Crosstalk of gut microbiota and serum/hippocampus metabolites in neurobehavioral impairments induced by zinc oxide nanoparticles

Nanoscale ◽  
2020 ◽  
Vol 12 (41) ◽  
pp. 21429-21439 ◽  
Author(s):  
Jianjun Chen ◽  
Shanshan Zhang ◽  
Chang Chen ◽  
Xuejun Jiang ◽  
Jingfu Qiu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Gut Microbiota ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle

Crosstalk of gut microbiota and metabolites in zinc oxide nanoparticle-induced neurobehavioral impairments.

scholarly journals A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticle and its application in wastewater treatment

2021 ◽  
Vol 11 (2) ◽  
Author(s):  
E. Y. Shaba ◽  
J. O. Jacob ◽  
J. O. Tijani ◽  
M. A. T. Suleiman
Keyword(s):  
Zinc Oxide ◽  
Metal Oxides ◽  
Zinc Oxide Nanoparticles ◽  
Textural Properties ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Synthesis Parameters ◽  
Metal Precursors ◽  
Removal Of Heavy Metals ◽  
Oxide Nanoparticle

AbstractIn this era, nanotechnology is gaining enormous popularity due to its ability to reduce metals, metalloids and metal oxides into their nanosize, which essentially alter their physical, chemical, and optical properties. Zinc oxide nanoparticle is one of the most important semiconductor metal oxides with diverse applications in the field of material science. However, several factors, such as pH of the reaction mixture, calcination temperature, reaction time, stirring speed, nature of capping agents, and concentration of metal precursors, greatly affect the properties of the zinc oxide nanoparticles and their applications. This review focuses on the influence of the synthesis parameters on the morphology, mineralogical phase, textural properties, microstructures, and size of the zinc oxide nanoparticles. In addition, the review also examined the application of zinc oxides as nanoadsorbent for the removal of heavy metals from wastewater.

Toxicity of zinc oxide nanoparticles to the annelid Enchytraeus crypticus in agar-based exposure media

2016 ◽  
Vol 70 (11) ◽  
Author(s):  
Kateřina Hrdá ◽  
Jakub Opršal ◽  
Petr Knotek ◽  
Miloslav Pouzar ◽  
Milan Vlček
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Water Soluble ◽  
Soluble Salt ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Zinc Oxide Nanoparticle ◽  
Enchytraeus Crypticus ◽  
Oxide Nanoparticle

AbstractToxicity of zinc oxide nanoparticle (ZnO-NPs) powder and water soluble salt of Zn (ZnCl

ANTIBACTERIAL ACTIVITY OF ZINC OXIDE NANOPARTICLE BY SONOCHEMICAL METHOD AND GREEN METHOD USING ZINGIBER OFFICINALE

2016 ◽  
Vol 2 (1) ◽  
pp. 11-15 ◽  
Author(s):  
S. Begila David
Keyword(s):  
Zinc Oxide ◽  
Antibacterial Activity ◽  
Zinc Oxide Nanoparticles ◽  
Size Variation ◽  
Volume Ratio ◽  
Oxide Nanoparticles ◽  
Sonochemical Method ◽  
Green Method ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle

Nanoparticles have made a steady progress in all the branches of science. It is used in biological applications including nanomedicine. Zinc oxide is also known as Zincite generally seen in a crystalline form. Zinc oxide nanoparticles are multifunctional. It has effective antibacterial activity. This study focuses on the synthesis of zinc oxide nanoparticle by the sonochemical and green method, characterized by XRD, SEM and to determine the antibacterial efficacy of green and chemical techniques.Results prove that green synthesized Zinc oxide nanoparticle shows the enhanced biocidal activity. In addition the current study has demonstrated that the particle size variation and surface area to volume ratio of green synthesized Zinc oxide nanoparticles are responsible for significant high antibacterial activity. From the result obtained it suggested that the biogenic green fabrication is a better choice due to eco-friendliness.

