Ca2+ participating self-assembly of an apoferritin nanostructure for nucleic acid drug delivery

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7347-7357 ◽  
Author(s):  
Haiqin Huang ◽  
Kang Sha ◽  
Hanitrarimalala Veroniaina ◽  
Ziheng Wu ◽  
Zhenghong Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Steric Hindrance ◽  
Self Assembly ◽  
Nucleic Acid Drug

One of the most encountered obstacles for utilizing nano-sized vehicles to implement the in vivo delivery of nucleic acid drugs (NADs) is overcoming the possible steric hindrance caused by their intrinsic size and charge.

Highly tumor-specific DNA nanostructures discovered by in vivo screening of a nucleic acid cage library and their applications in tumor-targeted drug delivery

Biomaterials ◽  
2019 ◽  
Vol 195 ◽  
pp. 1-12 ◽  
Author(s):  
Kyoung-Ran Kim ◽  
Seong Jae Kang ◽  
A-Young Lee ◽  
Dohyeon Hwang ◽  
Miri Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Targeted Drug Delivery ◽  
Dna Nanostructures ◽  
In Vivo Screening ◽  
Targeted Drug

Active-targeting and acid-sensitive pluronic prodrug micelles for efficiently overcoming MDR in breast cancer

2020 ◽  
Vol 8 (13) ◽  
pp. 2726-2737
Author(s):  
Cheng Xu ◽  
Jiaxi Xu ◽  
Yan Zheng ◽  
Qin Fang ◽  
Xiaodong Lv ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Drug Delivery ◽  
Self Assembly ◽  
Active Targeting

The mechanism of pluronic-based prodrug micelles self-assembly, drug delivery and anti-MDR in vivo.

Progress in Nanoparticulate Systems for Peptide, Proteins and Nucleic Acid Drug Delivery

2011 ◽  
Vol 12 (11) ◽  
pp. 1823-1839 ◽  
Author(s):  
Stanislaw Slomkowski ◽  
Mateusz Gosecki
Keyword(s):  
Drug Delivery ◽  
Nucleic Acid ◽  
Nanoparticulate Systems ◽  
Nucleic Acid Drug

scholarly journals Peptide Nanomaterials for Drug Delivery Applications

2020 ◽  
Vol 21 (4) ◽  
pp. 401-412 ◽  
Author(s):  
Sreekanth Pentlavalli ◽  
Sophie Coulter ◽  
Garry Laverty
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Diverse Range ◽  
Drug Molecules ◽  
Sustained Drug Delivery ◽  
Self Assembling ◽  
Wide Range ◽  
Methods Of Synthesis ◽  
Self Assembled

Self-assembled peptides have been shown to form well-defined nanostructures which display outstanding characteristics for many biomedical applications and especially in controlled drug delivery. Such biomaterials are becoming increasingly popular due to routine, standardized methods of synthesis, high biocompatibility, biodegradability and ease of upscale. Moreover, one can modify the structure at the molecular level to form various nanostructures with a wide range of applications in the field of medicine. Through environmental modifications such as changes in pH and ionic strength and the introduction of enzymes or light, it is possible to trigger self-assembly and design a host of different self-assembled nanostructures. The resulting nanostructures include nanotubes, nanofibers, hydrogels and nanovesicles which all display a diverse range of physico-chemical and mechanical properties. Depending on their design, peptide self-assembling nanostructures can be manufactured with improved biocompatibility and in vivo stability and the ability to encapsulate drugs with the capacity for sustained drug delivery. These molecules can act as carriers for drug molecules to ferry cargo intracellularly and respond to stimuli changes for both hydrophilic and hydrophobic drugs. This review explores the types of self-assembling nanostructures, the effects of external stimuli on and the mechanisms behind the assembly process, and applications for such technology in drug delivery.

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

scholarly journals In vivo and in vitro evaluation of dihydroartemisinin prodrug nanocomplexes as a nano-drug delivery system: characterization, pharmacokinetics and pharmacodynamics

RSC Advances ◽  
2020 ◽  
Vol 10 (29) ◽  
pp. 17270-17279 ◽  
Author(s):  
Guolian Ren ◽  
Pei Chen ◽  
Jiaqi Tang ◽  
Wenju Guo ◽  
Rongrong Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Self Assembly ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Lower Toxicity ◽  
Nano Drug Delivery ◽  
System Characterization ◽  
Assembly Technology

To develop new, more effective and lower toxicity antitumor dihydroartemisinin (DHA) nanocomplexes, a DHA prodrug synthesized in this study was used to prepare DHA prodrug self-assembled nanocomplexes (DHANPs) by molecular self-assembly technology.

