scholarly journals Long-term dry storage of an enzyme-based reagent system for ELISA in point-of-care devices

The Analyst ◽  
2014 ◽  
Vol 139 (6) ◽  
pp. 1456-1462 ◽  
Author(s):  
Sujatha Ramachandran ◽  
Elain Fu ◽  
Barry Lutz ◽  
Paul Yager
Keyword(s):  
Point Of Care ◽  
Dry Storage

A folding 2DPN device with incorporated dry reagents for automated ELISA.

Long-term dry storage of enzyme-based reagents for isothermal nucleic acid amplification in a porous matrix for use in point-of-care diagnostic devices

The Analyst ◽  
2020 ◽  
Vol 145 (21) ◽  
pp. 6875-6886 ◽  
Author(s):  
Sujatha Kumar ◽  
Ryan Gallagher ◽  
Josh Bishop ◽  
Enos Kline ◽  
Joshua Buser ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Glass Fiber ◽  
Point Of Care ◽  
Porous Matrix ◽  
Isothermal Amplification ◽  
Nucleic Acid Amplification ◽  
Isothermal Nucleic Acid Amplification ◽  
Dry Storage

Long-term dry storage of enzyme-based isothermal amplification reagents in glass fiber porous matrix for use in point-of-care devices.

Point of Care Neurosonogram in Neonates - Utility and Prognostic Value

2019 ◽  
Vol 2 ◽  
pp. 1
Author(s):  
Bhushita Lakhkar ◽  
M. M. Patil ◽  
Bhavana Lakhkar ◽  
Bhushan Lakhkar
Keyword(s):  
Neonatal Intensive Care ◽  
Point Of Care ◽  
Color Doppler ◽  
Periventricular Leukomalacia ◽  
Birth Asphyxia ◽  
Common Finding ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Doppler Study

Objective The study aimed to utilize the neurosonographic findings in neonates in early diagnosis, prediction of their long-term outcome, parental counseling, and early intervention. Methods The study was carried out in neonatal intensive care unit (NICU) of Shri BM Patil Medical College and Hospital. All preterms and term babies with neurological clinical findings were included in the study. Neurosonogram was done within first 7 days in preterms and when indicated in terms. Philips HD11XE ultrasound and color Doppler unit were used with a small footprint probe. Color Doppler images for vessels were performed for screening of vascular changes. Results A total of 215 babies were included, of which 80 (32%) were term and the rest were preterm. Mean weight of term babies was 2.8 kg and that of preterm was 1.2 kg.Among term babies, 78% showed ultrasound abnormality, and among preterm, 42%showed abnormalities. Among term babies, 60% and, among preterms, 30% had birth asphyxia. Periventricular leukomalacia was the most common and earliest finding followed by thalamic hyperechogenicity and intracranial hemorrhage. Intraventricular hemorrhage was more common in preterm babies. Other common finding in NICU was meningitis which was more common in pretrms. Among congenital anomalies, corpus callosal agenesis was more common. Conclusions Point of care ultrasonography along with Doppler study is very useful and safe to use in NICUs. It helps in diagnosis, patient management as well as prediction of many short- and long-term outcomes.

Investigations on potential methods for the long-term monitoring of the state of fuel elements in dry storage casks

Kerntechnik ◽  
2018 ◽  
Vol 83 (6) ◽  
pp. 513-522 ◽  
Author(s):  
U. Hampel ◽  
A. Kratzsch ◽  
R. Rachamin ◽  
M. Wagner ◽  
S. Schmidt ◽  
...  
Keyword(s):  
The State ◽  
Dry Storage ◽  
Long Term Monitoring ◽  
Potential Methods ◽  
Fuel Elements ◽  
Term Monitoring

scholarly journals Converging Robotic Technologies in Targeted Neural Rehabilitation: A Review of Emerging Solutions and Challenges

Sensors ◽  
2021 ◽  
Vol 21 (6) ◽  
pp. 2084
Author(s):  
Kostas Nizamis ◽  
Alkinoos Athanasiou ◽  
Sofia Almpani ◽  
Christos Dimitrousis ◽  
Alexander Astaras
Keyword(s):  
Point Of Care ◽  
Brain Activity ◽  
Technological Evolution ◽  
Future Directions ◽  
Specific Patient ◽  
Cord Injury ◽  
Hybrid Solutions ◽  
New Research ◽  
Rehabilitation Robotic

