Recent advances in β-lactam synthesis

2018 ◽  
Vol 16 (38) ◽  
pp. 6840-6852 ◽  
Author(s):  
Seyedmorteza Hosseyni ◽  
Aliasghar Jarrahpour
Keyword(s):  
Past Century ◽  
The Core ◽  
The Past ◽  
Recent Advances

During the past century, β-lactams have been identified as the core of penicillin and since then several strategies have been developed for their synthesis.

The lingering core of legal scholarship

Legal Studies ◽  
2010 ◽  
Vol 30 (3) ◽  
pp. 345-369 ◽  
Author(s):  
Susan Bartie
Keyword(s):  
Past Century ◽  
Legal Scholarship ◽  
The Core ◽  
The Past ◽  
The Future ◽  
The Way

The purpose of this paper is to consider how leading scholars are interpreting the role and status of the core tenets of legal scholarship in England and Australia – the tenets that have provided an element of unity in legal scholarship over the past century or so. Instead of focusing on the way that scholarship has diversified and expanded, the paper considers whether elements of the prior orthodoxy have remained: do the tenets persist, what status are they afforded and what impact will their presence have on the future identity of the discipline and its conception of law? The paper captures insights into the way that scholars – as opposed to administrators or managers – are interpreting changes in the discipline. It is based on the premise that scholarly attitudes can shape the discipline and that therefore such attitudes are worthy of study.

scholarly journals The many roads to psychosis: recent advances in understanding risk and mechanisms

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 1883 ◽  
Author(s):  
Carrie E. Bearden ◽  
Jennifer K. Forsyth
Keyword(s):  
Risk Factors ◽  
Mental Illness ◽  
Genetic Architecture ◽  
Biological Processes ◽  
The Core ◽  
The Past ◽  
Recent Advances ◽  
New Findings ◽  
The Many ◽  
Major Progress

Schizophrenia is a chronic and severe mental illness which frequently leads to substantial lifelong disability. The past five years have seen major progress in our understanding of the complex genetic architecture of this disorder. Two major barriers to understanding the core biological processes that underlie schizophrenia and developing better interventions are (1) the absence of etiologically defined biomarkers and (2) the clinical and genetic heterogeneity of the disorder. Here, we review recent advances that have led to changes in our understanding of risk factors and mechanisms involved in the development of schizophrenia. In particular, mechanistic and clinically oriented approaches have now converged on a focus on disruptions in early neurodevelopment and synaptic plasticity as being critical for both understanding trajectories and intervening to change them. Translating these new findings into treatments that substantively change the lives of patients is the next major challenge for the field.

scholarly journals Recent Advances in Vertically Aligned Nanowires for Photonics Applications

Micromachines ◽  
2020 ◽  
Vol 11 (8) ◽  
pp. 726
Author(s):  
Sehui Chang ◽  
Gil Lee ◽  
Young Song
Keyword(s):  
Packing Fraction ◽  
Future Directions ◽  
Structural Coloration ◽  
Light Emitting ◽  
Spectral Filters ◽  
Fabrication Cost ◽  
The Core ◽  
The Past ◽  
Recent Advances ◽  
Vertically Aligned

Over the past few decades, nanowires have arisen as a centerpiece in various fields of application from electronics to photonics, and, recently, even in bio-devices. Vertically aligned nanowires are a particularly decent example of commercially manufacturable nanostructures with regard to its packing fraction and matured fabrication techniques, which is promising for mass-production and low fabrication cost. Here, we track recent advances in vertically aligned nanowires focused in the area of photonics applications. Begin with the core optical properties in nanowires, this review mainly highlights the photonics applications such as light-emitting diodes, lasers, spectral filters, structural coloration and artificial retina using vertically aligned nanowires with the essential fabrication methods based on top-down and bottom-up approaches. Finally, the remaining challenges will be briefly discussed to provide future directions.

scholarly journals Scope and Key Areas of Medical Image Processing

2021 ◽  
pp. 76-85
Author(s):  
Mei- Ling
Keyword(s):  
Image Analysis ◽  
Medical Image ◽  
Clinical Image ◽  
Past Century ◽  
Image Transfer ◽  
Current Health ◽  
The Core ◽  
The Past ◽  
Wide Range ◽  
Health Monitoring Systems

