Biology of upper-body and lower-body adipose tissue—link to whole-body phenotypes

2014 ◽  
Vol 11 (2) ◽  
pp. 90-100 ◽  
Author(s):  
Fredrik Karpe ◽  
Katherine E. Pinnick
Keyword(s):  
Adipose Tissue ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body

Isotope tracer measures of meal fatty acid metabolism: reproducibility and effects of the menstrual cycle

2005 ◽  
Vol 288 (3) ◽  
pp. E547-E555 ◽  
Author(s):  
Ana Paola Uranga ◽  
James Levine ◽  
Michael Jensen
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Fatty Acid ◽  
Menstrual Cycle ◽  
Dietary Fat ◽  
Fatty Acid Uptake ◽  
Upper Body ◽  
Acid Oxidation ◽  
Acid Uptake ◽  
Lower Body

Oxidation and adipose tissue uptake of dietary fat can be measured by adding fatty acid tracers to meals. These studies were conducted to measure between-study variability of these types of experiments and assess whether dietary fatty acids are handled differently in the follicular vs. luteal phase of the menstrual cycle. Healthy normal-weight men ( n = 12) and women ( n = 12) participated in these studies, which were block randomized to control for study order, isotope ([3H]triolein vs. [14C]triolein), and menstrual cycle. Energy expenditure (indirect calorimetry), meal fatty acid oxidation, and meal fatty acid uptake into upper body and lower body subcutaneous fat (biopsies) 24 h after the experimental meal were measured. A greater portion of meal fatty acids was stored in upper body subcutaneous adipose tissue (24 ± 2 vs. 16 ± 2%, P < 0.005) and lower body fat (12 ± 1 vs. 7 ± 1%, P < 0.005) in women than in men. Meal fatty acid oxidation (3H2O generation) was greater in men than in women (52 ± 3 vs. 45 ± 2%, P = 0.04). Leg adipose tissue uptake of meal fatty acids was 15 ± 2% in the follicular phase of the menstrual cycle and 10 ± 1% in the luteal phase ( P = NS). Variance in meal fatty acid uptake was somewhat ( P = NS) greater in women than in men, although menstrual cycle factors did not contribute significantly. We conclude that leg uptake of dietary fat is slightly more variable in women than in men, but that there are no major effects of menstrual cycle on meal fatty acid disposal.

Recognition and prediction of driver’s whole body posture model

2022 ◽  
pp. 095440702110686
Author(s):  
Jun Wu ◽  
Jian Liu ◽  
Xiuyuan Li ◽  
Lingbo Yan ◽  
Libo Cao ◽  
...  
Keyword(s):  
Regression Model ◽  
Body Posture ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body ◽  
Key Factor ◽  
Upper Body Posture ◽  
Spatial Coordinates ◽  
Posture Prediction ◽  
Connection Length

The driver’s whole-body posture at the time of a collision is a key factor in determining the magnitude of injury to the driver. However, current researchs on driver posture models only consider the upper body posture of the driver, and the lower body area which is not perceived by sensors is not studied. This paper investigates the driver’s posture and establishes a 3D posture model of the driver’s whole body through the application of machine vision algorithms and regression model statistics. This study proposes an improved Kinect-OpenPose algorithm for identifying the 3D spatial coordinates of nine keypoints of the driver’s upper body. The posture prediction regression model of four keypoints of the lower body is established by conducting volunteer posture acquisition experiments on the developed simulated driving seat and analyzing the volunteer posture data through using the principal components of the upper body keypoints and the seat parameters. The experiments proved that the error of the regression model in this paper is minor than that of current studies, and the accuracy of the keypoint location and the keypoint connection length of the established driver whole body posture model is high, which provides implications for future studies.

Effects of epinephrine on regional free fatty acid and energy metabolism in men and women

1996 ◽  
Vol 270 (2) ◽  
pp. E259-E264 ◽  
Author(s):  
M. D. Jensen ◽  
P. E. Cryer ◽  
C. M. Johnson ◽  
M. J. Murray
Keyword(s):  
Adipose Tissue ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Fat Distribution ◽  
Normal Weight ◽  
Upper Body ◽  
Lower Body ◽  
Men And Women

