scholarly journals C-Peptide Versus Insulin: Relationships with Risk Biomarkers of Cardiovascular Disease in Metabolic Syndrome in Young Arab Females

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
A. Abdullah ◽  
H. Hasan ◽  
V. Raigangar ◽  
W. Bani-Issa
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Health Concern ◽  
Cross Sectional ◽  
C Peptide

Background. Obesity is a major health concern and is associated with metabolic syndrome (MetS) that increases the risk for cardiovascular disease (CVD). Since little is known about the relationships between MetS components and CVD in overweight/obese young Arab females, our study aimed at examining these relationships and further to explore the associations between connecting peptide (C-peptide) and insulin with these biomarkers.Subjects and Methods. In this cross-sectional study, 80 apparently healthy young Arab females were recruited and grouped by their body mass index (BMI) into normal-weight (GI) and overweight/obese (GII) groups.Results. The two groups significantly differed in BMI, waist circumference (WC) and values of biomarkers, namely, leptin, fasting insulin, uric acid (UA), insulin resistance (HOMA-IR), C-peptide, high-sensitivity C-reactive protein (hs-CRP), high-density lipoprotein cholesterol (HDL-C), systolic blood pressure (SBP), and diastolic blood pressure (DBP). C-peptide significantly correlated with WC, leptin, UA, and HDL-C and was predicted by three biomarkers; UA, WC and HDL-C. Whereas, insulin significantly correlated with only two biomarkers including leptin and DBP and was predicted by UA and DBP.Conclusions. The present study highlighted the association between MetS and CVD in young Arab females and the possible role of C-peptide in the prediction of CVD.

Melatonin and cryptochrome 2 in metabolic syndrome patients with or without diabetes: a cross-sectional study

2018 ◽  
Vol 35 (2) ◽  
Author(s):  
Ibrahim Abdul Kareem Al-Sarraf ◽  
Violet Kasabri ◽  
Amal Akour ◽  
Randa Naffa
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Overweight And Obesity ◽  
P Value ◽  
Metabolic Risk ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cryptochrome 2

Abstract Background Metabolic syndrome (MetS) is a cluster of metabolic risk factors which increases the chances for future cardiovascular diseases, as well as diabetes. The underlying causes of MetS include overweight and obesity, physical inactivity and genetic factors. Our intension here was to focus in this study on the importance of the chronobiology, represented by melatonin (MT) and cryptochrome 2 (CRY2), in developing MetS and type 2 diabetes mellitus (T2DM). Thus, we aimed to compare MT and CRY2 plasma levels and correlate both biomarkers with adiposity, atherogenicity and hematological indices in MetS and T2DM cohorts. Methods In a cross-sectional study, 28 normoglycemic lean subjects (controls), 29 normoglycemic MetS subjects and 30 MetS (pre-diabetic/diabetic) were recruited. Results MT (pg/mL) was elevated significantly in MetS arm p-value < 0.05, whereas CRY2 levels (ng/mL) were markedly higher in both MetS groups (non-diabetic and pre-diabetic/diabetic) (all with p-value < 0.001). A reciprocal MT-CRY2 relationship was observed in the MetS (non-diabetic) group (p-value = 0.003). Of note in the total study population, both MT and CRY2 proportionally correlated with each of the following: atherogenicity index of plasma (AIP), waist circumference (WC) and systolic blood pressure (SBP) (all with p-value < 0.05) for MT and CRY2, respectively). Whereas MT correlated inversely with high-density lipoprotein-cholesterol (HDL-C) (p-value < 0.05). Additionally, CRY2 correlated directly with each of the following: diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein (LDL-C), hip circumference (HC), body adiposity index (BAI), weight-to-height (WHtR) ratio, mean platelet volume (MPV) and platelet/lymphocyte ratio (PLR) (p-value < 0.05). Conclusion These findings substantiate that both metabolic risk biomarkers can be prognostic tools and pharmacotherapeutic targets to slowdown the accelerated nature of T2DM.

Abstract 3554: Metabolic Syndrome in Non-Obese Population: A Growing Concern

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Susana Martins ◽  
Nuno Cortez-Dias ◽  
Manuela Fiuza
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
High Blood Pressure ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
National Registry ◽  
Normal Weight ◽  
Cross Sectional ◽  
High Prevalence ◽  
Obese Population

