scholarly journals Differential associations of ankle and brachial blood pressures with diabetes and cardiovascular diseases: cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Hema Viswambharan ◽  
Chew Weng Cheng ◽  
Kirti Kain

AbstractIncreased brachial systolic blood-pressure (BP) predicts diabetes (T2DM) but is not fully effective. Value of absolute ankle systolic BP for T2DM compared to brachial systolic BP is not known. Our objectives were to assess independent relationships of ankle-systolic BP with T2DM and cardiovascular disease in Europeans and south Asians. Cross-sectional studies of anonymised data from registered adults (n = 1087) at inner city deprived primary care practices. Study includes 63.85% ethnic minority. Systolic BP of the left and right-brachial, posterior-tibial and dorsalis-pedis-arteries measured using a Doppler probe. Regression models’ factors were age, sex, ethnicity, body mass index (BMI) and waist height ratio (WHtR). Both brachial and ankle systolic-BP increase with diabetes in Europeans and south Asians. We demonstrated that there was a significant positive independent association of ankle BP with diabetes, regardless of age and sex compared to Brachial. There was stronger negative association of ankle blood pressure with cardiovascular disease, after adjustment for BMI, WHtR and ethnicity. Additionally, we found that ankle BP were significantly associated with cardiovascular disease in south Asians more than the Europeans; right posterior tibial. Ankle systolic BPs are superior to brachial BPs to identify risks of Type 2DM and cardiovascular diseases for enhanced patient care.

2021 ◽  
Author(s):  
Michal Kulecki ◽  
Dariusz Naskret ◽  
Mikolaj Kaminski ◽  
Dominika Kasprzak ◽  
Pawel Lachowski ◽  
...  

Abstract BackgroundPeople with type 1 diabetes mellitus (T1DM) have higher cardiovascular risk (CVR) compared to those from the general population. One of the markers of elevated CVR is a non-dipping pattern. Mean platelet volume (MPV) and platelet distribution width (PDW) are related to platelets' activation. Aortic systolic blood pressure (SBP Ao) has a better predictive value for cardiovascular disease than brachial systolic blood pressure (SBP Br). Hypertensives with non-dipping pattern have higher MPV than dippers. However, this relationship was never investigated among people with T1DM. This study aimed to investigate the association between central dipping pattern and platelets morphology in subjects with T1DM.MethodsWe measured SBPAo and SBPBr with a validated non-invasive brachial oscillometric device - Arteriograph 24 (TensioMed Ltd., Budapest, Hungary) - during twenty-four-hour analysis in T1DM subjects without diagnosed hypertension. The non-dipping pattern was defined as a nocturnal SBP Ao fall of less than 10%. We collected medical history, anthropometrical features, and laboratory results. The group was divided based on the dipping pattern for dippers and non-dippers. ResultsFrom total 62 subjects (32 males) aged 30.1 (25.7-37) years with T1DM duration 15.0 (9.0-20) years, 36 were non-dippers based on SBP Ao. Non-dipper group had significantly higher MPV (10.4 [10-10.7] fl vs 10.9 [10.3-11.5] fl; p = 0.03) and PDW (12.3 [11.7-12.8] fl vs 13.95 [11.7-15.1] fl; p=0.02) than dipper group. The groups did not differ in classic risk factors. Multivariate logistic regression revealed that MPV (OR: 3.74; 95% CI =1.48-9.45; p = 0.005) and daily insulin intake (OR: 445.11; 95% CI = 4.25 - 46597.42; p = 0.01) were independently positively associated with non-dipping pattern based on SBP Ao. PDW was also independently positively related to central non-dipping pattern (OR: 1.91; 95% CI = 1.22 - 3.00; p = 0.005).ConclusionsT1DM subjects with central non-dipping pattern have higher values of MPV and PDW than dippers. MPV and PDW are independently positively associated with SBP Ao non-dipping pattern among people with T1DM.


BJGP Open ◽  
2019 ◽  
Vol 3 (1) ◽  
pp. bjgpopen18X101636 ◽  
Author(s):  
Bjørn Gjelsvik ◽  
Anh Thi Tran ◽  
Tore J Berg ◽  
Åsne Bakke ◽  
Ibrahimu Mdala ◽  
...  

