Optical properties of hemicyanines with terminal amino groups and their applications in near-infrared fluorescent imaging of nucleoli

2014 ◽  
Vol 2 (40) ◽  
pp. 7065-7072 ◽  
Author(s):  
Jia-Tao Miao ◽  
Chen Fan ◽  
Ru Sun ◽  
Yu-Jie Xu ◽  
Jian-Feng Ge
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Water Solubility ◽  
Stokes Shift ◽  
Fluorescent Imaging ◽  
Amino Groups ◽  
Long Wave ◽  
Terminal Amino ◽  
Wave Emission ◽  
Low Cytotoxicity

A cellular dye with properties of long-wave emission, large Stokes shift, water solubility, low cytotoxicity, and good photostability is reported.

Synthesis and Properties of a Novel Conjugated Polyfluorene Derivative

2011 ◽  
Vol 306-307 ◽  
pp. 671-674
Author(s):  
Mei Yan ◽  
Wei Qiang Gao ◽  
Shen Guang Ge ◽  
Jia Dong Huang ◽  
Jing Hua Yu
Keyword(s):  
Optical Properties ◽  
Electronic Conductivity ◽  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Biological Sensors ◽  
Amino Groups ◽  
Strong Fluorescence ◽  
Suzuki Coupling Reaction ◽  
Palladium Catalyzed ◽  
Terminal Amino

A Novel Polyfluorene Derivative, Poly[(9,9-Bis(3'-(N,N-Dimethylamino)propyl)-2,7- Fluorene)-Alt-2,7-(9,9- P-Divinylbenzene)] (P-1) Was Synthesized by the Palladium-Catalyzed Suzuki Coupling Reaction and it’s Quaternized Ammonium Polyelectrolyte Derivatives Was Obtained through a Postpolymerization Treatment on the Terminal Amino Groups. the Electrochemical and Optical Properties of the Resulting Copolymers Was Fully Investigated. the Results Showed that the New Polyfluorene Derivative Had Potential Useful in Used as Materials for Electronic Conductivity, Chemical and Biological Sensors that Derive from its Highly Conductive and Strong Fluorescence.

scholarly journals Novel polythiophene derivative for dual-channel cell imaging

RSC Advances ◽  
2019 ◽  
Vol 9 (30) ◽  
pp. 17335-17340
Author(s):  
Fengyan Wang ◽  
Huiyun Xia ◽  
Siyu Pu ◽  
Ni Yan ◽  
Jiale Song ◽  
...  
Keyword(s):  
Optical Properties ◽  
Cell Imaging ◽  
Water Solubility ◽  
Dual Channel ◽  
Low Cytotoxicity ◽  
Polythiophene Derivative

PT-OH-PPR has good optical properties, good water solubility and low cytotoxicity, and could be used as a dual-channel cell imaging material.

Synthesis and Properties of a Novel Conjugated Polyfluorene Derivative

2011 ◽  
Vol 306-307 ◽  
pp. 709-712
Author(s):  
Mei Yan ◽  
Wei Qiang Gao ◽  
Shen Guang Ge ◽  
Jia Dong Huang ◽  
Jing Hua Yu
Keyword(s):  
Optical Properties ◽  
Electronic Conductivity ◽  
Coupling Reaction ◽  
Suzuki Coupling ◽  
Biological Sensors ◽  
Amino Groups ◽  
Strong Fluorescence ◽  
Suzuki Coupling Reaction ◽  
Palladium Catalyzed ◽  
Terminal Amino

A novel polyfluorene derivative, poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7- fluorene)-alt-2,7-(9,9- p-divinylbenzene)] (P-1) was synthesized by the palladium-catalyzed Suzuki coupling reaction and it’s quaternized ammonium polyelectrolyte derivatives was obtained through a postpolymerization treatment on the terminal amino groups. The electrochemical and optical properties of the resulting copolymers was fully investigated. The results showed that the new polyfluorene derivative had potential useful in used as materials for electronic conductivity, chemical and biological sensors that derive from its highly conductive and strong fluorescence.