Recent advances in the field of neural rehabilitation, facilitated through technological innovation and improved neurophysiological knowledge of impaired motor control, have opened up new research directions. Such advances increase the relevance of existing interventions, as well as allow novel methodologies and technological synergies. New approaches attempt to partially overcome long-term disability caused by spinal cord injury, using either invasive bridging technologies or noninvasive human–machine interfaces. Muscular dystrophies benefit from electromyography and novel sensors that shed light on underlying neuromotor mechanisms in people with Duchenne. Novel wearable robotics devices are being tailored to specific patient populations, such as traumatic brain injury, stroke, and amputated individuals. In addition, developments in robot-assisted rehabilitation may enhance motor learning and generate movement repetitions by decoding the brain activity of patients during therapy. This is further facilitated by artificial intelligence algorithms coupled with faster electronics. The practical impact of integrating such technologies with neural rehabilitation treatment can be substantial. They can potentially empower nontechnically trained individuals—namely, family members and professional carers—to alter the programming of neural rehabilitation robotic setups, to actively get involved and intervene promptly at the point of care. This narrative review considers existing and emerging neural rehabilitation technologies through the perspective of replacing or restoring functions, enhancing, or improving natural neural output, as well as promoting or recruiting dormant neuroplasticity. Upon conclusion, we discuss the future directions for neural rehabilitation research, diagnosis, and treatment based on the discussed technologies and their major roadblocks. This future may eventually become possible through technological evolution and convergence of mutually beneficial technologies to create hybrid solutions.

The effect of long-term annealing simulating the parameters of dry storage of VVER-1000 fuel rods on the mechanical properties of E110 alloy shells in the longitudinal direction

2021 ◽  
Vol 4 ◽  
pp. 42-49
Author(s):  
G. P. Kobylyansky ◽  
◽  
А. О. Mazaev ◽  
Е. А. Zvir ◽  
S. G. Eremin ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Yield Strength ◽  
Relative Elongation ◽  
Mechanical Test ◽  
Longitudinal Direction ◽  
Radiation Defects ◽  
Thermal Tests ◽  
Fuel Rods ◽  
Dry Storage

Presented are the results of mechanical tensile tests of longitudinal (segmental) samples cut from the midsection of claddings spent as VVER-1000 FA during one- and six-year campaigns and subject to thermal tests in helium at 480 °С during 468 full days. An average burnup of these fuel rods achieved ~ 20 and ~ 70 (MW·day)/kg U, respectively. The tests followed the examinations for cladding mechanical properties performed using the tests results for ring samples cut from the specified fuel rods. These fuel rods were tested in the experiments to determine impact of long-term thermal tests that model dry storage conditions on mechanical properties of Zr E110 claddings. Based on mechanical tests results at room temperature and at 380 °С there was determined as follows: ultimate strength sв, yield strength s0,2 and total relative elongation d0 of claddings length-wise on the fuel rod segments at the fuel column midsection. The obtained characteristics were compared to corresponding values for initial (unirradiated) cladding tubes and mechanical test results of the ring samples in the transverse direction. Long-term thermal tests have led to partial return to initial (before operation) values sв, s0,2 and d0 of radiation-hardened claddings; this return was more prominent in the longitudinal direction than in the transverse one. A radiation hardening decrease was accompanied with an increase in total relative elongation values in both cladding directions. Anisotropy of yield strength has changed as well. These changes can be explained by partial annealing of radiation defects, which are obstacles to dislocation movements during cladding strain. The morphology of above radiation defects is different in various sliding planes in texturized grains of cladding material.

scholarly journals A STUDY ON THE INITIAL CHARACTERISTICS OF DOMESTIC SPENT NUCLEAR FUELS FOR LONG TERM DRY STORAGE

2013 ◽  
Vol 45 (3) ◽  
pp. 377-384 ◽  
Author(s):  
JUSEONG KIM ◽  
HAKKYU YOON ◽  
DONGHAK KOOK ◽  
YONGSOO KIM
Keyword(s):  
Nuclear Fuels ◽  
Dry Storage

Specific outcomes of the research on the spent fuel long-term evolution in interim dry storage and deep geological disposal

2006 ◽  
Vol 352 (1-3) ◽  
pp. 246-253 ◽  
Author(s):  
C. Ferry ◽  
C. Poinssot ◽  
C. Cappelaere ◽  
L. Desgranges ◽  
C. Jegou ◽  
...  
Keyword(s):  
Long Term Evolution ◽  
Spent Fuel ◽  
Geological Disposal ◽  
Dry Storage ◽  
Term Evolution ◽  
Deep Geological Disposal

scholarly journals Testing a Real-Time Tenofovir Urine Adherence Assay for Monitoring and Providing Feedback to Preexposure Prophylaxis in Kenya (PUMA): Protocol for a Pilot Randomized Controlled Trial (Preprint)

