Repeatable deep-tissue activation of persistent luminescent nanoparticles by soft X-ray for high sensitivity long-term in vivo bioimaging

Nanoscale ◽  
2017 ◽  
Vol 9 (8) ◽  
pp. 2718-2722 ◽  
Author(s):  
Liang Song ◽  
Xia-Hui Lin ◽  
Xiao-Rong Song ◽  
Shan Chen ◽  
Xiao-Feng Chen ◽  
...  
Keyword(s):  
High Sensitivity ◽  
Deep Tissue ◽  
X Ray ◽  
Luminescent Nanoparticles

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

Synthesis of Trilaminar Core–Shell Au/α-Fe2O3@SnO2Nanocomposites and their Application for Nonenzymatic Dopamine Electrochemical Sensing

NANO ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. 1950138 ◽  
Author(s):  
Sai Zhang ◽  
Shijun Yue ◽  
Jiajia Li ◽  
Jianbin Zheng ◽  
Guojie Gao
Keyword(s):  
Electron Microscopy ◽  
High Sensitivity ◽  
Electrochemical Sensing ◽  
Synthesis Process ◽  
Core Shell ◽  
X Ray Diffraction ◽  
X Ray ◽  
Long Term Stability ◽  
Transmission Electron

Au nanoparticles anchored on core–shell [Formula: see text]-Fe2O3@SnO2 nanospindles were successfully constructed through hydrothermal synthesis process and used for fabricating a novel nonenzymatic dopamine (DA) sensor. The structure and morphology of the Au/[Formula: see text]-Fe2O3@SnO2 trilaminar nanohybrid film were characterized by scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM) and X-ray diffraction (XRD). The electrochemical properties of the sensor were investigated by cyclic voltammetry and amperometry. The experimental results suggest that the composites have excellent catalytic property toward DA with a wide linear range from 0.5[Formula: see text][Formula: see text]M to 0.47[Formula: see text]mM, a low detection limit of 0.17[Formula: see text][Formula: see text]M (S/[Formula: see text]) and high sensitivity of 397.1[Formula: see text][Formula: see text]A[Formula: see text]mM[Formula: see text][Formula: see text]cm[Formula: see text]. In addition, the sensor exhibits long-term stability, good reproducibility and anti-interference.

scholarly journals Photoacoustic reporter genes for noninvasive molecular imaging and theranostics

2020 ◽  
Vol 13 (03) ◽  
pp. 2030005
Author(s):  
Zhao Lei ◽  
Yun Zeng ◽  
Xiaofen Zhang ◽  
Xiaoyong Wang ◽  
Gang Liu
Keyword(s):  
Molecular Imaging ◽  
Fluorescent Proteins ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Reporter Genes ◽  
Biological Processes ◽  
Deep Tissue ◽  
Potential Applications ◽  
Improved Performance

Noninvasive molecular imaging makes the observation and comprehensive understanding of complex biological processes possible. Photoacoustic imaging (PAI) is a fast evolving hybrid imaging technology enabling in vivo imaging with high sensitivity and spatial resolution in deep tissue. Among the various probes developed for PAI, genetically encoded reporters attracted increasing attention of researchers, which provide improved performance by acquiring images of a PAI reporter gene’s expression driven by disease-specific enhancers/promoters. Here, we present a brief overview of recent studies about the existing photoacoustic reporter genes (RGs) for noninvasive molecular imaging, such as the pigment enzyme reporters, fluorescent proteins and chromoproteins, photoswitchable proteins, including their properties and potential applications in theranostics. Furthermore, the challenges that PAI RGs face when applied to the clinical studies are also examined.

scholarly journals X-ray-Fluorescence Imaging for In Vivo Detection of Gold-Nanoparticle-Labeled Immune Cells: A GEANT4 Based Feasibility Study

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5759
Author(s):  
Arthur Ungerer ◽  
Theresa Staufer ◽  
Oliver Schmutzler ◽  
Christian Körnig ◽  
Kai Rothkamm ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Cell Tracking ◽  
Immune Cell ◽  
High Sensitivity ◽  
Diagnostic Tools ◽  
Monte Carlo Simulation Study ◽  
X Ray ◽  
In Vivo Detection ◽  
Technological Developments

The growing field of cellular therapies in regenerative medicine and oncology calls for more refined diagnostic tools that are able to investigate and monitor the function and success of said therapies. X-ray Fluorescence Imaging (XFI) can be applied for molecular imaging with nanoparticles, such as gold nanoparticles (GNPs), which can be used in immune cell tracking. We present a Monte Carlo simulation study on the sensitivity of detection and associated radiation dose estimations in an idealized setup of XFI in human-sized objects. Our findings demonstrate the practicability of XFI in human-sized objects, as immune cell tracking with a minimum detection limit of 4.4 × 105 cells or 0.86 μg gold in a cubic volume of 1.78 mm3 can be achieved. Therefore, our results show that the current technological developments form a good basis for high sensitivity XFI.

X-ray recharged long afterglow luminescent nanoparticles MgGeO3:Mn2+,Yb3+,Li+ in the first and second biological windows for long-term bioimaging

Nanoscale ◽  
2020 ◽  
Vol 12 (26) ◽  
pp. 14037-14046 ◽  
Author(s):  
Shenghui Zheng ◽  
Junpeng Shi ◽  
Xiaoyan Fu ◽  
Chengcheng Wang ◽  
Xia Sun ◽  
...  
Keyword(s):  
X Ray ◽  
Long Afterglow ◽  
Luminescent Nanoparticles ◽  
Dual Window ◽  
Biological Windows

Nanosized dual window afterglow particles possess X-ray rechargeable and photo-stimulation properties for long-term bioimaging.

