scholarly journals A comprehensive review on biomarkers associated with painful temporomandibular disorders

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Mayank Shrivastava ◽  
Ricardo Battaglino ◽  
Liang Ye
Keyword(s):  
Temporomandibular Disorders ◽  
Orofacial Pain ◽  
Temporomandibular Disorder ◽  
Complex Nature ◽  
Complex Interplay ◽  
Orofacial Region ◽  
Neuroimaging Biomarkers ◽  
Relationship Of ◽  
Global Health Problem

AbstractPain of the orofacial region is the primary complaint for which patients seek treatment. Of all the orofacial pain conditions, one condition that possess a significant global health problem is temporomandibular disorder (TMD). Patients with TMD typically frequently complaints of pain as a symptom. TMD can occur due to complex interplay between peripheral and central sensitization, endogenous modulatory pathways, and cortical processing. For diagnosis of TMD pain a descriptive history, clinical assessment, and imaging is needed. However, due to the complex nature of pain an additional step is needed to render a definitive TMD diagnosis. In this review we explicate the role of different biomarkers involved in painful TMD. In painful TMD conditions, the role of biomarkers is still elusive. We believe that the identification of biomarkers associated with painful TMD may stimulate researchers and clinician to understand the mechanism underlying the pathogenesis of TMD and help them in developing newer methods for the diagnosis and management of TMD. Therefore, to understand the potential relationship of biomarkers, and painful TMD we categorize the biomarkers as molecular biomarkers, neuroimaging biomarkers and sensory biomarkers. In addition, we will briefly discuss pain genetics and the role of potential microRNA (miRNA) involved in TMD pain.

scholarly journals Associação entre a sintomatologia dolorosa e a disfunção temporomandibular

2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Wyllka Cyntya Galvão da Silva ◽  
Karolinne Domingos Medeiros ◽  
Eloisa Cesário Fernandes ◽  
Sandja Gabriela Oliveira ◽  
Caio Rodrigues Maia ◽  
...  
Keyword(s):  
Diagnostic Criteria ◽  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
Epidemiologic Study ◽  
Masticatory Muscles ◽  
Degenerative Disorders ◽  
International Conference On Bioinformatics ◽  
Research Diagnostic Criteria

