Influence of zinc oxide nanoparticles on anaerobic digestion of waste activated sludge and microbial communities

Zinc oxide nanoparticles (ZnO-NPs) are widely utilized, for example in manufacturing paints and in the cosmetic industry. In addition, there is raising interest in the application of NPs in stem cell research. However, cytotoxic, genotoxic and pro-inflammatory effects were shown for NPs. The aim of this study was to evaluate the impact of ZnO-NPs on cytokine secretion and differentiation properties of human adipose tissue-derived stromal cells (ASCs). Human ASCs were exposed to the subtoxic concentration of 0.2 µg/mL ZnO-NPs for 24 h. After four weeks of cultivation, adipogenic and osteogenic differentiation procedures were performed. The multi-differentiation potential was confirmed histologically and using polymerase chain reaction (PCR). In addition, the gene expression of IL-6, IL-8, vascular endothelial growth factor (VEGF) and caspase 3 was analyzed. Over the course of four weeks after ZnO-NPs exposure, no significant differences were detected in the gene expression of IL-6, IL-8, VEGF and caspase 3 compared to non-exposed cells. The differentiation was also not affected by the ZnO-NPs. These findings underline the fact, that functionality of ASCs is likely to be unaffected by ZnO-NPs, despite a long-term disposition of NPs in the cells, supposing that the starting concentration was safely in the non-toxic range. This might provide important information for single-use nanomedical applications of ZnO-NPs.

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Responses of anaerobic digestion of waste activated sludge to long-term stress of benzalkonium chlorides: Insights to extracellular polymeric substances and microbial communities

The Science of The Total Environment ◽

10.1016/j.scitotenv.2021.148957 ◽

2021 ◽

pp. 148957

Author(s):

Zhang-Wei He ◽

Wen-Zong Liu ◽

Cong-Cong Tang ◽

Bin Liang ◽

Ai-Juan Zhou ◽

...

Keyword(s):

Anaerobic Digestion ◽

Activated Sludge ◽

Microbial Communities ◽

Extracellular Polymeric Substances ◽

Waste Activated Sludge

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The impact of zinc oxide nanoparticles on phosphorus removal and the microbial community in activated sludge in an SBR

RSC Advances ◽

10.1039/c6ra19486a ◽

2016 ◽

Vol 6 (99) ◽

pp. 96706-96713 ◽

Cited By ~ 1

Author(s):

S. T. Wang ◽

W. Q. Wang ◽

Z. R. Zhang ◽

H. You

Keyword(s):

Zinc Oxide ◽

Microbial Community ◽

Activated Sludge ◽

Phosphorus Removal ◽

Zinc Oxide Nanoparticles ◽

Cell Membranes ◽

Oxide Nanoparticles ◽

Zno Nps ◽

The Impact

10 and 20 mg L−1 ZnO NPs damaged the integrity of cell membranes and the microbial community and affected phosphorus removal.

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Evaluation of the Effect of Nanoparticles Zinc Oxide/Camellia sinensis Complex on the Kidney of Rats Treated with Monosodium Glutamate: Antioxidant and Histological Approaches

Current Pharmaceutical Biotechnology ◽

10.2174/1389201020666190522075928 ◽

2019 ◽

Vol 20 (7) ◽

pp. 542-550 ◽

Cited By ~ 4

Author(s):

Nahla S. El-Shenawy ◽

Reham Z. Hamza ◽

Fawziah A. Al-Salmi ◽

Rasha A. Al-Eisa

Keyword(s):