Acceptor Engineering of Small Molecule Fluorophores for NIR-II Fluorescent and NIR-I Photoacoustic Imaging

2021 ◽  
Author(s):  
Yaxi Li ◽  
Hongli Zhou ◽  
Renzhe Bi ◽  
Xiuting Li ◽  
Menglei Zha ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Small Molecule ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
High Sensitivity ◽  
Tissue Penetration ◽  
Deep Tissue ◽  
Infrared Window

Fluorescence imaging in the second near-infrared window (NIR-II) has been an emerging technique in diverse in vivo applications with high sensitivity/resolution and deep tissue penetration. To date, the designing principle...

Long-term performance in vitro and in vivo of dual-energy X-ray absorptiometry

1995 ◽  
Vol 14 (2) ◽  
pp. 180-186 ◽  
Author(s):  
J. Y. Reginster ◽  
R. Deroisy ◽  
B. Zegels ◽  
I. Jupsin ◽  
A. Albert ◽  
...  
Keyword(s):  
Dual Energy ◽  
X Ray ◽  
Long Term Performance ◽  
Term Performance

Luminescence enhancement of CaF2:Nd3+nanoparticles in the second near-infrared window forin vivoimaging through Y3+doping

2018 ◽  
Vol 6 (8) ◽  
pp. 1238-1243 ◽  
Author(s):  
Zhen-feng Yu ◽  
Jun-peng Shi ◽  
Jin-lei Li ◽  
Peng-hui Li ◽  
Hong-wu Zhang
Keyword(s):  
Near Infrared ◽  
High Sensitivity ◽  
Deep Tissue ◽  
Luminescence Enhancement ◽  
Infrared Window

In vivoluminescent imaging in the second biological window (1000–1400 nm, NIR-II) has attracted increasing attention since it can provide high sensitivity to deep tissuein vivoimaging.

scholarly journals Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

2021 ◽  
Author(s):  
Arwin Groenewoud ◽  
Jie Yin ◽  
Maria Chiara Gelmi ◽  
Samar Alsafadi ◽  
Fariba Nemati ◽  
...  
Keyword(s):  
Uveal Melanoma ◽  
Drug Sensitivity ◽  
High Sensitivity ◽  
Term Survival ◽  
Molecular Features ◽  
Metastatic Lesions ◽  
Pdx Model ◽  
Xenograft Models

Uveal melanoma (UM) is the most common intraocular melanoma, derived from transformed melanocytes of the uvea. Although treatment of primary UM is usually successful, there is a high risk (up to 50%) of liver metastasis with negligible long-term survival. There are currently no reproducible patient-derived animal models that faithfully recapitulate the latter stages of metastatic dissemination of UM, hindering the discovery of curative treatments. To overcome this problem and to accelerate the development of new metastatic UM treatments, we developed a patient-derived zebrafish xenograft (zf-PDX) model, using spheroid cultures generated from metastatic and primary UM tissues. Engrafted UM cells derived from these spheroid cultures give rise to metastatic lesions and recapitulate the molecular features of UMs and their potential drug sensitivity. Importantly, harnessing this versatile model, we reveal a high sensitivity of circulating UM cells to ferroptosis induction in vivo by Erastin and RSL3. Our findings are further corroborated by supportive analysis of patient data implicating ferroptosis as a new, and druggable, target for the treatment of metastatic UM patients, specifically in those with BAP1 loss in the tumor.

scholarly journals Achalasia in Children—Clinical Presentation, Diagnosis, Long-Term Treatment Outcomes, and Quality of Life

2021 ◽  
Vol 10 (17) ◽  
pp. 3917
Author(s):  
Dorota Jarzębicka ◽  
Piotr Czubkowski ◽  
Joanna Sieczkowska-Gołub ◽  
Jarosław Kierkuś ◽  
Adam Kowalski ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
High Sensitivity ◽  
Esophageal Achalasia ◽  
Term Treatment ◽  
Pneumatic Dilatation ◽  
Diagnostic Approach ◽  
X Ray ◽  
Good Outcome ◽  
Long Term Treatment

Background: In spite of the introduction of peroral endoscopic myotomy (POEM), Heller myotomy (HM) remains the mainstay of treatment and the role of pneumatic dilatation (PD) is being debated. The aim of this study was to present a single-center experience in the diagnostic approach and treatment of esophageal achalasia (EA), including the long-term assessment of the QoL. Methods: Data collection was based on the retrospective analysis of clinical notes and prospective interviews with patients and their parents. Results: The study group consisted of 60 patients with EA (F: 26, M: 34), with a median age of 12.0 (1–17) years at diagnosis. The time from the first symptoms until the diagnosis was 1.0 year (0.5–2.0) and the most common were: regurgitation (91.3%), dysphagia (84.8%), and chest pain (47.8%). The diagnostic approach showed a high sensitivity for barium X-ray follow through, esophageal manometry, and endoscopy. Overall, a long-term good outcome of HM was achieved in 27 out of 37 patients (73%) and it was negatively affected by the time between the first symptoms and the diagnosis. Out of the 16 patients who underwent PD before HM, a good outcome was achieved in 14 patients (87.5%), compared to 13 out of 21 patients (62%) who only underwent HM (p = 0.22). Concomitant fundoplication was routinely performed, and 18% required post-operative endoscopic dilatation. At the end of the 12.1 (0.7–26.6)-year follow up, most patients had a good QoL, which significantly corresponded with the treatment outcomes. Conclusions: Patients suspected of EA should undergo a thorough clinical evaluation including a manometry, a barium X-ray, and an endoscopy. HM is a safe and effective treatment for achalasia and the outcome is not worsened by a preceding endoscopic PD. In most patients, HM alleviates symptoms, although an impaired QoL is common in long-term follow ups.

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