Involvement of glucosinolates in the resistance to zinc oxide nanoparticle-induced toxicity and growth inhibition in Arabidopsis

2021 ◽  
Author(s):  
Han Tao ◽  
Songshen Hu ◽  
Chuchu Xia ◽  
Mengyu Wang ◽  
Tonglin Wang ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Growth Inhibition ◽  
Zinc Oxide Nanoparticles ◽  
Crop Yields ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Textile Fibers ◽  
Zinc Oxide Nanoparticle ◽  
Synthetic Rubber ◽  
Oxide Nanoparticle

Zinc oxide nanoparticles (ZnO NPs) are widely used in the manufacture of textile fibers, synthetic rubber, and paint. However, crop yields and quality are threatened by the increased use of...

scholarly journals The Impact of Zinc Oxide Nanoparticle on LH, FSH, and Testosterone Hormones in Mature Male NMRI Rats

2020 ◽  
pp. 30-37 ◽  
Author(s):  
Ziba Mozaffari ◽  
Kazem Parivar ◽  
Nasim Hayati Roodbari ◽  
Shiva Irani
Keyword(s):  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Mature Male ◽  
Nano Particles ◽  
Male Rats ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
The Impact

Nanoparticles are widely applied in all aspects of modern life because of their unique features such as small size and high surface area. Several types of research have been carried out to discover the feasible detrimental impacts of Nano-particles on human reproduction. The purpose of this study was to examine the impact of zinc oxide nanoparticles in mature male rats through examining LH, FSH, and testosterone sex hormones. Therefore, 30 Naked Mole-Rat Initiative (NMRI) rats were divided into 5 groups. Different doses of zinc oxide nanoparticles (250, 500 and 700 mg.kg-1) were intra peritoneally injected to animals only once. Then, the serum level of luteinizing hormone (LH), Follicle Stimulating Hormone (FSH), and testosterone hormones were measured using Enzyme-Linked Immunosorbent Assay (ELISA) method after 21 days. The results were analyzed by ANOVA and Tukey tests. The results indicated that zinc oxide nanoparticles doses caused a significant increase in FSH and testosterone level of blood (Respectively) in 250 and 700mg.kg-1 in comparison with the control group. Moreover, this research illustrated that zinc oxide nanoparticle can cause a dose-related increase in Testosterone and FSH hormones levels while causing no significant change in LH hormone level.

scholarly journals Antioxidant and Anti-Inflammatory Potential of Chromium Picolinate Mediated Zinc Oxide Nanoparticle

2020 ◽  
pp. 118-121
Author(s):  
C. M. Aathira ◽  
Lakshminarayanan Arivarasu ◽  
S. Rajeshkumar
Keyword(s):  
Antioxidant Activity ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Protein Denaturation ◽  
The Body ◽  
Chromium Picolinate ◽  
Oxide Nanoparticles ◽  
Zinc Oxide Nanoparticle ◽  
Oxide Nanoparticle ◽  
Anti Inflammatory

Aim: To study the anti-inflammatory and antioxidant activity of chromium Picolinate mediated Zinc oxide nanoparticles. Introduction: Chromium is required by the body in a noticeable amount, even though it’s mechanism and required dietary allowance is not known clearly. It is found in supplements. It is expected to enhance insulin production and weight loss. Zinc oxide also has its own beneficial role in various biomedical applications. In the present study the antioxidant and anti-inflammatory potential of the chromium picolinate mediated Zinc oxide nanoparticle is evaluated. Nanoparticles are of great interest nowadays in research and study. The outcomes of using metal nanoparticles were fascinating as color pigments in luster and glass technology. Materials and Methods: DPPH assay for antioxidant activity and Protein denaturation assay was performed for anti-inflammatory activity. Results and Discussion: Chromium Picolinate mediated Zinc oxide nanoparticles showed good anti-inflammatory and antioxidant activity at higher concentration against standard.

