The first site was pineal (N=15) and bifocal (N=5). The treatment was surgery/biopsy/2º look surgery in 17 patients associated with chemotherapy/ radiotherapy, except in 2 (pure teratoma-surgery only) and 1 (chemo only). Three patients had diagnosis by tumor markers treated with chemo only (N=1) and chemotherapy/radiotherapy (N=2). The levels of aMT6s were between 0.2–3.2ug in all participants, except in one (14.8ug-biopsy, chemo and RT). CONCLUSION aMT6s levels found in most patients are below the expected for the general population suggesting that this is an appropriate marker for pineal tumors with melatonin deficiency. It may contribute to support future studies in this area and adoption of follow-up protocols, with eventual hormone supplementation and consequently improved quality of life.

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