BackgroundCoronary heart disease (CHD) and stroke are the major causes of death among people with diabetes.AimTo describe the prevalence and onset of CHD and stroke among patients with type 2 diabetes mellitus (T2DM) in primary care in Norway, and explore the quality of secondary prevention.Design & settingA cross-sectional study of data was undertaken from electronic medical records (EMRs) of 10 255 patients with T2DM in general practice. The study took place in five counties of Norway (Oslo, Akershus, Rogaland, Hordaland, and Nordland). Quality of care was assessed based on national guideline recommendations.MethodSummary statistics with adjustments and binary logistic regression models were used.ResultsIn total, 2260 patients (22.1%) had CHD and 759 (7.4%) had stroke. South Asians had significantly more CHD than ethnic Norwegians (29.5%, 95% confidence interval [CI] = 26.1 to 33.0 versus 21.5%, CI = 20.6 to 22.3) and other ethnic groups, and experienced onset of CHD or stroke at a mean of 7 years before Norwegians. In 47.9% of the patients, CHD was diagnosed before T2DM. Treatment target for low-density lipoprotein (LDL) cholesterol was reached for 30.0% and for systolic blood pressure (SBP) for 65.1% of the patients with CHD. Further, 20.9% of patients with CHD were present smokers, and only 5.0% of patients reached all four treatment targets (no smoking, HbA1c ≤7.0%, SBP <135 mmHg, LDL-cholesterol <1.8 mmol/l).ConclusionThe diagnosis of CHD preceded the diagnosis of T2DM in half of the patients. The prevalence of CHD was highest and onset earlier among ethnic South Asians. More intensive treatment of lipids, blood pressure, and smoking are needed in patients with T2DM and CHD.


2014 ◽  
Vol 71 (3) ◽  
pp. 245-250 ◽  
Author(s):  
Mirjana Marinkovic ◽  
Nevenka Ilic ◽  
Dragoljub Djokic ◽  
Vesna Andrejevic ◽  
Gordana Damjanovic ◽  
...  

Background/Aim. World Health Organization (WHO) studies on the global level have shown that one of the major problems of the public health is hypertension. Blood pressure level greater than 140/90 mmHg is directly and predictively linked to other cardiovascular diseases. The aim of this research was to determine the prevalence of hypertension and the risk groups among the adult population in the Sumadija District, Serbia. Methods. This cross-sectional study included 1.669 elderly population of the Sumadija District, aged 25-74. The study was performed according to the protocol of the Country Wide Integrated Noncommunicable Disease Intervention (CINDI) international program. Results. In the Sumadija District more than a half of the population aged 25-74 suffers from hypertension (53%). In the Sumadija District 9% of population has undiagnosed hypertension. In the group of people familiar with their high blood pressure problems, good disease control is achieved in only 46% of them. Statistically, hypertension occurs more frequently in males aged 45-74, of lower education, and in rural population. This is the target group for implementation of the high risk strategy. Statistically, there is a higher prevalence of hypertension in people suffering from myocardial infarction (p = 0.04), angina pectoris (p = 0.00), other cardiac diseases (cardiac insufficiency) (p = 0.00) and cerebrovascular crises (p = 0.04). Conclusion. A continuous increase of patients with hypertension, coupled with the developed complications and increase in cardiovascular diseases as a cause of death, points to the lack of effective access to prevention and early detection of these diseases in the primary health care among the risk groups in Sumadija.


2013 ◽  
Vol 12 (3) ◽  
pp. 40-42
Author(s):  
N. A. Koryagina ◽  
I. N. Ryamzina ◽  
A. I. Shaposhnikova ◽  
E. N. Koltyrina

Aim. To assess the prevalence of major risk factors (RFs) of cardiovascular disease (CVD) in a young working population.Material and methods. This cross-sectional study included 1832 respondents (70% men and 30% women; mean age 29,44±8,6 years). The levels of blood pressure (BP), total cholesterol (TCH), and body mass index (BMI), as well as the prevalence of smoking, were assessed.Results. Elevated office BP levels were registered in 10,5%, and isolated ambulatory arterial hypertension (AH) in 10%. Overall, AH prevalence in this young working population was 20%. Elevated BP was registered in 34,2% of individuals with hypercholesterolemia (TCH >5 mmol/l), compared to 18,2% in people with TCH <5 mmol/l (p<0,001).Conclusion. The most prevalent CVD RFs in working people under 40 were obesity and AH.


2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
A. Abdullah ◽  
H. Hasan ◽  
V. Raigangar ◽  
W. Bani-Issa

Background. Obesity is a major health concern and is associated with metabolic syndrome (MetS) that increases the risk for cardiovascular disease (CVD). Since little is known about the relationships between MetS components and CVD in overweight/obese young Arab females, our study aimed at examining these relationships and further to explore the associations between connecting peptide (C-peptide) and insulin with these biomarkers.Subjects and Methods. In this cross-sectional study, 80 apparently healthy young Arab females were recruited and grouped by their body mass index (BMI) into normal-weight (GI) and overweight/obese (GII) groups.Results. The two groups significantly differed in BMI, waist circumference (WC) and values of biomarkers, namely, leptin, fasting insulin, uric acid (UA), insulin resistance (HOMA-IR), C-peptide, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP). C-peptide significantly correlated with WC, leptin, UA, and HDL-C and was predicted by three biomarkers; UA, WC and HDL-C. Whereas, insulin significantly correlated with only two biomarkers including leptin and DBP and was predicted by UA and DBP.Conclusions. The present study highlighted the association between MetS and CVD in young Arab females and the possible role of C-peptide in the prediction of CVD.