2019 ◽  
Author(s):  
Paul Drain ◽  
Kenneth Ngure ◽  
Nelly Mugo ◽  
Matthew Spinelli ◽  
Purba Chatterjee ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Real Time ◽  
Point Of Care ◽  
Controlled Trial ◽  
Standard Of Care ◽  
Randomized Controlled ◽  
Preexposure Prophylaxis ◽  
Adherence Monitoring ◽  
First Time

BACKGROUND The worldwide expansion of preexposure prophylaxis (PrEP) with oral tenofovir-disoproxil-fumarate/emtricitabine will be critical to ending the HIV epidemic. However, maintaining daily adherence to PrEP can be difficult, and the accuracy of self-reported adherence is often limited by social desirability bias. Pharmacologic adherence monitoring (measuring drug levels in a biomatrix) has been critical to interpreting PrEP trials, but testing usually requires expensive equipment and skilled personnel. We have recently developed a point-of-care (POC) immunoassay to measure tenofovir in urine, allowing real-time adherence monitoring for the first time. OBJECTIVE The goal of this study is to examine a point-of-care adherence metric in PrEP to support and increase adherence via a randomized controlled trial. METHODS The paper describes the protocol for a pilot randomized controlled trial to test the acceptability, feasibility, and impact on long-term adherence of implementing a POC urine test to provide real-time adherence feedback among women on PrEP. Eligible women (n=100) will be HIV-negative, ≥18 years old, and recruited from a clinic in Kenya that provides PrEP. Participants will be randomized 1:1 to the intervention of providing real-time feedback via the assay versus standard of care adherence counseling. Acceptability by participants will be assessed by a quantitative survey, as well as by qualitative data collected via in-depth interviews (n=20) and focus group discussions (n=4 groups, 5-10 women each). Feasibility will be assessed by the proportion of women retained in the study, the mean number of missed visits, the proportion of planned urine assessments completed, and messages delivered, while in-depth interviews with providers (n=8) will explore the ease of administering the urine test. Tenofovir levels in hair will serve as long-term adherence metrics. A linear mixed-effects model will estimate the effect of the intervention versus standard of care on logarithmically transformed levels of tenofovir in hair. RESULTS This study has been funded by the National Institute of Health, approved by the Kenya Medical Research Institute Institutional Review Board, and will commence in June 2020. CONCLUSIONS A novel urine assay to measure and deliver information on adherence to PrEP in real-time will be tested for the first time in this trial planned among women on PrEP in Kenya. Study findings will inform a larger-scale trial assessing the impact of real-time adherence monitoring/feedback on HIV prevention. Improving adherence to PrEP will have long-term implications for efforts to end the HIV epidemic worldwide. CLINICALTRIAL ClinicalTrials.gov NCT03935464; https://clinicaltrials.gov/ct2/show/NCT03935464 INTERNATIONAL REGISTERED REPORT PRR1-10.2196/15029

scholarly journals Case of ventricular septal rupture following acute myocardial infarction

Ultrasound ◽  
2020 ◽  
Vol 28 (3) ◽  
pp. 196-201
Author(s):  
Natasha M Amorosi ◽  
Alison White
Keyword(s):  
Myocardial Infarction ◽  
Point Of Care ◽  
Initial Point ◽  
Signs And Symptoms ◽  
Adverse Outcomes ◽  
Point Of Care Ultrasound ◽  
Ventricular Septal Rupture ◽  
Long Term Outcomes

Ventricular septal rupture is a rare and potentially fatal complication of transmural myocardial infarction. Early identification utilising transthoracic echocardiography significantly improves long term outcomes in these patients. We report on a case of a 77-year-old male who presented with signs and symptoms of cardiac failure and a loud systolic murmur. The patient underwent an initial point-of-care ultrasound which revealed evidence of a transmural myocardial infarction and a high suspicion of an apical ventricular septal rupture. A complete transthoracic echocardiogram confirmed the septal rupture diagnosis and the patient subsequently underwent surgical repair of the ventricular rupture. This case highlights the role of echocardiography in decreasing adverse outcomes in patients with ventricular septal rupture.

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