scholarly journals Recurrence monitoring for ovarian cancer using a cell phone-integrated paper device to measure the ovarian cancer biomarker HE4/CRE ratio in urine

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Emily C. Kight ◽  
Iftak Hussain ◽  
Audrey K. Bowden ◽  
Frederick R. Haselton
Keyword(s):  
Ovarian Cancer ◽  
Cell Phone ◽  
Cancer Recurrence ◽  
Cure Rate ◽  
Flatbed Scanner ◽  
Significant Difference ◽  
A Cell ◽  
Paper Device ◽  
The Difference ◽  
Further Development

AbstractOvarian cancer has a poor cure rate and rates of relapse are high. Current recurrence detection is limited by non-specific methods such as blood testing and ultrasound. Based on reports that human epididymis four (HE4) / creatinine (CRE) ratios found in urine are elevated in ovarian cancers, we have developed a paper-based device that combines lateral flow technology and cell phone analysis to quantitatively measure HE4/CRE. Surrogate samples were used to test the performance over clinically expected HE4/CRE ratios. For HE4/CRE ratios of 2 to 47, the percent error was found to be 16.0% on average whether measured by a flatbed scanner or cell phone. There was not a significant difference between the results from the cell phone or scanner. Based on published studies, error in this method was less than the difference required to detect recurrence. This promising new tool, with further development, could be used at home or in low-resource settings to provide timely detection of ovarian cancer recurrence.

scholarly journals Effect of Intraperitoneal Administration of Paclitaxel Combined with Cisplatin in Treatment of Advanced Ovarian Cancer

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Li Zhao
Keyword(s):  
Ovarian Cancer ◽  
Intraperitoneal Administration ◽  
Advanced Ovarian Cancer ◽  
Control Group ◽  
Double Blind ◽  
T Lymphocyte Subsets ◽  
Significant Difference ◽  
The Difference ◽  
Experimental Group ◽  
Randomization Method

Objective: To analyze the effect of intraperitoneal administration of paclitaxel combined with cisplatin in treatment of advanced ovarian cancer. Method: Fifty-four patients with advanced ovarian cancer in our hospital were randomly selected from the beginning of July 2018 to the end of June 2019. The principle of grouping was based on double-blind randomization method. In experimental group, 27 patients were given intraperitoneal administration of paclitaxel combined with cisplatin. In control group, 27 patients were given intravenous administration of paclitaxel combined with cisplatin. Clinical data of the two groups were compared. Results: Short-term clinical efficacy and T lymphocyte subsets of experimental group were significantly improved when compared with control group. The difference was significant (P<0.05). There was no significant difference in adverse reactions between the two groups (P>0.05). Conclusion: The effect of intraperitoneal administration of paclitaxel combined with cisplatin is ideal for treatment of advanced ovarian cancer patients.

scholarly journals Expression levels of matrix metalloproteinases in ascites of patients with ovarian cancer and the relationship with pathological characteristics of ovarian cancer

2019 ◽  
Vol 6 (2) ◽  
pp. 12
Author(s):  
Shuna S ◽  
Ping L ◽  
Junfei W
Keyword(s):  
Ovarian Cancer ◽  
Matrix Metalloproteinase ◽  
Ovarian Tumor ◽  
Ovarian Tumors ◽  
Expression Levels ◽  
Benign Ovarian Tumor ◽  
Significant Difference ◽  
Malignant Ovarian Tumor ◽  
Serum Ca125 ◽  
The Difference

