Mammographic texture features associated with contralateral breast cancer in the WECARE Study

AbstractTo evaluate whether mammographic texture features were associated with second primary contralateral breast cancer (CBC) risk, we created a “texture risk score” using pre-treatment mammograms in a case–control study of 212 women with CBC and 223 controls with unilateral breast cancer. The texture risk score was associated with CBC (odds per adjusted standard deviation = 1.25, 95% CI 1.01–1.56) after adjustment for mammographic percent density and confounders. These results support the potential of texture features for CBC risk assessment of breast cancer survivors.

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Contralateral breast cancer: annual incidence and risk parameters.

Journal of Clinical Oncology ◽

10.1200/jco.1995.13.7.1578 ◽

1995 ◽

Vol 13 (7) ◽

pp. 1578-1583 ◽

Cited By ~ 135

Author(s):

P Broët ◽

A de la Rochefordière ◽

S M Scholl ◽

A Fourquet ◽

V Mosseri ◽

...

Keyword(s):

Breast Cancer ◽

Adjuvant Chemotherapy ◽

Contralateral Breast Cancer ◽

Clinical Stage ◽

Incidence Rates ◽

Contralateral Breast ◽

Annual Incidence ◽

Second Primary ◽

Unilateral Breast Cancer ◽

Increased Risk

PURPOSE To screen for factors that might predict the risk of developing metachronous contralateral breast cancer (CBC), taking into account the influence of local or distant recurrence, and to assess the annual incidence of CBC. PATIENTS AND METHODS Of 4,748 women with invasive unilateral breast cancer, clinical stage I to IIIa, treated between 1981 and 1987, 282 metachronous CBCs were diagnosed. Due to competing risks between the occurrence of CBC and other events, several options for multivariate analysis were considered. RESULTS The median follow-up time was 80 months (range, 1 to 158). The cumulative rate of CBC was 4.1% +/- 0.3% at 5 years, and the annual incidence rate of CBC increased slowly, while the risk of local recurrence and metastases decreased after the fourth year. Whichever model we chose, age less than 55 years (relative risk [RR] = 1.40) at the time of diagnosis of the first breast cancer, as well as the presence of lobular type carcinoma (RR = 1.50), was associated with an increased risk of developing a tumor in the contralateral breast. Adjuvant chemotherapy significantly decreased (RR = 0.54) the risk of CBC. CONCLUSION Lobular histology and age less than 55 years are found to increase the risk of CBC, while adjuvant chemotherapy significantly decreased the risk of CBC. The progressive rise in the annual incidence rates of CBC, together with the absence of a link between clinical prognostic factors of the first cancer and CBC, suggested that CBC can be considered as a second primary breast cancer.

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Relationship Between Potentially Modifiable Lifestyle Factors and Risk of Second Primary Contralateral Breast Cancer Among Women Diagnosed With Estrogen Receptor–Positive Invasive Breast Cancer

Journal of Clinical Oncology ◽

10.1200/jco.2009.23.1597 ◽

2009 ◽

Vol 27 (32) ◽

pp. 5312-5318 ◽

Cited By ~ 83

Author(s):

Christopher I. Li ◽

Janet R. Daling ◽

Peggy L. Porter ◽

Mei-Tzu C. Tang ◽

Kathleen E. Malone

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Cancer Survivors ◽

Invasive Breast Cancer ◽

Breast Cancer Survivors ◽

Contralateral Breast Cancer ◽

Contralateral Breast ◽

Alcoholic Beverages ◽

Second Primary

Purpose An outcome of considerable concern among breast cancer survivors is the development of second primary breast cancer. However, evidence regarding how potentially modifiable lifestyle factors modulate second breast cancer risk is limited. We evaluated the relationships between obesity, alcohol consumption, and smoking on risk of second primary invasive contralateral breast cancer among breast cancer survivors. Methods Utilizing a population-based nested case-control study design, we enrolled 365 patients diagnosed with an estrogen receptor–positive (ER+) first primary invasive breast cancer and a second primary contralateral invasive breast cancer, and 726 matched controls diagnosed with only an ER+ first primary invasive breast cancer. Obesity, alcohol use, and smoking data were ascertained from medical record reviews and participant interviews. Using conditional logistic regression we evaluated associations between these three exposures and second primary contralateral breast cancer risk. Results Obesity, consumption of ≥ 7 alcoholic beverages per week, and current smoking were all positively related to risk of contralateral breast cancer (odds ratio [OR], 1.4; 95% CI, 1.0 to 2.1; OR, 1.9; 95% CI, 1.1 to 3.2; and OR, 2.2; 95% CI, 1.2 to 4.0, respectively). Compared with women who consumed fewer than seven alcoholic beverages per week and were never or former smokers, women who consumed ≥ 7 drinks per week and were current smokers had a 7.2-fold (95% CI, 1.9 to 26.5) elevated risk of contralateral breast cancer. Conclusion Our population-based study adds to the limited available literature and suggests that obesity, smoking, and alcohol consumption influence contralateral breast cancer risk, affording breast cancer survivors three means of potentially reducing this risk.

