scholarly journals Extracellular vesicle mediated intercellular communication at the porcine maternal-fetal interface: A new paradigm for conceptus-endometrial cross-talk

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Mallikarjun Bidarimath ◽  
Kasra Khalaj ◽  
Rami T. Kridli ◽  
Frederick W. K. Kan ◽  
Madhuri Koti ◽  
...  
Keyword(s):  
Cross Talk ◽  
Intercellular Communication ◽  
Extracellular Vesicle ◽  
New Paradigm ◽  
Maternal Fetal Interface

scholarly journals Extracellular Vesicle-Dependent Cross-Talk in Cancer—Focus on Pancreatic Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Lise Nannan ◽  
Jean-Baptiste Oudart ◽  
Jean Claude Monboisse ◽  
Laurent Ramont ◽  
Sylvie Brassart-Pasco ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cross Talk ◽  
Extracellular Vesicle

scholarly journals Extracellular vesicle mediated embryo-endometrial cross talk during implantation and in pregnancy

2018 ◽  
Vol 36 (2) ◽  
pp. 189-198 ◽  
Author(s):  
Noble K. Kurian ◽  
Deepak Modi
Keyword(s):  
Cross Talk ◽  
Extracellular Vesicle ◽  
In Pregnancy

The Role of Extracellular Vesicle and Tunneling Nanotube-Mediated Intercellular Cross-Talk Between Mesenchymal Stem Cells and Human Peripheral T Cells

2016 ◽  
Vol 25 (23) ◽  
pp. 1818-1832 ◽  
Author(s):  
Zsolt Matula ◽  
Andrea Németh ◽  
Péter Lőrincz ◽  
Áron Szepesi ◽  
Anna Brózik ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Cross Talk ◽  
Extracellular Vesicle ◽  
Peripheral T Cells ◽  
Tunneling Nanotube

Regulation and mechanisms of extracellular vesicle biogenesis and secretion

2018 ◽  
Vol 62 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Crislyn D’Souza-Schorey ◽  
Jeffrey S. Schorey
Keyword(s):  
Tumor Microenvironment ◽  
Intercellular Communication ◽  
Membrane Vesicles ◽  
Cell Types ◽  
Extracellular Vesicle ◽  
Systemic Delivery ◽  
Heterogeneous Membrane ◽  
Vesicle Biogenesis ◽  
Infected Cells ◽  
Pathogenic Agents

EV (extracellular vesicle) biology is a rapidly expanding field. These heterogeneous membrane vesicles, which are shed from virtually all cell types, collectively represent a new dimension of intercellular communication in normal physiology and disease. They have been shown to deliver infectious and pathogenic agents to non-infected cells whereas in cancers they are thought to condition the tumor microenvironment. Their presence in body fluids and inherent capacity for systemic delivery point to their clinical promise. All of the above only intensifies the need to better understand the classification, mode of biogenesis, and contents of the different subtypes of EVs. This article focusses on vesicle subtypes labeled as exosomes and MVs (microvesicles) and discusses the biogenesis and release of these vesicles from cells.

scholarly journals Inter-kingdom cross-talk: the example of prokaryotes - eukaryotes communication

2011 ◽  
Vol 1 (3) ◽  
pp. 095-110 ◽  
Keyword(s):  
Human Health ◽  
Cross Talk ◽  
Intercellular Communication ◽  
Therapeutic Approach ◽  
Chemical Compounds ◽  
Multicellular Organisms

Some interactions between prokaryotes and between prokaryotes and eukaryotes are well known, but the intimate mechanisms of intercellular communication still remain fully unknown. Unicellular bacteria behave as multicellular organisms through intercellular communication. Microorganisms and their hosts communicate with each other by an array of chemical compounds (e.g. hormones and hormone-like molecules). Language and cross-talk between microorganisms and between them and their hosts determine specific behaviors. Inter-kingdom signalling has broad implications to evolution and human health, modulation of communication pathways being considered an effective future therapeutic approach.

scholarly journals Opposing functions for retromer and Rab11 in extracellular vesicle traffic at presynaptic terminals

2021 ◽  
Vol 220 (8) ◽  
Author(s):  
Rylie B. Walsh ◽  
Erica C. Dresselhaus ◽  
Agata N. Becalska ◽  
Matthew J. Zunitch ◽  
Cassandra R. Blanchette ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Intercellular Communication ◽  
Neurological Disease ◽  
Extracellular Vesicle ◽  
Membrane Recycling ◽  
Presynaptic Terminals ◽  
Vesicle Traffic ◽  
Retromer Complex ◽  
Shed Light ◽  
Competing Pathways

Neuronal extracellular vesicles (EVs) play important roles in intercellular communication and pathogenic protein propagation in neurological disease. However, it remains unclear how cargoes are selectively packaged into neuronal EVs. Here, we show that loss of the endosomal retromer complex leads to accumulation of EV cargoes including amyloid precursor protein (APP), synaptotagmin-4 (Syt4), and neuroglian (Nrg) at Drosophila motor neuron presynaptic terminals, resulting in increased release of these cargoes in EVs. By systematically exploring known retromer-dependent trafficking mechanisms, we show that EV regulation is separable from several previously identified roles of neuronal retromer. Conversely, mutations in rab11 and rab4, regulators of endosome-plasma membrane recycling, cause reduced EV cargo levels, and rab11 suppresses cargo accumulation in retromer mutants. Thus, EV traffic reflects a balance between Rab4/Rab11 recycling and retromer-dependent removal from EV precursor compartments. Our data shed light on previous studies implicating Rab11 and retromer in competing pathways in Alzheimer’s disease, and suggest that misregulated EV traffic may be an underlying defect.

