Author Correction: Differences in lung cancer characteristics and mortality rate between screened and non-screened cohorts

AbstractLung cancer is the leading cause of death worldwide. Especially, non-small cell lung cancer (NSCLC) has higher mortality rate than the other cancers. The high mortality rate is partially due to lack of efficient biomarkers for detection, diagnosis and prognosis. To find high efficient biomarkers for clinical diagnosis of NSCLC patients, we used gene differential expression and gene ontology (GO) to define a set of 26 tumor suppressor (TS) genes. The 26 TS genes were down-expressed in tumor samples in cohorts GSE18842, GSE40419, and GSE21933 and at stages 2 and 3 in GSE19804, and 15 TS genes were significantly down-expressed in tumor samples of stage 1. We used S-scores and N-scores defined in correlation networks to evaluate positive and negative influences of these 26 TS genes on expression of other functional genes in the four independent cohorts and found that SASH1, STARD13, CBFA2T3 and RECK were strong TS genes that have strong accordant/discordant effects and network effects globally impacting the other genes in expression and hence can be used as specific biomarkers for diagnosis of NSCLC cancer. Weak TS genes EXT1, PTCH1, KLK10 and APC that are associated with a few genes in function or work in a special pathway were not detected to be differentially expressed and had very small S-scores and N-scores in all collected datasets and can be used as sensitive biomarkers for diagnosis of early cancer. Our findings are well consistent with functions of these TS genes. GSEA analysis found that these 26 TS genes as a gene set had high enrichment scores at stages 1, 2, 3 and all stages.

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Leading cancers contributing to educational disparities in cancer mortality in the US, 2017

Cancer Causes & Control ◽

10.1007/s10552-021-01471-9 ◽

2021 ◽

Author(s):

Diana R. Withrow ◽

Neal D. Freedman ◽

James T. Gibson ◽

Mandi Yu ◽

Anna M. Nápoles ◽

...

Keyword(s):

Lung Cancer ◽

High School ◽

Mortality Rate ◽

Cancer Mortality ◽

Death Certificate ◽

Bachelor's Degree ◽

Educational Disparities ◽

Individual Level ◽

Death Certificate Data ◽

The Us

Abstract Purpose To inform prevention efforts, we sought to determine which cancer types contribute the most to cancer mortality disparities by individual-level education using national death certificate data for 2017. Methods Information on all US deaths occurring in 2017 among 25–84-year-olds was ascertained from national death certificate data, which include cause of death and educational attainment. Education was classified as high school or less (≤ 12 years), some college or diploma (13–15 years), and Bachelor's degree or higher (≥ 16 years). Cancer mortality rate differences (RD) were calculated by subtracting age-adjusted mortality rates (AMR) among those with ≥ 16 years of education from AMR among those with ≤ 12 years. Results The cancer mortality rate difference between those with a Bachelor's degree or more vs. high school or less education was 72 deaths per 100,000 person-years. Lung cancer deaths account for over half (53%) of the RD for cancer mortality by education in the US. Conclusion Efforts to reduce smoking, particularly among persons with less education, would contribute substantially to reducing educational disparities in lung cancer and overall cancer mortality.

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MOS Sensors Array for the Discrimination of Lung Cancer and At-Risk Subjects with Exhaled Breath Analysis

Chemosensors ◽

10.3390/chemosensors9080209 ◽

2021 ◽

Vol 9 (8) ◽

pp. 209

Author(s):

Davide Marzorati ◽

Luca Mainardi ◽

Giulia Sedda ◽

Roberto Gasparri ◽

Lorenzo Spaggiari ◽

...