Context: There is general consensus that prevalence of metabolic syndrome (MS) increases with body mass index (BMI), but less is known in normal weight individuals. Objectives: To determine the prevalence and likelihood of MS and its components in normal weight (NW: 18.5–24.9 kg/m 2 ), overweight (OW: 25–29.9 kg/m 2 ) and obese individuals (OB: ≥30 kg/m 2 ). NW parameters were further divided in the following: 18.5–20.9; 21–22.9; 23–24.9 kg/m 2 . Methods: Descriptive cross-sectional study representative of all regions of Portugal. Individuals ≥18 years visiting their general practicioner, irrespective of their reason for consulting, were asked to participate after informed consent in the national registry of MS prevalence (VALSIM). MS was defined by NCEP-ATP III criteria. Overall MS, each of its components, as well as gender and age-specific prevalences were estimated. Multivariate regression analysis was used to estimate the odds ratio (OR) of MS by age, gender and BMI. Results: A total of 16333 adults was analysed (mean age: 59±14 years; 61% women). The overall prevalence of MS was 29.4%. Risk of MS was higher in women and rose with age. The OR for MS in OW and OB was three and nine times, respectively. However, even non-obese population had an unexpected high prevalence of MS, particularlly in upper NW and OW Individuals. The analysis of each MS-component according to BMI showed that high blood pressure is highly prevalent in these Individuals, with relevance for those in lower NW. The occurence of fasting hyperglicemia (>110mg/dL) in NW and OW Individuals was 13.6% and 25.1%, respectively. Conclusions: Individuals in the upper normal-weight and overweight BMI range have a high prevalence of high blood pressure, fasting hyperglicemia and MS. Therefore, screening individuals with normal or slightly elevated BMI is important in the prevention of diabetes mellitus and cardiovascular disease. Prevalence of MS and individual components according to BMI

scholarly journals Risk of Cardiovascular Disease Related to Metabolic Syndrome in College Students: A Cross-Sectional Secondary Data Analysis

2019 ◽  
Vol 16 (19) ◽  
pp. 3708 ◽  
Author(s):  
Jang ◽  
Kim
Keyword(s):  
College Students ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Cardiovascular Diseases ◽  
Density Lipoprotein ◽  
Secondary Data ◽  
Cross Sectional Study ◽  
Female Students ◽  
Clinical Variable ◽  
Cross Sectional

Early detection of metabolic syndrome (MS) in young adults can lead to decreased aggravation and help prevent diabetes and cardiovascular diseases. This cross-sectional study aimed to identify the prevalence of MS and its components in Korean college students and was based on the Korean National Health and Nutrition Examination Survey, which used a stratified multistage probability sampling design. In total, 6.5% male and 4.1% female students had MS; of these, 26.6% of male and 25.8% of female students presented with at least one MS component. Height, weight, body mass index (BMI), waist circumference (WC), systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, high-density lipoprotein cholesterol, and triglycerides were significantly higher in men than in women, and all of these variables showed significant differences according to BMI. As the BMI increased, the level of each anthropometric, biochemical, and clinical variable increased. Although only a few students in Korea had three or more risk factors, the proportion of college students with one risk factor for MS was relatively high. Therefore, educational and intervention programs should be conducted in college students with overweight or obesity so that they can change their lifestyle to reduce the risk of cardiovascular diseases and diabetes.

scholarly journals A study of correlation of pulmonary function test in patients with metabolic syndrome with different components of metabolic syndrome

2022 ◽  
Author(s):  
Prabhu S. ◽  
Sudha Karbari
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Pulmonary Function ◽  
Pulmonary Function Tests ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Forced Expiratory Volume ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Social

Background: The increasing incidence of metabolic syndrome has been on the rise especially in urban population and leading to increased risk of cardiovascular disease (CVD) and diabetes mellitus. It has been associated with impairment of pulmonary functions. However, there is limited data regarding the association with individual components of metabolic syndrome and overall effect on components of pulmonary functions.Methods: This is a cross sectional study consisting of 50 subjects with metabolic syndrome. All the subjects underwent pulmonary function tests and the association between different components of metabolic syndrome and pulmonary function were examined using unpaired t-test and Pearson’s partial correlation coefficient. This data was analysed by using statistical package for the social sciences (SPSS) version 12.0.Results: In females, moderate negative significant correlation was seen between forced vital capacity (FVC) and systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting blood sugar (FBS), triglyceride (TG), waist circumference (WC) and body mass index (BMI) whereas positive weak non-significant correlation was seen between FVC and high density lipoprotein cholesterol (HDLC), while no such relation was found with forced expiratory volume in one second (FEV1). In males, negative, moderate significant correlation was seen between FVC and FBS whereas strong, positive, significant correlation was seen between FVC and WC; between FVC and BMI. Negative, moderate, significant correlation was seen between FEV1 and WC; between FEV1 and BMI.Conclusions: Our study concluded that there was a significant impact of FBS and WC on decreasing FVC on both genders with minimally significant impact of other components of metabolic syndrome on FVC with no effect on FEV1 hence indicating a restrictive pattern of pulmonary function derangement. Hence, further studies with larger sample size is needed to confirm whether there are direct or indirect mechanisms through which insulin resistance could affect pulmonary function.