Introdução: A Disfunção Temporomandibular (DTM) é um quadro patológico que afeta o sistema estomatognático e, frequentemente, acompanhada de dor. Objetivos: Aferir o nível de dor dos pacientes portadores de DTM e a prevalência de sintomatologia articular e muscular. Percebeu-se que a relação entre a origem da DTM e a sintomatologia dolorosa é pouco relatada na literatura. Materiais e Métodos: Trata-se de um estudo descritivo, observacional de corte transversal, desenvolvido com 30 pacientes com DTM, diagnosticado pelo Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). A amostra foi determinada pelas estimativas de atendimento. A associação entre a sintomatologia e a origem da DTM foram verificadas através do teste qui-quadrado, com intervalos de confiança (95%). Foi usada uma ficha clínica para a coleta de dados com idade, gênero e nível da dor, que foi aferido através da Escala Visual Analógica de dor. Resultados: Constatou-se que 26 pacientes eram do sexo feminino e 4 do sexo masculino. Quinze apresentaram idade inferior a 36,5 anos, e os outros uma idade superior a esta. Quanto a origem da DTM, 19 tinham desordem articular e 11 muscular. A categoria moderada foi o nível mais prevalente, seguida do intenso. Determinou-se que não houve associação estatisticamente significante entre as variáveis deste estudo com a DTM. Conclusão: Constatou-se que, os fatores etiológicos analisados isoladamente não influenciam de forma única no desenvolvimento da DTM, mas poderão atuar em conjunto com outros fatores, já que a sua causa é multifatorial.Descritores: Dimensão Vertical; Boca Edêntula; Dor Facial; Síndrome da Disfunção da Articulação Temporomandibular.ReferênciasDworkin SF, LeResche L. Research diagnostic criteria for temporomandibular disorders: review, criteria, examinations and specifications, critique. J Craniomandib Disord. 1992;6(4):301-55.Gonçalves DAG, Bigal ME, Jales LCF, Camparis CM, Speciali JG. Headache and symptoms of temporomandibular disorders: an epidemiologic study. Headache. 2010;50(2):231-41.Piccin CF, Pozzebon D, Chiodelli L, Boufleus J, Pasinato F, Corrêa ECR. Aspectos clínicos e psicossociais avaliados por critérios de diagnóstico para disfunção temporomandibular. Revista Cefac. 2016;18(1):113-19.Winocur E, Emodi-Perlman A. Occlusion, orthodontic treatment and temporomandibular disorders: myths and scientific evidences. in: Orthodonthics-basis aspects and clinical considerations. In Tech. 2012.Jorge JMS, Dini C, Santos L, Camara de Bem SH, Custodio W. Associação entre dimensão vertical de oclusão e transtornos temporomandibulares. ClipeOdonto – UNITAU. 2016;8(1):44- 50.Bayma PTC, Feltrin PP, Dias CAS, Costa JF, Laganá DC, Inoue RT. Temporomandibular disorders in otolaryngology patients. RGO (Porto Alegre). 2010;58(3):313-17.Martinez JE, Grassi DC, Marques LG. Análise da aplicabilidade de três instrumentos de avaliação de dor em distintas unidades de atendimento: ambulatório, enfermaria e urgência. Rev Bras Reumatol. 2011;51(4):299-308.Slade GD, Ohrbach R, Greenspan JD, Fillingim RB, Bair E, Sanders AE et al. Painful temporomandibular disorder: decade of discovery from OPPERA studies. J Dental Res. 2016; 95(10):1084-92.Rauhala K., Oikarinen KS, Raustia AM. Role of temporomandibular disorders (TMD) in facial pain: occlusion, muscle and TMJ pain. Cranio. 1999;17(4):254-61.Manfredini D, Favero L, Gregorini G, Cocilovo F, Guarda-Nardini L. Natural course of temporomandibular disorders with low painrelated impairment: a 2-to-3-year follow-up study. J Oral Rehabil. 2013;40(6):436-42.Freitas LS. Associação da disfunção Temporomandibular com o polimorfismo 102T-C do gene receptor da serotonina HTR2A [tese]. São José do Rio Preto: Faculdade de Medicina do São José do Rio Preto – FAMERP; 2011.Tanaka E, Detamore MS, Mercuri LG. Degenerative disorders of the temporomandibular joint: etiology, diagnosis, and treatment. J Dent Res. 2008;87(4):296-307.Lopes PRR, Campos PSF, Nascimento RJM. Dor e inflamação nas disfunções temporomandibulares: revisão de literatura dos últimos quatro anos. R Ci med biol. 2011;10(3):317-25.Wang X, Guo H, Wang Y, Yi X. The effects of estrogen on cytoplasmic ca2+ concentration of masticatory muscles myoblast in acid condition. 5th International Conference on Bioinformatics and Biomedical Engineering (iCBBE); 10-12 May 2011; Wuhan, China. Anais. Disponível em http://www.icbbe.org/2011/Proceeding2010.aspx.Cairns BE. Pathophysiology of TMD Pain—Basic Mechanisms and Their Implications for pharmacotherapy. J Oral Rehabil. 2010; 37(6):391-410.Portinho CP, Razera MV, Splitt BI, Gorgen ARH, Faller GJ, Collares MVM. Apresentação clínica inicial em pacientes com disfunção Temporomandibular. Rev Bras Cir Craniomaxilofac. 2012;15(3):109-12.

scholarly journals The relationship of occlusal disharmonies and symptoms of temporomandibular disorders

2006 ◽  
Vol 134 (9-10) ◽  
pp. 380-385 ◽  
Author(s):  
Slobodan Dodic ◽  
Darinka Stanisic-Sinobad ◽  
Miroslav Vukadinovic
Keyword(s):  
Temporomandibular Disorders ◽  
Function Analysis ◽  
Temporomandibular Disorder ◽  
Control Group ◽  
Asymptomatic Group ◽  
Posterior Teeth ◽  
Average Value ◽  
Significant Difference ◽  
Relationship Of ◽  
Contact Position

Introduction: The influence of occlusal condition on the onset of temporomandibular disorder (TMD) has been strongly debated for many years and is still the source of controversy. Until 1980s, the occlusal factors such as the presence of uncured malocclusions, discrepancies between intercuspal position (ICP) and retruded contact position (RCP) greater than two millimeters, occlusal abnormality, particularly mediotrusion and retrusion, and loss of posterior teeth were considered the primary causes of TMD. Objective: The objective of our study was to find correlation of occlusion disharmonies (difference between ICP and RCP) and present sings and symptoms of TMD. Method: The study involved 60 subjects between 18 and 26 years of age who were divided in two groups. The study group consisted of 30 subjects between 18 and 26 years of age with sings and symptoms of temporomandibular disorders (TMD). TMD was confirmed according to Helkimo index. An average value of Helkimo index in this group was 1. The control group included 30 subjects between 20 and 25 years of age without TMD sings and symptoms. An average value of Helkimo index in this group was 0. The function analysis of cinematic centers position in RCP and ICP was performed in each subject using the computer pantograph Arcus-Digma (KaVo EWL GmbH, Leutkirch, Germany). Results: The results of our study showed that the translation tracing of cinematic points from RCP to ICP was significantly different in TMD subjects and asymptomatic group (p>0.16). In addition, the study revealed that 53.4 % of subjects with sings and symptoms of temporomandibular disorders had marked translation in the lower temporomandibular joint (0.61-1.2 mm) what directed to intracapsular disorders. Conclusion: The results of our study suggested significant difference of RCP and ICP between subjects with sings and symptoms of the temporomandibular disorders and subjects without sings and symptoms.

