Preparation and properties of a biodegradable poly(lactide-co-glycolide)/poly(trimethylene carbonate) porous composite scaffold for bone tissue engineering

2020 ◽  
Vol 44 (34) ◽  
pp. 14632-14641 ◽  
Author(s):  
Jin Qi ◽  
Yu Zhang ◽  
Xiliang Liu ◽  
Qianmao Zhang ◽  
Chengdong Xiong
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Porous Scaffold ◽  
Composite Scaffold ◽  
High Porosity ◽  
Trimethylene Carbonate ◽  
Porous Composite ◽  
Biodegradable Poly ◽  
Good Biocompatibility ◽  
Interconnected Pore

New biodegradable PLGA/PTMC composite porous scaffold with high porosity, mechanical properties, significant homogeneous, interconnected pore network and good biocompatibility.

Fabrication and evaluation of polylactic acid/pectin composite scaffold via freeze extraction for tissue engineering

2020 ◽  
Vol 40 (5) ◽  
pp. 421-431
Author(s):  
Mohd Syahir Anwar Hamzah ◽  
Saiful Izwan Abd Razak ◽  
Mohammed Rafiq Abdul Kadir ◽  
Siti Pauliena Mohd Bohari ◽  
Nadirul Hasraf Mat Nayan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Polylactic Acid ◽  
Cell Attachment ◽  
Porous Scaffold ◽  
Composite Scaffold ◽  
Engineering Material ◽  
Water Contact ◽  
Good Biocompatibility ◽  
Proliferation In Vitro

AbstractThis work reports the fabrication and characterizations of porous scaffold made up of polylactic acid (PLA) with the inclusion of pectin (1, 3, 5, 7, 9, 11 wt%) for potential tissue engineering material. The composite scaffold was prepared using a facile method of freeze extraction. Based on the physical evaluations, the scaffold was suggested to be optimum at 5 wt% of pectin loading. Water contact angle of the scaffold was significantly reduced to 46.5o with the inclusion of 5 wt% of pectin. Morphological and topographic of the PLA scaffold revealed that the pectin induced more porous structure and its surface became rougher which was suitable for cell attachment and proliferation. In vitro studies of the PLA/pectin composite scaffold using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromidelt (MTT) assay revealed good biocompatibility whereas Live-Dead kit assay resulted in 91% cell viability after 7 days of incubation.

scholarly journals Preparation of open-porous stereocomplex PLA/PBAT scaffolds and correlation between their morphology, mechanical behavior, and cell compatibility

RSC Advances ◽  
2018 ◽  
Vol 8 (23) ◽  
pp. 12933-12943 ◽  
Author(s):  
Yuan Kang ◽  
Peng Chen ◽  
Xuetao Shi ◽  
Guangcheng Zhang ◽  
Chaoli Wang
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Behavior ◽  
High Porosity ◽  
Engineering Applications ◽  
Cell Compatibility ◽  
Biodegradable Scaffolds ◽  
Good Biocompatibility

For tissue engineering applications, it is essential that biodegradable scaffolds have accessible mechanical properties, high porosity, and good biocompatibility to support the formation of new tissues.

Hybrid nanostructured hydroxyapatite–chitosan composite scaffold: bioinspired fabrication, mechanical properties and biological properties

2015 ◽  
Vol 3 (23) ◽  
pp. 4679-4689 ◽  
Author(s):  
Ya-Ping Guo ◽  
Jun-Jie Guan ◽  
Jun Yang ◽  
Yang Wang ◽  
Chang-Qing Zhang ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Composite Scaffold ◽  
Biological Properties ◽  
Chitosan Composite

A bioinspired strategy has been developed to fabricate a hybrid nanostructured hydroxyapatite–chitosan composite scaffold for bone tissue engineering.

Preparation of Nano-Fibrous Poly(L-lactic acid) Scaffold with Hierarchical Pores

2011 ◽  
Vol 418-420 ◽  
pp. 303-306
Author(s):  
Xue Jun Wang ◽  
Tao Lou ◽  
Guo Jun Song
Keyword(s):  
Tissue Engineering ◽  
Lactic Acid ◽  
Pore Size ◽  
Composite Scaffold ◽  
Compressive Modulus ◽  
High Porosity ◽  
Nano Composite ◽  
Hierarchical Pores ◽  
Fiber Size ◽  
Hierarchical Pore

In this study, a nano-fibrous PLLA scaffold with hierarchical pore was sucessfully fabricated using combined TIPS and particle leaching method.The scaffold had a nano-fibrous PLLA matrix (fiber size 100-800 nm), an interconnective hierarchical pores (1.0- 425 μm), high porosity (>96%). The compressive modulus of scaffold with different pore size was between 0.16 MPa to 0.2 Mpa and it decreased with the increased salt size embedded in. The new nano composite scaffold is potentially a very promising scaffold for tissue engineering.