Biosynthesis and Characterization of Zinc Oxide Nanoparticles for the Systemic Treatment of Patients with Lymphoma in Nursing Care

2020 ◽  
Vol 12 (1) ◽  
pp. 137-143
Author(s):  
Lingling Meng ◽  
Lina Du ◽  
Yaqiong Shen ◽  
Shan Cong ◽  
Qiuyan Zhai ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Zno Nanoparticles ◽  
Zinc Oxide Nanoparticles ◽  
Systemic Treatment ◽  
Oxide Nanoparticles ◽  
Zno Nps ◽  
Environment Friendly ◽  
Oxide Nanoparticle ◽  
T Lymphoma

Zinc oxide (ZnO) nanoparticles recently are of significant consideration because of their applications as nontoxic metal oxides. This study is mainly intended to improve a simple, efficient, and environment-friendly method for preparation of ZnO nanoparticles. This process has been developed based on plant-intervened synthesis by making use of microwave Saturejahortensis aqueous extract. We have further characterized the obtained Zinc oxide nanoparticles by using different techniques. Additionally, their cytotoxic potential was inspected via MTT assay against both B lymphoma, A20 and T lymphoma, EL4 cells lines. The zinc oxide nanoparticle exposed cells for about 24 h showed diminished cell viability in the tested cell lines where EL4 cells has been reduced to 75% of control after 24 h, whereas A20 cells were lowered to 68% of control. ZnO-NPs have proficiently hindered EL4 cell DNA synthesis at 100 μg concentration whereas completely blocked the DNA proliferation at about 50 g concentration. However, A20 cells besides presented similar propensity, thus exploring the ZnO-NPs potential to treat lymphomas.

scholarly journals Optimisation of Zinc Oxide Nanoparticle Biosynthesis Using Saccharomyces Cerevisiae with Box-Behnken Design

2021 ◽  
Vol 72 (1) ◽  
pp. 79-89
Author(s):  
Fitry Mulyani ◽  
M. Diki Permana ◽  
Safri Ishmayana ◽  
Iman Rahayu ◽  
Diana Rakhmawaty Eddy
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Zinc Oxide ◽  
Incubation Time ◽  
Zinc Acetate ◽  
Zinc Oxide Nanoparticles ◽  
Oxide Nanoparticles ◽  
Optimum Conditions ◽  
Box Behnken Design ◽  
Nanoparticle Biosynthesis ◽  
Oxide Nanoparticle

Zinc oxide nanoparticles have wide applications as catalysts, antimicrobial agents, drug delivery agents, etc. because of their intrinsic properties. Various methods can be applied to synthesise nanoparticles, one of which is the biosynthesis process. Biosynthesis is more eco-friendly than chemical and physical methods. In the present study, the optimisation of zinc oxide nanoparticle biosynthesis using the yeast Saccharomyces cerevisiae was performed by applying a response surface method called the Box�Behnken design (BBD). Three factors were optimised in the present study, namely the concentration of zinc acetate as the precursor (X1), concentration of the S. cerevisiae fermentation broth (X2), and the incubation time (X3). The mass of zinc oxide nanoparticles (Y) was recorded as the response of the experiment. The product was then characterised by fourier transform infrared spectroscopy (FTIR), X-Ray diffraction (XRD), scanning electron microscopy/energy dispersive spectroscopy (SEM/EDS), and particle size analyser (PSA). The optimum conditions for the preparation of zinc oxide nanoparticles were found to be 0.3 M, 100% (v/v), and 24 h as the zinc acetate concentration, medium concentration, and incubation time, respectively. The FTIR analysis showed peaks at ~600 cm−1, which is characteristic for ZnO stretching. From the XRD result, the ZnO nanoparticles with hexagonal structure was confirm. The SEM/EDS analysis confirmed that the morphology was spherical and showed the major energy emission for zinc and oxygen. Moreover, the PSA analysis revealed that the smallest size was 218.6 nm (12%) when the synthesis was performed at the optimum conditions, while when the incubation time was prolonged for 120 h, the size decreased to 134.2 nm.

