Do we need to consider age and gender for accurate diagnosis of myocardial infarction?

Diagnosis ◽  
2016 ◽  
Vol 3 (4) ◽  
pp. 175-181 ◽  
Author(s):  
Matthias Mueller-Hennessen ◽  
Evangelos Giannitsis
Keyword(s):  
Myocardial Infarction ◽  
Clinical Signs ◽  
High Sensitivity ◽  
Healthy Population ◽  
Age And Gender ◽  
Therapeutic Consequences ◽  
Gender And Age ◽  
And Gender ◽  
Universal Definition ◽  
Almost All

AbstractAccording to the universal definition, a diagnosis of acute myocardial infarction (AMI) can be made in the presence of a kinetic change of cardiac troponin (cTn) with at least one value above the 99th percentile of a healthy population together with clinical signs of myocardial ischemia. Thus, differences in 99th percentile cut-off values may have important diagnostic and therapeutic consequences for the correct AMI diagnosis. Following the introduction of high-sensitivity (hs) cTn assays with the ability to detect cTn in virtually every healthy individual, almost all available hs Tn assays suggest to use solitary 99th percentile cut-offs. However, several findings have questioned the use of a solitary cut-off for AMI diagnosis, as apparent age- and gender-dependent differences were found concerning the 99th percentile cut-off value. Moreover, there is an increasing number of studies which suggest a relevant diagnostic and prognostic benefit, when age- or gender-specific cut-offs values are used in comparison to general cut-offs. In contrast, other studies observed only a small impact on diagnostic reclassification and risk stratification. Given these ambiguous findings, there is currently no clear evidence for the use of age- and/or gender-dependent 99th percentiles. This review gives an overview of the rationale for gender- and age-dependent differences in cTn biomarker findings and discusses the implementation of these findings into clinical practice.

Age and gender features of clinical course COVID-19

2021 ◽  
Vol 2021 (2) ◽  
pp. 4-9
Author(s):  
OM Kovalyova ◽  
Keyword(s):  
Clinical Signs ◽  
Scientific Data ◽  
Age And Gender ◽  
Gender And Age ◽  
Different Populations ◽  
And Gender ◽  
Definition Of ◽  
The Impact ◽  
The Relationship ◽  
Gender Features

The article presents the review of modern publications devoted the assessment the impact of age and gender on susceptibility, clinical manifestation and outcome of COVID-19 infection. Statistical data on rate of COVID-19 in relation to age categories and adverse clinical signs of disease in different populations are shown. Old and older ages are the predictors of severe coronavirus course and mortality are emphasized. Gender features of coronavirus infection have been described according to gender cardiology with taken in account the disproportion of hypertension and coronary heart disease in male and female. Due to the scientific research the gender and age peculiarities of immune response to virus infection is considered. The definition of hypothesis “immunosenescence” underlying adverse outcome due to COVID-19 in older patients is taken. Gender peculiarities of COVID-19 are presented by evident scientific data according to the relationship between sex hormone and immune inflammation factors

scholarly journals Age and Gender as Cyber Attribution Features in Keystroke Dynamic-Based User Classification Processes

Electronics ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 835
Author(s):  
Ioannis Tsimperidis ◽  
Cagatay Yucel ◽  
Vasilios Katos
Keyword(s):  
High Accuracy ◽  
Keystroke Dynamics ◽  
Time Intervals ◽  
Age And Gender ◽  
Common Features ◽  
User Classification ◽  
Gender And Age ◽  
And Gender ◽  
Keystroke Dynamic

Keystroke dynamics are used to authenticate users, to reveal some of their inherent or acquired characteristics and to assess their mental and physical states. The most common features utilized are the time intervals that the keys remain pressed and the time intervals that are required to use two consecutive keys. This paper examines which of these features are the most important and how utilization of these features can lead to better classification results. To achieve this, an existing dataset consisting of 387 logfiles is used, five classifiers are exploited and users are classified by gender and age. The results, while demonstrating the application of these two characteristics jointly on classifiers with high accuracy, answer the question of which keystroke dynamics features are more appropriate for classification with common classifiers.

