scholarly journals Blautia genus associated with visceral fat accumulation in adults 20–76 years of age

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Naoki Ozato ◽  
Shinichiro Saito ◽  
Tohru Yamaguchi ◽  
Mitsuhiro Katashima ◽  
Itoyo Tokuda ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Relative Abundance ◽  
Visceral Fat ◽  
Population Based ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Genus Level ◽  
Gut Microbe ◽  
Bacteroidetes Phylum ◽  
Firmicutes Phylum

Abstract The gut microbiota is reported to be related to obesity, and visceral fat is reported to be strongly associated with cardiovascular disease and overall mortality. However, the association between the gut microbiota and obesity has mainly been studied using body mass index (BMI) as a proxy for obesity. We investigated the relationship of both visceral fat and BMI with the gut microbiota stratified by sex in a population-based cross-sectional study of Japanese men and women 20–76 years of age (n = 1001). Women with a higher visceral fat area (VFA) harboured a higher relative abundance of the Firmicutes phylum (P for trend <0.001) and a lower relative abundance of the Bacteroidetes phylum (P for trend 0.030), whereas men with higher VFA harboured a lower relative abundance of the Firmicutes phylum (P for trend 0.076) and a higher relative abundance of the Bacteroidetes phylum (P for trend 0.013). Similar results were obtained using BMI as an index, but the differences were not significant in men. At the genus level, Blautia was the only gut microbe significantly and inversely associated with VFA regardless of sex. In conclusion, at the genus level we found that Blautia was the only gut microbe significantly and inversely associated with VFA, regardless of sex.

scholarly journals Association between breath methane concentration and visceral fat area: a population-based cross-sectional study

2020 ◽  
Vol 14 (2) ◽  
pp. 026008
Author(s):  
Naoki Ozato ◽  
Shinichiro Saito ◽  
Tohru Yamaguchi ◽  
Mitsuhiro Katashima ◽  
Itoyo Tokuda ◽  
...  
Keyword(s):  
Visceral Fat ◽  
Methane Concentration ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Breath Methane

scholarly journals Lifestyle modifications result in alterations in the gut microbiota in obese children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ky Young Cho
Keyword(s):  
Gut Microbiota ◽  
Normal Weight ◽  
Rrna Gene ◽  
Weight Changes ◽  
Obese Children ◽  
Lifestyle Modifications ◽  
Cross Sectional ◽  
Fat Loss ◽  
Link Type ◽  
Firmicutes Phylum

Abstract Background The association between the gut microbiota and pediatric obesity was analyzed in a cross-sectional study. A prospective study of obese children was conducted to assess the gut microbial alterations after a weight change. We collected fecal samples from obese children before and after a 2-month weight reduction program that consisted of individual counseling for nutritional education and physical activity, and we performed 16S rRNA gene amplicon sequencing using an Illumina MiSeq platform. Results Thirty-six participants, aged 7 to 18 years, were classified into the fat loss (n = 17) and the fat gain (n = 19) groups according to the change in total body fat (%) after the intervention. The baseline analysis of the gut microbiota in the preintervention stages showed dysbiotic features of both groups compared with those of normal-weight children. In the fat loss group, significantly decreased proportions of Bacteroidetes phylum, Bacteroidia class, Bacteroidales order, Bacteroidaceae family, and Bacteroides genus, along with increased proportions of Firmicutes phylum, Clostridia class, and Clostridiales order, were observed after intervention. The microbial richness was significantly reduced, without a change in beta diversity in the fat loss group. The fat gain group showed significantly deceased proportions of Firmicutes phylum, Clostridia class, Clostridiales order, Lachnospiraceae family, and Eubacterium hallii group genus, without a change in diversity after the intervention. According to the functional metabolic analysis by the Phylogenetic Investigation of Communities by Reconstruction of Unobserved States 2, the “Nitrate Reduction VI” and “Aspartate Superpathway” pathways were predicted to increase significantly in the fat loss group. The cooccurring networks of genera were constructed and showed the different microbes that drove the changes between the pre- and postintervention stages in the fat loss and fat gain groups. Conclusions This study demonstrated that lifestyle modifications can impact the composition, richness, and predicted functional profiles of the gut microbiota in obese children after weight changes. Trial registration ClinicalTrials.govNCT03812497, registration date January 23, 2019, retrospectively registered.