scholarly journals Effects of Electron Irradiation on Optical Properties of Bismuth-Doped Phosphosilicate Fiber

2020 ◽  
Author(s):  
Alexander V. Kir’yanov ◽  
Arindam Halder
Keyword(s):  
Optical Properties ◽  
Electron Irradiation ◽  
Near Infrared ◽  
Stokes Shift ◽  
High Energy ◽  
Active Centers ◽  
Laser Applications ◽  
High Energy Electrons ◽  
Phosphosilicate Fiber ◽  
Overall Resistance

The basic optical properties of yttrium-phosphosilicate fiber doped with bismuth (Bi) are assessed in both pristine state and that established after bombardment by a beam of high-energy electrons. The fiber has been developed and fabricated with a target to use it for laser applications in visible/near-infrared (VIS/NIR) domain. In this chapter, the main attention is paid to the dramatic changes in absorption spectra of the fiber under electron irradiation. Meanwhile, we reveal its overall resistance to irradiation in terms of emissive potential and bleaching contrast at excitation into the absorption bands of bismuth-related active centers. Besides, we report a new effect of large dose-dependent Stokes shift, experienced by the fiber’s cutoff wavelength, which arises due to refractive index rise in its core area. The laws obeyed by the fiber’s characteristics vs. dose are examined for possible applications in dosimetry.

Optical Properties of Carbon Nanotubes: Near-Infrared Induced Hyperthermia as Therapy for Brain Tumors

2007 ◽  
Vol 1065 ◽  
Author(s):  
Lewis Gomez-De Arco ◽  
Meng-Tse Chen ◽  
Weijun Wang ◽  
Thomas Vernier ◽  
Paul Pagnini ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Optical Properties ◽  
Brain Tumors ◽  
Tumor Cells ◽  
Near Infrared ◽  
Primary Brain Tumor ◽  
Fluorescent Imaging ◽  
Brain Tumor Cells ◽  
Functionalization Of Carbon Nanotubes ◽  
Organic Fluorophore

ABSTRACTIn this work chemical functionalization of carbon nanotubes was conducted with the aim of improving their ability to be integrated into biological systems. Functionalized SWNT demonstrated to be an excellent vehicle to translocate a highly conjugated organic fluorophore across the cell membrane while causing little toxicity to the cells. Functionalized SWNT were introduced into different lines of the primary brain tumor cells Glioblastoma Multiforme (GBM). Once within the cell interior, the optical properties of the SWNT were used for both fluorescent imaging characterization and selective killing of tumor cells that had exhibited high SWNT uptake levels upon exposure to NIR radiation. Propidium iodide (PI) was employed as an indicator to determine the number of cells with compromised plasma membrane. Cell surviving ratio of as little as 10-20 percent were found in samples with intracellular nanotubes exposed to NIR radiation while a cell surviving ratio of about 95 percent was typical in irradiated samples without intracellular nanotubes. Control samples showed cell surviving ratios comparable to exposed samples without intracellular nanotubes. This study reveals new insights upon the influence of SWNT optical properties in the physicochemical processes within cells and how they can be used to develope therapy for cancerous brain tumors.

Fluorescent proteins for in vivo imaging, where's the biliverdin?

2020 ◽  
Vol 48 (6) ◽  
pp. 2657-2667
Author(s):  
Felipe Montecinos-Franjola ◽  
John Y. Lin ◽  
Erik A. Rodriguez
Keyword(s):  
Hydrogen Peroxide ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Fluorescent Protein ◽  
Fluorescent Proteins ◽  
Fluorescent Imaging ◽  
Infrared Light ◽  
Red Fluorescent Protein ◽  
Color Palette