scholarly journals No Self Without Salience: Affective and Self-relevance Ratings of 552 Emotionally Valenced and Neutral Dutch Words

2021 ◽  
Author(s):  
Lora I. Dimitrova ◽  
Eline M. Vissia ◽  
Hanneke Geugies ◽  
Hedwig Hofstetter ◽  
Sima Chalavi ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Emotional Valence ◽  
Age And Gender ◽  
Gender And Age ◽  
Main Effect ◽  
Emotional Salience ◽  
And Gender ◽  
The Relationship

AbstractIt is unknown how self-relevance is dependent on emotional salience. Emotional salience encompasses an individual's degree of attraction or aversion to emotionally-valenced information. The current study investigated the interconnection between self and salience through the evaluation of emotional valence and self-relevance. 56 native Dutch participants completed a questionnaire assessing valence, intensity, and self-relevance of 552 Dutch nouns and verbs. One-way repeated-measures ANCOVA investigated the relationship between valence and self, age and gender. Repeated-measures ANCOVA also tested the relationship between valence and self with intensity ratings and effects of gender and age. Results showed a significant main effect of valence for self-relevant words. Intensity analyses showed a main effect of valence but not of self-relevance. There were no significant effects of gender and age. The most important finding presents that self-relevance is dependent on valence. These findings concerning the relationship between self and salience opens avenues to study an individual's self-definition.

scholarly journals Soft Biometrics for a Socially Assistive Robotic Platform

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Pierluigi Carcagnì ◽  
Dario Cazzato ◽  
Marco Del Coco ◽  
Pier Luigi Mazzeo ◽  
Marco Leo ◽  
...  
Keyword(s):  
Real Time ◽  
Humanoid Robot ◽  
Field Of View ◽  
Robotic Platform ◽  
Time System ◽  
Real Time System ◽  
Age And Gender ◽  
Gender And Age ◽  
And Gender ◽  
Assistive Robotic

AbstractIn thiswork, a real-time system able to automatically recognize soft-biometric traits is introduced and used to improve the capability of a humanoid robot to interact with humans. In particular the proposed system is able to estimate gender and age of humans in images acquired from the embedded camera of the robot. This knowledge allows the robot to properly react with customized behaviors related to the gender/age of the interacting individuals. The system is able to handle multiple persons in the same acquired image, recognizing the age and gender of each person in the robot’s field of view. These features make the robot particularly suitable to be used in socially assistive applications.

3333Contemporary mortality rates in myocardial infarction patients in Sweden: a tale of two registries

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
J Siverskog ◽  
M Janzon ◽  
L.-Å Levin ◽  
J Alfredsson ◽  
M Henriksson
Keyword(s):  
Myocardial Infarction ◽  
Intensive Care ◽  
Patient Characteristics ◽  
Primary Diagnosis ◽  
Age And Gender ◽  
Quality Registry ◽  
Mortality Outcome ◽  
Mortality Difference ◽  
And Gender ◽  
One Year

Abstract Background Sweden has contributed to the understanding of the long-term prognosis after myocardial infarction (MI) utilising the quality registry SWEDEHEART, including patients admitted to heart intensive care, and the National Patient Registry (PAR), based on administrative records for Swedish hospitals. As registration procedures differ between the registries, and not all MI patients are admitted to heart intensive care, MI patients identified in SWEDEHEART and PAR, respectively, will yield different cohorts of patients. This may result in different epidemiological research findings regarding prognosis after MI. Purpose To study MI populations identified in SWEDEHEART and PAR, respectively, and investigate potential differences in mortality outcome. Methods Patients hospitalised with an MI primary diagnosis (ICD-10 I21) between 2002 and 2015 were identified using SWEDEHEART and PAR. The analysis time started at the date of hospital admission and survivors were followed for 365 days. Kaplan-Meier analysis was used to estimate survival by cohort category controlling for age and gender. Results Excluding cases with invalid data (n=1,905), 225,612 and 282,118 SWEDEHEART and PAR patients, respectively, were identified. We found 213,367 patients in both SWEDEHEART and PAR, whereas 12,245 and 68,751 patients were unique to SWEDEHEART and PAR, respectively. The one-year survival probability after MI in the SWEDEHEART population was 0.841, compared to 0.788 in PAR (Figure). This discrepancy can be explained by high mortality among patients not covered by SWEDEHEART and persists after controlling for age and gender (Table). To what extent differences in registration procedures and other patient characteristics can explain the mortality difference is an area for further research. One-year survival by age and gender Age ± 1 year Male Female PAR S.H. Diff. PAR S.H. Diff. 65 0.922 0.936 0.015 0.919 0.936 0.017 70 0.893 0.909 0.016 0.889 0.908 0.019 75 0.829 0.858 0.029 0.834 0.860 0.026 80 0.743 0.783 0.040 0.768 0.800 0.033 85 0.625 0.677 0.052 0.662 0.705 0.042 One-year survival after MI Conclusion Estimated one-year survival for MI patients differs by up to 5 percentage points depending on the registry used. Although further research is needed to fully understand these differences, epidemiological findings regarding MI prognosis should be interpreted in light of registry type used and population represented. Acknowledgement/Funding Region Östergötland