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Risk factors for contralateral breast cancer in postmenopausal breast cancer survivors in the NIH-AARP Diet and Health Study

Cancer Causes & Control ◽

10.1007/s10552-021-01432-2 ◽

2021 ◽

Author(s):

Cody Ramin ◽

Maeve Mullooly ◽

Sara J. Schonfeld ◽

Pragati G. Advani ◽

Clara Bodelon ◽

...

Keyword(s):

Breast Cancer ◽

Risk Factors ◽

Cancer Survivors ◽

Breast Cancer Survivors ◽

Contralateral Breast Cancer ◽

Postmenopausal Breast Cancer ◽

Contralateral Breast ◽

Health Study

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Abstract P1-09-04: Association between a breast cancer polygenic risk score and contralateral breast cancer risk

10.1158/1538-7445.sabcs18-p1-09-04 ◽

2019 ◽

Author(s):

I Kramer ◽

MJ Hooning ◽

N Mavaddat ◽

S Canisius ◽

R Keeman ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Risk Score ◽

Contralateral Breast Cancer ◽

Contralateral Breast ◽

Polygenic Risk Score ◽

Polygenic Risk

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Contralateral breast cancer: Effect of stage on survival after unilateral breast cancer.

Journal of Clinical Oncology ◽

10.1200/jco.2012.30.27_suppl.69 ◽

2012 ◽

Vol 30 (27_suppl) ◽

pp. 69-69

Author(s):

Lori Uyeno ◽

Carolyn E. Behrendt ◽

Laura Kruper ◽

Steven L. Chen ◽

Courtney Vito

Keyword(s):

Breast Cancer ◽

African American ◽

African American Women ◽

Breast Cancer Survivors ◽

Contralateral Breast Cancer ◽

Prophylactic Mastectomy ◽

Early Stage ◽

Contralateral Breast ◽

Advanced Stage ◽

The Impact

69 Background: Contralateral breast cancer (CBC) is the most common malignancy among breast cancer survivors. We investigated the impact of CBC on overall survival (OS) after unilateral primary breast cancer (UPBC) in women treated with mastectomy. Methods: Using the Surveillance Epidemiology End Results registry, we identified women age 25-80 diagnosed 1998-2006 with UPBC stage 0-III, treated with mastectomy and free of CBC at 1-year landmark. Subjects were split into test and validation samples. Follow-up continued until the earliest occurrence: death, end of 2008, or age 85. Primary risk factor was incident CBC, a time-dependent variable categorized as advanced-stage (IIB-IV), early-stage (0-IIA), or none. Proportional hazards regression adjusted for primary tumor characteristics, treatment including contralateral prophylactic mastectomy (CPM), demographics, and aging. Results: Subjects (n= 109,411, age 53.7[+12.7] years at UPBC diagnosis) were followed median 51 months. Most UPBC were early stage (63%), moderately/poorly differentiated (78%), ER+PR+ (52%). Few (9.8%) women underwent CPM at primary diagnosis. Incident CBC (n=867, 0.79%) was diagnosed median 23.5 (95% CI 1.2-72) months beyond the 1-year landmark. Test and validation samples did not differ. Only CBC of stage IIB-IV increased mortality; early stage CBC had no effect on OS. Among CBC cases, advanced stage was independently associated with aggressive UPBC (more positive nodes; larger tumor; greater extension), African-American race, and shorter time from UPBC. Conclusions: Among women who undergo mastectomy +/-CPM for UPBC, few develop CBC, which impacts survival only when diagnosed at advanced stage. Efforts to improve survival after UPBC should emphasize earlier detection and prevention of advanced-stage CBC, especially in African-American women and women with more aggressive UPBC. [Table: see text]

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Contralateral Breast Cancer in BRCA1 and BRCA2 Mutation Carriers

Journal of Clinical Oncology ◽

10.1200/jco.2004.04.033 ◽

2004 ◽

Vol 22 (12) ◽

pp. 2328-2335 ◽

Cited By ~ 441

Author(s):

Kelly Metcalfe ◽

Henry T. Lynch ◽

Parviz Ghadirian ◽

Nadine Tung ◽

Ivo Olivotto ◽

...