scholarly journals Long-Term Testosterone Administration Increases Visceral Fat in Female to Male Transsexuals1

1997 ◽  
Vol 82 (7) ◽  
pp. 2044-2047 ◽  
Author(s):  
Jolanda M. H. Elbers ◽  
Henk Asscheman ◽  
Jacob C. Seidell ◽  
Jos A. J. Megens ◽  
Louis J. G. Gooren
Keyword(s):  
Confidence Interval ◽  
Visceral Fat ◽  
Causal Relation ◽  
Magnetic Resonance Images ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Fat Depots ◽  
Testosterone Administration ◽  
The Mean

The amount of intraabdominal (visceral) fat is an important determinant of disturbances in lipid and glucose metabolism. Cross-sectional studies in women have found associations between high androgen levels and visceral fat accumulation. The causal relation between these phenomena is unknown. We, therefore, studied prospectively the effect of testosterone administration on body fat distribution in 10 young, nonobese, female to male transsexuals undergoing sex reassignment. Before, after 1 yr, and after 3 yr of testosterone administration, magnetic resonance images were obtained at the level of the abdomen, hip, and thigh to quantify both sc and visceral fat depots. After 1 yr of testosterone administration, sc fat depots at all levels showed significant reductions compared to baseline measurements. The mean visceral fat area did not change significantly, but subjects who gained weight in the first year after testosterone administration showed an increase in visceral fat. After 3 yr of testosterone administration, sc fat depots were no longer significantly lower compared to pretreatment measurements, but the mean visceral fat depot had increased significantly by 13 cm2 (95% confidence interval, 4–22 cm2), a relative increase of 47% (95% confidence interval, 8–91%) from baseline. The increase in visceral fat was most pronounced in those subjects who had gained weight. We conclude that long term testosterone administration in young, nonobese, female subjects increases the amount of visceral fat. In addition, an increase in weight in this hyperandrogenic state leads to a preferential storage of fat in the visceral depot.

scholarly journals Cross-sectional study of the association between day-to-day home blood pressure variability and visceral fat area measured using the dual impedance method

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0206945 ◽  
Author(s):  
Junko Kuwabara ◽  
Koichiro Kuwahara ◽  
Yoshihiro Kuwabara ◽  
Shinji Yasuno ◽  
Yasuaki Nakagawa ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Visceral Fat ◽  
Blood Pressure Variability ◽  
Cross Sectional Study ◽  
Home Blood Pressure ◽  
Impedance Method ◽  
Sectional Study ◽  
Visceral Fat Area ◽  
Cross Sectional

scholarly journals Dysbiosis of Gut Microbiota and Its Relationship with the Regulatory T Cells in Patients with Aplastic Anemia 

2021 ◽  
Author(s):  
Mengxiao Ren ◽  
Yongqin Ge ◽  
Jindan Qi ◽  
Shengli Xue ◽  
Miao Miao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Aplastic Anemia ◽  
Treg Cell ◽  
Relative Abundance ◽  
Treg Cells ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Cell Counts ◽  
And Control ◽  
Healthy Participants