Zinc Oxide ◽

Camellia Sinensis ◽

Zinc Oxide Nanoparticles ◽

Morphological Changes ◽

Monosodium Glutamate ◽

Oxide Nanoparticles ◽

High Dose ◽

Enzymatic Antioxidants ◽

Zno Nps ◽

Tea Extract

Background: Zinc oxide nanoparticles (ZnO NPs) are robustly used biomedicine. Moreover, no study has been conducted to explore the consequence of green synthesis of ZnO NPs with Camellia sinensis (green tea extract, GTE) on kidneys of rats treated with monosodium glutamate (MSG). Methods: Therefore, the objective of the research was designed to explore the possible defensive effect of GTE/ZnO NPs against MSG-induced renal stress investigated at redox and histopathological points. Results: The levels of urea and creatinine increased as the effect of a high dose of MSG, in addition, the myeloperoxidase and xanthine oxidase activates were elevated significantly with the high dose of MSG. The levels of non-enzymatic antioxidants (uric acid, glutathione, and thiol) were decreased sharply in MSG-treated rats as compared to the normal group. Conclusion: The data displayed that GTE/ZnO NPs reduced the effects of MSG significantly by reduction of the level peroxidation and enhancement intracellular antioxidant. These biochemical findings were supported by histopathology evaluation, which showed minor morphological changes in the kidneys of rats.

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Zinc oxide nanoparticles help to enhance plant growth and alleviate abiotic stress: A review

Current Protein and Peptide Science ◽

10.2174/1389203721666201016144848 ◽

2020 ◽

Vol 21 ◽

Author(s):

Mohammad Faizan ◽

Fangyuan Yu ◽

Chen Chen ◽

Ahmad Faraz ◽

Shamsul Hayat

Keyword(s):

Zinc Oxide ◽

Plant Growth ◽

Abiotic Stresses ◽

Zinc Oxide Nanoparticles ◽

Growth And Yield ◽

Oxide Nanoparticles ◽

Main Concern ◽

Negative Effects ◽

Zno Nps ◽

Agricultural Yield

: Abiotic stresses arising from atmosphere change belie plant growth and yield, leading to food reduction. The cultivation of a large number of crops in the contaminated environment is a main concern of environmentalists in the present time. To get food safety, a highly developed nanotechnology is a useful tool for promoting food production and assuring sustainability. Nanotechnology helps to better production in agriculture by promoting the efficiency of inputs and reducing relevant losses. This review examines the research performed in the past to show how zinc oxide nanoparticles (ZnO-NPs) are influencing the negative effects of abiotic stresses. Application of ZnO-NPs is one of the most effectual options for considerable enhancement of agricultural yield globally under stressful conditions. ZnO-NPs can transform the agricultural and food industry with the help of several innovative tools in reversing oxidative stress symptoms induced by abiotic stresses. In addition, the effect of ZnO-NPs on physiological, biochemical, and antioxidative activities in various plants have also been examined properly. This review summarizes the current understanding and the future possibilities of plant-ZnO-NPs research.

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Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate

Nanomaterials ◽

10.3390/nano11030713 ◽

2021 ◽

Vol 11 (3) ◽

pp. 713

Author(s):

Nina Melnikova ◽

Alexander Knyazev ◽

Viktor Nikolskiy ◽

Peter Peretyagin ◽

Kseniia Belyaeva ◽

...

Keyword(s):

Wound Healing ◽

Zinc Oxide ◽

Bacterial Cellulose ◽

Zinc Oxide Nanoparticles ◽

Wound Dressings ◽

Oxide Nanoparticles ◽

Burn Wound ◽

Zno Nps ◽

Wound Model ◽

And Oxidative Stress

A design of new nanocomposites of bacterial cellulose (BC) and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) for the production of wound dressings is proposed. The sizes of crystalline BC and ZnO NPs (5–25%) corresponded to 5–6 nm and 10–18 nm, respectively (powder X-ray diffractometry (PXRD), Fourier-infrared (FTIR), ultraviolet (UV), atomic absorption (AAS) and photoluminescence (PL) spectroscopies). The biological activity of the wound dressings “BC-ZnO NPs-BDP” was investigated in rats using a burn wound model. Morpho-histological studies have shown that more intensive healing was observed during treatment with hydrophilic nanocomposites than the oleophilic standard (ZnO NPs-BDP oleogel; p < 0.001). Treatment by both hydrophilic and lipophilic agents led to increases in antioxidant enzyme activity (superoxide dismutase (SOD), catalase) in erythrocytes and decreases in the malondialdehyde (MDA) concentration by 7, 10 and 21 days (p < 0.001). The microcirculation index was restored on the 3rd day after burn under treatment with BC-ZnO NPs-BDP wound dressings. The results of effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation, reducing hypoxia and oxidative stress in a burn wound.

