scholarly journals Prediction of non-muscle invasive bladder cancer recurrence using machine learning of quantitative nuclear features

2021 ◽  
Author(s):  
Naoto Tokuyama ◽  
Akira Saito ◽  
Ryu Muraoka ◽  
Shuya Matsubara ◽  
Takeshi Hashimoto ◽  
...  
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Bladder Cancer ◽  
Random Forest ◽  
Machine Learning Algorithms ◽  
Invasive Bladder Cancer ◽  
Support Vector ◽  
Muscle Invasive Bladder Cancer ◽  
Nuclear Atypia ◽  
Muscle Invasive

AbstractNon-muscle invasive bladder cancer (NMIBC) generally has a good prognosis; however, recurrence after transurethral resection (TUR), the standard primary treatment, is a major problem. Clinical management after TUR has been based on risk classification using clinicopathological factors, but these classifications are not complete. In this study, we attempted to predict early recurrence of NMIBC based on machine learning of quantitative morphological features. In general, structural, cellular, and nuclear atypia are evaluated to determine cancer atypia. However, since it is difficult to accurately quantify structural atypia from TUR specimens, in this study, we used only nuclear atypia and analyzed it using feature extraction followed by classification using Support Vector Machine and Random Forest machine learning algorithms. For the analysis, 125 patients diagnosed with NMIBC were used; data from 95 patients were randomly selected for the training set, and data from 30 patients were randomly selected for the test set. The results showed that the support vector machine-based model predicted recurrence within 2 years after TUR with a probability of 90% and the random forest-based model with probability of 86.7%. In the future, the system can be used to objectively predict NMIBC recurrence after TUR.

scholarly journals Intravesical Prostatic Protrusion and Prognosis of Non-Muscle Invasive Bladder Cancer: Analysis of Long-Term Data over 5 Years with Machine-Learning Algorithms

2021 ◽  
Vol 10 (18) ◽  
pp. 4263
Author(s):  
Junghoon Lee ◽  
Min Soo Choo ◽  
Sangjun Yoo ◽  
Min Chul Cho ◽  
Hwancheol Son ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bladder Cancer ◽  
Machine Learning Algorithms ◽  
Invasive Bladder Cancer ◽  
Support Vector ◽  
Recurrence Free Survival ◽  
Bladder Tumors ◽  
Muscle Invasive Bladder Cancer ◽  
Free Survival ◽  
Muscle Invasive

We aim to investigate the significance of intravesical prostate protrusion (IPP) on the prognosis of non-muscle invasive bladder cancer (NMIBC) after the transurethral resection of bladder tumors (TURBT). For newly diagnosed NMIBC, we retrospectively analyzed the association between prognosis and IPP for at least a 5-year follow-up. A degree of IPP over 5 mm in a preoperative CT scan was classified as severe. The primary endpoint was recurrence-free survival, and the secondary endpoint was progression-free survival. The machine learning (ML) algorithm of a support vector machine was used for predictive model development. Of a total of 122 patients, ultimately, severe IPP was observed in 33 patients (27.0%). IPP correlated positively with age, BPH, recurrence, and prognosis. Severe IPP was significantly higher in the recurrence group and reduced in the recurrence-free survival group (p = 0.038, p =0.032). Severe IPP independently increased the risk of intravesical recurrence by 2.6 times. The addition of IPP to the known oncological risk factors in the prediction model using the ML algorithm improved the predictability of cancer recurrence by approximately 6%, to 0.803. IPP was analyzed as a potential independent risk factor for NMIBC recurrence and progression after TURBT. This anatomical feature of the prostate could affect the recurrence of bladder tumors.

scholarly journals Automated tumour budding quantification by machine learning augments TNM staging in muscle-invasive bladder cancer prognosis

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Nicolas Brieu ◽  
Christos G. Gavriel ◽  
Ines P. Nearchou ◽  
David J. Harrison ◽  
Günter Schmidt ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bladder Cancer ◽  
Tnm Staging ◽  
Cancer Prognosis ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Muscle Invasive ◽  
Tumour Budding

scholarly journals Identification of Immunological Features Enables Survival Prediction of Muscle-Invasive Bladder Cancer Patients Using Machine Learning