Physicochemical and Drug Delivery Aspects of Lipid-Based Liquid Crystalline Nanoparticles: A Case Study of Intravenously Administered Propofol

2006 ◽  
Vol 6 (9) ◽  
pp. 3017-3024 ◽  
Author(s):  
Markus Johnsson ◽  
Justas Barauskas ◽  
Andreas Norlin ◽  
Fredrik Tiberg
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Liquid Crystalline ◽  
Drug Loading ◽  
Drug Substances ◽  
Physicochemical Features ◽  
Liquid Crystalline Nanoparticles ◽  
Effect Duration

Liquid crystalline nanoparticles (LCNP) formed through lipid self-assembly have a range of attractive properties as in vivo drug delivery carriers. In particular they offer: a wide solubilization spectrum, and consequently high drug payloads; effective encapsulation; stabilization and protection of sensitive drug substances. Here we present basic physicochemical features of non-lamellar LCNP systems with a focus on intravenous drug applications. This is exemplified by the formulation properties and in vivo behavior using the drug substance propofol; a well-known anesthetic agent currently used in clinical practice in the form of a stable emulsion. In order to appraise the drug delivery features of the LCNP system the current study was carried out with a marketed propofol emulsion product as reference. In this comparison the propofol-LCNP formulation shows several useful features including: higher drug-loading capacity, lower fat-load, excellent stability, modified pharmacokinetics, and an indication of increased effect duration.

Self-assembly hydrogels as multifunctional drug delivery of paclitaxel for synergistic tumour-targeting and biocompatibility in vitro and in vivo

2017 ◽  
Vol 69 (8) ◽  
pp. 967-977 ◽  
Author(s):  
Chang Shu ◽  
Eboka M.B. Sabi-mouka ◽  
Xiaoliang Wang ◽  
Li Ding
Keyword(s):  
Drug Delivery ◽  
Self Assembly ◽  
Tumour Targeting

scholarly journals FRET Ratiometric Nanoprobes for Nanoparticle Monitoring

Biosensors ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 505
Author(s):  
Guangze Yang ◽  
Yun Liu ◽  
Jisi Teng ◽  
Chun-Xia Zhao
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Drug Release ◽  
Self Assembly ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
The Self ◽  
Fundamental Understanding ◽  
Nanoparticle Drug Delivery

Fluorescence labelling is often used for tracking nanoparticles, providing a convenient assay for monitoring nanoparticle drug delivery. However, it is difficult to be quantitative, as many factors affect the fluorescence intensity. Förster resonance energy transfer (FRET), taking advantage of the energy transfer from a donor fluorophore to an acceptor fluorophore, provides a distance ruler to probe NP drug delivery. This article provides a review of different FRET approaches for the ratiometric monitoring of the self-assembly and formation of nanoparticles, their in vivo fate, integrity and drug release. We anticipate that the fundamental understanding gained from these ratiometric studies will offer new insights into the design of new nanoparticles with improved and better-controlled properties.

Reversible assembly-disassembly of plasmonic spherical nucleic acid enabling temperature-self-controllable and biomarker-activatable photothermal effect

2021 ◽  
Author(s):  
Lixian Huang ◽  
Jinling Zhang ◽  
Lifang Pang ◽  
Shengqiang Hu ◽  
Liangliang Zhang ◽  
...  
Keyword(s):  
Nucleic Acid ◽  
Nucleic Acids ◽  
Melting Temperature ◽  
Self Assembly ◽  
The Self ◽  
Photothermal Effect ◽  
Spherical Nucleic Acid ◽  
Photothermal Heating ◽  
Spherical Nucleic Acids

Since the photothermal heating of plasmonic spherical nucleic acids (pSNAs) depended on the self-assembly level and melting temperature (Tm), temperature-self-controllable and biomarker-activatable photothermal effect in vivo was thus achieved using...

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