Over the past century, scientific advances in diagnostic devices have offered new potential for noninvasive diagnoses and entrenched computed tomography as a critical component of today's health services. The multidisciplinary field of health image analysis is one of the key areas of innovation that represents these achievements. This area of rapid growth deals with a wide range of operations that support the whole data flow in current health monitoring systems (from raw data capture through digital image transfer). These technologies now have better spatial and luminance resolutions, as well as quicker collection periods, resulting in a large volume of high critical image files that must be appropriately processed and evaluated in order to provide reliable diagnostics findings. This article examines the core kinds of clinical image analysis, as well as the background of various imaging technologies and the major difficulties and developments in the field.

scholarly journals Volcanic eruptions recorded in an ice core from Collins Ice Cap, King George Island, Antarctica

1999 ◽  
Vol 29 ◽  
pp. 121-125 ◽  
Author(s):  
Han Jiankan ◽  
Xie Zichu ◽  
Dai Fengnian ◽  
Zhang Wanchang
Keyword(s):  
Volcanic Activity ◽  
Ice Core ◽  
Volcanic Eruptions ◽  
South Shetland Islands ◽  
Past Century ◽  
King George Island ◽  
The Core ◽  
The Past ◽  
Ice Cap ◽  
Eruptive Cycles

AbstractCareful mineral and structural analyses have revealed the characteristics of volcanic ash in the nine horizons of an 80.2 m ice core from Collins Ice Cap, King George Island, Antarctica.Under the assumption of steady state, the Dansgaard-Johnsen flow model was employed to date the core. The volcanic eruptive sequence established for the South Shetland Islands region since AD 1650 shows seven volcanic eruptive cycles during the past 340 years covered by the ice core. It seems that during the period 1875-1925 there was frequent volcanic activity, with perhaps many eruptions at Deception Island. The years 1650-1800 appear to have been a quiet period, followed by a more turbulent century. The past century is basically a tranquil era except for two turbulent epochs at the beginning of the century and in the 1950s-70s.Many of the volcanic eruptions in the ice-core sequence are found in the previously reported records for this region. The few that are not in the records should be further investigated. The absence of any 1967-70 eruption trace in the core suggests that this period may represent a minimum in volcanic activity.

The zoonotic potential of bat-borne coronaviruses

2020 ◽  
Vol 4 (4) ◽  
pp. 365-381
Author(s):  
Ny Anjara Fifi Ravelomanantsoa ◽  
Sarah Guth ◽  
Angelo Andrianiaina ◽  
Santino Andry ◽  
Anecia Gentles ◽  
...  
Keyword(s):  
Genetic Material ◽  
Field Research ◽  
Sympatric Species ◽  
Animal Origin ◽  
Mammalian Host ◽  
Past Century ◽  
The Past ◽  
Novel Host ◽  
Horseshoe Bat ◽  
Human Infections

Seven zoonoses — human infections of animal origin — have emerged from the Coronaviridae family in the past century, including three viruses responsible for significant human mortality (SARS-CoV, MERS-CoV, and SARS-CoV-2) in the past twenty years alone. These three viruses, in addition to two older CoV zoonoses (HCoV-229E and HCoV-NL63) are believed to be originally derived from wild bat reservoir species. We review the molecular biology of the bat-derived Alpha- and Betacoronavirus genera, highlighting features that contribute to their potential for cross-species emergence, including the use of well-conserved mammalian host cell machinery for cell entry and a unique capacity for adaptation to novel host environments after host switching. The adaptive capacity of coronaviruses largely results from their large genomes, which reduce the risk of deleterious mutational errors and facilitate range-expanding recombination events by offering heightened redundancy in essential genetic material. Large CoV genomes are made possible by the unique proofreading capacity encoded for their RNA-dependent polymerase. We find that bat-borne SARS-related coronaviruses in the subgenus Sarbecovirus, the source clade for SARS-CoV and SARS-CoV-2, present a particularly poignant pandemic threat, due to the extraordinary viral genetic diversity represented among several sympatric species of their horseshoe bat hosts. To date, Sarbecovirus surveillance has been almost entirely restricted to China. More vigorous field research efforts tracking the circulation of Sarbecoviruses specifically and Betacoronaviruses more generally is needed across a broader global range if we are to avoid future repeats of the COVID-19 pandemic.