Objective: To explore the expression levels of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) in ascites in ovarian tumor and provide a theoretical basis for the diagnosis and prognosis evaluation of ovarian cancer ascites.Methods: ELISA was used to detect the levels of MMP-2 and MMP-9 in ascites samples from 73 cases of patients with malignant ovarian tumor, and RIA was used to detect the expression level of CA125 in the serum in these patients.Results: The expression levels of MMP-2 and MMP-9 in ascites in malignant ovarian tumor were higher than those in ascites in benign ovarian tumor (t = 8.08, 10.39, p < .01), and the difference was of statistical significance. The expression levels of MMP-2 and MMP-9 in patients with stage III and IV malignant ovarian tumors were higher than those in patients with stage I and II malignant ovarian tumors, and the difference was statistically significant (t = 2.75, 2.75, p < .05). There was no statistically significant difference in the expression levels of MMP-2 and MMP-9 among the patients with different pathological types, different histological grades, lymph node metastasis or not, different ascites volumes and different residual lesions (p > .05). The sensitivities of detecting MMP-2 and MMP-9 in ascites were 76.0% and 88.0%, respectively, which were significantly higher than those of ascites cytological examinations (χ2 = 4.61, 12.74, p < .05), but in comparison with serum CA125, there was no statistically significant difference (p > .05). The specificities of detecting MMP-2 and MMP-9 in ascites were 78.3% and 82.6%, respectively, which were significantly lower than those of ascites cytological examinations (χ2 = 5.61, 4.38, p < .05), but in comparison with serum CA125, there was no statistically significant difference (χ2 = 1.64, 2.68, p < .05).Conclusions: The levels of MMP-2 and MMP-9 in ascites may be markers for the differential diagnosis of benign and malignant ovarian lesions, and they are related to the prognosis in patients with malignant ovarian tumors.

scholarly journals Describing the evolution of mobile technology usage for Latino patients and comparing findings to national mHealth estimates

2016 ◽  
Vol 23 (5) ◽  
pp. 979-983 ◽  
Author(s):  
Sanjay Arora ◽  
Kelsey Ford ◽  
Sophie Terp ◽  
Tiffany Abramson ◽  
Ryan Ruiz ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Mobile Technology ◽  
Technology Use ◽  
Cell Phone ◽  
Safety Net ◽  
Language Preference ◽  
National Estimates ◽  
A Cell ◽  
The Difference ◽  
Heath Care

Abstract Objectives Describe the change in mobile technology used by an urban Latino population between 2011 and 2014, and compare findings with national estimates. Materials and Methods Patients were surveyed on medical history and mobile technology use. We analyzed specific areas of mobile health capacity stratified by chronic disease, age, language preference, and educational attainment. Results Of 2144 Latino patients, the percentage that owned a cell phone and texted were in-line with Pew estimates, but app usage was not. Patients with chronic disease had reduced access to mobile devices ( P  &lt; .001) and lower use of mobile phone functionalities. Discussion Prior research suggests that Latinos can access mHealth; however, we observed lower rates among Latino patients actively seeking heath care. Conclusion Published national estimates do not accurately reflect the mobile technology use of Latino patients served by our public safety-net facility. The difference is greater for older, less educated patients with chronic disease.

scholarly journals High Preoperative Serum sVCAM-1 Concentration as a Predictor of Early Ovarian Cancer Recurrence

2020 ◽  
Author(s):  
Marina Jakimovska ◽  
Katarina Černe ◽  
Ivan Verdenik ◽  
Borut Kobal
Keyword(s):  
Ovarian Cancer ◽  
Serum Level ◽  
Serum Concentration ◽  
Cancer Recurrence ◽  
Potential Marker ◽  
Preoperative Serum ◽  
Significant Difference ◽  
Group A ◽  
Group B