Upper-body and lower-body adipocytes respond differently to physiological catecholamines in vitro. It is not known whether this is true in vivo or whether gender differences exist in the regional adipose tissue responses to epinephrine. These studies were therefore conducted to examine free fatty acid (FFA) release ([3H]palmitate) from lower-body (leg), splanchnic, and upper-body adipose tissue in normal-weight adult men (n = 8) and women (n = 7). In response to intravenous epinephrine (10 ng.kg-1.min-1), palmitate release increased (P < 0.01) in both men (168 +/- 10 to 221 +/- 15 mumol/min) and women (177 +/- 12 to 234 +/- 18 mumol/min). Basal leg palmitate release was similar in women and men (16.8 +/- 2.9 and 12.4 +/- 1.3 mumol/min, P = not significant) but doubled (P < 0.01) in response to epinephrine in men and was virtually unchanged in women. Splanchnic palmitate release increased (P < 0.05) in men (n = 6) but not in women (n = 6), whereas nonsplanchnic upper-body palmitate release increased more in women than in men. Upper-body (splanchnic and nonsplanchnic) palmitate release increased (P < 0.05) in both men and women in response to epinephrine. In summary, lower-body adipose tissue FFA release increased in response to epinephrine in men but not women, whereas upper-body palmitate release increased in both groups. These findings are consistent with some in vitro findings and suggest that catecholamine action may play a role in determining gender-based differences in body fat distribution.

Leptin production during early starvation in lean and obese women

2000 ◽  
Vol 278 (2) ◽  
pp. E280-E284 ◽  
Author(s):  
Samuel Klein ◽  
Jeffrey F. Horowitz ◽  
Michael Landt ◽  
Stephen J. Goodrick ◽  
Vidya Mohamed-Ali ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Upper Body ◽  
Whole Body ◽  
Obese Women ◽  
Local Production ◽  
Abdominal Adipose Tissue ◽  
Arterial Concentration ◽  
Relative Decline ◽  
Plasma Leptin ◽  
Subcutaneous Adipose

We evaluated abdominal adipose tissue leptin production during short-term fasting in nine lean [body mass index (BMI) 21 ± 1 kg/m2] and nine upper body obese (BMI 36 ± 1 kg/m2) women. Leptin kinetics were determined by arteriovenous balance across abdominal subcutaneous adipose tissue at 14 and 22 h of fasting. At 14 h of fasting, net leptin release from abdominal adipose tissue in obese subjects (10.9 ± 1.9 ng ⋅ 100 g tissue ⋅ − 1 ⋅ min− 1) was not significantly greater than the values observed in the lean group (7.6 ± 2.1 ng ⋅ 100 g− 1 ⋅ min− 1). Estimated whole body leptin production was approximately fivefold greater in obese (6.97 ± 1.18 μg/min) than lean subjects (1.25 ± 0.28 μg/min) ( P < 0.005). At 22 h of fasting, leptin production rates decreased in both lean and obese groups (to 3.10 ± 1.31 and 10.5 ± 2.3 ng ⋅ 100 g adipose tissue− 1 ⋅ min− 1, respectively). However, the relative declines in both arterial leptin concentration and local leptin production in obese women (arterial concentration 13.8 ± 4.4%, local production 10.0 ± 12.3%) were less ( P < 0.05 for both) than the relative decline in lean women (arterial concentration 39.0 ± 5.5%, local production 56.9 ± 13.0%). This study demonstrates that decreased leptin production accounts for the decline in plasma leptin concentration observed after fasting. However, compared with lean women, the fasting-induced decline in leptin production is blunted in women with upper body obesity. Differences in leptin production during fasting may be responsible for differences in the neuroendocrine response to fasting previously observed in lean and obese women.

Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr

2000 ◽  
Vol 89 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Ian Janssen ◽  
Steven B. Heymsfield ◽  
ZiMian Wang ◽  
Robert Ross
Keyword(s):  
Skeletal Muscle ◽  
Gender Differences ◽  
Body Weight ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body ◽  
Large Measure ◽  
Imaging Protocol ◽  
Men And Women ◽  
Magnetic Resonance Imaging Protocol

We employed a whole body magnetic resonance imaging protocol to examine the influence of age, gender, body weight, and height on skeletal muscle (SM) mass and distribution in a large and heterogeneous sample of 468 men and women. Men had significantly ( P < 0.001) more SM in comparison to women in both absolute terms (33.0 vs. 21.0 kg) and relative to body mass (38.4 vs. 30.6%). The gender differences were greater in the upper (40%) than lower (33%) body ( P < 0.01). We observed a reduction in relative SM mass starting in the third decade; however, a noticeable decrease in absolute SM mass was not observed until the end of the fifth decade. This decrease was primarily attributed to a decrease in lower body SM. Weight and height explained ∼50% of the variance in SM mass in men and women. Although a linear relationship existed between SM and height, the relationship between SM and body weight was curvilinear because the contribution of SM to weight gain decreased with increasing body weight. These findings indicate that men have more SM than women and that these gender differences are greater in the upper body. Independent of gender, aging is associated with a decrease in SM mass that is explained, in large measure, by a decrease in lower body SM occurring after the fifth decade.

