A lysozyme corona complex for the controlled pharmacokinetic release of probucol from mesoporous silica particles

Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic properties, yet, its sensitivity to light, oxygen, and heat, and its low solubility in water renders its preservation and bioavailability challenging. To increase its bioaccessibility, we fabricated nanoliposomes and chitosan-coated nanoliposomes encapsulating curcumin, and we evaluated the systems in terms of their physicochemical characteristics and release profiles in simulated gastrointestinal mediums. Chitosan-coating enhanced the stability of nanoliposomes and slowed the release of curcumin in the simulated gastrointestinal (GI) environment. This study demonstrates that nanoliposomes and chitosan-coated nanoliposomes are promising carriers for poorly soluble lipophilic compounds with low oral bioavailability, such as curcumin.

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Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽

10.3390/molecules25030742 ◽

2020 ◽

Vol 25 (3) ◽

pp. 742 ◽

Cited By ~ 4

Author(s):

Thashini Moodley ◽

Moganavelli Singh

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Drug Delivery Vehicles ◽

Biological Compatibility ◽

Delivery Vehicles ◽

Efficient Loading ◽

Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

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Comparative release kinetics of small drugs (ibuprofen and acetaminophen) from multifunctional mesoporous silica nanoparticles

Journal of Materials Chemistry B ◽

10.1039/c9tb02494h ◽

2020 ◽

Vol 8 (10) ◽

pp. 2096-2106 ◽

Cited By ~ 6

Author(s):

Eun-Bi Lim ◽

Tran Anh Vy ◽

Sang-Wha Lee

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Intermolecular Interactions ◽

Mesoporous Silica Nanoparticles ◽

Release Kinetics ◽

Kinetics Of

Multifunctional mesoporous silica nanoparticles (MSNs) can confer dynamically varied release kinetics depending on the intermolecular interactions between model drugs and functional decorations on the MSNs.

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Ordered mesoporous silicates as matrices for controlled release of drugs

Acta Pharmaceutica ◽

10.2478/v1007-010-0037-4 ◽

2010 ◽

Vol 60 (4) ◽

pp. 373-385 ◽

Cited By ~ 37

Author(s):

Tina Ukmar ◽

Odon Planinšek

Keyword(s):

Controlled Release ◽

Uv Light ◽

Release Kinetics ◽

Stimuli Responsive ◽

Mesoporous Silicates ◽

Ordered Mesoporous ◽

Poorly Soluble ◽

Model Drug ◽

Kinetics Of

Ordered mesoporous silicates as matrices for controlled release of drugs Interest in and thereby also development of ordered mesoporous silicates as drug delivery devices have grown immensely over the past few years. On hand selected cases from the literature, the power of such systems as delivery devices has been established. Specifically, it is shown how it is possible to enhance the release kinetics of poorly soluble drugs by embedding them in mesoporous silicates. Further critical factors governing the structure and release of the model drug itraconazole incorporated in an SBA-15 matrix are briefly reviewed. The possibility of functionalizing the surface of mesoporous matrices also under harsher conditions offers a broad platform for the design of stimuli-responsive drug release, including pH responsive systems and systems which respond to the presence of specific ions, reducing agents, magnetic field or UV light, whose efficiency and biocompatibility has been established in vitro.

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A Hierarchical Study on Load/Release Kinetics of Guest Molecules into/from Mesoporous Silica Thin Films

The Journal of Physical Chemistry C ◽

10.1021/jp110852p ◽

2011 ◽

Vol 115 (14) ◽

pp. 6581-6590 ◽

Cited By ~ 35

Author(s):

Hong-Yuan Lian ◽

Yung-He Liang ◽

Yusuke Yamauchi ◽

Kevin C.-W. Wu

Keyword(s):

Thin Films ◽

Mesoporous Silica ◽

Release Kinetics ◽

Guest Molecules ◽

Silica Thin Films ◽

Load Release ◽

Kinetics Of

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Formulations and evaluation of Cyclodextrin complexed Ceadroxil loaded nanosponges

International Journal of Drug Delivery ◽

10.5138/09750215.2180 ◽

2017 ◽

Vol 9 (3) ◽

pp. 84 ◽

Cited By ~ 2

Author(s):

Pawan Dubey ◽

Hemant Kumar Sharma ◽

Sunil Shah ◽

Chandra Kishore Tyagi ◽

Amol R. Chandekar ◽

...

Keyword(s):