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Photocatalytic activity and anti-microbial application of synthesized Zinc oxide nanoparticles (ZnO Nps) towards remediation of hospital waste water (HWW)

Materials Today Proceedings ◽

10.1016/j.matpr.2021.05.176 ◽

2021 ◽

Author(s):

Asma M. Tatagar ◽

Javed I. Moodi ◽

Jyothi C. Abbar ◽

M.A. Phaniband

Keyword(s):

Waste Water ◽

Zinc Oxide ◽

Photocatalytic Activity ◽

Zinc Oxide Nanoparticles ◽

Oxide Nanoparticles ◽

Zno Nps ◽

Hospital Waste

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Biosynthesis of Zinc Oxide Nanoparticles from Acacia nilotica (L.) Extract to Overcome Carbapenem-Resistant Klebsiella Pneumoniae

Molecules ◽

10.3390/molecules26071919 ◽

2021 ◽

Vol 26 (7) ◽

pp. 1919

Author(s):

Elsayim Rasha ◽

AlOthman Monerah ◽

Alkhulaifi Manal ◽

Ali Rehab ◽

Doud Mohammed ◽

...

Keyword(s):

Electron Microscopy ◽

Zinc Oxide ◽

Klebsiella Pneumoniae ◽

Zinc Oxide Nanoparticles ◽

Acacia Nilotica ◽

Oxide Nanoparticles ◽

Zno Nps ◽

X Ray ◽

Carbapenem Resistant

Recently, concerns have been raised globally about antimicrobial resistance, the prevalence of which has increased significantly. Carbapenem-resistant Klebsiella pneumoniae (KPC) is considered one of the most common resistant bacteria, which has spread to ICUs in Saudi Arabia. This study was established to investigate the antibacterial activity of biosynthesized zinc oxide nanoparticles (ZnO-NPs) against KPC in vitro and in vivo. In this study, we used the aqueous extract of Acacia nilotica (L.) fruits to mediate the synthesis of ZnO-NPs. The nanoparticles produced were characterized by UV-vis spectroscopy, zetasizer and zeta potential analyses, X-ray diffraction (XRD) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), and transmission electron microscopy (TEM). The antimicrobial activity of ZnO-NPs against KPC was determined via the well diffusion method, and determining minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC), the results showed low MIC and MBC when compared with the MIC and MBC of Imipenem and Meropenem antibiotics. The results of in vitro analysis were supported by the results upon applying ZnO-NP ointment to promote wound closure of rats, which showed better wound healing than the results with imipenem ointment. The biosynthesized ZnO-NPs showed good potential for use against bacteria due to their small size, applicability, and low toxicity to human cells.

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Scolicidal activity of biosynthesized zinc oxide nanoparticles by Mentha longifolia L. leaves against Echinococcus granulosus protoscolices

Emergent Materials ◽

10.1007/s42247-021-00264-9 ◽

2021 ◽

Author(s):

Bushra H. Shnawa ◽

Samir M. Hamad ◽

Azeez A. Barzinjy ◽

Payman A. Kareem ◽

Mukhtar H. Ahmed

Keyword(s):

Zinc Oxide ◽

Zinc Oxide Nanoparticles ◽

Public Health Problem ◽

Analytical Techniques ◽

Oxide Nanoparticles ◽

Zno Nps ◽

Leaf Extracts ◽

X Ray ◽

Morphological Alterations ◽

Mentha Longifolia

AbstractCystic echinococcosis is a public health problem in developing countries that practice sheep breeding extensively. In the current study, the protoscolicidal activity of biosynthesized zinc oxide nanoparticles (ZnO NPs) derived from Mentha longifolia L. leaf extracts was investigated. The resultant ZnO NPs were characterized by means of various analytical techniques, such as ultraviolet–visible (UV–Vis) spectrometry, Fourier transform infrared (FT-IR) spectrophotometry, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis. The results showed that the ZnO NP had the highest scolicidal activity at 400 ppm concentration after 150 min of exposure time, showing 100% mortality rate. The treated protoscolices exhibited loss of viability with several morphological alterations. Hence, an easy and effective green synthesis of ZnO NPs, with efficient scolicidal potential, is reported in this study.

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