Prevalence and predictors of metabolic syndrome among healthy Saudi Adults

2012 ◽  
Vol 12 (2) ◽  
pp. 78-80 ◽  
Author(s):  
Abdullah M Alzahrani ◽  
Abdullah M Karawagh ◽  
Fahad M Alshahrani ◽  
Tariq A Naser ◽  
Almoutaz Alkhier Ahmed ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
National Guard ◽  
Fasting Blood Glucose ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Gulf Region ◽  
Cross Sectional ◽  
Important Health ◽  
High Triglyceride

The prevalence of metabolic syndrome was determined as a cross-sectional study among 600 healthy Saudi adults (52% males and 58% aged 35–50 years) attending National Guard clinics using the definition proposed by National Cholesterol Education Program Adult Treatment Panel III. The prevalence of metabolic syndrome was 21%. Only one third of the participants had normal weight (body mass index = 18.5–24.9). Central obesity based on waist circumferences was noted in 21% of males and 22% of females. Low high-density lipoprotein-C showed the highest prevalence (29%) followed by high triglyceride (24%). About 14% of participants had impaired fasting blood glucose (≥ 110 mg/dl). Only 6% had high blood pressure (≥ 130/85 mmHg). More than three quarters (77.3%) of the respondents had > 1 component of metabolic syndrome. In conclusion, metabolic syndrome needs to be addressed as an important health problem in the Gulf region.

scholarly journals Comparison of metabolic syndrome criteria in obese and overweight children

2010 ◽  
Vol 50 (5) ◽  
pp. 295 ◽  
Author(s):  
Astrid Anastasia Malonda ◽  
Helena Anneke Tangkilisan
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Waist Circumference ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Overweight Child ◽  
Test Results ◽  
Overweight Children ◽  
Obese Children ◽  
Cross Sectional

Background Metabolic syndrome (MS) is a group of disorders which occur in relation to increasing body weight. Only a few studies have reported the differences in the fulfillment of MS criteria between obese and overweight children, and none were from Indonesia.Objective To detennine the differences in metabolic syndrome disorders between obese and overweight children.Methods A cross-sectional study was conducted in Manado from May to August 2010. The diagnosis of MS is established by fulfilling three of five criteria: waist circumference  ≥90th percentile, blood pressure ≥ 90th  percentile, fasting blood sugar (FBS) ≥ 100 mg/dL, triglycerides  ≥110 mg/dL and high density lipoprotein (HDL) ≤40 mg/dL. Obesity was defined as body mass index (BMI) of> 3 SD and overweight as BMI of 2-3 SD. Results Results ere analyzed by x2 and t-test. Results Thirty obese and 30 overweight children aged 10-14years were examined for the disorders of MS. Twenty􀁄three obese and 4 overweight children had waist circumferences  ≥90th percentile. Seventeen obese and 3 overweight children had blood pressure  ≥90th percentile. No significant differences in FBS, HDL, and triglycerides were observed between the two groups. Thirteen obese children met the MS inclusion criteria, while only 1 overweight child did so (P<0.001).Conclusions High blood pressure (≥90th percentile) and waist circumference (≥90th  percentile) occurred were observed at higher frequency in obese children than in overweight children. The occurrence of MS in obese children was significantly higher than in overweight children.

scholarly journals Prevalence of Metabolic Syndrome in Women With Polycystic Ovarian Diseases in a Outdoor Setting

2013 ◽  
Vol 23 (2) ◽  
pp. 18-21
Author(s):  
Shahanara Chowdhury ◽  
Afroza Ferdous
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Serum Prolactin ◽  
Obese Women ◽  
Cross Sectional ◽  
Outdoor Setting ◽  
Increased Risk ◽  
Ovarian Diseases

Polycystic ovarian diseases (PCOD) is a condition associated with chronic anovulation, insulin resistance and androgen access. Women with this syndrome are at increased risk of metabolic syndrome. The aim of the present study was to determine the prevalence of metabolic syndrome (MBS) in women with PCOD in a private outdoor setting in different ages and body mass index (BMI). A cross sectional study was conducted in a private clinic setting. A total of 146 women with PCOD ages between 15-40 years included. The prevalence of metabolic syndrome and its components in these population were the outcomes. Height, weight, waist circumference, blood pressure and the laboratory tests (FBS,TSH,HDLC, serum prolactin, triglycerides and total cholesterol) were measured in this population. The prevalence of MBS in PCOD women was 24% (36 cases). The rate of central obesity, FBS more than 110 mg/dl, triglycerides more than 150 mg/dl, high-density lipoprotein cholesterol levels (HDL-C) less than 50 mg/dl, and blood pressure 130/85 mmHg in PCOD women was 29.45% (43), 4.10% (6), 34.93% (51), 66.43% (97), and 10.27% (15), respectively. The risk of MBS was increased in older and the obese women (BMI 30 kg/m2). The present study showed that women with PCOD have high prevalence of MBS & its individual components, particularly decreased HDL-C. JCMCTA 2012 ; 23 (2): 18-21

scholarly journals Association of breastfeeding and risk of metabolic syndrome and its components in postmenopausal parous women: Korea national health and nutrition examination survey (2010 ~ 2016)