2020 ◽  
Author(s):  
Christos G Gavriel ◽  
Neofytos Dimitriou ◽  
Nicolas Brieu ◽  
Ines P Nearchou ◽  
Ognjen Arandjelović ◽  
...  
Keyword(s):  
Machine Learning ◽  
Bladder Cancer ◽  
Statistical Significance ◽  
Tnm Staging ◽  
Clinical Staging ◽  
Invasive Bladder Cancer ◽  
Survival Prediction ◽  
Muscle Invasive Bladder Cancer ◽  
Tissue Samples ◽  
Muscle Invasive

AbstractClinical staging and prognosis of muscle-invasive bladder cancer (MIBC) routinely includes assessment of patient tissue samples by a pathologist. Recent studies corroborate the importance of image analysis in identifying and quantifying immunological markers from tissue samples that can provide further insights into patient prognosis. In this paper, we apply multiplex immunofluorescence on MIBC tissue sections to capture whole slide images and quantify potential prognostic markers related to lymphocytes, macrophages, tumour buds, and PD-L1. We propose a machine learning based approach for the prediction of 5 year prognosis with different combinations of image, clinical, and spatial features. An ensemble model comprising several functionally different models successfully stratifies MIBC patients into two risk groups with high statistical significance (p value < 1e − 05). Critical to improving MIBC survival rates, our method classifies correctly 71.4% of the patients who succumb to MIBC within 5 years, significantly higher than the 28.6% of the current clinical gold standard, the TNM staging system.

scholarly journals Execution Assessment of Machine Learning Algorithms for Spam Profile Detection on Instagram

2021 ◽  
Vol 10 (3) ◽  
pp. 1889-1894
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Random Forest ◽  
Nearest Neighbor ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Support Vector ◽  
Learning Tools ◽  
Learning Models ◽  
K Nearest Neighbor

Witheverypassingsecondsocialnetworkcommunityisgrowingrapidly,becauseofthat,attackershaveshownkeeninterestinthesekindsofplatformsandwanttodistributemischievouscontentsontheseplatforms.Withthefocus on introducing new set of characteristics and features forcounteractivemeasures,agreatdealofstudieshasresearchedthe possibility of lessening the malicious activities on social medianetworks. This research was to highlight features for identifyingspammers on Instagram and additional features were presentedto improve the performance of different machine learning algorithms. Performance of different machine learning algorithmsnamely, Multilayer Perceptron (MLP), Random Forest (RF), K-Nearest Neighbor (KNN) and Support Vector Machine (SVM)were evaluated on machine learning tools named, RapidMinerand WEKA. The results from this research tells us that RandomForest (RF) outperformed all other selected machine learningalgorithmsonbothselectedmachinelearningtools.OverallRandom Forest (RF) provided best results on RapidMiner. Theseresultsareusefulfortheresearcherswhoarekeentobuildmachine learning models to find out the spamming activities onsocialnetworkcommunities.

scholarly journals Detecting Real-Time Fall of Elderly People Using Machine Learning

2021 ◽  
Vol 9 (12) ◽  
pp. 1913-1918
Author(s):  
Prathima P
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Random Forest ◽  
Elderly People ◽  
Fall Detection ◽  
Machine Learning Algorithms ◽  
Supervised Machine Learning ◽  
Support Vector ◽  
False Alarms ◽  
Severe Injuries

Abstract: Fall is a significant national health issue for the elderly people, generally resulting in severe injuries when the person lies down on the floor over an extended period without any aid after experiencing a great fall. Thus, elders need to be cared very attentively. A supervised-machine learning based fall detection approach with accelerometer, gyroscope is devised. The system can detect falls by grouping different actions as fall or non-fall events and the care taker is alerted immediately as soon as the person falls. The public dataset SisFall with efficient class of features is used to identify fall. The Random Forest (RF) and Support Vector Machine (SVM) machine learning algorithms are employed to detect falls with lesser false alarms. The SVM algorithm obtain a highest accuracy of 99.23% than RF algorithm. Keywords: Fall detection, Machine learning, Supervised classification, Sisfall, Activities of daily living, Wearable sensors, Random Forest, Support Vector Machine

scholarly journals Interpolation of Instantaneous Air Temperature Using Geographical and MODIS Derived Variables with Machine Learning Techniques

