scholarly journals Rational design of pyrrole derivatives with aggregation-induced phosphorescence characteristics for time-resolved and two-photon luminescence imaging

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Jianhui Yang ◽  
Yahui Zhang ◽  
Xinghui Wu ◽  
Wenbo Dai ◽  
Dan Chen ◽  
...  
Keyword(s):  
Rational Design ◽  
Near Infrared ◽  
Photon Absorption ◽  
Pyrrole Derivatives ◽  
Time Resolved ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Nir Light ◽  
Emission Lifetime ◽  
Good Biocompatibility

AbstractPure organic room-temperature phosphorescent (RTP) materials have been suggested to be promising bioimaging materials due to their good biocompatibility and long emission lifetime. Herein, we report a class of RTP materials. These materials are developed through the simple introduction of an aromatic carbonyl to a tetraphenylpyrrole molecule and also exhibit aggregation-induced emission (AIE) properties. These molecules show non-emission in solution and purely phosphorescent emission in the aggregated state, which are desirable properties for biological imaging. Highly crystalline nanoparticles can be easily fabricated with a long emission lifetime (20 μs), which eliminate background fluorescence interference from cells and tissues. The prepared nanoparticles demonstrate two-photon absorption characteristics and can be excited by near infrared (NIR) light, making them promising materials for deep-tissue optical imaging. This integrated aggregation-induced phosphorescence (AIP) strategy diversifies the existing pool of bioimaging agents to inspire the development of bioprobes in the future.

scholarly journals Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

2013 ◽  
Vol 371 (1995) ◽  
pp. 20120129 ◽  
Author(s):  
John V. Garcia ◽  
Fan Zhang ◽  
Peter C. Ford
Keyword(s):  
Nitric Oxide ◽  
Cross Sections ◽  
Near Infrared ◽  
Single Photon ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Nir Light ◽  
Photon Excitation ◽  
Ultraviolet Wavelength

Multi-photon excitation allows one to use tissue transmitting near-infrared (NIR) light to access excited states with energies corresponding to single-photon excitation in the visible or ultraviolet wavelength ranges. Here, we present an overview of the application of both simultaneous and sequential multi-photon excitation in studies directed towards the photochemical delivery (‘uncaging’) of bioactive small molecules such as nitric oxide (NO) to physiological targets. Particular focus will be directed towards the use of dyes with high two-photon absorption cross sections and lanthanide ion-doped upconverting nanoparticles as sensitizers to facilitate the uncaging of NO using NIR excitation.

Two-photon absorption spectra of a near-infrared 2-azaazulene polymethine dye: solvation and ground-state symmetry breaking

2013 ◽  
Vol 15 (20) ◽  
pp. 7666 ◽  
Author(s):  
Honghua Hu ◽  
Olga V. Przhonska ◽  
Francesca Terenziani ◽  
Anna Painelli ◽  
Dmitry Fishman ◽  
...  
Keyword(s):  
Symmetry Breaking ◽  
Absorption Spectra ◽  
Ground State ◽  
Near Infrared ◽  
Photon Absorption ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Polymethine Dye

scholarly journals Two-Photon Time-Gated In Vivo Imaging of Dihydrolipoic-Acid-Decorated Gold Nanoclusters

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7744
Author(s):  
Ye Tian ◽  
Ming Wei ◽  
Lijun Wang ◽  
Yuankai Hong ◽  
Dan Luo ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Gold Nanoclusters ◽  
Photon Absorption ◽  
Gold Nanocluster ◽  
Time Resolved ◽  
Dihydrolipoic Acid ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Time Resolved Imaging

Due to the unique advantages of two-photon technology and time-resolved imaging technology in the biomedical field, attention has been paid to them. Gold clusters possess excellent physicochemical properties and low biotoxicity, which make them greatly advantageous in biological imaging, especially for in vivo animal imaging. A gold nanocluster was coupled with dihydrolipoic acid to obtain a functionalized nanoprobe; the material displayed significant features, including a large two-photon absorption cross-section (up to 1.59 × 105 GM) and prolonged fluorescence lifetime (>300 ns). The two-photon and time-resolution techniques were used to perform cell imaging and in vivo imaging.