Noninvasive fluorescent imaging requires far-red and near-infrared fluorescent proteins for deeper imaging. Near-infrared light penetrates biological tissue with blood vessels due to low absorbance, scattering, and reflection of light and has a greater signal-to-noise due to less autofluorescence. Far-red and near-infrared fluorescent proteins absorb light >600 nm to expand the color palette for imaging multiple biosensors and noninvasive in vivo imaging. The ideal fluorescent proteins are bright, photobleach minimally, express well in the desired cells, do not oligomerize, and generate or incorporate exogenous fluorophores efficiently. Coral-derived red fluorescent proteins require oxygen for fluorophore formation and release two hydrogen peroxide molecules. New fluorescent proteins based on phytochrome and phycobiliproteins use biliverdin IXα as fluorophores, do not require oxygen for maturation to image anaerobic organisms and tumor core, and do not generate hydrogen peroxide. The small Ultra-Red Fluorescent Protein (smURFP) was evolved from a cyanobacterial phycobiliprotein to covalently attach biliverdin as an exogenous fluorophore. The small Ultra-Red Fluorescent Protein is biophysically as bright as the enhanced green fluorescent protein, is exceptionally photostable, used for biosensor development, and visible in living mice. Novel applications of smURFP include in vitro protein diagnostics with attomolar (10−18 M) sensitivity, encapsulation in viral particles, and fluorescent protein nanoparticles. However, the availability of biliverdin limits the fluorescence of biliverdin-attaching fluorescent proteins; hence, extra biliverdin is needed to enhance brightness. New methods for improved biliverdin bioavailability are necessary to develop improved bright far-red and near-infrared fluorescent proteins for noninvasive imaging in vivo.

Coupling of Steroid O-(Carboxymethyl)oxime Derivatives with Single-Protected α,ω-Diaminoalkanes

1999 ◽  
Vol 64 (12) ◽  
pp. 2035-2043 ◽  
Author(s):  
Vladimír Pouzar ◽  
Ivan Černý ◽  
Pavel Drašar
Keyword(s):  
Trifluoroacetic Acid ◽  
Protecting Groups ◽  
Oxime Group ◽  
Amino Groups ◽  
New Approach ◽  
Terminal Amino ◽  
Oxime Derivatives

New approach to the synthesis of steroid oximes bearing O-substituents with terminal amino groups was described. The easily accessible steroid O-(carboxymethyl)oximes were reacted with single-protected Boc-α,ω-diaminoalkanes to give corresponding amide intermediates. From them the Boc protecting groups were cleaved with trifluoroacetic acid to afford the desired steroid derivatives with terminal amino groups. The procedure was succesfully tested on steroids with O-(carboxymethyl)oxime group in positions 7 and 17. The decomposition of target products was observed during deprotection of substituted 19-oximes.

scholarly journals The Effect of Nitrogen Incorporation on the Optical Properties of Si-Rich a-SiCx Films Deposited by VHF PECVD

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 637
Author(s):  
Hongliang Li ◽  
Zewen Lin ◽  
Yanqing Guo ◽  
Jie Song ◽  
Rui Huang ◽  
...  
Keyword(s):  
Optical Properties ◽  
Near Infrared ◽  
Chemical Vapor ◽  
Wide Bandgap ◽  
Nonradiative Recombination ◽  
Very High Frequency ◽  
N Content ◽  
High Frequency Plasma ◽  
Frequency Plasma ◽  
N Incorporation

The influence of N incorporation on the optical properties of Si-rich a-SiCx films deposited by very high-frequency plasma-enhanced chemical vapor deposition (VHF PECVD) was investigated. The increase in N content in the films was found to cause a remarkable enhancement in photoluminescence (PL). Relative to the sample without N incorporation, the sample incorporated with 33% N showed a 22-fold improvement in PL. As the N content increased, the PL band gradually blueshifted from the near-infrared to the blue region, and the optical bandgap increased from 2.3 eV to 5.0 eV. The enhancement of PL was suggested mainly from the effective passivation of N to the nonradiative recombination centers in the samples. Given the strong PL and wide bandgap of the N incorporated samples, they were used to further design an anti-counterfeiting label.

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