Erratum: An evaluation of the sensitivity and specificity of energy expenditure measured by heart rate and the Goldberg cut-off for energy intake: basal metabolic rate for identifying mis-reporting of energy intake by adults and children: a retrospective analysis

Abstract Design and rationale: Obesity results from energy intake exceeding energy expenditure (EE) over a prolonged period. Many anti-obesity drugs are designed to decrease energy intake. However, their potential impact on EE is not well documented. We designed a placebo-controlled, double-blind, randomized cross-over study to determine the acute effects of several FDA-approved anti-obesity drugs on basal metabolic rate (BMR) under well-controlled conditions. Protocol and inclusion criteria: This ongoing study is limited to healthy males of all ethnicities aged 18–35 years with a BMI of 18.5 to 25.0 kg/m2. Following an overnight stay in the Metabolic Clinical Research Unit, fasting subjects were measured from 8:00am to 12:00pm in a whole-room indirect calorimeter, which was maintained at a thermoneutral temperature (26.7±0.9°C) to prevent non-shivering thermogenesis. The six treatments include placebo, caffeine as the positive control (300 mg), phentermine (37.5 mg), topiramate (200 mg), Qsymia (phentermine 15 mg / topiramate 92 mg), and naltrexone (100 mg), with a 1-week outpatient washout period after each treatment. Drug-naïve subjects received a single dose of each drug to minimize potential metabolic adaptations that may occur with weight-loss or chronic use. The prespecified primary outcome was a ≥5% increase in BMR vs. placebo for each drug. This difference can be detected for 16 subjects with 0.83 power at α=0.05 allowing for ≤25% dropout. Secondary outcomes include respiratory quotient (RQ), heart rate (HR), mean arterial pressure (MAP), and self-reported hunger. Preliminary data: To date, 7 subjects were recruited and 6 have completed the study (26.1±4.3 years, BMI 23.1±1.4 kg/m2, body fat percentage 18.4±4.1%). Interim analysis using paired t-tests shows, compared to placebo, caffeine trended towards increasing EE (1.17±0.07 vs. 1.27±0.12 kcal/min; p=0.07) and increased MAP by 5.5±4.2% (88±2 vs. 93±4; p<0.05), but did not change heart rate (59±10 vs. 61±13 bpm). Naltrexone increased EE by 5.9±4.3% (p<0.05). No treatments altered resting RQ compared to placebo (0.83±0.05). Phentermine increased resting HR, both alone (15.7±7.9%, p<0.01) and in Qsymia (9.2±3.6%, p<0.05), compared to placebo. Of the five drug-treatments, only Qsymia reduced self-reported hunger scores compared to placebo. Summary and future directions: Anti-obesity drugs may increase energy expenditure by upregulating sympathetic nervous system activity. Combined with appetite suppression, the impact on energy balance can lead to weight loss. We aim to complete our study to determine whether these drugs can acutely increase EE with minimal cardiovascular side-effects and compare our findings with long-term interventions.

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A Comparison of Self-Reported Energy Intake With Total Energy Expenditure Estimated by Accelerometer and Basal Metabolic Rate in African-American Women With Type 2 Diabetes

Diabetes Care ◽

10.2337/diacare.27.3.663 ◽

2004 ◽

Vol 27 (3) ◽

pp. 663-669 ◽

Cited By ~ 46

Author(s):

C. D. Samuel-Hodge ◽

L. M. Fernandez ◽

C. F. Henriquez-Roldan ◽

L. F. Johnston ◽

T. C. Keyserling

Keyword(s):

Type 2 Diabetes ◽

African American ◽

Energy Expenditure ◽

Metabolic Rate ◽

Total Energy ◽

African American Women ◽

Energy Intake ◽

Basal Metabolic Rate ◽

Total Energy Expenditure

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Growth and nutritional requirements

10.1093/med/9780198759928.003.0002 ◽

2018 ◽

Author(s):

John Puntis

Keyword(s):

Body Weight ◽

Energy Expenditure ◽

Metabolic Rate ◽

Energy Intake ◽

Basal Metabolic Rate ◽

Physiological Function ◽

Nutritional Requirements ◽

Nutrient Requirements ◽

Maintain Body Weight ◽

Normal Physiological Function

Energy intake must equal energy expenditure to maintain body weight. For children to grow, energy intake must be greater than energy expenditure. Basal metabolic rate is the amount of energy needed to maintain normal physiological function. Nutrient requirements at different ages are widely available.