Abstract Background: Role of soluble vascular cell adhesion molecule-1 (sVCAM-1) in ovarian cancer is largely unclear. It was shown that mesothelial expression mediates tumour cell invasion and is associated with metastases in advanced ovarian cancer.Results: Mean sVCAM-1 serum concentration in all patients before operation was 1564.68 ± 435.65 ng/ml while mean ascites level was 801.84 ±244.35 ng/ml. Follow up period was minimum 27 and the maximum 58 months. Patients were divided in two groups according to time to recurrence. Group A: 20 patients with disease progress or relapse within 12 months (mean serum level 1660.54±417.93 ng/ml; mean ascites level 827.92±290.36) and group B: 17 patients with tumour relapse after more than 12 months (mean serum level 451.91±441.15ng/ml; mean ascites level 771.16±179.93). There was statistically significant difference in serum concentration and not in ascites concentrations of sVCAM-1, grade, histology and stage and tumour between the groups. There was a correlation between serum and ascites concentrations in group A and not in the patients from group B. Increased sVCAM-1 concentration in serum and ascites relates to advance ovarian cancer.Conclusions: This is the first study demonstrating that higher serum sVCAM-1 concentrations at the time of diagnosis might be predictive for early relapse. Serum sVCAM-1 can be potential marker for ovarian cancer follow-up.

scholarly journals Mere Presence of a Cell Phone: Effects on Academic Ability

2020 ◽  
Vol 3 (1) ◽  
pp. 18-30
Author(s):  
Vanessa C. Boila ◽  
Tru E. Kwong ◽  
Jaimey E. Hintz
Keyword(s):  
Cell Phone ◽  
Sentence Comprehension ◽  
Academic Ability ◽  
Wide Range Achievement Test ◽  
Wide Range ◽  
Significant Difference ◽  
A Cell ◽  
Mere Presence ◽  
And Mathematics ◽  
Present Group

Prior research has suggested that cell phone use in the classroom and during learning-related tasks is detrimental to academic performance. Recently, the mere presence of a cell phone has been found to negatively affect relationships and to impair performance on learning and cognitive tasks. This study explored whether the presence (visibility without use) of a cell phone negatively impacts one’s performance on tests measuring preexisting academic ability. The study evaluated 45 participants; some were enrolled in an introductory psychology course, and others were members of the public. Three subtests from the Wide Range Achievement Test (WRAT-4) were completed: spelling, sentence comprehension, and mathematics. During testing, half of the participants had cell phones, and the other half did not. Statistical analyses revealed no significant difference between the cell phone-present and cell phone-absent group on the sentence comprehension (p=.52), spelling (p=.07), and mathematics subtest (p=.11). Unexpectedly, a non-significant trend was observed in the opposite direction; that is, the cell phone-present group outperformed the cell phone-absent group on all subtests. Therefore, the original hypothesis suggesting that the cell phone-present group would be significantly poorer at demonstrating preexisting skills on tests of academic ability in comparison to the cell phone-present group was not supported.

scholarly journals The Comparison of Neutropenia and Peripheral Neuropathy Condition as an Impact of 3-hours and 24-hour Paclitaxel Infusion of Paclitaxel-Carboplatin Chemotherapy on Ovarian Cancer Patients

Pain medicine ◽  
2019 ◽  
Vol 4 (2) ◽  
pp. 41-52
Author(s):  
Primandono Perbowo ◽  
Brahmana Askandar ◽  
Ratna Soebady ◽  
Ahcmad Bashory
Keyword(s):  
Ovarian Cancer ◽  
Peripheral Neuropathy ◽  
Adjuvant Therapy ◽  
Cancer Patients ◽  
Differential Count ◽  
Study Group ◽  
Infusion Group ◽  
Significant Difference ◽  
The Difference ◽  
Statistic Result

This study is aimed to compare the difference of neutropenia with peripheral neuropathy condition, after administration of 3 hours and 24 hours Paclitaxel infusion in adjuvant therapy with Paclitaxel­Carboplatin toward patient with ovarian carcinoma. The method that used was experimental research with samples randomized after consecutively recruited based on inclusive criteria. Before and every after chemotherapy, NCS was performed and differential count laboratories’ test and then analysed with T­test and Chi­square test. The result showed that from three times administration of 3 hours Paclitaxel­Carboplatin infusion group, the neutropenia condition after first up to third chemotherapy was 20 %, 30 %, 30 %, and the peripheral neuropathy condition was 30 %, 60 %, 50 % respectively. Meanwhile, in 24 hours Paclitaxel­Carboplatin infusion group, the incident of neutropenia after first up to third chemotherapy was 40 %, 50 %, 40 %, and the incident of peripheral neuropathy was 20 %, 20 %, 20 % respectively. The statistic result was p > 0.05. Hence, there was no significant difference in neutropenia and peripheral neuropathy incident on two study group.