Keyword(s):

Lung Cancer ◽

Survival Rate ◽

Mortality Rate ◽

Early Diagnosis ◽

Gas Sensor ◽

Electronic Nose ◽

Gas Sensors ◽

Breath Analysis ◽

Exhaled Breath ◽

Exhaled Breath Analysis

Lung cancer is characterized by a tremendously high mortality rate and a low 5-year survival rate when diagnosed at a late stage. Early diagnosis of lung cancer drastically reduces its mortality rate and improves survival. Exhaled breath analysis could offer a tool to clinicians to improve the ability to detect lung cancer at an early stage, thus leading to a reduction in the associated survival rate. In this paper, we present an electronic nose for the automatic analysis of exhaled breath. A total of five a-specific gas sensors were embedded in the electronic nose, making it sensitive to different volatile organic compounds (VOCs) contained in exhaled breath. Nine features were extracted from each gas sensor response to exhaled breath, identifying the subject breathprint. We tested the electronic nose on a cohort of 80 subjects, equally split between lung cancer and at-risk control subjects. Including gas sensor features and clinical features in a classification model, recall, precision, and accuracy of 78%, 80%, and 77% were reached using a fourfold cross-validation approach. The addition of other a-specific gas sensors, or of sensors specific to certain compounds, could improve the classification accuracy, therefore allowing for the development of a clinical tool to be integrated in the clinical pipeline for exhaled breath analysis and lung cancer early diagnosis.

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The correlation between hemostatic parameters and mortality rate in patients with non-small cell lung cancer

Hematology Reports ◽

10.4081/hr.2021.8361 ◽

2021 ◽

Vol 13 (3) ◽

Author(s):

Noni Novisari Soeroso ◽

Fannie Rizki Ananda ◽

Ganda Samosir ◽

Herman Hariman ◽

Putri Chairani Eyanoer

Keyword(s):

Lung Cancer ◽

Mortality Rate ◽

Cancer Progression ◽

Poor Prognosis ◽

Analytical Study ◽

Small Cell ◽

Small Cell Lung ◽

Significant Difference ◽

D Dimer

The increasing level of hemostatic parameters and tumor markers were associated with cancer progression and poor prognosis, particularly in NSCLC. The objective of this study is to determine whether there was a correlation between hemostatic parameters and mortality rate in patients with NSCLC. This was a prospective analytical study with a pretest-posttest design which included 41 patients with diagnosis of NSCLC. Plasma levels of PT, APTT, TT, D-dimer, and fibrinogen were measured before initiation of chemotherapy and remeasured after 4 cycles or 6 cycles of chemotherapy, based on the clinical condition of patients. Then, patients were followed up for 1 year to evaluate the mortality rate. The majority of subjects were male (85.4%) with adenocarcinoma (75.6%). There was no significant difference in mean between adenocarcinoma and squamous cell carcinoma (P>0.05). Most patients died after one month of follow up (61%). The parameters which could predict high mortality rate in NSCLC were prolonged PT and the increased of D-dimer with RR>1, although they had not significant in statistical analysis (P>0.05). There is no correlation between hemostatic parameters and mortality rate in patients with NSCLC.

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Delivery of miR-320a-3p by gold nanoparticles combined with photothermal therapy for directly targeting Sp1 in lung cancer

Biomaterials Science ◽

10.1039/d1bm01124c ◽

2021 ◽

Author(s):

Jiefei Peng ◽

Ranran Wang ◽

Wanru Sun ◽

Minhua Huang ◽

Rong Wang ◽

...

Keyword(s):

Lung Cancer ◽

Overall Survival ◽

Gold Nanoparticles ◽

Mortality Rate ◽

Photothermal Therapy ◽

Therapeutic Targets ◽

Novel Therapeutic

Lung cancer is the second most common tumor and has the highest mortality rate. Both novel therapeutic targets and approaches are needed to improve the overall survival of patients with...

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A New Multiparametric Classification in Lung Cancer Patients - S.M.I.G.

Tumori Journal ◽

10.1177/030089168306900511 ◽

1983 ◽

Vol 69 (5) ◽

pp. 437-443 ◽

Cited By ~ 2

Author(s):

Claudio Modini ◽

Mario Albertucci ◽

Franco Cicconetti ◽

Donatella Tirindelli Danesi ◽

Renzo Cristiani ◽

...