PCSK9 inhibition for LDL lowering and beyond – implications for patients with peripheral artery disease

VASA ◽  
2018 ◽  
Vol 47 (3) ◽  
pp. 165-176 ◽  
Author(s):  
Katrin Gebauer ◽  
Holger Reinecke
Keyword(s):  
Cardiovascular Risk ◽  
Risk Reduction ◽  
Ldl Receptor ◽  
Density Lipoprotein ◽  
Past Century ◽  
Pcsk9 Inhibitors ◽  
Cardiovascular Risk Reduction ◽  
Simultaneous Application ◽  
The Past ◽  
Pcsk9 Inhibition

Abstract. Low-density lipoprotein cholesterol (LDL-C) has been proven to be a causal factor of atherosclerosis and, along with other triggers like inflammation, the most frequent reason for peripheral arterial disease. Moreover, a linear correlation between LDL-C concentration and cardiovascular outcome in high-risk patients could be established during the past century. After the development of statins, numerous randomized trials have shown the superiority for LDL-C reduction and hence the decrease in cardiovascular outcomes including mortality. Over the past decades it became evident that more intense LDL-C lowering, by either the use of highly potent statin supplements or by additional cholesterol absorption inhibitor application, accounted for an even more profound cardiovascular risk reduction. Proprotein convertase subtilisin/kexin type 9 (PCSK9), a serin protease with effect on the LDL receptor cycle leading to its degradation and therefore preventing continuing LDL-C clearance from the blood, is the target of a newly developed monoclonal antibody facilitating astounding LDL-C reduction far below to what has been set as target level by recent ESC/EAS guidelines in management of dyslipidaemias. Large randomized outcome trials including subjects with PAD so far have been able to prove significant and even more intense cardiovascular risk reduction via further LDL-C debasement on top of high-intensity statin medication. Another approach for LDL-C reduction is a silencing interfering RNA muting the translation of PCSK9 intracellularly. Moreover, PCSK9 concentrations are elevated in cells involved in plaque composition, so the potency of intracellular PCSK9 inhibition and therefore prevention or reversal of plaques may provide this mechanism of action on PCSK9 with additional beneficial effects on cells involved in plaque formation. Thus, simultaneous application of statins and PCSK9 inhibitors promise to reduce cardiovascular event burden by both LDL-C reduction and pleiotropic effects of both agents.

Archaeology in the Past Century

1901 ◽  
Vol 51 (1309supp) ◽  
pp. 20976-20977
Author(s):  
W. M. Flinders Petrje
Keyword(s):  
Past Century ◽  
The Past

Soziale Disziplinierung im flexiblen Kapitalismus

2004 ◽  
Vol 34 (136) ◽  
pp. 339-356
Author(s):  
Tobias Wölfle ◽  
Oliver Schöller
Keyword(s):  
Social Welfare ◽  
Second Step ◽  
Social Rights ◽  
Federal Law ◽  
Capitalist Development ◽  
The Core ◽  
The Past ◽  
The Impact ◽  
Municipal Level

Under the term “Hilfe zur Arbeit” (aid for work) the federal law of social welfare subsumes all kinds of labour disciplining instruments. First, the paper shows the historical connection of welfare and labour disciplining mechanisms in the context of different periods within capitalist development. In a second step, against the background of historical experiences, we will analyse the trends of “Hilfe zur Arbeit” during the past two decades. It will be shown that by the rise of unemployment, the impact of labour disciplining aspects of “Hilfe zur Arbeit” has increased both on the federal and on the municipal level. For this reason the leverage of the liberal paradigm would take place even in the core of social rights.

Adaptations of Time Travel Narratives in Japanese Multimedia: Nurturing Eudaimonia across Time and Space

2014 ◽  
Vol 7 (2) ◽  
pp. 136-151 ◽  
Author(s):  
Sung-Ae Lee
Keyword(s):  
Travel Narratives ◽  
Time Travel ◽  
Cultural Knowledge ◽  
Human Beings ◽  
The Core ◽  
The Past ◽  
Life Styles ◽  
Concern For Others ◽  
The Future ◽  
Live Action

To displace a character in time is to depict a character who becomes acutely conscious of his or her status as other, as she or he strives to comprehend and interact with a culture whose mentality is both familiar and different in obvious and subtle ways. Two main types of time travel pose a philosophical distinction between visiting the past with knowledge of the future and trying to inhabit the future with past cultural knowledge, but in either case the unpredictable impact a time traveller may have on another society is always a prominent theme. At the core of Japanese time travel narratives is a contrast between self-interested and eudaimonic life styles as these are reflected by the time traveller's activities. Eudaimonia is a ‘flourishing life’, a life focused on what is valuable for human beings and the grounding of that value in altruistic concern for others. In a study of multimodal narratives belonging to two sets – adaptations of Tsutsui Yasutaka's young adult novella The Girl Who Leapt Through Time and Yamazaki Mari's manga series Thermae Romae – this article examines how time travel narratives in anime and live action film affirm that eudaimonic living is always a core value to be nurtured.

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