Abstract Background: The characteristics of gut microbiota (GM) and its relationship with the Regulatory T Cells (Treg) remains unclear in patients with aplastic anemia (AA). Methods: This study was a cross-sectional survey which included 12 AA patients consisted of 6 with severity aplastic anemia (SAA) and 6 with non-severity aplastic anemia (NSAA) and 6 healthy participants. The GM and its relationship with the Treg cells of AA patients were analyzed. Results: The results showed that the presence of compositional differences in the GM structure between the AA and Control groups. The bacterial communities were depleted of Clostridia class (e.g., Lachnospiraceae ND3007, Lachnospiraceae XPB1014, Lachnolostridium, Ruminococcaceae UCG 013 and Butyricicoccus genus) in AA group, especially in SAA group. Inversely, the relative abundance of Lactobacillus and Streptococcus genus from Bacilli class were increased significantly in patients with SAA. The relative abundance of Lachnospiraceae (r=0.663, p=0.029), Clostridiaceae 1 (r=0.619, p=0.042) and Clostridiales vadinBB60 group family (r=0.674, p=0.023) which from Clostridia class, were positively correlated with the Treg cell counts. Conclusion: We speculated that the decrease of some bacteria from Clostridia class may participate in the pathophysiological process of AA through reducing the Treg cell counts. Notwithstanding the low sample size, our data provided some clues that the treatment strategy of AA could start by adjusting the imbalance of GM, increasing Treg cell counts to improve the suppression of bone marrow hematopoiesis.

scholarly journals A Cross-Sectional Study: Predicting Health Risks Among Female University Students

2020 ◽  
Vol 13 (1) ◽  
pp. 316-322
Author(s):  
Qassim I. Muaidi ◽  
Mohammad Ahsan
Keyword(s):  
Waist Circumference ◽  
Health Risks ◽  
Visceral Fat ◽  
Linear Regression Analysis ◽  
Cross Sectional Study ◽  
Anthropometric Measurements ◽  
Height Ratio ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Waist Height Ratio

Background: Good health is very important in our lives and plays a significant role. Many health risks are associated with an unhealthy lifestyle. These risks are responsible for raising the risk of chronic heart diseases and other health complications. Females are not exempted from these issues. Objective: To identify the obesity-associated health risks of female students by using selected anthropometric measurements. Methods: A cross-sectional study was conducted including 300 females aged 20.82 ± 5.23 years from the college of applied medical sciences, Imam Abdulrahman bin Faisal University. The anthropometric measurements (body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio) were taken with the help of an auto-calibrated bioelectric impedance device. The waist-height ratio was determined by dividing waist circumference with height. Cross tabulation was done to scrutinize the participant’s levels at risk and high risk. Linear regression analysis was done to see the relationship and prediction between selected anthropometric measurements. Results: The finding showed that BMI level was high in 55% of participants, Waist-height ratio over the average level was 46.67% and 21% of participants had a visceral fat area on risk. Linear regression analysis showed a strong association among body mass index, percentage of body fat, visceral fat area, waist circumference, waist-hip ratio,and waist-height ratio and statistically significant to each other at the 0.01 level. Conclusion: The selected anthropometric measurements can be used to identify health-related risks. Though, when any anthropometric measurement dichotomized as standard or high, BMI is the best measure to predict health risk.

scholarly journals Association of adiposity with thyroid nodules: a cross-sectional study of a healthy population in Beijing, China

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Hui-xia Yang ◽  
Yu Zhong ◽  
Wei-hua Lv ◽  
Feng Zhang ◽  
Hong Yu
Keyword(s):  
Visceral Fat ◽  
Thyroid Nodules ◽  
Binary Logistic Regression ◽  
Cross Sectional Study ◽  
Continuous Variable ◽  
Overweight And Obesity ◽  
Healthy Population ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Beijing China