scholarly journals Drinkers in the micro-social environment of the inhabitants of Ukraine. Age and gender characteristics

2021 ◽  
pp. 4-11
Author(s):  
Igor Linskiy ◽  
Valerii Kuzminov ◽  
Oleksandr Minko ◽  
Hanna Kozhyna ◽  
Yevheniia Grynevych ◽  
...  
Keyword(s):  
Alcohol Problems ◽  
Subjective Perception ◽  
Age And Gender ◽  
Main Research ◽  
Gender And Age ◽  
Comparison Groups ◽  
Gender Characteristics ◽  
And Gender ◽  
Research Consortium ◽  
Ukrainian Society

The purpose of the work is to determine in the Ukrainian society the scale of harm inflicted by drinkers to other persons, as well as the gender and age characteristics of this harm. In four regions of Ukraine (Kharkiv, Lugansk and Zaporizhzhia regions, Kyiv), during 2018-2020, 1,742 people were examined from three qualitatively different comparison groups: patients with alcohol dependence (393 people); their healthy relatives (274 people) and representatives of the general population (1075 people). The main research tool was the questionnaire of the international research consortium GENAHTO (Gender, Alcohol, and Harms to Others). It was shown that, in general, drinkers are present in the microsocial environment of 27.62 % of the surveyed healthy respondents. Extrapolation of this indicator to the entire population of Ukraine suggests that the total number of people who suffer in one way or another due to the drinkers in their environment is about 11.6 million people. In addition, the drinkers frequency in the environment of respondents can be used to determine the real number of people with alcohol problems in our country. Preliminary calculations indicate that this number is from 1.5 to 2.2 million people. The drinkers frequency in the environment of the respondents significantly depends on the age of the latter. The highest values of this indicator are characteristic of the respondents in the age category 40—59 years old” (31.43 % for men and 41.27 % for women). The subjective perception of harm from drinkers in the environment grows steadily with increasing age of the respondents, while this growth is most pronounced in women.

scholarly journals Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 Units.

2020 ◽  
Author(s):  
Francesco Carubbi ◽  
Lia Salvati ◽  
Alessia Alunno ◽  
Fabio Maggi ◽  
Erika Borghi ◽  
...  
Keyword(s):  
Ct Scan ◽  
Time Course ◽  
Mediastinal Lymph Node ◽  
Clinical Signs ◽  
Pulmonary Involvement ◽  
Imaging Data ◽  
Age And Gender ◽  
Disease Outcomes ◽  
Wide Range ◽  
And Gender

Abstract The coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of imaging findings, depending on disease severity and time course. We conducted a retrospective evaluation of hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement, in order to identify relationships between clinical, serological, imaging data and disease outcomes in patients with COVID-19. Clinical and serological records of patients admitted to two COVID-19 Units of the Abruzzo region in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively evaluated.Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR=14.5, 95% CI=2.3-90.9, p=0.004), the presence of septal thickening (OR=8.2, 95% CI=1.6-40.9, p=0.011) and the presence of mediastinal lymph node enlargement (OR=12.0, 95% CI=1.1-127.5, p=0.039) independently of age and gender.We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease outcomes. The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.