scholarly journals NIR-Responsive Lysosomotropic Phototrigger: ʽAIE + ESIPTʼ Active Naphthalene Based Single Component Photoresponsive Nanocarrier with Two-Photon Uncaging and Real-Time Monitoring Ability

2021 ◽  
Author(s):  
Biswajit Roy ◽  
Rakesh Mengji ◽  
Samrat Roy ◽  
Bipul Pal ◽  
Avijit Jana ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Real Time ◽  
Near Infrared ◽  
Single Component ◽  
Photon Absorption ◽  
Real Time Monitoring ◽  
Two Photon ◽  
Nir Light

In recent times, organelle-targeted drug delivery systems gained tremendous attention due to the site specific delivery of active drug molecules resulting in enhanced bioefficacy. In this context, the phototriggered drug delivery system (DDS) for releasing an active molecule is superior as it provides spatial and temporal control over the release. So far, near infrared (NIR) light responsive organelle targeted DDS has not yet been developed. Hence, we introduced a two-photon NIR-light responsive lysosome targeted ʽAIE + ESIPTʼ active single component DDS based on naphthalene chromophore. The Two-photon absorption cross-section of our DDS is 142 GM at 850 nm. The DDS was converted into pure organic nanoparticles for biological applications. Our nano-DDS is capable of selective targeting, AIE-luminogenic imaging, and drug release within the lysosome. In vitro studies using cancerous cell lines showed that our single component photoresponsive nanocarrier exhibited enhanced cytotoxicity and real-time monitoring ability of the drug release.

scholarly journals Polyfluorenylacetylene for near-infrared laser protection: polymer synthesis, optical limiting mechanism and relationship between molecular structure and properties

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53785-53796 ◽  
Author(s):  
Gang Zhao ◽  
Yan Feng ◽  
Shanyi Guang ◽  
Hongyao Xu ◽  
Naibo Lin ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Near Infrared ◽  
Optical Limiting ◽  
High Thermal Stability ◽  
Photon Absorption ◽  
Structure And Properties ◽  
Absorption Mechanism ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Good Solubility

The incorporation of styryl/stilbene–fluorene into polyacetylenes not only endowed the polymers with novel near-infrared optical limiting properties based on a two-photon absorption mechanism but good solubility and high thermal stability.

scholarly journals Two-photon excited deep-red and near-infrared emissive organic co-crystals

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu Wang ◽  
Huang Wu ◽  
Penghao Li ◽  
Su Chen ◽  
Leighton O. Jones ◽  
...  
Keyword(s):  
Cross Sections ◽  
Optical Materials ◽  
Near Infrared ◽  
Infrared Emission ◽  
Photon Absorption ◽  
Electromagnetic Spectrum ◽  
Absorption Bands ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Near Infrared Emission

Abstract Two-photon excited near-infrared fluorescence materials have garnered considerable attention because of their superior optical penetration, higher spatial resolution, and lower optical scattering compared with other optical materials. Herein, a convenient and efficient supramolecular approach is used to synthesize a two-photon excited near-infrared emissive co-crystalline material. A naphthalenediimide-based triangular macrocycle and coronene form selectively two co-crystals. The triangle-shaped co-crystal emits deep-red fluorescence, while the quadrangle-shaped co-crystal displays deep-red and near-infrared emission centered on 668 nm, which represents a 162 nm red-shift compared with its precursors. Benefiting from intermolecular charge transfer interactions, the two co-crystals possess higher calculated two-photon absorption cross-sections than those of their individual constituents. Their two-photon absorption bands reach into the NIR-II region of the electromagnetic spectrum. The quadrangle-shaped co-crystal constitutes a unique material that exhibits two-photon absorption and near-infrared emission simultaneously. This co-crystallization strategy holds considerable promise for the future design and synthesis of more advanced optical materials.

scholarly journals Functional CdS-Au Nanocomposite for Efficient Photocatalytic, Photosensitizing, and Two-Photon Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 715
Author(s):  
Katarzyna C. Nawrot ◽  
Dominika Wawrzyńczyk ◽  
Oleksii Bezkrovnyi ◽  
Leszek Kępiński ◽  
Bartłomiej Cichy ◽  
...  
Keyword(s):  
Light Exposure ◽  
Water Soluble ◽  
Photon Absorption ◽  
Photoluminescence Intensity ◽  
Oxidation Reactions ◽  
Au Nps ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Emission Lifetime ◽  
Efficient Charge