2021 ◽  
Vol 79 (1) ◽  
Author(s):  
Jusuk Lee ◽  
Taehong Kim
Keyword(s):  
Metabolic Syndrome ◽  
Laboratory Data ◽  
Multivariate Logistic Regression Analysis ◽  
Density Lipoprotein ◽  
Cross Sectional Study ◽  
Korean Women ◽  
Cross Sectional ◽  
Increased Risk ◽  
Nationally Representative ◽  
Study Participants

Abstract Background Understanding the relationship between breastfeeding (BF) and metabolic syndrome (Mets) is important for maternal long-term health benefits and disease prevention. This study aimed to examine the association between BF and Mets and its components among postmenopausal parous Korean women. Methods This cross-sectional study on 10,356 Korean women used nationally representative data from the KNHANES from 2010 to 2016. Anthropometric, laboratory data and manual BP were measured. A multivariate logistic regression analysis was conducted to examine the association of BF with Mets and its components after adjusting for potential confounding variables. A p-value < 0.05 was to be considered statistically significant. Results Mets was present in 42% of the study participants. The BF group had low household income and education level. The prevalence of Mets in the BF group was higher than that in the non-BF group (42.69% vs. 34.76%, p <  0.001). BF was associated with increased risk of Mets (odds ratio [OR]: 1.4, 95% confidence interval [CI]: 1.18–1.65, p <  0.001). The BF group was at higher risks for diabetes (OR: 1.5, 95%CI: 1.14–1.98), hypertension (OR: 1.32, 95%CI: 1.03–1.68), hypertriglyceridemia (OR: 1.42, 95%CI: 1.02–1.99) and low high-density lipoprotein cholesterol (OR: 1.32, 95%CI: 1.06–1.65). Conclusion In this study, BF did not affect decreasing the prevalence of Mets and its components.

scholarly journals Serum paraoxonase-1 activity is associated with light to moderate alcohol consumption: the PREVEND cohort study

2018 ◽  
Vol 108 (6) ◽  
pp. 1283-1290 ◽  
Author(s):  
Eke G Gruppen ◽  
Stephan J L Bakker ◽  
Richard W James ◽  
Robin P F Dullaart
Keyword(s):  
Alcohol Consumption ◽  
Linear Regression Analysis ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
High Sensitivity ◽  
Population Based ◽  
Cross Sectional Study ◽  
Paraoxonase 1 ◽  
Phenyl Acetate ◽  
Cross Sectional

ABSTRACT Background Paraoxonase-1 (PON-1) is a high-density lipoprotein (HDL)-associated enzyme with antioxidative properties, which may protect against the development of cardiovascular disease. Alcohol consumption increases HDL cholesterol, but the extent to which alcohol consumption gives rise to higher serum PON-1 activity is uncertain. Objective In a population-based study, we determined the relation of serum PON-1 activity with alcohol consumption when taking account of HDL cholesterol and apolipoprotein A-I (apoA-I), its major apolipoprotein. Design A cross-sectional study was performed in 8224 participants of the Prevention of Renal and Vascular End-Stage Disease (PREVEND) cohort. Alcohol consumption was categorized as 1) no/rarely (25.3%); 2) 0.1–10 g/d (49.3%); 3) 10–30 g/d (20.1%); and 4) >30 g/d (5.2%) with 1 drink equivalent to 10 g alcohol. Serum PON-1 activity was measured as its arylesterase activity (phenyl acetate as substrate). Results Median serum PON-1 activity was 50.8, 53.1, 54.4, and 55.7 U/L in the 4 categories of alcohol consumption, respectively (P < 0.001). Its increase paralleled the increments in HDL cholesterol and apoA-I. Notably, there was no further increase in PON-1 activity, HDL cholesterol, and apoA-I when alcohol consumption was increased from 10–30 g/d to >30 g/d. Multivariable linear regression analysis demonstrated that PON-1 activity was related to alcohol consumption independently from clinical covariates, high sensitivity C-reactive protein, and lipid concentrations, including HDL cholesterol (P < 0.001 for each category of alcohol consumption with no alcohol consumption as the reference category). Notably, as inferred from standardized β-coefficients, there was no difference in PON-1 activity between 10–30 g alcohol/d and >30 g alcohol/d. Conclusions Alcohol consumption is associated with an increase in serum PON-1 activity, but its effect seems to reach a plateau with alcohol consumption of 10–30 g/d.

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