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Energy Balance and Energy Availability During a Selection Course for Belgian Paratroopers

Military Medicine ◽

10.1093/milmed/usab140 ◽

2021 ◽

Author(s):

Patrick Mullie ◽

Pieter Maes ◽

Laurens van Veelen ◽

Damien Van Tiggelen ◽

Peter Clarys

Keyword(s):

Physical Activity ◽

Energy Balance ◽

Energy Expenditure ◽

Metabolic Rate ◽

Energy Intake ◽

Rest Metabolic Rate ◽

Negative Energy ◽

Fat Free Mass ◽

Negative Energy Balance ◽

Energy Availability

ABSTRACT Introduction Adequate energy supply is a prerequisite for optimal performances and recovery. The aims of the present study were to estimate energy balance and energy availability during a selection course for Belgian paratroopers. Methods Energy expenditure by physical activity was measured with accelerometer (ActiGraph GT3X+, ActiGraph LLC, Pensacola, FL, USA) and rest metabolic rate in Cal.d−1 with Tinsley et al.’s equation based on fat-free mass = 25.9 × fat-free mass in kg + 284. Participants had only access to the French individual combat rations of 3,600 Cal.d−1, and body fat mass was measured with quadripolar impedance (Omron BF508, Omron, Osaka, Japan). Energy availability was calculated by the formula: ([energy intake in foods and beverages] − [energy expenditure physical activity])/kg FFM−1.d−1, with FFM = fat-free mass. Results Mean (SD) age of the 35 participants was 25.1 (4.18) years, and mean (SD) percentage fat mass was 12.0% (3.82). Mean (SD) total energy expenditure, i.e., the sum of rest metabolic rate, dietary-induced thermogenesis, and physical activity, was 5,262 Cal.d−1 (621.2), with percentile 25 at 4,791 Cal.d−1 and percentile 75 at 5,647 Cal.d−1, a difference of 856 Cal.d−1. Mean daily energy intake was 3,600 Cal.d−1, giving a negative energy balance of 1,662 (621.2) Cal.d−1. Mean energy availability was 9.3 Cal.kg FFM−1.d−1. Eleven of the 35 participants performed with a negative energy balance of 2,000 Cal.d−1, and only five participants out of 35 participants performed at a less than 1,000 Cal.d−1 negative energy balance level. Conclusions Energy intake is not optimal as indicated by the negative energy balance and the low energy availability, which means that the participants to this selection course had to perform in suboptimal conditions.

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The standard energetics of mammalian carnivores: Felidae and Hyaenidae

Canadian Journal of Zoology ◽

10.1139/z00-167 ◽

2000 ◽

Vol 78 (12) ◽

pp. 2227-2239 ◽

Cited By ~ 26

Author(s):

Brian K McNab

Keyword(s):

Energy Expenditure ◽

Metabolic Rate ◽

Basal Metabolic Rate ◽

Body Temperatures ◽

Basal Rate ◽

The Family ◽

Small Muscle ◽

Arboreal Habit ◽

High Basal Metabolic Rate ◽

Low Rate

Data concerning the energy expenditure of nine species in the family Felidae and one species in the family Hyaenidae are presented, all of which were obtained under standard conditions. An examination of basal rates of metabolism in these felids and in two species reported in the literature indicates that basal rate is primarily correlated with body mass; of these species, nine have a high basal metabolic rate by general mammalian standards, the two exceptions being the margay and jaguarundi. The low basal metabolic rate of the margay may be related to its arboreal habit in association with small muscle mass, but the reason for the low rate in the jaguarundi is unknown. The omnivorous striped hyaena and termitivorous aardwolf have typical mammalian basal rates. Felids that weigh less than 7 kg have slightly low minimal thermal conductances relative to mammals generally; larger species have high conductances. Felids have slightly high body temperatures.

