scholarly journals Dietary intake and food sources of one-carbon metabolism nutrients in preschool aged children

2018 ◽  
Vol 73 (8) ◽  
pp. 1179-1193
Author(s):  
Rachael M. Taylor ◽  
Roger Smith ◽  
Clare E. Collins ◽  
Tiffany-Jane Evans ◽  
Alexis J. Hure
Keyword(s):  
Dietary Intake ◽  
Carbon Metabolism ◽  
Food Sources ◽  
One Carbon Metabolism ◽  
Preschool Aged Children

Dietary Intake of Nutrients Involved in One-Carbon Metabolism and Risk of Gastric Cancer: A Prospective Study

2019 ◽  
Vol 71 (4) ◽  
pp. 605-614 ◽  
Author(s):  
Pierre-Antoine Dugué ◽  
Julie K. Bassett ◽  
Maree T. Brinkman ◽  
Melissa C. Southey ◽  
Jihoon E. Joo ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dietary Intake ◽  
Prospective Study ◽  
Carbon Metabolism ◽  
One Carbon Metabolism ◽  
A Prospective Study

scholarly journals Dietary intake of nutrients involved in folate-mediated one-carbon metabolism and risk for endometrial cancer

2018 ◽  
Vol 48 (2) ◽  
pp. 474-488
Author(s):  
Jana Lu ◽  
Britton Trabert ◽  
Linda M Liao ◽  
Ruth M Pfeiffer ◽  
Kara A Michels
Keyword(s):  
Endometrial Cancer ◽  
Dietary Intake ◽  
Carbon Metabolism ◽  
One Carbon Metabolism

scholarly journals Dietary intake of nutrients involved in one-carbon metabolism and risk of urothelial cell carcinoma: A prospective cohort study

2018 ◽  
Vol 143 (2) ◽  
pp. 298-306 ◽  
Author(s):  
Pierre-Antoine Dugué ◽  
Maree T. Brinkman ◽  
Allison M. Hodge ◽  
Julie K. Bassett ◽  
Damien Bolton ◽  
...  
Keyword(s):  
Cohort Study ◽  
Dietary Intake ◽  
Cell Carcinoma ◽  
Prospective Cohort Study ◽  
Carbon Metabolism ◽  
Prospective Cohort ◽  
Urothelial Cell ◽  
Urothelial Cell Carcinoma ◽  
One Carbon Metabolism

scholarly journals Association between Dietary Intake of One-Carbon Metabolism Nutrients in the Year before Pregnancy and Birth Anthropometry

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 838
Author(s):  
Marion Lecorguillé ◽  
Sandrine Lioret ◽  
Blandine de Lauzon-Guillain ◽  
Erwan de Gavelle ◽  
Anne Forhan ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Fetal Growth ◽  
Dietary Patterns ◽  
Carbon Metabolism ◽  
Nutrient Intake ◽  
Vitamin Supplementation ◽  
Reduced Rank Regression ◽  
Maternal Characteristics ◽  
Rank Regression ◽  
One Carbon Metabolism

Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) nutrients are essential for DNA methylation in the periconception period. We aimed to characterize dietary patterns of 1638 women from the EDEN mother-child cohort in the year before pregnancy according to the contribution of OCM nutrients and to study the association of such patterns with anthropometric measurements at birth. Dietary intake before pregnancy was assessed by using a semi-quantitative food frequency questionnaire. We used the reduced-rank regression (RRR) method to identify dietary patterns using OCM nutrients as intermediate variables. We ran linear regressions models to study the association between dietary patterns scores and birth weight, length, head circumference, gestational age, and sex-specific z-scores, adjusting for maternal characteristics and vitamin supplementation before and during pregnancy. Three patterns, “varied and balanced”, “vegetarian tendency”, and “bread and starchy food” were identified, explaining 58% of the variability in OCM nutrient intake. Higher scores on the “varied and balanced” pattern tended to be associated with higher birth length and weight. In mainly well-nourished young French women, we did not find evidence that variability in OCM nutrient intake has major effects on fetal growth.

scholarly journals Dietary intake of one-carbon metabolism nutrients and DNA methylation in peripheral blood

2018 ◽  
Vol 108 (3) ◽  
pp. 611-621 ◽  
Author(s):  
James A Chamberlain ◽  
Pierre-Antoine Dugué ◽  
Julie K Bassett ◽  
Allison M Hodge ◽  
Maree T Brinkman ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Dietary Intake ◽  
Food Frequency Questionnaire ◽  
Carbon Metabolism ◽  
Peripheral Blood ◽  
Gene Promoters ◽  
Food Frequency ◽  
Genome Wide ◽  
One Carbon Metabolism ◽  
Log Linear

