scholarly journals Microencapsulated sunblock nanoparticles based on zeolitic imidazole frameworks for safe and effective UV protection

RSC Advances ◽  
2018 ◽  
Vol 8 (22) ◽  
pp. 12315-12321 ◽  
Author(s):  
Lixian Xu ◽  
Di Wu ◽  
Bingrong Zhou ◽  
Yang Xu ◽  
Wenjuan Wang ◽  
...  
Keyword(s):  
Uv Protection ◽  
Uv Filters ◽  
Uv Filter ◽  
Transdermal Absorption ◽  
Zeolitic Imidazole Frameworks

Microencapsulation of UV filters into ZIFs could improve UV photoprotection and minimize the deleterious effects of UV filter transdermal absorption.

scholarly journals Microencapsulated UV filter@ZIF-8 based sunscreens for broad spectrum UV protection

RSC Advances ◽  
2020 ◽  
Vol 10 (56) ◽  
pp. 34254-34260 ◽  
Author(s):  
Anu Sharma ◽  
Abhishek Kumar ◽  
Changning Li ◽  
Rakesh Kumar Sharma ◽  
Mark T. Swihart
Keyword(s):  
Broad Spectrum ◽  
Uv Protection ◽  
Uv Filters ◽  
Uv Filter ◽  
Organic Uv Filters

Encapsulation of organic UV filters in ZIF-8 nanoparticles produces a safer, more stable, and more effective sunscreen.

scholarly journals Sinapic Acid Esters: Octinoxate Substitutes Combining Suitable UV Protection and Antioxidant Activity

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 782 ◽  
Author(s):  
Cédric Peyrot ◽  
Matthieu M. Mention ◽  
Fanny Brunissen ◽  
Florent Allais
Keyword(s):  
Antioxidant Activity ◽  
Antioxidant Properties ◽  
Sinapic Acid ◽  
Uv Protection ◽  
Uv Filters ◽  
Free Phenol ◽  
Naturally Occurring ◽  
Ester Moiety ◽  
Sar Study ◽  
Acid Esters

In 2021, Hawaii will permanently ban the use and sale of octinoxate-based sunscreens as studies have shown serious impacts of such UV filters on the coral reef. This ban, which could be generalized to other countries, highlights the extreme need to offer alternative UV filters that are not only effective in terms of sun protection, but also healthy with regards to human health and the environment. In this context, a wide library of p-hydroxycinnamic esters deriving from naturally occurring sinapic acid has been synthesized using a Knoevenagel–Doebner condensation. The UV filtering activities as well as the antioxidant properties of these sinapic acid esters were then investigated. The results showed promising UVB protection and antioxidant efficacy. A Structure–Activity Relationship (SAR) study on the sinapic acid esters highlighted the need of a free phenol to, as expected, observe antioxidant activity, but also to obtain a higher intensity of protection. Moreover, the nature of the ester moiety also proved to be a key structural feature for the UV absorbance, as higher steric hindrance on the ester moiety leads to more active compounds. The judicious structural design of sinapic esters thus provides promising compounds combining UV protection and antioxidant activity.

scholarly journals Preparation and Characterization of Organic/Inorganic Composite UV Filter Microcapsules by Sol-Gel Method

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Pey-Shiuan Wu ◽  
Chia-Hui Lin ◽  
Yi-Ching Kuo ◽  
Chih-Chien Lin
Keyword(s):  
Sodium Alginate ◽  
Interfacial Polymerization ◽  
Sol Gel ◽  
Cross Linking ◽  
Uv Filters ◽  
Uv Filter ◽  
Gel Method ◽  
Sol Gel Method ◽  
Inorganic Composite ◽  
Organic Uv Filters

