The topography of fibrous scaffolds modulates the paracrine function of Ad-MSCs in the regeneration of skin tissues

2019 ◽  
Vol 7 (10) ◽  
pp. 4248-4259 ◽  
Author(s):  
Ruiying Huang ◽  
Jian Wang ◽  
Haoxiang Chen ◽  
Xuelei Shi ◽  
Xiaocheng Wang ◽  
...  
Keyword(s):  
Wound Healing ◽  
3D Printing ◽  
Therapeutic Effect ◽  
Tissue Regeneration ◽  
Skin Tissue ◽  
Fibrous Scaffolds ◽  
Regeneration Of Skin

A tissue engineered skin is designed and fabricated by 3D printing, which has a therapeutic effect on wound healing and skin tissue regeneration.

Development and Characterization of Squalene-Loaded Topical Agar-Based Emulgel Scaffold: Wound Healing Potential in Full-Thickness Burn Model

2020 ◽  
pp. 153473462092162
Author(s):  
T. S. Shanmugarajan ◽  
N. Kalai Selvan ◽  
Varuna Naga Venkata Arjun Uppuluri
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Macrophage Polarization ◽  
Negative Control ◽  
Skin Tissue ◽  
Self Healing ◽  
Full Thickness ◽  
Burn Wound ◽  
Burn Wound Healing ◽  
Tissue Defects

Full-thickness burns pose a major challenge for clinicians to handle because of their restricted self-healing ability. Even though several approaches have been implemented for repairing these burnt skin tissue defects, all of them had unsatisfactory outcomes. Moreover, during recent years, skin tissue engineering techniques have emerged as a promising approach to improve skin tissue regeneration and overcome the shortcomings of the traditional approaches. Although previous literatures report the wound healing effects of the squalene oil, in the current study, for the first time, we developed a squalene-loaded emulgel-based scaffold as a novel approach for potential skin regeneration. This squalene-loaded agar-based emulgel scaffold was fabricated by using physical cross-linking technique using lecithin as an emulsifier. Characterization studies such as X-ray diffraction, Fourier-transform infrared spectroscopy, and field emission scanning electron microscopy revealed the amorphous nature, chemical interactions, and cross-linked capabilities of the developed emulgel scaffold. The squalene-loaded emulgel scaffold showed excellent wound contraction when compared with the agar gel and negative control. In case of the histopathology and recent immunohistochemistry findings, it was clearly evidenced that squalene-loaded emulgel promoted faster rate of the revascularization and macrophage polarization in order to enhance the burn wound healing. Moreover, the findings also revealed that the incorporation of squalene oil into the formulation enhances collagen deposition and accelerates the burnt skin tissue regeneration process. Finally, we conclude that the squalene-loaded emulgel scaffold could be an effective formulation used in the treatment of the burnt skin tissue defects.

Carbon nanodot impregnated fluorescent nanofibers for in vivo monitoring and accelerating full-thickness wound healing

2017 ◽  
Vol 5 (32) ◽  
pp. 6645-6656 ◽  
Author(s):  
Pallabi Pal ◽  
Bodhisatwa Das ◽  
Prabhash Dadhich ◽  
Arun Achar ◽  
Santanu Dhara
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Noninvasive Monitoring ◽  
Nanofibrous Scaffold ◽  
Skin Tissue ◽  
Full Thickness ◽  
In Vivo Monitoring ◽  
Full Thickness Wound

Development of an intrinsically fluorescent nanofibrous scaffold of polycaprolactone–gelatin for skin tissue regeneration and noninvasive monitoring of scaffold activity in vivo.

scholarly journals Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamed Nosrati ◽  
Reza Aramideh Khouy ◽  
Ali Nosrati ◽  
Mohammad Khodaei ◽  
Mehdi Banitalebi-Dehkordi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
The Body ◽  
Key Factors ◽  
Potential Applications ◽  
Nanocomposite Scaffolds

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

scholarly journals 3D Printing for Soft Tissue Regeneration and Applications in Medicine

Biomedicines ◽  
2021 ◽  
Vol 9 (4) ◽  
pp. 336
Author(s):  
Sven Pantermehl ◽  
Steffen Emmert ◽  
Aenne Foth ◽  
Niels Grabow ◽  
Said Alkildani ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Additive Manufacturing ◽  
Soft Tissue ◽  
3D Printing ◽  
Tissue Regeneration ◽  
Research Area ◽  
Modern Medicine ◽  
Soft Tissue Regeneration ◽  
General Overview

The use of additive manufacturing (AM) technologies is a relatively young research area in modern medicine. This technology offers a fast and effective way of producing implants, tissues, or entire organs individually adapted to the needs of a patient. Today, a large number of different 3D printing technologies with individual application areas are available. This review is intended to provide a general overview of these various printing technologies and their function for medical use. For this purpose, the design and functionality of the different applications are presented and their individual strengths and weaknesses are explained. Where possible, previous studies using the respective technologies in the field of tissue engineering are briefly summarized.

Nano-/Microfibrous Cotton-Wool-Like 3D Scaffold with Core–Shell Architecture by Emulsion Electrospinning for Skin Tissue Regeneration

2017 ◽  
Vol 3 (12) ◽  
pp. 3563-3575 ◽  
Author(s):  
Pallabi Pal ◽  
Pavan Kumar Srivas ◽  
Prabhash Dadhich ◽  
Bodhisatwa Das ◽  
Dhrubajyoti Maulik ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Skin Tissue ◽  
Core Shell ◽  
Cotton Wool ◽  
3D Scaffold
Sign in / Sign up

Export Citation Format

Share Document