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Underreporting of energy intake among Japanese women aged 18–20 years and its association with reported nutrient and food group intakes

Public Health Nutrition ◽

10.1079/phn2004635 ◽

2004 ◽

Vol 7 (7) ◽

pp. 911-917 ◽

Cited By ~ 39

Author(s):

Hitomi Okubo ◽

Satoshi Sasaki

Keyword(s):

Metabolic Rate ◽

Energy Intake ◽

Basal Metabolic Rate ◽

Food Group ◽

Young Female ◽

Dietary Intakes ◽

Food Groups ◽

Female Population ◽

Reporting Accuracy ◽

Diet History Questionnaire

AbstractObjectives:To evaluate the ratio of energy intake to basal metabolic rate (EI/BMR) among young female Japanese adults, and to compare the lifestyle and dietary characteristics between relatively low and high reporters.Design:Dietary intakes were assessed over a 1-month period with a validated, self-administered, diet history questionnaire, and lifestyle variables were assessed by a second questionnaire designed for this survey. The ratio of EI/BMR was calculated from reported energy intake and estimated basal metabolic rate.Subjects:In total, 1889 female Japanese university students aged 18–20 years who were enrolled in dietetics courses.Results:Ninety-five per cent of the subjects were classified into a non-obese group (body mass index (BMI) <25 kg m−2; mean±standard deviation (SD): 20.8±2.6 kg m−2). EI/BMR was 1.43±0.40 (mean±SD). Sixty-eight per cent of the subjects showed an EI/BMR level below the possibly balanced value of 1.56, 37% showed EI/BMR below the minimum survival value of 1.27 and 2% of the subjects showed EI/BMR exceeding the maximum value for a sustainable lifestyle of 2.4. BMI, body weight and BMR decreased significantly with the increase in EI/BMR (P<0.001). The percentage of energy from carbohydrate was significantly higher, whereas those from fat and protein were significantly lower, among the lower EI/BMR groups. As for food groups, a significantly declining trend from the lowest to the highest EI/BMR groups was observed for cereals.Conclusion:Underreporting, rather than overreporting, of energy intake was predominant in this relatively lean Japanese female population. BMI was the most important factor affecting the reporting accuracy of energy intake.

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Seasonal Energetics of Mountain Chickadees and Juniper Titmice

The Condor ◽

10.1093/condor/102.3.635 ◽

2000 ◽

Vol 102 (3) ◽

pp. 635-644 ◽

Cited By ~ 6

Author(s):

Sheldon J. Cooper

Keyword(s):

Energy Expenditure ◽

Metabolic Rate ◽

Breeding Season ◽

Basal Metabolic Rate ◽

Energy Requirements ◽

Daily Energy Expenditure ◽

Poecile Gambeli ◽

Daily Energy ◽

Metabolic Data ◽

Mountain Chickadees

Abstract I used behavioral, meteorological, and laboratory metabolism data to calculate daily energy expenditure (DEE) in seasonally acclimatized Mountain Chickadees (Poecile gambeli) and Juniper Titmice (Baeolophus griseus). Analyses of laboratory metabolic data revealed that foraging energy requirements were not significantly higher than alert perching energy requirements. Respective DEE of chickadees and titmice were 48.8 kJ day−1 and 48.3 kJ day−1 in summer and 66.3 kJ day−1 and 98.7 kJ day−1 in winter. DEE as a multiple of basal metabolic rate (BMR) was 2.31 in summer chickadees and 1.91 in summer titmice. DEE was 2.70 times BMR in winter chickadees and 3.43 times BMR in winter titmice. The marked increase in calculated DEE in winter birds compared to summer is in contrast to a pattern of increased DEE in the breeding season for several avian species. These data suggest that winter may be a period of even greater stringency for small birds than previously believed.

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