Octyl methoxycinnamate and butyl methoxydibenzoylmethane are organic UV filters with poor photostability and will become photoallergy or phototoxic substance when exposed to ultraviolet radiation. The organic UV filters coated by microcapsules can reduce the photodegradation and avoid direct contact with the skin. Through microencapsulation, the application of UV filters in cosmetics becomes more effective and safer. This study first used the sol-gel method to create organic/inorganic composite UV filter microcapsules. We used sodium alginate as a shell material of the microcapsule to encapsulate UV filters. CaCO3 and tetraethyl orthosilicate (TEOS) were used as cross-linking agents, and sorbitan monooleate (Span 80) and polyoxyethylenesorbitan monooleate (Tween 80) were used as emulsifiers in the interfacial polymerization method for preparation. The results indicated that the microcapsules with 3 g of CaCO3 cross-linking agents had a similar particle size and better entrapment efficiency. The average sizes were 61.0 ± 4.9 μm and 48.6 ± 4.7 μm, and entrapment efficiencies were 75.3 ± 1.9% and 74.8 ± 1.7% for octyl methoxycinnamate and butyl methoxydibenzoylmethane, respectively. Utilizing sodium alginate as a cross-linking agent is better than TEOS due to the higher calcium content. In vitro transdermal delivery analysis showed that the release rate became steady.

Biobased Nanoparticles for Broadband UV Protection with Photostabilized UV Filters

2016 ◽  
Vol 8 (48) ◽  
pp. 32655-32660 ◽  
Author(s):  
Douglas R. Hayden ◽  
Arnout Imhof ◽  
Krassimir P. Velikov
Keyword(s):  
Uv Protection ◽  
Uv Filters

scholarly journals The Involvement of Xanthone and (E)-Cinnamoyl Chromophores for the Design and Synthesis of Novel Sunscreening Agents

2020 ◽  
Vol 22 (1) ◽  
pp. 34
Author(s):  
Justyna Popiół ◽  
Agnieszka Gunia-Krzyżak ◽  
Karolina Słoczyńska ◽  
Paulina Koczurkiewicz-Adamczyk ◽  
Kamil Piska ◽  
...  
Keyword(s):  
Uv Radiation ◽  
Broad Spectrum ◽  
Estrogenic Activity ◽  
Spectroscopic Properties ◽  
Skin Aging ◽  
Systemic Absorption ◽  
Uv Filters ◽  
Wet Milling ◽  
Uv Filter ◽  
Sunscreening Agents

Excessive UV exposure contributes to several pathological conditions like skin burns, erythema, premature skin aging, photodermatoses, immunosuppression, and skin carcinogenesis. Effective protection from UV radiation may be achieved with the use of sunscreens containing UV filters. Currently used UV filters are characterized by some limitations including systemic absorption, endocrine disruption, skin allergy induction, and cytotoxicity. In the research centers all over the world new molecules are developed to improve the safety, photostability, solubility, and absorption profile of new derivatives. In our study, we designed and synthesized seventeen novel molecules by combining in the structures two chromophores: xanthone and (E)-cinnamoyl moiety. The ultraviolet spectroscopic properties of the tested compounds were confirmed in chloroform solutions. They acted as UVB or UVA/UVB absorbers. The most promising compound 9 (6-methoxy-9-oxo-9H-xanthen-2-yl)methyl (E)-3-(2,4-dimethoxyphenyl)acrylate) absorbed UV radiation in the range 290–369 nm. Its photoprotective activity and functional photostability were further evaluated after wet milling and incorporation in the cream base. This tested formulation with compound 9 possessed very beneficial UV protection parameters (SPFin vitro of 19.69 ± 0.46 and UVA PF of 12.64 ± 0.32) which were similar as broad-spectrum UV filter tris-biphenyl triazine. Additionally, compound 9 was characterized by high values of critical wavelength (381 nm) and UVA/UVB ratio (0.830) thus it was a good candidate for broad-spectrum UV filter and it might protect skin against UVA-induced photoaging. Compound 9 were also shown to be photostable, non-cytotoxic at concentrations up to 50 µM when tested on five cell lines, and non-mutagenic in Ames test. It also possessed no estrogenic activity, according to the results of MCF-7 breast cancer model. Additionally, its favorable lipophilicity (miLogP = 5.62) does not predispose it to penetrate across the skin after topical application.

scholarly journals Towards symmetry driven and nature inspired UV filter design

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Michael D. Horbury ◽  
Emily L. Holt ◽  
Louis M. M. Mouterde ◽  
Patrick Balaguer ◽  
Juan Cebrián ◽  
...  
Keyword(s):  
Ultraviolet Radiation ◽  
Radiation Exposure ◽  
Endocrine Disruption ◽  
Ultrafast Spectroscopy ◽  
Filter Design ◽  
Antioxidant Potential ◽  
Uv Filters ◽  
Next Generation ◽  
Uv Filter ◽  
Ultraviolet Radiation Exposure