Lactone Ring ◽

Release Kinetics ◽

Major Drawback ◽

Zeta Potentials ◽

Poorly Soluble ◽

Dosing Intervals ◽

And Control ◽

Kinetics Of ◽

Derivatives Of

Cefadroxil (CFD) is a broad spectrum antibiotic that acts against an extensive variety of bacteria, including Gram-positive and Gram-negative bacteria. The major drawback of orally administered drug like cefadroxil is its shorter half life of 1.2 hrs. The goal of the study is to prolong the drug release, producing a desired blood serum level, reduction in drug toxicity and improving the patient compliance by prolonging the dosing intervals. Cyclodextrin-based nanosponges (NS) are a novel class of cross-linked derivatives of cyclodextrins. They have been used to increase the solubility of poorly soluble actives, to protect the labile groups and control the release. This study aimed at formulating complexes of CFDwith three types of β-cyclodextrin NS obtained with different cross-linking ratio (viz. 1:2, 1:4 and 1:8 on molar basis with the cross-linker) to protect the lactone ring from hydrolysis and to prolong the release kinetics of CFD. Crystalline (F1:2, F1:4 and F1:8) and paracrystalline NS formulations were prepared. XRPD, DSC and FTIR studies confirmed the interactions of CFDwith NS. XRPD showed that the crystallinity of CFD decreased after loading. CFD was loaded as much as 21%, 37% and 13% w/w in F1:2 , F1:4 and F1:8, respectively while the paracrystalline NS formulations gave a loading of about 10% w/w or lower. The particle sizes of the loaded NS formulations were between 450 and 600 nm with low polydispersity indices. The zeta potentials were sufficiently high (-20 to -25 mV) to obtain a stable colloidal nanosuspension. The in vitro studies indicated a slow and prolonged CFD release over a period of 24 h. The NS formulations protected the lactone ring of CFD after their incubation in physiological conditions at 37°C for 24 h with a 80% w/w of intact lactone ring when compared to only around 20% w/w of plain CFD.

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Feasibility Study of Mesoporous Silica Particles for Pulmonary Drug Delivery: Therapeutic Treatment with Dexamethasone in a Mouse Model of Airway Inflammation

Pharmaceutics ◽

10.3390/pharmaceutics11040149 ◽

2019 ◽

Vol 11 (4) ◽

pp. 149 ◽

Cited By ~ 5

Author(s):

Tina Gulin-Sarfraz ◽

Sofia Jonasson ◽

Elisabeth Wigenstam ◽

Eva von Haartman ◽

Anders Bucht ◽

...

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Airway Inflammation ◽

Local Treatment ◽

Drug Carriers ◽

Silica Particles ◽

Therapeutic Modality ◽

Porous Carrier ◽

Poorly Soluble ◽

Aqueous Dispersibility

Diseases in the respiratory tract rank among the leading causes of death in the world, and thus novel and optimized treatments are needed. The lungs offer a large surface for drug absorption, and the inhalation of aerosolized drugs are a well-established therapeutic modality for local treatment of lung conditions. Nanoparticle-based drug delivery platforms are gaining importance for use through the pulmonary route. By using porous carrier matrices, higher doses of especially poorly soluble drugs can be administered locally, reducing their side effects and improving their biodistribution. In this study, the feasibility of mesoporous silica particles (MSPs) as carriers for anti-inflammatory drugs in the treatment of airway inflammation was investigated. Two different sizes of particles on the micron and nanoscale (1 µm and 200 nm) were produced, and were loaded with dexamethasone (DEX) to a loading degree of 1:1 DEX:MSP. These particles were further surface-functionalized with a polyethylene glycol–polyethylene imine (PEG–PEI) copolymer for optimal aqueous dispersibility. The drug-loaded particles were administered as an aerosol, through inhalation to two different mice models of neutrophil-induced (by melphalan or lipopolysaccharide) airway inflammation. The mice received treatment with either DEX-loaded MSPs or, as controls, empty MSPs or DEX only; and were evaluated for treatment effects 24 h after exposure. The results show that the MEL-induced airway inflammation could be treated by the DEX-loaded MSPs to the same extent as free DEX. Interestingly, in the case of LPS-induced inflammation, even the empty MSPs significantly down-modulated the inflammatory response. This study highlights the potential of MSPs as drug carriers for the treatment of diseases in the airways.

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Nanoporous Gold Monolith for High Loading of Unmodified Doxorubicin and Sustained Co-Release of Doxorubicin-Rapamycin

Nanomaterials ◽

10.3390/nano11010208 ◽

2021 ◽

Vol 11 (1) ◽

pp. 208 ◽

Cited By ~ 1

Author(s):

Jay K. Bhattarai ◽

Dharmendra Neupane ◽

Bishal Nepal ◽

Alexei V. Demchenko ◽

Keith J. Stine

Keyword(s):

Release Kinetics ◽

Protein Corona ◽

Nanoporous Gold ◽

High Loading ◽

Vis Spectroscopy ◽

Zero Order Release ◽

Plausible Mechanism ◽

Ph Conditions ◽

Kinetics Of ◽

Potential Use

Nanoparticles (NPs) have been widely explored for delivering doxorubicin (DOX), an anticancer drug, to minimize cardiotoxicity. However, their efficiency is marred by a necessity to chemically modify DOX, NPs, or both and low deposition of the administered NPs on tumors. Therefore, alternative strategies should be developed to improve therapeutic efficacy and decrease toxicity. Here we report the possibility of employing a monolithic nanoporous gold (np-Au) rod as an implant for delivering DOX. The np-Au has very high DOX encapsulation efficiency (>98%) with maximum loading of 93.4 mg cm−3 without any chemical modification required of DOX or np-Au. We provide a plausible mechanism for the high loading of DOX in np-Au. The DOX sustained release for 26 days from np-Au in different pH conditions at 37 °C, which was monitored using UV-Vis spectroscopy. Additionally, we encased the DOX-loaded np-Au with rapamycin (RAPA)-trapped poly(D,L-lactide-co-glycolide) (PLGA) to fabricate an np-Au@PLGA/RAPA implant and optimized the combinatorial release of DOX and RAPA. Further exploiting the effect of the protein corona around np-Au and np-Au@PLGA/RAPA showed zero-order release kinetics of DOX. This work proves that the np-Au-based implant has the potential to be used as a DOX carrier of potential use in cancer treatment.

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