Abstract Background The relationship between thyroid nodules (TNs) and adiposity is controversial. This paper describes a cross-sectional investigation performed to determine the existence of any such relationship. To assess adiposity, body mass index (BMI) and visceral fat area (VFA) were utilized. Methods Between January 1, 2017 and March 3, 2019. Three thousand five hundred thirty four healthy people were examined using thyroid ultrasonography, visceral fat and anthropometric measurements, laboratory tests and questionnaire interview. Binary logistic regression analyses were used. Results Of the 3534 healthy subjects, 58.69% (2074/3534) of the subjects had TNs. A total of 55.91% (1976/3534) had BMI ≥ 25 kg/m2 and 39.67% (1402/3534) had VFA ≥ 100 cm2. After adjustment to address confounders, BMI-based overweight and obesity levels only correlated with higher risk TNs when used as a continuous variable (OR = 1.031, 95% CI: 1.008–1.055, P = 0.008), while VFA was both a continuous variable (OR = 1.003, 95% CI: 1.000–1.005, P = 0.034) and a categorical variable (OR = 1.198, 95% CI: 1.014–1.417, P = 0.034) associated with significantly elevated risk of TNs. Analyzing the subgroups, BMI ≥ 25 kg/m2 (OR = 1.500, 95% CI: 1.110–2.026, P = 0.008) was significantly correlated with TN risk in individuals with TG ≥ 1.7 mmol/L. VFA ≥ 100 cm2 correlated with the TN risk irrespective of age (< 50 years: OR = 1.374, 95% CI: 1.109–1.703, P = 0.004; ≥ 50 years: OR = 1.367, 95% CI: 1.063–1.759, P = 0.015) and in the following subgroups: women (OR = 4.575, 95% CI: 2.558–8.181, P = 0.000), FBG ≥ 6.1 mmol/L (OR = 1.522, 95% CI: 1.048–2.209, P = 0.027), and TG ≥ 1.7 mmol/L (OR = 1.414, 95% CI: 1.088–1.838, P = 0.010). Conclusions Adiposity correlates with TNs. To assess TN risk in Chinese individuals, VFA is better than BMI.

scholarly journals Does a “Cushion Effect” Really Exist? A Morphomic Analysis of Vulnerable Road Users with Serious Blunt Abdominal Injury

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 1006
Author(s):  
Yu-San Tee ◽  
Chi-Tung Cheng ◽  
Chi-Hsun Hsieh ◽  
Shih-Ching Kang ◽  
Chih-Yuan Fu ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Visceral Fat ◽  
Motor Vehicle ◽  
Subcutaneous Fat ◽  
Abdominal Injury ◽  
Visceral Fat Area ◽  
Cross Sectional ◽  
Road Users ◽  
Severity Of Injury ◽  
Vulnerable Road Users

Introduction: The severity of injury from motor vehicle crashes (MVCs) depends on complex biomechanical factors, and the bodily features of the injured person account for some of these factors. By assuming that vulnerable road users (VRUs) have limited protection resulting from vehicles and safety equipment, the current study analyzed the characteristics of fat distribution measured by computed tomography (CT) imaging and investigated the existence of a “cushion effect” in VRUs. Materials and Methods: This retrospective study enrolled 592 VRUs involved in MVCs who underwent CT scans. Visceral fat area and subcutaneous fat cross-sectional area were measured and adjusted according to total body area (TBA) and are presented as the visceral fat ratio and the subQ fat ratio (subcutaneous fat ratio). Risk factors for serious abdominal injury (maximum abbreviated injury scale (MAISabd ≥ 3)) resulting from MVCs were determined by univariate and multivariate analysis. Results: MAISabd ≥ 3 was observed in 104 (17.6%) of the patients. The subQ fat ratio at the L4 vertebral level was significantly lower in the MAISabd ≥ 3 group than in the MAISabd < 3 group (24.9 ± 12.0 vs. 28.1 ± 11.9%; p = 0.015). A decreased L4 subQ fat ratio was associated with a higher risk for MAISabd ≥ 3 in multivariate analysis (odds ratio 0.063; 95% CI 0.008–0.509; p = 0.009). Conclusion: The current study supported the “cushion effect” theory, and protection was apparently provided by subcutaneous fat tissue. This concept may further improve vehicle and safety designation in the future.

scholarly journals Alterations of the Gut Microbiota in Patients With Coronavirus Disease 2019 or H1N1 Influenza