Abstract In plants, sinapate esters offer crucial protection from the deleterious effects of ultraviolet radiation exposure. These esters are a promising foundation for designing UV filters, particularly for the UVA region (400 – 315 nm), where adequate photoprotection is currently lacking. Whilst sinapate esters are highly photostable due to a cis-trans (and vice versa) photoisomerization, the cis-isomer can display increased genotoxicity; an alarming concern for current cinnamate ester-based human sunscreens. To eliminate this potentiality, here we synthesize a sinapate ester with equivalent cis- and trans-isomers. We investigate its photostability through innovative ultrafast spectroscopy on a skin mimic, thus modelling the as close to true environment of sunscreen formulas. These studies are complemented by assessing endocrine disruption activity and antioxidant potential. We contest, from our results, that symmetrically functionalized sinapate esters may show exceptional promise as nature-inspired UV filters in next generation sunscreen formulations.

Avobenzone encapsulated in modified dextrin for improved UV protection and reduced skin penetration

2016 ◽  
Vol 70 (6) ◽  
Author(s):  
Chia-Ching Li ◽  
Li-Huei Lin ◽  
Hsun-Tsing Lee ◽  
Jing-Ru Tsai
Keyword(s):  
Differential Scanning Calorimetry ◽  
Thermogravimetric Analysis ◽  
Inclusion Complexes ◽  
Skin Penetration ◽  
Uv Protection ◽  
Skin Damage ◽  
Protection Factor ◽  
Scanning Calorimetry ◽  
Uv Filter

AbstractThe present study used differential scanning calorimetry, thermogravimetric analysis, and UV spectrometry to examine: i) the encapsulation of an organic UV filter 1-(4-methoxyphenyl)-3-(4-tert-butylphenyl)propane-1,3-dione (avobenzone) within modified dextrin and ii) the characteristics of these inclusion complexes (MDA). The properties of avobenzone emulsions with and without encapsulation in modified dextrin, the in vitro UV protection factor, dissolution and release, and the skin penetrability of avobenzone were also examined. The presence of inclusion complexes significantly decreased the tendency of the UV filter to penetrate the skin. In addition, such inclusion complexes should effectively prevent skin damage from radiation extending from the UVA to the UVC.

Synthesis, characterisation and aquatic ecotoxicity of the UV filter hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate (DHHB) and its chlorinated by-products

2016 ◽  
Vol 13 (1) ◽  
pp. 119 ◽  
Author(s):  
Gorica Grbović ◽  
Olga Malev ◽  
Darko Dolenc ◽  
Roberta Sauerborn Klobučar ◽  
Želimira Cvetković ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Transformation Products ◽  
Model Organisms ◽  
Uv Filters ◽  
Uv Filter ◽  
Starting Compound ◽  
Similar Range ◽  
Set Up ◽  
Toxic Potential ◽  
By Products

Environmental context Various UV-filtering chemicals are added to sunscreens in order to protect humans from the harmful effects of the sun. As a consequence of disinfection processes in swimming pools, sunscreen components may be chlorinated and change their structure and properties, leading to derivatives with higher toxicity. The safety of sunscreen components as well as that of their transformation products during their use requires further study. Abstract In this work is presented a synthesis pathway for the UV filter hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate (DHHB) and its chlorinated by-products in order to investigate the transformation behaviour and toxicity changes of DHHB during chlorination disinfection treatment. Acute toxicity was measured using standardised tests with aquatic model organisms. The potency of DHHB was compared with other benzophenone-like UV filters tested in the same experimental set-up. The toxicity of chlorinated compounds tested with photobacteria was found to be in a similar range to that of the starting compound. Microalgae were more sensitive to DHHB than to its chlorinated by-products, whereas daphnids were affected more by DHHB’s chlorinated products. The comparative toxicity data showed DHHB and even more its chlorinated by-products as more highly biologically potent to daphnids than other tested UV filters. The toxic potential of benzophenone-like UV filters should be interpreted together with data on their chemical properties, chlorination effects and affected organisms.