Keyword(s):

Lung Cancer ◽

Growth Rate ◽

Mortality Rate ◽

Cancer Patients ◽

Cell Type ◽

Tnm System ◽

Lung Cancer Patients ◽

The Difference

The classification of bronchogenic carcinoma as a function of the prognosis is still an open field. The evaluation of stage, by use of the TNM system, and histologic cell type is not sufficient to guarantee a correct prognosis. The growth rate of the neoplasm is another important parameter. We propose a classification that takes into account the stage (S), histologic cell type (M), immune status (I) and the growth rate of the primary tumor (G): S.M.I.G. We studied 90 lung cancer patients according to the S.M.I.G. classification and we observed that their prognoses were directly correlated with their S.M.I.G. scores (the higher the score, the higher the 10-month mortality rate). The mortality rates within the first 10 months of follow-up were respectively 0%, 0%, 36.36%, 68%, 90.9% for the 5 groups obtained by S.M.I.G. The difference is statistically significant (P < 0.0075) and there is a linear correlation between the mortality rate and the score assigned to each group (R = 0.943; P < 0.05). The S.M.I.G. classification can predict the prognosis more efficiently than the usual classification (TNM) and histological cell type.

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Lung cancer mortality rate falling among men, rising among women

Lung Cancer ◽

10.1016/0169-5002(96)84227-9 ◽

1995 ◽

Vol 13 (3) ◽

pp. 325

Keyword(s):

Lung Cancer ◽

Mortality Rate ◽

Cancer Mortality ◽

Lung Cancer Mortality

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Curative-intent resection for bronchogenic carcinoma in patients with prior spinal cord injury: The Department of Veterans Affairs experience

Journal of Clinical Oncology ◽

10.1200/jco.2006.24.18_suppl.17127 ◽

2006 ◽

Vol 24 (18_suppl) ◽

pp. 17127-17127

Author(s):

L. S. Brunworth ◽

D. Dharmasena ◽

K. S. Virgo ◽

F. E. Johnson

Keyword(s):

Lung Cancer ◽

Spinal Cord ◽

Spinal Cord Injury ◽

Mortality Rate ◽

Bronchogenic Carcinoma ◽

Veterans Affairs ◽

Department Of Veterans Affairs ◽

Curative Intent ◽

Cord Injury ◽

Morbid Conditions

17127 Background: There are approximately 250,000 people with spinal cord injury (SCI) in the US, and they have a high prevalence of smoking. A literature search yielded no published information concerning the clinical course of SCI patients who subsequently develop bronchogenic carcinoma and undergo pulmonary resection for this condition. We hypothesized that poorer outcomes of surgery would be observed in this population, as compared to neurally-intact patients. Methods: We conducted a study of all veterans at Department of Veterans Affairs (DVA) Medical Centers during fiscal years 1993–2002 who were diagnosed with SCI, subsequently developed non-small cell lung cancer and were then surgically treated with curative intent. Inclusion criteria included American Spinal Injury Association type A injury (complete loss of neural function distal to the injury site) and traumatic etiology. Data were compiled from national DVA datasets and supplemented by operative reports, pathology reports, progress notes, and discharge summaries. Results: Of 12,634 patients who underwent surgery for bronchogenic carcinoma, 55 also had codes for prior SCI; 7 were evaluable. The mean age was 64. Five (71%) had one or more co-morbid conditions in addition to their spinal cord injuries. All 7 underwent pulmonary lobectomy. Post-operative complications occurred in 4 patients (57%). Two patients died post-operatively on days 29 and 499, yielding a 30-day mortality rate of 14% and an in-hospital mortality rate of 29%. Conclusions: We believe this isthe only report in the English language literature on this topic. SCI patients with resectable bronchogenic carcinoma have a high incidence of co-morbid conditions. Those who undergo curative-intent surgery have high morbidity and mortality rates. This evidence suggests that SCI should be considered a risk factor for adverse outcomes of surgery for primary lung cancer, strengthening the case for alternative treatments. No significant financial relationships to disclose.

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