We demonstrate a low-temperature synthesis of hydrophilic, penicillamine-stabilized hybrid CdS-Au nanoparticles (NPs) utilizing different Au concentrations. The obtained hybrid nanomaterials exhibit photoluminescence quenching and emission lifetime reduction in comparison with their raw semiconductor CdS NPs counterparts. An increase of concentration of Au present at the surface of CdS leads to lower photoluminescence intensity and faster emission decays, suggesting more efficient charge separation when larger Au domains are present. For photocatalysis studies, we performed methylene blue (MB) absorption measurements under irradiation in the presence of CdS-Au NPs. After 1 h of light exposure, we observed the absorbance decrease to about 35% and 10% of the initial value for the CdS-5Au and CdS-7.5Au (the hybrid NPs obtained in a presence of 5.0 and 7.5 mM Au), respectively, which indicates MB reduction caused by electrons effectively separated from holes on metal surface. In further similar photocatalysis experiments, we measured bovine serum albumin (BSA) integrated photoluminescence intensity quenching in the presence of CdS-Au NPs, with a 50% decrease being obtained for CdS-2.5Au NPs and CdS-5Au NPs, with a faster response rate detected for the system prepared with a higher Au concentration. The results suggest hole-driven reactive oxygen species (ROS) production, causing BSA degeneration. Finally, we performed two-photon excited emission (TPEE) measurements for CdS-5Au NPs, obtaining their two-photon absorption (TPA) cross-section values up to 15.8 × 103 GM (Goeppert-Mayer units). We conclude that the obtained water-soluble CdS-Au NPs exhibit potential triple functionalities as photocatalysts for reduction and oxidation reactions as well as materials for two-photon absorption applications, so that they may be considered as future theranostics.

Nondegenerate and degenerate two-photon absorption in cuprous oxide thin film

2019 ◽  
Vol 28 (02) ◽  
pp. 1950015 ◽  
Author(s):  
Huijun Liang ◽  
Qunchao Ma ◽  
Jian Liu ◽  
Xinwei Shi ◽  
Gongjin Yang ◽  
...  
Keyword(s):  
Thin Film ◽  
Cuprous Oxide ◽  
Near Infrared ◽  
Rf Magnetron Sputtering ◽  
Photonic Devices ◽  
Photon Absorption ◽  
Oxide Thin Film ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Nir Absorption

A cuprous oxide (Cu2O) thin film was prepared by radio-frequency (RF) magnetron sputtering. The crystal structure, linear transmission spectrum and film thickness were characterized by X-ray diffraction (XRD), ultraviolet–visible–near infrared (UV–Vis–NIR) absorption spectroscopy and ellipsometry. By performing the pump-probe and [Formula: see text]-scan technique, respectively, nondegenerate and degenerate two-photon absorption (D-TPA) coefficients of the Cu2O thin film at several different excitation wavelengths were experimentally determined. The nondegenerate two-photon absorption (ND-TPA) coefficient always exhibits larger magnitude than the corresponding D-TPA coefficient. In particular, the ND-TPA coefficient shows a maximum value of [Formula: see text][Formula: see text]cm/GW. This study indicates that the cuprous oxide could be a potential material for ultrafast nonlinear photonic devices based on two-photon absorption due to its large ND-TPA coefficient.

scholarly journals Highly efficient singlet oxygen generation, two-photon photodynamic therapy and melanoma ablation by rationally designed mitochondria-specific near-infrared AIEgens

2020 ◽  
Vol 11 (9) ◽  
pp. 2494-2503 ◽  
Author(s):  
Zheng Zheng ◽  
Haixiang Liu ◽  
Shaodong Zhai ◽  
Haoke Zhang ◽  
Guogang Shan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Molecular Engineering ◽  
Photon Absorption ◽  
Oxygen Generation ◽  
Two Photon Absorption ◽  
Two Photon ◽  
Singlet Oxygen Generation ◽  
Highly Efficient

Mitochondria-targeted photosensitizers with highly efficient singlet oxygen generation, bright near-infrared AIE and good two-photon absorption are obtained through ingenious molecular engineering for cancer cell-selective photodynamic therapy.

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