scholarly journals Crosstalk of gut microbiota and serum/hippocampus metabolites in neurobehavioral impairments induced by oral zinc oxide nanoparticles exposure

2020 ◽  
Author(s):  
jianjun Chen ◽  
Shanshan Zhang ◽  
Chang Chen ◽  
Xuejun Jiang ◽  
Jingfu Qiu ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Gut Microbiota ◽  
Gut Microbiome ◽  
Zinc Oxide Nanoparticles ◽  
Oral Exposure ◽  
Oxide Nanoparticles ◽  
Rrna Gene ◽  
Environmental Toxicants ◽  
Microbial Composition ◽  
Α Diversity

Abstract Background Gut microbiome can be readily influenced by external factors, such as diet, antibiotic, bacterial/viral infection and environmental toxicants. Gut microbiota-mediated effects of engineered nanomaterials as such become the new frontiers in nanotoxicology. Methods An integrated approach combining 16S rRNA gene sequencing and liquid chromatography-mass spectrometry (LC-MS) metabolomics was used to determine the potential mechanistic pathway by which disturbed gut microbiota induced by ZnONPs might modulate host physiology and neurobehavior. Results Herein, we showed oral exposure to zinc oxide nanoparticles (ZnONPs), one typical kinds of nanomaterials used widely in the food industry, could cause the neurobehavioral dysfunctions in mice, manifested by spatial learning and memory deficits and locomotor activity inhibition. Our mechanistic results elucidated that ZnONPs exposure led to a marked disturbance of gut microbial composition but did not alter the microbiome α-diversity indexes. We also provided new evidence that neurobehavioral impairments induced by ZnONPs was closely associated with perturbation in the gut microbiota composition that were both specific to changes of neurobehavior-related genes (such as Bdnf and Dlg4 ) and correlated with serum and hippocampal metabolic disorders. Our data further identified a unique metabolite [DG(15:0/0:0/22:4n6)] that linked the relationships among gut microbiota, metabolites and neurobehavior-related genes. Conclusions ZnONPs exposure not only alters the gut microbiome community but also substantially disturbs its metabolic profiles, and therefore leading to neurobehavioral impairments vi gut-brain axis. These findings will provide a novel view for understanding the ZnONPs neurotoxicity through gut-brain axis and may lead to new potential prevention and treatment strategies.

scholarly journals Bioengineered Zinc Oxide Nanoparticles for Anti-Oxidant Applications

2019 ◽  
Vol 8 (4S2) ◽  
pp. 1003-1006
Keyword(s):  
Antioxidant Activity ◽  
Zinc Oxide ◽  
Zinc Oxide Nanoparticles ◽  
Lemon Juice ◽  
Oxide Nanoparticles ◽  
Biogenic Synthesis ◽  
Synthesis Of Nanoparticles ◽  
Anti Oxidant ◽  
Oxide Nanoparticle ◽  
Dose Dependent

Zinc oxide nanoparticles find its versatile application in medicine and industry when compared with other metal nanoparticles. The present study focuses on biogenic synthesis of Zinc Oxide nanoparticles (ZnONPs) using lemon juice extract. Lemon juice extracts contains natural alkaloids and flavonoids which acts as reducing agent for the synthesis of nanoparticles. The synthesized zinc oxide nanoparticle is characterized by Scanning Electron Microscopy (SEM) and FTIR. FTIR results showed the presence of functional groups which represents ZnONPs and reducing groups responsible for the reduction. The SEM observation reveals the synthesized ZnONPs are cube shaped. The obtained nanoparticle was further studied for toxicity using zebrafish embryos. Toxicity results suggested that the toxicity is dose dependent. Malformations in the embryos such as yolk sac edema and twisted tail were seen in higher concentrations. The antioxidant activity of the synthesized ZnONPs was carried out using DPPH assay. Results implied that the antioxidant activity was also concentration dependent.

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