2019 ◽  
Author(s):  
Marcos Ruiz-Álvarez ◽  
Francisco Alonso-Sarría ◽  
Francisco Gomariz-Castillo
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Random Forest ◽  
Linear Regression ◽  
Air Temperature ◽  
Satellite Data ◽  
Multivariate Linear Regression ◽  
Machine Learning Algorithms ◽  
Machine Learning Techniques ◽  
Support Vector

Several methods have been tried to estimate air temperature using satellite imagery. In this paper, the results of two machine learning algorithms, Support Vector Machine and Random Forest, are compared with Multivariate Linear Regression, TVX and Ordinary kriging. Several geographic, remote sensing and time variables are used as predictors. The validation is carried out using four different statistics on a daily basis allowing the use of ANOVA to compare the results. The main conclusion is that Random Forest with residual kriging produces the best results (R$^2$=0.612 $\pm$ 0.019, NSE=0.578 $\pm$ 0.025, RMSE=1.068 $\pm$ 0.027, PBIAS=-0.172 $\pm$ 0.046), whereas TVX produces the least accurate results. The environmental conditions in the study area are not really suited to TVX, moreover this method only takes into account satellite data. On the other hand, regression methods (Support Vector Machine, Random Forest and Multivariate Linear Regression) use several parameters that are easily calculated from a Digital Elevation Model, adding very little difficulty to the use of satellite data alone. The most important variables in the Random Forest Model were satellite temperature, potential irradiation and cdayt, a cosine transformation of the julian day.

scholarly journals Machine learning in the diagnosis of Myocardial Infarction with Non-Obstructive Coronary Arteries

2021 ◽  
Vol 42 (Supplement_1) ◽  
Author(s):  
M J Espinosa Pascual ◽  
P Vaquero Martinez ◽  
V Vaquero Martinez ◽  
J Lopez Pais ◽  
B Izquierdo Coronel ◽  
...  
Keyword(s):  
Machine Learning ◽  
Myocardial Infarction ◽  
Support Vector Machine ◽  
Logistic Regression ◽  
Random Forest ◽  
Obstructive Coronary Artery Disease ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Classification Model ◽  
Support Vector

Abstract Introduction Out of all patients admitted with Myocardial Infarction, 10 to 15% have Myocardial Infarction with Non-Obstructive Coronaries Arteries (MINOCA). Classification algorithms based on deep learning substantially exceed traditional diagnostic algorithms. Therefore, numerous machine learning models have been proposed as useful tools for the detection of various pathologies, but to date no study has proposed a diagnostic algorithm for MINOCA. Purpose The aim of this study was to estimate the diagnostic accuracy of several automated learning algorithms (Support-Vector Machine [SVM], Random Forest [RF] and Logistic Regression [LR]) to discriminate between people suffering from MINOCA from those with Myocardial Infarction with Obstructive Coronary Artery Disease (MICAD) at the time of admission and before performing a coronary angiography, whether invasive or not. Methods A Diagnostic Test Evaluation study was carried out applying the proposed algorithms to a database constituted by 553 consecutive patients admitted to our Hospital with Myocardial Infarction. According to the definitions of 2016 ESC Position Paper on MINOCA, patients were classified into two groups: MICAD and MINOCA. Out of the total 553 patients, 214 were discarded due to the lack of complete data. The set of machine learning algorithms was trained on 244 patients (training sample: 75%) and tested on 80 patients (test sample: 25%). A total of 64 variables were available for each patient, including demographic, clinical and laboratorial features before the angiographic procedure. Finally, the diagnostic precision of each architecture was taken. Results The most accurate classification model was the Random Forest algorithm (Specificity [Sp] 0.88, Sensitivity [Se] 0.57, Negative Predictive Value [NPV] 0.93, Area Under the Curve [AUC] 0.85 [CI 0.83–0.88]) followed by the standard Logistic Regression (Sp 0.76, Se 0.57, NPV 0.92 AUC 0.74 and Support-Vector Machine (Sp 0.84, Se 0.38, NPV 0.90, AUC 0.78) (see graph). The variables that contributed the most in order to discriminate a MINOCA from a MICAD were the traditional cardiovascular risk factors, biomarkers of myocardial injury, hemoglobin and gender. Results were similar when the 19 patients with Takotsubo syndrome were excluded from the analysis. Conclusion A prediction system for diagnosing MINOCA before performing coronary angiographies was developed using machine learning algorithms. Results show higher accuracy of diagnosing MINOCA than conventional statistical methods. This study supports the potential of machine learning algorithms in clinical cardiology. However, further studies are required in order to validate our results. FUNDunding Acknowledgement Type of funding sources: None. ROC curves of different algorithms

