Development of fluorescent probes based on protection–deprotection of the key functional groups for biological imaging

2015 ◽  
Vol 44 (15) ◽  
pp. 5003-5015 ◽  
Author(s):  
Yonghe Tang ◽  
Dayoung Lee ◽  
Jiaoliang Wang ◽  
Guanhan Li ◽  
Jinghua Yu ◽  
...  
Keyword(s):  
Functional Groups ◽  
Fluorescent Probes ◽  
Biological Imaging ◽  
Fluorescent Imaging ◽  
Amino Groups ◽  
Imaging Probes ◽  
Key Functional Groups

This review highlights the recent protection–deprotection methods of aldehyde, hydroxyl, or amino groups for the development of fluorescent imaging probes.

ChemInform Abstract: Development of Fluorescent Probes Based on Protection-Deprotection of the Key Functional Groups for Biological Imaging

ChemInform ◽  
2015 ◽  
Vol 46 (36) ◽  
pp. no-no
Author(s):  
Yonghe Tang ◽  
Dayoung Lee ◽  
Jiaoliang Wang ◽  
Guanhan Li ◽  
Jinghua Yu ◽  
...  
Keyword(s):  
Functional Groups ◽  
Fluorescent Probes ◽  
Biological Imaging ◽  
Key Functional Groups

scholarly journals Bicyclic 1,3a,6a-Triazapentalene Chromophores: Synthesis, Spectroscopy and Their Use as Fluorescent Sensors and Probes

Chemosensors ◽  
2021 ◽  
Vol 9 (1) ◽  
pp. 16
Author(s):  
Yingchun Wang ◽  
Tomas Opsomer ◽  
Wim Dehaen
Keyword(s):  
Stokes Shift ◽  
Substituent Effects ◽  
Visible Spectrum ◽  
Fluorescent Sensors ◽  
Biological Imaging ◽  
Fluorescent Imaging ◽  
Fluorescence Properties ◽  
Imaging Probes ◽  
Synthetic Methodologies ◽  
Aromatic Heterocyclic

The 1,3a,6a-triazapentalene (TAP) is an aromatic heterocyclic fluorescent dye with interesting features such as its small size, large Stokes shift, solvatochromism, and emission wavelengths that are spread across the visible spectrum. TAPs have been synthesized via different synthetic strategies involving click−cyclization−aromatization domino reactions, gold-catalyzed cyclization of propargyl triazoles or triazolization of acetophenones. As a result, TAPs with diverse substitution patterns were obtained, showing varying fluorescence properties. Based on these properties, several TAPs have been selected and studied as fluorescent imaging probes in living cells and as sensors. This mini review provides an overview of the research on the bicyclic TAPs and does not comment on the literature about benzo or otherwise fused systems. The synthetic methodologies for the preparation of TAPs, the substituent effects on the fluorescence properties, and the behavior of the TAP core as an element of biological imaging probes and sensors are discussed.

Cu2+ Biological Imaging Probes Based on Different Sensing Mechanisms

2019 ◽  
Vol 26 (21) ◽  
pp. 3958-4002 ◽  
Author(s):  
Caixia Yin ◽  
Jiawei Li ◽  
Fangjun Huo
Keyword(s):  
Fluorescent Probes ◽  
Intramolecular Proton Transfer ◽  
Research Area ◽  
Biological Imaging ◽  
Biological Applications ◽  
Transfer Energy ◽  
Metal Element ◽  
Imaging Probes ◽  
Active Research ◽  
Active Research Area

In recent years, fluorescent probes have recently attracted attention from researchers. As a vital trace metal element, Cu2+ has an important role in the human body and environment. Therefore, the development and design of Cu2+ small-molecular fluorescent probes has been an active research area. This review focuses on the developments in the area of small-molecular fluorescent probes for Cu2+ in biological applications according to different sensing mechanisms including charge transfer (CT), electron transfer, energy transfer, excited-state intramolecular proton transfer (ESIPT).

Recent advances in quinazolinones as an emerging molecular platform for luminescent materials and bioimaging

2021 ◽  
Vol 8 (8) ◽  
pp. 1867-1889
Author(s):  
Zhiming Xing ◽  
Wanhui Wu ◽  
Yongxiang Miao ◽  
Yingqun Tang ◽  
Youkang Zhou ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Biological Imaging ◽  
Luminescence Properties ◽  
Luminescent Materials ◽  
Future Outlook ◽  
Recent Advances

This review summarized recent advances relating to the luminescence properties of quinazolinones and their applications in fluorescent probes, biological imaging and luminescent materials. Their future outlook is also included.

scholarly journals Biological nanoscale fluorescent probes: From structure and performance to bioimaging

2020 ◽  
Vol 39 (1) ◽  
pp. 209-221
Author(s):  
Jiafeng Wan ◽  
Xiaoyuan Zhang ◽  
Kai Zhang ◽  
Zhiqiang Su
Keyword(s):  
Fluorescent Probes ◽  
Organic Dyes ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
High Sensitivity ◽  
Biological Imaging ◽  
Fluorescent Materials ◽  
And Performance