Prevalence of Sign and Symptoms of Temporomandibular Joint Disorders in Pakistani Population at Sheikhupura, Lahore: A Gender comparison

2021 ◽  
Vol 15 (8) ◽  
pp. 2166-2168
Author(s):  
Ashfaq-ur- Rahim ◽  
Muhammad Nauman ◽  
Sadiq Ali ◽  
Saima Ihsan ◽  
Tannaza Qayyum ◽  
...  
Keyword(s):  
Temporomandibular Joint ◽  
Temporomandibular Disorders ◽  
Orofacial Pain ◽  
Temporomandibular Disorder ◽  
Signs And Symptoms ◽  
Temporomandibular Joint Disorders ◽  
Female Ratio ◽  
Pakistani Population ◽  
Female Predominance ◽  
History Of

Background: Temporomandibular disorders have been considered as a common orofacial pain condition. The term temporomandibular pain dysfunction (TMPD) is used synonymously with myofacial pain dysfunction disorder/syndrome, temporomandibular disorder, craniomandibular disorder and many other terms. Objective: To evaluate the prevalence of signs and symptoms of temporo-mandibular joint disorder (TMD). Study Design: Descriptive cross-sectional study Place and Duration of Study: Department of Oral and Maxillofacial Surgery, Faryal Dental College, Sheikhupura , Lahore, Pakistan from 1st February 2019 to 31st May 2021. Methodology: One hundred adolescents aged 15 to 60 years were enrolled. A detailed history about the chief complaint was taken and clinical examination was done. Temporomandibular joint examination performed included Auscultation for temporomandibular joint sounds like clicking and crepitus and palpation of both TMJs and associated muscles for evaluation of pain. Results: The most common signs of temporomandibular joint disorders were temporomandibular joint pain 78%, temporomandibular joint clicking 53% and trismus 29%. The most prevalent predisposing factors of temporomandibular joint disorders were parafunctional habits 40%, unknown factors 23% and history of road traffic accident/history of difficult extractions 9%. Male to female ratio showed female predominance (P = 0.001). Conclusion: Signs and symptoms of temporomandibular joint disorders were prevalent in Pakistani population with a clear female predominance. Key words: Temporomandibular disorders, Temporomandibular joint, Orofacial pain, Bruxism, Headache, Pain

scholarly journals Self-medication in patients with temporomandibular disorders

2014 ◽  
Vol 17 (4) ◽  
pp. 82 ◽  
Author(s):  
Isabela Maddalena Dias ◽  
Lilian Alves Guedes ◽  
Patricia Cataldo de Felipe Cordeiro ◽  
Isabel Cristina Gonçalves Leite ◽  
Fabíola Pessoa Pereira Leite
Keyword(s):  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
Self Medication ◽  
Main Complaint ◽  
Constant Pain ◽  
High Prevalence ◽  
Orofacial Region ◽  
School Of Dentistry ◽  
Clinical Problems

<p>Temporomandibular Disorders (TMD) are a set of painful and / or functional clinical problems that affect the joints and / or muscles of the orofacial region. The practice of self-medication, defined as the consumption of unprescribed drugs, is explained in most TMD patient cases by the occurrence of constant pain, producing discomfort and fatigue, while performing essential functions such as chewing, speaking, and swallowing, causing a drop in the quality of life of patients who have this disorder. Because of this, many see medication as a quick and sufficient means of addressing the problem of pain, and do not seek help from a professional. This study therefore aimed to evaluate, through guided interviews, the practice of self-medication in patients with temporomandibular disorder. The researchers interviewed 115 patients who were referred for treatment at the Diagnosis and Treatment Service for Patients with Temporomandibular Disorder (TMJ Service), School of Dentistry, Federal University of Juiz de Fora. In the sample studied there was a high prevalence of self-medication among the patients interviewed, of whom 71.3% used medication without a prescription, with a majority being female (84.14%). Headache was the main complaint reported by patients who self-medicated (39.53%), analgesics the most used drug class (58.13%), and most of the pain relief drugs were acquired through old prescriptions (40.25%). Thus, this work emphasizes the importance of guiding the patient and the professional regarding this practice.</p>

scholarly journals Analyzing Menton Deviation in Posteroanterior Cephalogram in Early Detection of Temporomandibular Disorder