The Neuromuscular Qualities of Higher- and Lower-Level Mixed-Martial-Arts Competitors

2017 ◽  
Vol 12 (5) ◽  
pp. 612-620 ◽  
Author(s):  
Lachlan P. James ◽  
Emma M. Beckman ◽  
Vincent G. Kelly ◽  
G. Gregory Haff
Keyword(s):  
Martial Arts ◽  
Bench Press ◽  
Isometric Force ◽  
Average Power ◽  
Dynamic Strength ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body ◽  
Mixed Martial Arts ◽  
Body Dynamic

Purpose:To determine whether the maximal strength, impulse, and power characteristics of competitive mixed-martial-arts (MMA) athletes differ according to competition level.Methods:Twenty-nine male semiprofessional and amateur MMA competitors were stratified into either higher-level (HL) or lower-level (LL) performers on the basis of competition grade and success. The 1-repetition-maximum (1RM) squat was used to assess lower-body dynamic strength, and a spectrum of impulse, power, force, and velocity variables were evaluated during an incremental-load jump squat. In addition, participants performed an isometric midthigh pull (IMTP) and 1RM bench press to determine whole-body isometric force and upper-body dynamic strength capabilities, respectively. All force and power variables were expressed relative to body mass (BM).Results:The HL competitors produced significantly superior values across a multitude of measures. These included 1RM squat strength (1.84 ± 0.23 vs 1.56 ± 0.24 kg BM; P = .003), in addition to performance in the incremental-load jump squat that revealed greater peak power (P = .005–.002), force (P = .002–.004), and velocity (P = .002–.03) at each load. Higher measures of impulse (P = .01–.04) were noted in a number of conditions. Average power (P = .002–.02) and velocity (P = .01–.04) at all loads in addition to a series of rate-dependent measures were also superior in the HL group (P = .005–.02). The HL competitors’ 1RM bench-press values approached significantly greater levels (P = .056) than the LL group’s, but IMTP performance did not differ between groups.Conclusions:Maximal lower-body neuromuscular capabilities are key attributes distinguishing HL from LL MMA competitors. This information can be used to inform evidenced-based training and performance-monitoring practices.

Effects of Sitting and Standing Work Postures on Short-Term Typing Performance and Discomfort

2016 ◽  
Vol 60 (1) ◽  
pp. 460-464 ◽  
Author(s):  
Gourab Kar ◽  
Alan Hedge
Keyword(s):  
Repeated Measures ◽  
Upper Body ◽  
Whole Body ◽  
Body Region ◽  
Lower Body ◽  
Analog Scale ◽  
Short Term ◽  
Work Posture ◽  
Body Discomfort ◽  
Typing Task

The study evaluated effects of sitting and standing work postures on objective short-term computer typing performance and perceived discomfort. A randomized, repeated measures, study design was used to assess typing performance and perceived discomfort for 12 participants on a 15-minute computer-typing task. Typing performance was measured by number of characters typed and number of errors. Perceived discomfort was measured for the whole body, as well as for upper body and lower body, using a visual analog scale. Results suggest that for a short-term computer typing task, compared to a sitting work posture a standing work posture leads to fewer typing errors without impacting typing speed. Overall levels of perceived discomfort for the whole body are similar for sitting and standing work postures. However, for perceived discomfort there is an interaction of work posture and body region - upper body discomfort is higher in the sitting work posture while lower body discomfort is higher in the standing work posture.

scholarly journals The onset time of balance control during walking is phase-independent, but the magnitude of the response is not

2019 ◽  
Author(s):  
Hendrik Reimann ◽  
Tyler Fettrow ◽  
David Grenet ◽  
Elizabeth D. Thompson ◽  
John J. Jeka
Keyword(s):  
Nervous System ◽  
Gait Cycle ◽  
Center Of Pressure ◽  
Body Movement ◽  
Reaction Force ◽  
The Body ◽  
Upper Body ◽  
Whole Body ◽  
Lower Body ◽  
The Central Nervous System

AbstractThe human body is mechanically unstable during walking. Maintaining upright stability requires constant regulation of muscle force by the central nervous system to push against the ground and move the body mass in the desired way. Activation of muscles in the lower body in response to sensory or mechanical perturbations during walking is usually highly phase-dependent, because the effect any specific muscle force has on the body movement depends upon the body configuration. Yet the resulting movement patterns of the upper body after the same perturbations are largely phase-independent. This is puzzling, because any change of upper-body movement must be generated by parts of the lower body pushing against the ground. How do phase-dependent muscle activation patterns along the lower body generate phase-independent movement patterns of the upper body? We hypothesize that in response to a perceived threat to balance, the nervous system generates a functional response by pushing against the ground in any way possible with the current body configuration. This predicts that the changes in the ground reaction force patterns following a balance perturbation should be phase-independent. Here we test this hypothesis by disturbing upright balance using Galvanic vestibular stimulation at three different points in the gait cycle. We measure the resulting changes in whole-body center of mass movement and the location of the center of pressure of the ground reaction force. We find that the whole-body balance response is not phase-independent as expected: balance responses are initiated faster and are smaller following a disturbance late in the gait cycle. Somewhat paradoxically, the initial center of pressure changes are larger for perturbations late in the gait cycle. The onset of the center of pressure changes however, does not depend on the phase of the perturbation. The results partially support our hypothesis of a phase-independent functional balance response underlying the phase-dependent recruitment of different balance mechanisms at different points of the gait cycle. We conclude that the central nervous system recruits any available mechanism to push against the ground to maintain balance as fast as possible in response to a perturbation, but the different mechanisms do not have equal strength.

