Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 units

AbstractThe coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of imaging findings, depending on disease severity and time course. We conducted a retrospective evaluation of hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement, in order to identify relationships between clinical, serological, imaging data and disease outcomes in patients with COVID-19. Clinical and serological records of patients admitted to two COVID-19 Units of the Abruzzo region in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively evaluated. Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR = 14.5, 95% CI 2.3–90.9, p = 0.004), the presence of septal thickening (OR = 8.2, 95% CI 1.6–40.9, p = 0.011) and the presence of mediastinal lymph node enlargement (OR = 12.0, 95% CI 1.1–127.5, p = 0.039) independently of age and gender. We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease outcomes. The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.

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Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 Units.

10.21203/rs.3.rs-103672/v1 ◽

2020 ◽

Author(s):

Francesco Carubbi ◽

Lia Salvati ◽

Alessia Alunno ◽

Fabio Maggi ◽

Erika Borghi ◽

...

Keyword(s):

Ct Scan ◽

Time Course ◽

Mediastinal Lymph Node ◽

Clinical Signs ◽

Pulmonary Involvement ◽

Imaging Data ◽

Age And Gender ◽

Disease Outcomes ◽

Wide Range ◽

And Gender

Abstract The coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of imaging ﬁndings, depending on disease severity and time course. We conducted a retrospective evaluation of hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement, in order to identify relationships between clinical, serological, imaging data and disease outcomes in patients with COVID-19. Clinical and serological records of patients admitted to two COVID-19 Units of the Abruzzo region in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively evaluated.Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR=14.5, 95% CI=2.3-90.9, p=0.004), the presence of septal thickening (OR=8.2, 95% CI=1.6-40.9, p=0.011) and the presence of mediastinal lymph node enlargement (OR=12.0, 95% CI=1.1-127.5, p=0.039) independently of age and gender.We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease outcomes. The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.

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AB0652 FERRITIN IS ASSOCIATED WITH THE SEVERITY OF LUNG INVOLVEMENT BUT NOT WITH WORSE PROGNOSIS IN PATIENTS WITH COVID-19: DATA FROM TWO ITALIAN COVID-19 UNITS

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.61 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 1359.3-1359

Author(s):

F. Carubbi ◽

A. Alunno ◽

L. Salvati ◽

C. Ferri ◽

D. Grassi

Keyword(s):

Ct Scan ◽

Time Course ◽

Vascular System ◽

Clinical Signs ◽

Pulmonary Involvement ◽

Imaging Features ◽

Age And Gender ◽

Disease Outcomes ◽

Wide Range ◽

And Gender

Background:The coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation and a wide range of imaging findings, depending on disease severity and time course. The pathophysiology is complex, involving immune and hematologic systems, epithelial cells and vascular system and to date reliable biomarkers aimed at stratifying patients and predicting worse outcomes have not been identifiedObjectives:The aim of this study was to describe clinical, serological and CT imaging features of a cohort of patients with COVID-19 pneumonia and identify possible relationships between the variables and disease outcomes (admission to intensive care unit (ICU) and/or death).Methods:We evaluated hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement. Clinical and serological records of patients admitted to two COVID-19 Units in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively collected.Results:Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR=14.5, 95% CI=2.3-90.9, p=0.004), the presence of septal thickening (OR=8.2, 95% CI=1.6-40.9, p=0.011) and the presence of mediastinal lymph node enlargement (OR=12.0, 95% CI=1.1-127.5, p=0.039) independently of age and gender.Conclusion:We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender, but not with disease outcomes (admission to ICU/death). The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.Disclosure of Interests:None declared.