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Trelia Boel ◽  
Ervina Sofyanti ◽  
Erliera Sufarnap
Keyword(s):  
Early Detection ◽  
Symmetry Group ◽  
Significant Relationship ◽  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
Facial Asymmetry ◽  
Craniofacial Anomalies ◽  
Significant Difference ◽  
Relationship Of ◽  
The Relationship

Introduction. Some clinicians believed that mandibular deviation leads to facial asymmetry and it also had a correlation with temporomandibular disorders (TMDs). Posteroanterior (PA) cephalogram was widely reported as a regular record in treating facial asymmetry and craniofacial anomalies. The objective of this study was to analyze the relationship of menton deviation in PA cephalogram with temporomandibular disorders (TMDs) symptoms. Materials and Methods. TMJ function was initially screened based on TMD-DI questionnaire. PA cephalogram of volunteer subjects with TMDs (n=37) and without TMDs (n=33) with mean age of 21.61±2.08 years was taken. The menton deviation was measured by the distance (mm) from menton point to midsagittal reference (MSR) horizontally, using software digitized measurement, and categorized as asymmetric if the value is greater than 3 mm. The prevalence and difference of menton deviation in both groups were evaluated by unpaired t-test. Result. The prevalence of symmetry group showed that 65.9% had no TMDs with mean of 1,815 ± 0,71 mm; in contrast, the prevalence of asymmetry group showed that 95.5% reported TMDs with mean of 3,159 ± 1,053 mm. There was a significant difference of menton deviation to TMDs (p=0.000) in subjects with and without TMDs. Conclusion. There was a significant relationship of menton deviation in PA cephalogram with TMDs based on TMD-DI index.

The Role of Pharmacy in the Management of Patients with Temporomandibular Disorders and Orofacial Pain

1998 ◽  
Vol 38 (3) ◽  
pp. 354-363 ◽  
Author(s):  
Gayle A. Brazeau ◽  
Henry A. Gremillion ◽  
Charles G. Widmer ◽  
Parker E. Mahan ◽  
Melvin B. Benson ◽  
...  
Keyword(s):  
Temporomandibular Disorders ◽  
Orofacial Pain

scholarly journals Glia and Orofacial Pain: Progress and Future Directions

2021 ◽  
Vol 22 (10) ◽  
pp. 5345
Author(s):  
Yi Ye ◽  
Elizabeth Salvo ◽  
Marcela Romero-Reyes ◽  
Simon Akerman ◽  
Emi Shimizu ◽  
...  
Keyword(s):  
Nervous System ◽  
Molecular Mechanisms ◽  
Orofacial Pain ◽  
Ganglion Cells ◽  
Temporomandibular Joint Dysfunction ◽  
Future Directions ◽  
Central Processing ◽  
Orofacial Region ◽  
The Central Nervous System

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide. Research on the molecular mechanisms of orofacial pain has predominately focused on the role of neurons underlying nociception. However, aside from neural mechanisms, non-neuronal cells, such as Schwann cells and satellite ganglion cells in the peripheral nervous system, and microglia and astrocytes in the central nervous system, are important players in both peripheral and central processing of pain in the orofacial region. This review highlights recent molecular and cellular findings of the glia involvement and glia–neuron interactions in four common orofacial pain conditions such as headache, dental pulp injury, temporomandibular joint dysfunction/inflammation, and head and neck cancer. We will discuss the remaining questions and future directions on glial involvement in these four orofacial pain conditions.

scholarly journals The impact of occlusal support on temporomandibular disorders: a literature review

2021 ◽  
pp. 201010582110237
Author(s):  
Minh Son Nguyen ◽  
Mare Saag ◽  
Triin Jagomägi ◽  
Quang Hai Nguyen ◽  
Ülle Voog-Oras
Keyword(s):  
Temporomandibular Joint ◽  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
Aetiological Factor ◽  
Posterior Teeth ◽  
Number Of Teeth ◽  
Osseous Changes ◽  
Masticatory System ◽  
The Impact