2018 ◽  
Vol 26 (4) ◽  
pp. 356-364 ◽  
Author(s):  
Jose M Mostaza ◽  
Carlos Lahoz ◽  
Miguel A Salinero-Fort ◽  
Juan Cardenas

Aims Nonagenarians are a fast growing segment of industrialized countries' populations. Despite a greater risk of cardiovascular disease, there are limited data about their use of preventive therapies and factors guiding decisions regarding their prescription. The aim of this study was to evaluate the prevalence of cardiovascular diseases and the patterns of use of cardiovascular treatments in subjects ≥90 years old. Methods Population-based, cross-sectional study, in all nonagenarians residing in the Community of Madrid (Spain). Data were obtained from their electronic clinical records in primary care. Results Data were available from 59,423 subjects (mean age 93.3 years, 74.2% female, 13.5% with dementia). Prevalence of cardiovascular disease was 24.1% (10.9% with coronary artery disease (CAD), 13.1% with cerebrovascular disease (CVD) and 2.7% with peripheral artery disease(PAD)). In primary prevention, the use of statins and antiplatelet agents was 21.9% and 26.7%, respectively. Of subjects with vascular disease 27.7% were receiving a combined preventive strategy (use of antithrombotics, plus statins, plus blood pressure below 140/90 mmHg). Factors favourably associated with a combined preventive strategy were: female sex (odds ratio (OR) 1.29; 95% confidence interval (CI): 1.11–1.49), being independent versus totally dependent (OR 1.94; 95% CI: 1.43–2.65), diabetes (OR 1.42; 95% CI: 1.20–1.68), and negatively, age (OR 0.87; 95% CI: 0.85–0.90), CVD versus CAD (OR 0.41; 95% CI: 0.35–0.47), PAD versus CAD (OR 0.23; 95% CI: 0.18–0.30), dementia (OR 0.61; 95% CI: 0.49–0.76) and nursing home residency (OR 0.73; 95% CI: 0.57–0.93). Conclusion Nonagenarians have a great burden of cardiovascular diseases and receive a great number of preventive therapies, even in primary prevention, despite their unproven efficacy at these ages.


2010 ◽  
Vol 128 (1) ◽  
pp. 10-13 ◽  
Author(s):  
Ivete Cristina Teixeira Canti ◽  
Márcia Komlós ◽  
Sérgio Hofmeister Martins-Costa ◽  
José Geraldo Lopes Ramos ◽  
Edison Capp ◽  
...  

CONTEXT AND OBJECTIVE: Preeclampsia is a gestational disease that occurs mainly among nulliparous women after the 20th week of gestation, and frequently close to delivery. The effects of preeclampsia on women's blood pressure over the long term are still controversial. Patients with recurrent preeclampsia or preeclampsia in the early stages of pregnancy appear to present higher risk of hypertension. The aim of this study was to determine the risk factors for cardiovascular disease among women with preeclampsia 10 years earlier. DESIGN AND SETTING: Cross-sectional study at Hospital de Clínicas de Porto Alegre (HCPA). METHODS: Forty women with preeclampsia and 14 normotensive pregnant women followed up 10 or more years earlier at HCPA underwent clinical and laboratory examinations. Spearman's correlation coefficient was used to correlate body mass index (BMI) and systolic and diastolic pressures. The risk of developing hypertension was measured using the chi-square test. P < 0.05 was considered significant. RESULTS: The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure (P = 0.047), BMI (P = 0.019) and abdominal circumference (P = 0.026). They presented positive correlations between BMI and diastolic blood pressure (0.341; P = 0.031) and between BMI and systolic blood pressure (0.407; P = 0.009). CONCLUSION: The patients with preeclampsia 10 or more years earlier had significantly higher diastolic blood pressure, BMI and abdominal circumference than did the control group. This emphasizes the importance of long-term follow-up assessment for cardiovascular risk factors among patients with preeclampsia.


2021 ◽  
pp. 105477382110300
Author(s):  
Zeying Qin ◽  
Songli Mei ◽  
Tingting Gao ◽  
Leilei Liang ◽  
Chuanen Li ◽  
...  