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Information and information resources in COVID-19: Awareness, control, and prevention

Journal of Librarianship and Information Science ◽

10.1177/09610006211016519 ◽

2021 ◽

pp. 096100062110165

Author(s):

Mohammadhiwa Abdekhoda ◽

Fatemeh Ranjbaran ◽

Asghar Sattari

Keyword(s):

Low Cost ◽

Information Resources ◽

Age And Gender ◽

Use Of Resources ◽

Strategic Approach ◽

Wide Range ◽

Data Collection Instrument ◽

Control And Prevention ◽

And Gender ◽

And Control

This study was conducted with the aim of evaluating the role of information and information resources in the awareness, control, and prevention of COVID-19. This study was a descriptive-analytical survey in which 450 participants were selected for the study. The data collection instrument was a researcher-made questionnaire. Descriptive and inferential statistics were used to analyze the data through SPSS. The findings show that a wide range of mass media has become well known as information resources for COVID-19. Other findings indicate a significant statistical difference in the rate of using information resources during COVID-19 based on age and gender; however, this difference is not significant regarding the reliability of information resources with regard to age and gender. Health information has an undisputable role in the prevention and control of pandemic diseases such as COVID-19. Providing accurate, reliable, and evidence-based information in a timely manner for the use of resources and information channels related to COVID-19 can be a fast and low-cost strategic approach in confronting this disease.

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Reference values of thoracic aorta and pulmonary artery diameters by age and gender in healthy Chinese adults assessed by cardiac magnetic resonance imaging: data from national center for cardiovascular diseases of China

The International Journal of Cardiovascular Imaging ◽

10.1007/s10554-020-02116-9 ◽

2021 ◽

Author(s):

Shuang Li ◽

Baiyan Zhuang ◽

Gang Yin ◽

Xinling Yang ◽

Shihua Zhao ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Cardiac Magnetic Resonance ◽

Cardiovascular Diseases ◽

Magnetic Resonance ◽

Imaging Data ◽

Resonance Imaging ◽

Magnetic Resonance Imaging Data ◽

Chinese Adults ◽

Age And Gender ◽

And Gender

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Method of Measuring Psychological Defense

Experimental Psychology (Russia) ◽

10.17759/exppsy.2020130213 ◽

2020 ◽

Vol 13 (2) ◽

pp. 194-209

Author(s):

E.R. Pilyugin ◽

R.F. Suleimanov

Keyword(s):

Defense Mechanisms ◽

Research Process ◽

Psychometric Characteristics ◽

Age And Gender ◽

Psychological Defense ◽

Wide Range ◽

And Gender

The authors suggests a psychodiagnostic method for measuring 20 defense mechanisms. The advantages of this method are the simplicity of the research process, the independence of the result from the researcher personality, and the wide range of measured defense mechanisms. The psychometric characteristics of the method are given: validity, discriminativity, reliability, represenativeness. The age and gender statistical limits of norms are determined.

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Age and gender features of clinical course COVID-19

Shidnoevropejskij zurnal vnutrisnoi ta simejnoi medicini ◽

10.15407/internalmed2021.02.004 ◽

2021 ◽

Vol 2021 (2) ◽

pp. 4-9

Author(s):

OM Kovalyova ◽

Keyword(s):

Clinical Signs ◽

Scientific Data ◽

Age And Gender ◽

Gender And Age ◽

Different Populations ◽

And Gender ◽

Definition Of ◽

The Impact ◽

The Relationship ◽

Gender Features

The article presents the review of modern publications devoted the assessment the impact of age and gender on susceptibility, clinical manifestation and outcome of COVID-19 infection. Statistical data on rate of COVID-19 in relation to age categories and adverse clinical signs of disease in different populations are shown. Old and older ages are the predictors of severe coronavirus course and mortality are emphasized. Gender features of coronavirus infection have been described according to gender cardiology with taken in account the disproportion of hypertension and coronary heart disease in male and female. Due to the scientific research the gender and age peculiarities of immune response to virus infection is considered. The definition of hypothesis “immunosenescence” underlying adverse outcome due to COVID-19 in older patients is taken. Gender peculiarities of COVID-19 are presented by evident scientific data according to the relationship between sex hormone and immune inflammation factors