Keyword(s):

Breast Cancer ◽

Contralateral Breast Cancer ◽

Brca Mutation ◽

Brca1 Mutation ◽

Brca2 Mutation ◽

Contralateral Breast ◽

Second Primary ◽

Brca1 And Brca2 ◽

Breast Cancer Death ◽

Actuarial Risk

Purpose To estimate the risk of contralateral breast cancer in BRCA1 and BRCA2 carriers after diagnosis and to determine which factors are predictive of the risk of a second primary breast cancer. Patients and Methods Patients included 491 women with stage I or stage II breast cancer, for whom a BRCA1 or BRCA2 mutation had been identified in the family. Patients were followed from the initial diagnosis of cancer until contralateral mastectomy, contralateral breast cancer, death, or last follow-up. Results The actuarial risk of contralateral breast cancer was 29.5% at 10 years. Factors that were predictive of a reduced risk were the presence of a BRCA2 mutation (v BRCA1 mutation; hazard ratio [HR], 0.73; 95% CI, 0.47 to 1.15); age 50 years or older at first diagnosis (v ≤ 49 years; HR, 0.63; 95% CI, 0.36 to 1.10); use of tamoxifen (HR, 0.59; 95% CI, 0.35 to 1.01); and history of oophorectomy (HR, 0.44; 95% CI, 0.21 to 0.91). The effect of oophorectomy was particularly strong in women first diagnosed prior to age 49 years (HR, 0.24; 95% CI, 0.07 to 0.77). For women who did not have an oophorectomy or take tamoxifen, the 10-year risk of contralateral cancer was 43.4% for BRCA1 carriers and 34.6% for BRCA2 carriers. Conclusion The risk of contralateral breast cancer in women with a BRCA mutation is approximately 40% at 10 years, and is reduced in women who take tamoxifen or who undergo an oophorectomy.

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Assessing the Effect of Lifetime Contralateral Breast Cancer Risk on the Selection of Contralateral Prophylactic Mastectomy for Unilateral Breast Cancer

Clinical Breast Cancer ◽

10.1016/j.clbc.2017.09.010 ◽

2018 ◽

Vol 18 (2) ◽

pp. e205-e218 ◽

Cited By ~ 1

Author(s):

John V. Hegde ◽

Xiaoyan Wang ◽

Deanna J. Attai ◽

Maggie L. DiNome ◽

Amy Kusske ◽

...

Keyword(s):

Breast Cancer ◽

Breast Cancer Risk ◽

Cancer Risk ◽

Contralateral Breast Cancer ◽

Prophylactic Mastectomy ◽

Contralateral Prophylactic Mastectomy ◽

Contralateral Breast ◽

Unilateral Breast Cancer ◽

Selection Of

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Machine Learning Methods to Identify Genetic Correlates of Radiation-Associated Contralateral Breast Cancer in the WECARE Study

10.1101/547422 ◽

2019 ◽

Author(s):

Sangkyu Lee ◽

Xiaolin Liang ◽

Meghan Woods ◽

Anne S. Reiner ◽

Duncan Thomas ◽

...

Keyword(s):

Breast Cancer ◽

Machine Learning ◽

Contralateral Breast Cancer ◽

Area Under The Curve ◽

Contralateral Breast ◽

Dependent Manner ◽

Nucleotide Polymorphisms ◽

Unilateral Breast Cancer ◽

Validation Data ◽

Increased Risk

AbstractThe purpose of this study is to identify germline single nucleotide polymorphisms (SNPs) that optimally predict radiation-associated contralateral breast cancer (RCBC) and to provide new biological insights into the carcinogenic process. Fifty-two women with contralateral breast cancer and 153 women with unilateral breast cancer were identified within the Women’s Environmental Cancer and Radiation Epidemiology (WECARE) Study who were at increased risk of RCBC because they were ≤ 40 years of age at first diagnosis of breast cancer and received a scatter radiation dose > 1 Gy to the contralateral breast. A previously reported algorithm, preconditioned random forest regression, was applied to predict the risk of developing RCBC. The resulting model produced an area under the curve of 0.62 (p=0.04) on hold-out validation data. The biological analysis identified the cyclic AMP-mediated signaling and Ephrin-A as significant biological correlates, which were previously shown to influence cell survival after radiation in an ATM-dependent manner. The key connected genes and proteins that are identified in this analysis were previously identified as relevant to breast cancer, radiation response, or both. In summary, machine learning/bioinformatics methods applied to genome-wide genotyping data have great potential to reveal plausible biological correlates associated with the risk of RCBC.

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