scholarly journals Effectiveness of Frangipani Leaf Extract (Plumeria alba Linn.) as a UV Filter

2021 ◽  
Vol 20 (2) ◽  
pp. 191-200
Author(s):  
Irein Kusuma Angreini ◽  
Aniek Prasetyaningsih ◽  
Vinsa Cantya Prakasita
Keyword(s):  
Crude Extract ◽  
Clinical Symptoms ◽  
Pearson Correlation ◽  
Negative Control Group ◽  
Negative Control ◽  
Control Group ◽  
Uv Filters ◽  
Uv Filter

UV filters are necessary since UV rays are harmful to human skin. UV filter compounds in commercial sunscreen products can cause adverse effects. Thus, natural UV filters containing flavonoids, e.g. Frangipani (Plumeria alba Linn.) leaves, are needed. This research examined the use of flavonoids from P. alba leaf as a UV filter with in vitro and in vivo. Maceration was performed with 70% ethyl alco-hol and liquid-liquid extraction for flavonoid purification. Parameters tested were total flavonoid compounds, SPF value, and clinical symptoms of the melanogenesis inhibition scoring. The purification result was 43.6%. The flavonoid concentration in pure extract (64.4 mg QE /g) was higher than crude extract (57.6 mg QE/g). The highest SPF value (33.88) was observed in pure extract at 1400 mg/mL, while the same concentration of crude extract resulted in a lower SPF value (33.06). Pearson correlation analysis (0.536) indicated a di-rectly proportional relationship between SPF value and extract concentration. In vivo analysis was performed by scoring between 0-4 following the severity of erythema. After 21 days of sunlight exposure, the worst erythema was found in the negative control group (score 1.292). The best result was found in the group treated with pure extract 1400 mg/ml (score 0.542).

Occurrence of widely used organic UV filters in lake and river sediments

2012 ◽  
Vol 9 (2) ◽  
pp. 139 ◽  
Author(s):  
Dominic Kaiser ◽  
Olaf Wappelhorst ◽  
Matthias Oetken ◽  
Jörg Oehlmann
Keyword(s):  
Risk Assessment ◽  
Lake Sediments ◽  
Sediment Sample ◽  
Aquatic Environment ◽  
River Sediments ◽  
Freshwater Ecosystems ◽  
Gas Chromatography Mass Spectrometry ◽  
Uv Filters ◽  
Uv Filter ◽  
Organic Uv Filters

Environmental contextPersonal care products containing organic chemicals to filter the sun’s UV rays are produced and used on a broad scale worldwide. Consequently, these organic UV filters are now widespread in the environment. We investigate the occurrence of seven common organic UV filters in river and lake sediments thereby providing valuable data for the future environmental risk assessment of these chemicals to the benthic community of freshwater ecosystems. AbstractPersonal care products (PCPs) are produced and used in huge amounts. These formulations are permanently introduced into the aquatic environment during regular use, mainly through municipal sewage treatment plants. Although there is increasing concern about PCP residues in the aquatic environment, little is known about the extent and level of contamination. The occurrence and concentrations of the seven most frequently used ultraviolet (UV) filters in river and lake sediments have been investigated over a 6-month period by gas chromatography–mass spectrometry: benzophenone-3 (BP-3), 3-benzyliden camphor (3-BC), butyl-methoxydibenzoylmethane (B-MDM), ethylhexyl dimethyl p-aminobenzoic acid (ED-PABA), ethylhexyl-methoxycinnamate (EHMC), 3′-(4′-methylbenzyliden)camphor (4-MBC) and octocrylene (OCR). B-MDM, EHMC and OCR were identified as major contaminants. They were present in every sediment sample with maximum concentrations of 62.2, 6.8 and 642 µg kg–1. 3-BC and ED-PABA could not be detected in any sediment sample. The temporal distribution profile and concentrations of UV filters differed between lakes and rivers. Whereas concentrations of all UV filters in river sediments were low and constant over time, lake sediments exhibited high UV-filter levels during summer and concentrations dropped in autumn. These findings support risk assessment activities and contribute to a better understanding of the magnitude of contamination with organic UV-filter substances in aquatic ecosystems.

Sign in / Sign up

Export Citation Format

Share Document