The Evolution of Augmentative Communication and the Importance of Alternate Access

2011 ◽  
Vol 20 (1) ◽  
pp. 34-37 ◽  
Author(s):  
David Chapple
Keyword(s):  
Augmentative And Alternative Communication ◽  
Cell Phone ◽  
Handheld Devices ◽  
Alternative Communication ◽  
Access Methods ◽  
The Past ◽  
Communication Device ◽  
Internet Browser ◽  
A Cell ◽  
Development Of Language

Abstract Over the past 20 years, there have been many advances in the computer industry as well as in augmentative and alternative communication (AAC) devices. Computers are becoming more compact and have multiple purposes, such as the iPhone, which is a cell phone, mp3 player, and an Internet browser. AAC devices also have evolved to become multi-purpose devices; the most sophisticated devices have functionality similar to the iPhone and iPod. Recently, the idea of having the iPhone and iPad as a communication device was initiated with the development of language applications specifically for this format. It might be true that this idea could become the future of AAC devices; however, there are major access issues to overcome before the idea is a reality. This article will chronicle advancements in AAC devices, specifically on access methods, throughout the years, towards the transition to handheld devices. The newest technologies hold much promise with both features and affordability factors being highly attractive. Yet, these technologies must be made to incorporate alternate access if they are to meet their fullest potential as AAC tools.

Cranial crassicaudiasis in two coastal dolphin species from South Africa is predominantly a disease of immature individuals

2020 ◽  
Vol 139 ◽  
pp. 93-102 ◽  
Author(s):  
MF Van Bressem ◽  
P Duignan ◽  
JA Raga ◽  
K Van Waerebeek ◽  
N Fraijia-Fernández ◽  
...  
Keyword(s):  
South Africa ◽  
Bone Development ◽  
Bottlenose Dolphins ◽  
Fatal Outcome ◽  
Population Level ◽  
Cape Coast ◽  
Osteolytic Lesions ◽  
Immune Mediated ◽  
Significant Difference ◽  
The Difference

Crassicauda spp. (Nematoda) infest the cranial sinuses of several odontocetes, causing diagnostic trabecular osteolytic lesions. We examined skulls of 77 Indian Ocean humpback dolphins Sousa plumbea and 69 Indo-Pacific bottlenose dolphins Tursiops aduncus, caught in bather-protecting nets off KwaZulu-Natal (KZN) from 1970-2017, and skulls of 6 S. plumbea stranded along the southern Cape coast in South Africa from 1963-2002. Prevalence of cranial crassicaudiasis was evaluated according to sex and cranial maturity. Overall, prevalence in S. plumbea and T. aduncus taken off KZN was 13 and 31.9%, respectively. Parasitosis variably affected 1 or more cranial bones (frontal, pterygoid, maxillary and sphenoid). No significant difference was found by gender for either species, allowing sexes to be pooled. However, there was a significant difference in lesion prevalence by age, with immature T. aduncus 4.6 times more likely affected than adults, while for S. plumbea, the difference was 6.5-fold. As severe osteolytic lesions are unlikely to heal without trace, we propose that infection is more likely to have a fatal outcome for immature dolphins, possibly because of incomplete bone development, lower immune competence in clearing parasites or an over-exuberant inflammatory response in concert with parasitic enzymatic erosion. Cranial osteolysis was not observed in mature males (18 S. plumbea, 21 T. aduncus), suggesting potential cohort-linked immune-mediated resistance to infestation. Crassicauda spp. may play a role in the natural mortality of S. plumbea and T. aduncus, but the pathogenesis and population level impact remain unknown.

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