Performance of a porous composite scaffold containing silk fibroin: Applied research repair on oral jaw epithelial defects

2020 ◽  
Vol 10 (4) ◽  
pp. 490-502
Author(s):  
Huajun Zhu ◽  
Chunyu Qian ◽  
Wanshu Xiao ◽  
Qiang Zhang ◽  
Zili Ge
Keyword(s):  
Mechanical Properties ◽  
Contact Angle ◽  
Silk Fibroin ◽  
Composite Scaffold ◽  
Epithelial Tissue ◽  
Porous Composite ◽  
Clinical Value ◽  
Freeze Dried ◽  
Silk Fibroin Film ◽  
Oral Epithelial

Application research on repairing oral and maxillofacial epithelial defects with filin-protein porous composite scaffold. The silk fibroin solution was synthesized by hydrothermal synthesis, and the film was prepared by stirring and pouring. Then silk fibroin film and silk fibroin freeze-dried support were prepared by stirring and smooth casting. It was characterized by FTIR, mechanical properties, dissolution detection, contact Angle and SEM. To evaluate the performance of this material in repairing rabbit oral mucosa and rabbit skin epithelial defects. The characterization shows that the material has good contact Angle, mechanical properties, dissolution and biocompatibility. It has good repair function to rabbit oral epithelial tissue and skin epithelial tissue. Silk fibroin has excellent and unique properties. It has good development prospects and great clinical value in tissue regeneration.

Biomineralization of Electrospun Nano-HA/PHB GTR Membrane

2007 ◽  
Vol 330-332 ◽  
pp. 695-698 ◽  
Author(s):  
Dong Hua Guan ◽  
Chun Peng Huang ◽  
Ji Liu ◽  
Kun Tian ◽  
Lin Niu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Electrospinning Process ◽  
Nanometer Scale ◽  
High Porosity ◽  
The Novel ◽  
Mineral Crystal ◽  
Novel Technology ◽  
Air Jet

Poly 3-hydroxybutyrate (PHB) as a kind of polysaccharides has been proved promising for tissue engineering because of its biocompatibility and biodegradability. But its poor mechanical properties and hydrophilicity limit its application. In order to explore a new useful porch to improve the performance of PHB-based GTR membrane, membrane composed of nano-HA / PHB composite was manufactured through the air/jet electrospinning process which can potentially generate nanometer scale diameter fibers and enlarge surface area of materials while maintaining high porosity. Successively, the biomineralization behavior of the membrane in supersaturated calcification solution (SCS) was studied. The Results of this investigation show that the successfully manufactured porous nano-HA/PHB membrane has high activity in SCS and its ability of inducing the formation of mineral crystal in vitro than that of the unfilled PHB membrane. It can be concluded that the addition of nano-HA and the novel technology could improve the performance of the PHB-based GTR membrane.

Computational Design and Optimization of Nerve Guidance Conduits for Improved Mechanical Properties and Permeability

2019 ◽  
Vol 141 (5) ◽  
Author(s):  
Shuo Zhang ◽  
Sanjairaj Vijayavenkataraman ◽  
Geng Liang Chong ◽  
Jerry Ying Hsi Fuh ◽  
Wen Feng Lu
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Mechanical Strength ◽  
Tensile Modulus ◽  
Computational Design ◽  
Structural Features ◽  
Nerve Tissue ◽  
High Porosity ◽  
Engineering Research ◽  
Design And Optimization

Nerve guidance conduits (NGCs) are tubular tissue engineering scaffolds used for nerve regeneration. The poor mechanical properties and porosity have always compromised their performances for guiding and supporting axonal growth. Therefore, in order to improve the properties of NGCs, the computational design approach was adopted to investigate the effects of different NGC structural features on their various properties, and finally, design an ideal NGC with mechanical properties matching human nerves and high porosity and permeability. Three common NGC designs, namely hollow luminal, multichannel, and microgrooved, were chosen in this study. Simulations were conducted to study the mechanical properties and permeability. The results show that pore size is the most influential structural feature for NGC tensile modulus. Multichannel NGCs have higher mechanical strength but lower permeability compared to other designs. Square pores lead to higher permeability but lower mechanical strength than circular pores. The study finally selected an optimized hollow luminal NGC with a porosity of 71% and a tensile modulus of 8 MPa to achieve multiple design requirements. The use of computational design and optimization was shown to be promising in future NGC design and nerve tissue engineering research.

Fabrication of a chitosan/bioglass three-dimensional porous scaffold for bone tissue engineering applications

2014 ◽  
Vol 2 (38) ◽  
pp. 6611-6618 ◽  
Author(s):  
Jun Yang ◽  
Teng Long ◽  
Nan-Fei He ◽  
Ya-Ping Guo ◽  
Zhen-An Zhu ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Porous Scaffold ◽  
Three Dimensional ◽  
Bone Defects ◽  
Engineering Applications

A chitosan/bioglass three-dimensional porous scaffold with excellent biocompatibility and mechanical properties has been developed for the treatment of bone defects.

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