scholarly journals Global Adoption of High-Sensitivity Cardiac Troponins and the Universal Definition of Myocardial Infarction

2019 ◽  
Vol 65 (3) ◽  
pp. 484-489 ◽  
Author(s):  
Atul Anand ◽  
Anoop S V Shah ◽  
Agim Beshiri ◽  
Allan S Jaffe ◽  
Nicholas L Mills
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Troponin ◽  
Clinical Pathways ◽  
High Sensitivity ◽  
Diagnosis And Management ◽  
Coronary Syndrome ◽  
Diagnostic Threshold ◽  
Serial Sampling ◽  
Universal Definition ◽  
Definition Of

Abstract BACKGROUND The universal definition of myocardial infarction (UDMI) standardizes the approach to the diagnosis and management of myocardial infarction. High-sensitivity cardiac troponin testing is recommended because these assays have improved precision at low concentrations, but concerns over specificity may have limited their implementation. METHODS We undertook a global survey of 1902 medical centers in 23 countries evenly distributed across 5 continents to assess adoption of key recommendations from the UDMI. Respondents involved in the diagnosis and management of patients with suspected acute coronary syndrome completed a structured telephone questionnaire detailing the primary biomarker, diagnostic thresholds, and clinical pathways used to identify myocardial infarction. RESULTS Cardiac troponin was the primary diagnostic biomarker at 96% of surveyed sites. Only 41% of centers had adopted high-sensitivity assays, with wide variation from 7% in North America to 60% in Europe. Sites using high-sensitivity troponin more frequently used serial sampling pathways (91% vs 78%) and the 99th percentile diagnostic threshold (74% vs 66%) than sites using previous-generation assays. Furthermore, high-sensitivity institutions more often used earlier serial sampling (≤3 h) and accelerated diagnostic pathways. Fewer than 1 in 5 high-sensitivity sites had adopted sex-specific thresholds (18%). CONCLUSIONS There has been global progress toward the recommendations of the UDMI, particularly in the use of the 99th percentile diagnostic threshold and serial sampling. However, high-sensitivity assays are still used by a minority of sites, and sex-specific thresholds by even fewer. Additional efforts are required to improve risk stratification and diagnosis of patients with myocardial infarction.

Changes regarding Age and Correlations between Serum Lipids and Body Mass Index in Humankind

2002 ◽  
Vol 41 (03) ◽  
pp. 202-208 ◽  
Author(s):  
I. Yamasawa ◽  
S. Kamohara ◽  
M. Shiota ◽  
T. Komori ◽  
Y. Watanabe ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Body Mass ◽  
Serum Lipids ◽  
Density Lipoprotein ◽  
Atherogenic Index ◽  
Health Examination ◽  
Age And Gender ◽  
Gender And Age ◽  
Specialized Care ◽  
And Gender

Summary Objectives: To improve insight into age and gender related distributions of serum lipids and their correlation with body mass index (BMI). Methods: Serum lipids embracing atherogenic index (AI) and BMI were analyzed from the results obtained in 19,823 men and 14,788 women undergoing a health examination between 1986 and 1996. Results: The changes in total cholesterol (TC), triglyceride (TG), AI and BMI differed regarding gender. Although high-density lipoprotein-cholesterol (HDL-C) showed a flat pattern for all ages in both genders, its level in women was higher than in men. The ratio of the number in the unsuitable range to those in the suitable range increased with age as to TC in both sexes, then more than half of the population have an unsuitable level in the sixth decade. As for the correlation between serum lipids and BMI: TC, TG and AI correlated positively, but HDL-C correlated negatively. There were significant gaps between both age and gender. Conclusions: We suggest that the normal range of values of serum lipids needs to be revised according to gender and age to evaluate the risk status for a cardio-cerebrovascular disease more precisely in the field of preventive medicine. Simpler guidelines are preferable in specialized care as well as in general practice, particularly since computer technology is not yet universally adapted. In the near future, when computed information technology will be as common as the electricity and the telephone are current on the whole earth, all guidelines will have to be computed on the spot and personally.

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