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THE CONGRUENCE BETWEEN CRANIOMETRIC OF ADULTS HEAD CT SCAN WITH AGE AND GENDER A STUDY IN RADIODIAGNOSTIC DEPARTMENT OF dr. SOETOMO GENERAL HOSPITAL SURABAYA AT AUGUST-DECEMBER 2019

International Journal of Research Publications ◽

10.47119/ijrp100591820201386 ◽

2020 ◽

Vol 59 (1) ◽

Author(s):

D.A. Soraya ◽

L. Mardiyana ◽

B. Soeprijanto

Keyword(s):

Ct Scan ◽

General Hospital ◽

Age And Gender ◽

Head Ct ◽

And Gender

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Do we need to consider age and gender for accurate diagnosis of myocardial infarction?

Diagnosis ◽

10.1515/dx-2016-0023 ◽

2016 ◽

Vol 3 (4) ◽

pp. 175-181 ◽

Cited By ~ 1

Author(s):

Matthias Mueller-Hennessen ◽

Evangelos Giannitsis

Keyword(s):

Myocardial Infarction ◽

Clinical Signs ◽

High Sensitivity ◽

Healthy Population ◽

Age And Gender ◽

Therapeutic Consequences ◽

Gender And Age ◽

And Gender ◽

Universal Definition ◽

Almost All

AbstractAccording to the universal definition, a diagnosis of acute myocardial infarction (AMI) can be made in the presence of a kinetic change of cardiac troponin (cTn) with at least one value above the 99th percentile of a healthy population together with clinical signs of myocardial ischemia. Thus, differences in 99th percentile cut-off values may have important diagnostic and therapeutic consequences for the correct AMI diagnosis. Following the introduction of high-sensitivity (hs) cTn assays with the ability to detect cTn in virtually every healthy individual, almost all available hs Tn assays suggest to use solitary 99th percentile cut-offs. However, several findings have questioned the use of a solitary cut-off for AMI diagnosis, as apparent age- and gender-dependent differences were found concerning the 99th percentile cut-off value. Moreover, there is an increasing number of studies which suggest a relevant diagnostic and prognostic benefit, when age- or gender-specific cut-offs values are used in comparison to general cut-offs. In contrast, other studies observed only a small impact on diagnostic reclassification and risk stratification. Given these ambiguous findings, there is currently no clear evidence for the use of age- and/or gender-dependent 99th percentiles. This review gives an overview of the rationale for gender- and age-dependent differences in cTn biomarker findings and discusses the implementation of these findings into clinical practice.

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Prevalence of chondrocalcinosis in the temporomandibular joint in patients with chondrocalcinosis of the knee or wrist

Dentomaxillofacial Radiology ◽

10.1259/dmfr.20190450 ◽

2020 ◽

Vol 49 (7) ◽

pp. 20190450

Author(s):

Inneke Willekens ◽

Abdallah Fares ◽

Hannes Devos ◽

Maryam Shahabpour ◽

Leon Lenchik ◽

...

Keyword(s):

Ct Scan ◽

Temporomandibular Joint ◽

Ct Scans ◽

Crystal Deposition ◽

Age And Gender ◽

Gender Distribution ◽

Head Ct ◽

Radiological Evidence ◽

And Gender

Objective: The aim of this study was to investigate the prevalence of TMJ chondrocalcinosis on head CT scans in patients with chondrocalcinosis of the knee or wrist. Methods and materials: 227 patients with radiological evidence of calcifications on knee or wrist radiographs had a head CT scan obtained for unrelated purposes. CT scans were retrospectively reviewed for the presence of temporomandibular crystal deposition. Prevalence, bilaterality, age and gender distribution were determined. Results: 41 of 227 (18%) of patients had TMJ chondrocalcinosis. TMJ chondrocalcinosis was more common in females (17%) than males (1%). It was more commonly unilateral (68%) than bilateral (32%). Conclusion: In patients with peripheral calcific disease, the TMJ is more commonly involved than previously reported and this is more common in females compared to males.

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