ABSTRACT Background Folate and other one-carbon metabolism nutrients are essential to enable DNA methylation to occur, but the extent to which their dietary intake influences methylation in adulthood is unclear. Objective We assessed associations between dietary intake of these nutrients and DNA methylation in peripheral blood, overall and at specific genomic locations. Design We conducted a cross-sectional study using baseline data and samples from 5186 adult participants in the Melbourne Collaborative Cohort Study (MCCS). Nutrient intake was estimated from a food-frequency questionnaire. DNA methylation was measured by using the Illumina Infinium HumanMethylation450 BeadChip array (HM450K). We assessed associations of intakes of folate, riboflavin, vitamins B-6 and B-12, methionine, choline, and betaine with methylation at individual cytosine-guanine dinucleotides (CpGs), and with median (genome-wide) methylation across all CpGs, CpGs in gene bodies, and CpGs in gene promoters. We also assessed associations with methylation at long interspersed nuclear element 1 (LINE-1), satellite 2 (Sat2), and Arthrobacter luteus restriction endonuclease (Alu) repetitive elements for a subset of participants. We used linear mixed regression, adjusting for age, sex, country of birth, smoking, energy intake from food, alcohol intake, Mediterranean diet score, and batch effects to assess log-linear associations with dietary intake of each nutrient. In secondary analyses, we assessed associations with low or high intakes defined by extreme quintiles. Results No evidence of log-linear association was observed at P < 10−7 between the intake of one-carbon metabolism nutrients and methylation at individual CpGs. Low intake of riboflavin was associated with higher methylation at CpG cg21230392 in the first exon of PROM1 (P = 5.0 × 10−8). No consistent evidence of association was observed with genome-wide or repetitive element measures of methylation. Conclusion Our findings suggest that dietary intake of one-carbon metabolism nutrients in adulthood, as measured by a food-frequency questionnaire, has little association with blood DNA methylation. An association with low intake of riboflavin requires replication in independent cohorts. This study was registered at http://www.clinicaltrials.gov as NCT03227003.

scholarly journals Promoter Methylation of E-Cadherin, p16, and RAR-β2Genes in Breast Tumors and Dietary Intake of Nutrients Important in One-Carbon Metabolism

2011 ◽  
Vol 63 (7) ◽  
pp. 1143-1150 ◽  
Author(s):  
Meng-Hua Tao ◽  
Joel B. Mason ◽  
Catalin Marian ◽  
Susan E. McCann ◽  
Mary E. Platek ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Promoter Methylation ◽  
Carbon Metabolism ◽  
Breast Tumors ◽  
One Carbon Metabolism ◽  
E Cadherin

scholarly journals Association Between Dietary Intake of One-Carbon Metabolism-Related Nutrients and Fluorosis in Guizhou, China

2021 ◽  
Vol 8 ◽  
Author(s):  
Ting Chen ◽  
Na Tao ◽  
Sheng Yang ◽  
Dafang Cao ◽  
Xun Zhao ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Carbon Metabolism ◽  
Cross Sectional Study ◽  
Folate Intake ◽  
Dietary Vitamin ◽  
Vitamin B ◽  
Inverse Association ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
One Carbon Metabolism

Objective: This study aimed to investigate the associations between dietary one-carbon metabolism-related nutrients (betaine, choline, methionine, folate, vitamin B6, and vitamin B12) and fluorosis among the Chinese population in an area known for coal-burning fluorosis.Methods: A cross-sectional study was conducted, with 653 fluorosis patients and 241 non-fluorosis participants. Dietary intake was acquired using a validated semi-quantitative 75-item food frequency questionnaire. The risk associations were assessed by unconditional logistical regression.Results: We observed a significant inverse association between dietary betaine, total choline, methionine, folate, vitamin B6, and choline species and fluorosis. The adjusted OR (95% CI) in the highest quartile of consumption compared with the lowest were 0.59 (0.37–0.94) (P-trend = 0.010) for betaine intake, 0.45 (0.28–0.73) (P-trend = 0.001) for total choline intake, 0.45 (0.28–0.72) (P-trend &lt; 0.001) for methionine intake, 0.39 (0.24–0.63) (P-trend &lt; 0.001) for folate intake, 0.38 (0.24–0.62) (P-trend &lt; 0.001) for vitamin B6 intake, and 0.46 (0.28–0.75) (P-trend = 0.001) for total choline plus betaine intake. Dietary intakes of choline-containing compounds, phosphatidylcholine, free choline, glycerophosphocholine, and phosphocholine were also inversely associated with lower fluorosis (all P-trend &lt; 0.05). No significant associations were observed between dietary vitamin B12 or sphingomyelin and fluorosis.Conclusion: The present study suggested that the higher dietary intakes of specific one-carbon metabolism-related nutrients, such as betaine, choline, methionine, folate, and vitamin B6, are associated with lower fluorosis prevalence.

Genetic Variation: Impact on Folate (and Choline) Bioefficacy

2010 ◽  
Vol 80 (45) ◽  
pp. 319-329 ◽  
Author(s):  
Allyson A. West ◽  
Marie A. Caudill
Keyword(s):  
Carbon Metabolism ◽  
Genetic Variants ◽  
Plasma Homocysteine ◽  
Water Soluble ◽  
Gene Interactions ◽  
Dietary Folate ◽  
Methyl Donors ◽  
Common Genetic Variants ◽  
One Carbon Metabolism ◽  
The Impact

Folate and choline are water-soluble micronutrients that serve as methyl donors in the conversion of homocysteine to methionine. Inadequacy of these nutrients can disturb one-carbon metabolism as evidenced by alterations in circulating folate and/or plasma homocysteine. Among common genetic variants that reside in genes regulating folate absorptive and metabolic processes, homozygosity for the MTHFR 677C > T variant has consistently been shown to have robust effects on status markers. This paper will review the impact of genetic variants in folate-metabolizing genes on folate and choline bioefficacy. Nutrient-gene and gene-gene interactions will be considered along with the need to account for these genetic variants when updating dietary folate and choline recommendations.

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