scholarly journals A Comparative Study on Supervised Machine Learning Algorithms for Copper Recovery Quality Prediction in a Leaching Process

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2119
Author(s):  
Victor Flores ◽  
Claudio Leiva
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Artificial Neural Network ◽  
Support Vector Machine ◽  
Random Forest ◽  
Mining Industry ◽  
Machine Learning Algorithms ◽  
Copper Recovery ◽  
Support Vector ◽  
Copper Mining

The copper mining industry is increasingly using artificial intelligence methods to improve copper production processes. Recent studies reveal the use of algorithms, such as Artificial Neural Network, Support Vector Machine, and Random Forest, among others, to develop models for predicting product quality. Other studies compare the predictive models developed with these machine learning algorithms in the mining industry as a whole. However, not many copper mining studies published compare the results of machine learning techniques for copper recovery prediction. This study makes a detailed comparison between three models for predicting copper recovery by leaching, using four datasets resulting from mining operations in Northern Chile. The algorithms used for developing the models were Random Forest, Support Vector Machine, and Artificial Neural Network. To validate these models, four indicators or values of merit were used: accuracy (acc), precision (p), recall (r), and Matthew’s correlation coefficient (mcc). This paper describes the dataset preparation and the refinement of the threshold values used for the predictive variable most influential on the class (the copper recovery). Results show both a precision over 98.50% and also the model with the best behavior between the predicted and the real values. Finally, the obtained models have the following mean values: acc = 0.943, p = 88.47, r = 0.995, and mcc = 0.232. These values are highly competitive when compared with those obtained in similar studies using other approaches in the context.

scholarly journals APLICAÇÃO DE MACHINE LEARNING NA IDENTIFICAÇÃO DE E-MAILS COMO SPAM

2021 ◽  
Vol 12 (3) ◽  
pp. 31-38
Author(s):  
Michelle Tais Garcia Furuya ◽  
Danielle Elis Garcia Furuya
Keyword(s):  
Machine Learning ◽  
Support Vector Machine ◽  
Random Forest ◽  
Nearest Neighbors ◽  
Machine Learning Algorithms ◽  
The Other ◽  
Support Vector ◽  
K Nearest Neighbors ◽  
Mail Service ◽  
E Mail

The e-mail service is one of the main tools used today and is an example that technology facilitates the exchange of information. On the other hand, one of the biggest obstacles faced by e-mail services is spam, the name given to the unsolicited message received by a user. The machine learning application has been gaining prominence in recent years as an alternative for efficient identification of spam. In this area, different algorithms can be evaluated to identify which one has the best performance. The aim of the study is to identify the ability of machine learning algorithms to correctly classify e-mails and also to identify which algorithm obtained the greatest accuracy. The database used was taken from the Kaggle platform and the data were processed bythe Orange software with four algorithms: Random Forest (RF), K-Nearest Neighbors (KNN), Support Vector Machine (SVM) and Naive Bayes (NB). The division of data in training and testing considers 80% of the data for training and 20% for testing. The results show that Random Forest was the best performing algorithm with 99% accuracy.

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