This study explores the association between life satisfaction and depression among patients with cardiovascular diseases and whether this association is mediated by self-esteem. A cross-sectional study was conducted in a third-grade hospital. We examined 300 patients with cardiovascular diseases with a mean age of 62.00 years (females, 133). Life satisfaction was associated with depression. Adding self-esteem to the model weakened the strength of the association between the two. Moreover, 34.2% of the effect of life satisfaction on depression could be explained by self-esteem. We found that self-esteem could totally explain the effect of life satisfaction on depression among patients with cardiovascular diseases.


2020 ◽  
Vol 11 (4) ◽  
pp. 6855-6859
Author(s):  
Ismail Y ◽  
Haja Nazeer Ahamed ◽  
Vijaya Vara Prasad M ◽  
Vadivelan Ramachandran

Recent Indian study protocol designed for the supervision of cardiovascular disease instructed as well as better therapeutic achievement underneath the accustomed cardiovascular disease inhabitants. After all, a few people (25%) of heart-related problems inhabitants being conscious, 80% of the people were treated; besides just 20% were composed. This study was conducted as a cross-sectional study laminated arbitrary examine and inspected during the period of 4th Mar 2017 to 3rd July 2017 in the form of order. The model framework was put up pedestal scheduled, the portal system of the area inhabitants record as of inhabitants in the sequence of Nellore. Analytical clue, hypertension situation, and way of life behavior of the contributors were revealed. Hereby observed hypertension occurrence, consciousness, therapy, management, and drugs. The study appearance 57.2% of observed inhabitants to exist confidential the same as blood pressure living being conscious of their earlier analysis of blood pressure. This deliberation has been observed as a laminated casual inspect characterizing the Indian developed inhabitants in city areas of Nellore, India. As well as-discussed training procedure was attended with employing a definitive covenant and tool and makes certain the superiority of the fact compilation agenda. This hypertension wellbeing control can be taught the communal base and it prevents the public from cardiovascular disease avoidance plan may be effectual and humanizing to manage the blood pressure.


Circulation ◽  
2015 ◽  
Vol 131 (suppl_1) ◽  
Author(s):  
Sanjay Rampal ◽  
Juhee Cho ◽  
Yuni Choi ◽  
Yiyi Zhang ◽  
Di Zhao ◽  
...  

Introduction: Diet is a complex exposure of unquestionable relevance for cardiovascular disease (CVD) risk. South Korea, a population with traditionally low rates of CVD, has changed in recent decades from a traditional diet to more Western and modern dietary patterns. The impact of these changes are uncertain. Hypothesis: We aimed to evaluate the hypothesis that non-traditional dietary patterns were associated with an increased prevalence of hypertension in a large sample of young and middle-aged Korean adults. Methods: We conducted a cross sectional study of 220,979 adult men and women who underwent a screening health examination between January 2011 and December 2013 at the Kangbuk Samsung Total Healthcare Center in Seoul and Suwon, South Korea who did not have any history of cardiovascular disease, cancer, diabetes, hypertension, or dyslipidemia. Diet was assessed using a validated 103-item food frequency questionnaire and principal component analysis was used to derive three major dietary patterns: Western Korean, characterized by higher intakes of noodles, red meat, processed meat, raw or salted fish, shellfish, poultry, soda, and alcohol; Traditional Korean, characterized by higher intakes of vegetables, mushrooms, preserved vegetables, soya and other beans, fruits, fish, and seaweed; and Modern Korean, characterized by higher intakes of bread and cereals, milk and dairy products, snacks, and pizza, and lower intakes of alcohol, rice, and preserved vegetables. Hypertension was defined as having a systolic blood pressure ≥140 mmHg and/or a diastolic blood pressure ≥ 90 mmHg. Systolic hypertension was defined as having a systolic blood pressure ≥140 mmHg. Results: The prevalence of hypertension was 2.9%. In fully adjusted multivariable models, the odds ratios for hypertension comparing the 90th to the 10th percentile of dietary scores were 1.58 (95%CI 1.42, 1.75), 1.11 (95%CI 1.01, 1.21), 0.73 (95%CI 0.66, 0.81) for Western, Traditional, and Modern Korean dietary patterns, respectively. The corresponding odds ratios for systolic hypertension were 1.50 (95%CI 1.28, 1.76), 1.17 (95%CI 1.01, 1.36), and 0.68 (95%CI 0.58, 0.79), respectively. Conclusion: In this large cross-sectional study of young and middle-aged Korean men and women, diet transition to a more Western pattern, characterized by higher intake of meats and alcohol, was associated with a higher prevalence of hypertension and may be associated with increased CVD risk.


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