2020 ◽  
Vol 71 (10) ◽  
pp. 2669-2678 ◽  
Author(s):  
Silan Gu ◽  
Yanfei Chen ◽  
Zhengjie Wu ◽  
Yunbo Chen ◽  
Hainv Gao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Relative Abundance ◽  
Influenza A ◽  
Gastrointestinal Symptoms ◽  
Area Under The Curve ◽  
H1n1 Influenza ◽  
Cross Sectional Study ◽  
Microbial Composition ◽  
Cross Sectional ◽  
Influenza A H1n1

Abstract Background Coronavirus disease 2019 (COVID-19) is an emerging serious global health problem. Gastrointestinal symptoms are common in COVID-19 patients, and severe acute respiratory syndrome coronavirus 2 RNA has been detected in stool specimens. However, the relationship between the gut microbiome and disease remains to be established. Methods We conducted a cross-sectional study of 30 patients with COVID-19, 24 patients with influenza A(H1N1), and 30 matched healthy controls (HCs) to identify differences in the gut microbiota by 16S ribosomal RNA gene V3–V4 region sequencing. Results Compared with HCs, COVID-19 patients had significantly reduced bacterial diversity; a significantly higher relative abundance of opportunistic pathogens, such as Streptococcus, Rothia, Veillonella, and Actinomyces; and a lower relative abundance of beneficial symbionts. Five biomarkers showed high accuracy for distinguishing COVID-19 patients from HCs with an area under the curve (AUC) up to 0.89. Patients with H1N1 displayed lower diversity and different overall microbial composition compared with COVID-19 patients. Seven biomarkers were selected to distinguish the 2 cohorts (AUC = 0.94). Conclusions The gut microbial signature of patients with COVID-19 was different from that of H1N1 patients and HCs. Our study suggests the potential value of the gut microbiota as a diagnostic biomarker and therapeutic target for COVID-19, but further validation is needed.

scholarly journals Association Between Visceral Fat and Brain Cortical Thickness in the Elderly: A Neuroimaging Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Jaelim Cho ◽  
Seongho Seo ◽  
Woo-Ram Kim ◽  
Changsoo Kim ◽  
Young Noh
Keyword(s):  
Cortical Thickness ◽  
Visceral Fat ◽  
Reference Group ◽  
Subcutaneous Fat ◽  
Additive Model ◽  
The Elderly ◽  
Brain Regions ◽  
Magnetic Resonance Images ◽  
Visceral Fat Area ◽  
Cross Sectional

BackgroundDespite emerging evidence suggesting that visceral fat may play a major role in obesity-induced neurodegeneration, little evidence exists on the association between visceral fat and brain cortical thickness in the elderly.PurposeWe aimed to examine the association between abdominal fat and brain cortical thickness in a Korean elderly population.MethodsThis cross-sectional study included elderly individuals without dementia (n = 316). Areas of visceral fat and subcutaneous fat (cm2) were estimated from computed tomography scans. Regional cortical thicknesses (mm) were obtained by analyzing brain magnetic resonance images. Given the inverted U-shaped relationship between visceral fat area and global cortical thickness (examined using a generalized additive model), visceral fat area was categorized into quintiles, with the middle quintile being the reference group. A generalized linear model was built to explore brain regions associated with visceral fat. The same approach was used for subcutaneous fat.ResultsThe mean (standard deviation) age was 67.6 (5.0) years. The highest quintile (vs. the middle quintile) group of visceral fat area had reduced cortical thicknesses in the global [β = –0.04 mm, standard error (SE) = 0.02 mm, p = 0.004], parietal (β = –0.04 mm, SE = 0.02 mm, p = 0.01), temporal (β = –0.05 mm, SE = 0.02 mm, p = 0.002), cingulate (β = –0.06 mm, SE = 0.02 mm, p = 0.01), and insula lobes (β = –0.06 mm, SE = 0.03 mm, p = 0.02). None of the regional cortical thicknesses significantly differed between the highest and the middle quintile groups of subcutaneous fat area.ConclusionThe findings suggest that a high level of visceral fat, but not subcutaneous fat, is associated with a reduced cortical thickness in the elderly.

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