Temporomandibular disorders are a multifactorial disease. Occlusal support and the number of teeth in dentition have significant effects on the masticatory system. The current study aims to review the role of occlusal support in association with findings of temporomandibular disorders. Data sources were PubMed, Web of Science and Google Scholar, with 1411 citations published over the period 1992–2019. The selection criteria stipulated that articles must have reported the association between the number of teeth, occlusal unit, occlusal support and temporomandibular disorders. A total of 15 full-text articles was finally accessed for eligibility in the current review. The studies on temporomandibular disorders were collected from various sources, including articles reporting temporomandibular disorder symptoms ( n=1), temporomandibular disorder signs ( n=5), temporomandibular joint osseous changes ( n=1), temporomandibular joint dysfunction using the Helkimo index ( n=2), and temporomandibular disorder classification ( n=6). Of these articles, significant associations were found between: the number of missing teeth and temporomandibular disorders ( n=5); the number of occlusal units and occlusal supports and temporomandibular disorders ( n=3); the position of the lost occlusal units and temporomandibular disorders ( n=1). Loss of the occlusal unit has more impact on temporomandibular disorders than the loss of posterior teeth. The total loss of unilateral occlusal support seems to be an aetiological factor for temporomandibular disorders, and maintenance of balanced posterior occlusal support has a role in the prevention and management of temporomandibular disorders.

scholarly journals Temporomandibular disorders: Guidelines and Self-Care for Patients During COVID-19 Pandemic

2020 ◽  
Vol 23 (2) ◽  
Author(s):  
Simone Saldanha Ignacio de Oliveira ◽  
Sergio Luiz Melo Gonçalvez ◽  
Karin De Mello Weig ◽  
Thales Ribeiro Magalhães Filho ◽  
Omar Efrain Roque Martinez ◽  
...  
Keyword(s):  
Social Isolation ◽  
Latin American ◽  
Temporomandibular Disorders ◽  
Orofacial Pain ◽  
Temporomandibular Disorder ◽  
Management Strategies ◽  
Self Care ◽  
Signs And Symptoms ◽  
Cochrane Library ◽  
Increased Risk

Background: Temporomandibular disorder (TMD) belongs to a heterogeneous group of musculoskeletal and neuromuscular conditions involving the temporomandibular joint complex, musculature and adjacent components. These conditions can generate signs and symptoms and be influenced by an altered biopsychosocial condition. Objective: This study aims to seek information to assist the patient in the presence of TMD signs and symptoms and Orofacial Pain, associated with the period of social isolation during the COVID-19 pandemic. Material and methods: For the preparation of this manual, a bibliographic search was performed in the databases PubMed, Latin American and Caribbean Health Sciences Literature (LILACS), BBO (BVS), Scopus, Web of Science and The Cochrane Library, using the keywords: orofacial pain, temporomandibular disorders, bruxism, stress, anxiety, biopsychosocial, diagnosis, self-care with important information on how to reduce and control the signs and symptoms of TMD and Orofacial Pain in this moment of pandemic that we are experiencing a social detachment. Results: The results show that the pandemic of COVID-19 and the need for social isolation, generates psychological impact that raises the pattern of anxiety and can directly affect patients with bruxism and TMD. Conclusion: Psychological factors associated with the pandemic can lead to an increased risk of developing, worsening and perpetuating bruxism, especially waking bruxism and TMD, so dentists should be aware of the occurrence of signs and symptoms to manage the multifactorial aspects of this condition. At that time, individual self-management strategies are advised for the patient, which consist of self-massage techniques, body education, exercise practices, sleep hygiene, meditation and making available the use of tools and online devices that facilitate this activity.KeywordsOrofacial pain; Temporomandibular disorders; Bruxism; Stress; Anxiety; Biopsychosocial; Diagnosis; Self-care; COVID-19.

Attachment Styles, Physical Proximity, and Relational Satisfaction

2014 ◽  
Vol 4 (2) ◽  
pp. 106-112
Author(s):  
Anita Shrivastava ◽  
Andrea Burianova
Keyword(s):  
Attachment Styles ◽  
Romantic Relationship ◽  
Distinct Type ◽  
Relational Satisfaction ◽  
Long Distance ◽  
Avoidant Attachment ◽  
Geographic Separation ◽  
Relationship Of ◽  
Attachment Dimensions

This study aimed to explore the relationships between attachment styles, proximity, and relational satisfaction. This was achieved by assessing a distinct type of long distance romantic relationship of flying crews, compared with proximal (non-flying crew) romantic relationships. The responses of 139 expatriate professionals revealed significant associations between proximity and anxious and avoidant attachment dimensions. The role of the avoidant dimension in comparison with that of the anxious dimension was found to be a significant predictor of relational satisfaction. This study contributes significantly toward addressing the role of proximity and attachment in relational satisfaction in a new context of geographic separation.

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