scholarly journals Whole body, adipose tissue, and forearm norepinephrine kinetics in lean and obese women

1998 ◽  
Vol 275 (5) ◽  
pp. E830-E834 ◽  
Author(s):  
Simon W. Coppack ◽  
Jeffrey F. Horowitz ◽  
Deanna S. Paramore ◽  
Philip E. Cryer ◽  
Henry D. Royal ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Adipose Tissue ◽  
Body Mass ◽  
Fat Free Mass ◽  
Upper Body ◽  
Whole Body ◽  
Obese Women ◽  
Abdominal Vein ◽  
Subcutaneous Abdominal Adipose Tissue ◽  
Forearm Vein

We evaluated whole body and regional (subcutaneous abdominal adipose tissue and forearm) norepinephrine (NE) kinetics in seven lean (body mass index 21.3 ± 0.5 kg/m2) and six upper body obese (body mass index 36.4 ± 0.4 kg/m2) women who were matched on fat-free mass. NE kinetics were determined by infusing [3H]NE and obtaining blood samples from a radial artery, a deep forearm vein draining mostly skeletal muscle, and an abdominal vein draining subcutaneous abdominal fat. Mean systemic NE spillover tended to be higher in obese (2.82 ± 0.49 nmol/min) than in lean (2.53 ± 0.40 nmol/min) subjects, but the differences were not statistically significant. Adipose tissue and forearm NE spillover rates into plasma were greater in lean (0.91 ± 0.08 pmol ⋅ 100 g tissue−1 ⋅ min−1and 1.01 ± 0.09 pmol ⋅ 100 ml tissue−1 ⋅ min−1, respectively) than in obese (0.26 ± 0.05 pmol ⋅ 100 g tissue−1 ⋅ min−1and 0.58 ± 0.11 pmol ⋅ 100 ml tissue−1 ⋅ min−1, respectively) subjects ( P < 0.01). These results demonstrate that adipose tissue is an active site for NE metabolism in humans. Adipose tissue NE spillover is considerably lower in obese than in lean women, which may contribute to the lower rate of lipolysis per kilogram of fat mass observed in obesity.

Whole body and abdominal lipolytic sensitivity to epinephrine is suppressed in upper body obese women

2000 ◽  
Vol 278 (6) ◽  
pp. E1144-E1152 ◽  
Author(s):  
Jeffrey F. Horowitz ◽  
Samuel Klein
Keyword(s):  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Lipolytic Activity ◽  
Fat Free Mass ◽  
Upper Body ◽  
Whole Body ◽  
Tissue Blood Flow ◽  
Obese Women ◽  
Epinephrine Infusion ◽  
Subcutaneous Adipose

We measured whole body and regional lipolytic and adipose tissue blood flow (ATBF) sensitivity to epinephrine in 8 lean [body mass index (BMI): 21 ± 1 kg/m2] and 10 upper body obese (UBO) women (BMI: 38 ± 1 kg/m2; waist circumference >100 cm). All subjects underwent a four-stage epinephrine infusion (0.00125, 0.005, 0.0125, and 0.025 μg ⋅ kg fat-free mass−1 ⋅ min−1) plus pancreatic hormonal clamp. Whole body free fatty acid (FFA) and glycerol rates of appearance (Ra) in plasma were determined by stable isotope tracer methodology. Abdominal and femoral subcutaneous adipose tissue lipolytic activity was determined by microdialysis and 133Xe clearance methods. Basal whole body FFA Ra and glycerol Ra were both greater ( P < 0.05) in obese (449 ± 31 and 220 ± 12 μmol/min, respectively) compared with lean subjects (323 ± 44 and 167 ± 21 μmol/min, respectively). Epinephrine infusion significantly increased FFA Ra and glycerol Ra in lean (71 ± 21 and 122 ± 52%, respectively; P < 0.05) but not obese subjects (7 ± 6 and 39 ± 10%, respectively; P = not significant). In addition, lipolytic and ATBF sensitivity to epinephrine was blunted in abdominal but not femoral subcutaneous adipose tissue of obese compared with lean subjects. We conclude that whole body lipolytic sensitivity to epinephrine is blunted in women with UBO because of decreased sensitivity in upper body but not lower body subcutaneous adipose tissue.

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