scholarly journals miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1

2020 ◽  
Vol 6 (18) ◽  
pp. eaay3051 ◽  
Author(s):  
Fumihiko Urabe ◽  
Nobuyoshi Kosaka ◽  
Yurika Sawa ◽  
Yusuke Yamamoto ◽  
Kagenori Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cancer Progression ◽  
High Throughput ◽  
Intercellular Communication ◽  
Extracellular Vesicle ◽  
Prostate Cancer Cells ◽  
Biological Phenomena ◽  
Vesicle Secretion

Extracellular vesicles (EVs) are involved in intercellular communication during cancer progression; thus, elucidating the mechanism of EV secretion in cancer cells will contribute to the development of an EV-targeted cancer treatment. However, the biogenesis of EVs in cancer cells is not fully understood. MicroRNAs (miRNAs) regulate a variety of biological phenomena; thus, miRNAs could regulate EV secretion. Here, we performed high-throughput miRNA-based screening to identify the regulators of EV secretion using an ExoScreen assay. By using this method, we identified miR-26a involved in EV secretion from prostate cancer (PCa) cells. In addition, we found that SHC4, PFDN4, and CHORDC1 genes regulate EV secretion in PCa cells. Furthermore, the progression of the PCa cells suppressing these genes was inhibited in an in vivo study. Together, our findings suggest that miR-26a regulates EV secretion via targeting SHC4, PFDN4, and CHORDC1 in PCa cells, resulting in the suppression of PCa progression.

scholarly journals Emerging roles of extracellular vesicles in the intercellular communication for exercise-induced adaptations

2020 ◽  
Vol 319 (2) ◽  
pp. E320-E329
Author(s):  
Joshua Denham ◽  
Sarah J. Spencer
Keyword(s):  
Extracellular Vesicles ◽  
Intercellular Communication ◽  
Biological Material ◽  
Molecular Mechanisms ◽  
Health Benefits ◽  
Extracellular Vesicle ◽  
Therapeutic Interventions ◽  
Current Evidence ◽  
Future Research ◽  
Age Related

Complex organisms rely heavily on intercellular communication. The rapidly expanding field of extracellular vesicle biology has made it clear that the necessary intercellular communication occurs partly through their paracrine and endocrine actions. Extracellular vesicles are nanoscale lipid membranes (30–2,000 nm in diameter) that shuttle functional biological material between cells. They are released from numerous tissues and are isolated from nearly all biofluids and cell cultures. Although their biogenesis, cell targeting, and functional roles are incompletely understood, they appear to have crucial roles in physiological and disease processes. Their enormous potential to serve as sensitive biomarkers of disease and also new therapeutic interventions for diseases have gained them considerable attention in recent years. Regular physical exercise training confers systemic health benefits and consequently prevents many age-related degenerative diseases. Many of the molecular mechanisms responsible for the salubrious effects of exercise are known, yet a common underlying mechanism potentially responsible for the holistic health benefits of exercise has only recently been explored (i.e., via extracellular vesicle transport of biological material). Here, we provide an overview of extracellular vesicle biology before outlining the current evidence on the capacity for a single bout and chronic exercise to elicit changes in extracellular vesicle content and modulate their molecular cargo (e.g., small RNAs). We highlight areas for future research and emphasize their potential utility as biomarkers and therapeutic strategies of disease and its prevention.

scholarly journals Size Sorting of Exosomes by Tuning the Thicknesses of the Electric Double Layers on a Micro-Nanofluidic Device

Micromachines ◽  
2020 ◽  
Vol 11 (5) ◽  
pp. 458 ◽  
Author(s):  
Satoko Fujiwara ◽  
Kyojiro Morikawa ◽  
Tatsuro Endo ◽  
Hideaki Hisamoto ◽  
Kenji Sueyoshi
Keyword(s):  
Intercellular Communication ◽  
Extracellular Vesicle ◽  
Double Layers ◽  
Biological Functions ◽  
Electric Double Layers ◽  
Size Sorting ◽  
Nanofluidic Device

Exosomes, a type of extracellular vesicle with a diameter of 30–150 nm, perform key biological functions such as intercellular communication. Recently, size sorting of exosomes has received increasing attention in order to clarify the correlation between their size and components. However, such sorting remains extremely difficult. Here, we propose to sort their size by controlling their electrokinetic migration in nanochannels in a micro-nanofluidic device, which is achieved by tuning the thickness of the electric double layers in the nanochannels. This approach was demonstrated experimentally for exosomes smaller than 250 nm. Using different running buffer concentrations (1 × 10−3, 1 × 10−4, and 1 × 10−5 M), most of the exosomes larger than 140, 110, and 80 nm were successfully cut off at the downstream of the nanochannels, respectively. Therefore, it is clarified that the proposed method is applicable for the size sorting of exosomes.

scholarly journals Extracellular vesicle cross-talk in the bone marrow microenvironment: implications in multiple myeloma

Oncotarget ◽  
2016 ◽  
Vol 7 (25) ◽  
pp. 38927-38945 ◽  
Author(s):  
Jinheng Wang ◽  
Sylvia Faict ◽  
Ken Maes ◽  
Elke De Bruyne ◽  
Els Van Valckenborgh ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Bone Marrow ◽  
Cross Talk ◽  
Extracellular Vesicle ◽  
Bone Marrow Microenvironment
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