Abstract In recent years, nanomaterials have attracted lots of attention from researchers due to their unique properties. Nanometer fluorescent materials, such as organic dyes, semiconductor quantum dots (QDs), metal nano-clusters (MNCs), carbon dots (CDs), etc., are widely used in biological imaging due to their high sensitivity, short response time, and excellent accuracy. Nanometer fluorescent probes can not only perform in vitro imaging of organisms but also achieve in vivo imaging. This provides medical staff with great convenience in cancer treatment. Combined with contemporary medical methods, faster and more effective treatment of cancer is achievable. This article explains the response mechanism of three-nanometer fluorescent probes: the principle of induced electron transfer (PET), the principle of fluorescence resonance energy transfer (FRET), and the principle of intramolecular charge transfer (ICT), showing the semiconductor QDs, precious MNCs, and CDs. The excellent performance of the three kinds of nano fluorescent materials in biological imaging is highlighted, and the application of these three kinds of nano fluorescent probes in targeted biological imaging is also introduced. Nanometer fluorescent materials will show their significance in the field of biomedicine.

scholarly journals Competitive Biological Activities of Chitosan and Its Derivatives: Antimicrobial, Antioxidant, Anticancer, and Anti-Inflammatory Activities

2018 ◽  
Vol 2018 ◽  
pp. 1-13 ◽  
Author(s):  
Suyeon Kim
Keyword(s):  
Water Solubility ◽  
Biological Activities ◽  
Biological Properties ◽  
Biomedical Science ◽  
Amino Groups ◽  
Chitosan Oligosaccharides ◽  
Primary Amino ◽  
Anti Inflammatory ◽  
Key Functional Groups ◽  
Application Fields

Chitosan is obtained from alkaline deacetylation of chitin, and acetamide groups are transformed into primary amino groups during the deacetylation. The diverse biological activities of chitosan and its derivatives are extensively studied that allows to widening the application fields in various sectors especially in biomedical science. The biological properties of chitosan are strongly depending on the solubility in water and other solvents. Deacetylation degree (DDA) and molecular weight (MW) are the most decisive parameters on the bioactivities since the primary amino groups are the key functional groups of chitosan where permits to interact with other molecules. Higher DDA and lower MW of chitosan and chitosan derivatives demonstrated higher antimicrobial, antioxidant, and anticancer capacities. Therefore, the chitosan oligosaccharides (COS) with a low polymerization degree are receiving a great attention in medical and pharmaceutical applications as they have higher water solubility and lower viscosity than chitosan. In this review articles, the antimicrobial, antioxidant, anticancer, anti-inflammatory activities of chitosan and its derivatives are highlighted. The influences of physicochemical parameters of chitosan like DDA and MW on bioactivities are also described.

Optical properties of hemicyanines with terminal amino groups and their applications in near-infrared fluorescent imaging of nucleoli

2014 ◽  
Vol 2 (40) ◽  
pp. 7065-7072 ◽  
Author(s):  
Jia-Tao Miao ◽  
Chen Fan ◽  
Ru Sun ◽  
Yu-Jie Xu ◽  
Jian-Feng Ge
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Water Solubility ◽  
Stokes Shift ◽  
Fluorescent Imaging ◽  
Amino Groups ◽  
Long Wave ◽  
Terminal Amino ◽  
Wave Emission ◽  
Low Cytotoxicity

A cellular dye with properties of long-wave emission, large Stokes shift, water solubility, low cytotoxicity, and good photostability is reported.

Aminopropyl Embedded Silica Films as Potent Substrates in DNA Microarray Applications

2005 ◽  
Vol 873 ◽  
Author(s):  
Kristjan Saal ◽  
Margo Plaado ◽  
Ilmar Kink ◽  
Ants Kurg ◽  
Valter Kiisk ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Dna Microarray ◽  
Fluorescent Probes ◽  
Background Noise ◽  
Sol Gel ◽  
Primer Extension ◽  
Hybrid Films ◽  
Amino Groups ◽  
Silica Films ◽  
Binding Rate

AbstractSol-gel derived silane hybrid films composing of (3-aminopropyl)trimethoxysilane–tetramethoxysilane (APTMS-TMOS) have been shown to have properties that make the films suitable for DNA microarray applications. The ability of the films to bind DNA was studied using aminated 25-mer oligonucleotide DNA and 1, 4-phenylenediisothiocyanate linker. The binding of DNA onto the films was shown to depend on films' composition i.e. the binding rate decreased with the decrease of APTMS content in the film. The arrayed primer extension (APEX) analysis showed reversed tendency – fluorescence signals of bound probes increased with the decrease of APTMS content in the film. The background noise was low and the fluorescent probes were clearly outlined. The density of functional amino groups on the films was estimated by fluorescence spectroscopy.

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