Antibacterial AIE polycarbonates endowed with selective imaging by adjusting electrostaticity of the mixed-charge backbone

2021 ◽  
Author(s):  
Junyong Zhang ◽  
Wencheng Liang ◽  
Lianlei Wen ◽  
Zhimin Lu ◽  
Yan Xiao ◽  
...  
Keyword(s):  
Infectious Diseases ◽  
Effective Treatment ◽  
Ring Opening ◽  
Antibacterial Property

Combining rapid microbial discrimination with antibacterial property, multi-functional biomacromolecules provide timely diagnoses and effective treatment on infectious diseases. Through a two-step approach of organocatalytic ring-opening copolymerization and thiol-ene modification, aggregation-induced...

scholarly journals Advanced strategies for development of vaccines against human bacterial pathogens

2021 ◽  
Vol 37 (4) ◽  
Author(s):  
Abhinay Sharma ◽  
Pooja Sanduja ◽  
Aparna Anand ◽  
Pooja Mahajan ◽  
Carlos A. Guzman ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Infectious Diseases ◽  
Effective Treatment ◽  
Bacterial Pathogens ◽  
Vaccine Design ◽  
Human Beings ◽  
Rational Vaccine Design ◽  
New Vaccines

AbstractInfectious diseases are one of the main grounds of death and disabilities in human beings globally. Lack of effective treatment and immunization for many deadly infectious diseases and emerging drug resistance in pathogens underlines the need to either develop new vaccines or sufficiently improve the effectiveness of currently available drugs and vaccines. In this review, we discuss the application of advanced tools like bioinformatics, genomics, proteomics and associated techniques for a rational vaccine design.

scholarly journals Fatigue in sarcoidosis: Detection and treatment

2012 ◽  
Vol 140 (1-2) ◽  
pp. 104-109 ◽  
Author(s):  
Violeta Vucinic ◽  
Mirjana Stojkovic ◽  
Branislava Milenkovic ◽  
Jelica Videnovic-Ivanov ◽  
Vesna Skodric-Trifunovic ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Infectious Diseases ◽  
Effective Treatment ◽  
Organ Involvement ◽  
Medical Conditions ◽  
Prominent Symptom ◽  
Objective Parameter ◽  
Definition Of ◽  
Exact Definition

Fatigue is a prominent symptom in a large number of medical conditions, malignant and infectious diseases. Fatigue is also a prominent symptom of sarcoidosis. The occurrence of fatigue in sarcoidosis is well known but exact incidence has not been established and varies from 30-70% of patients depending on age, sex and organ involvement by the granulomatous process. The exact definition of fatigue varies broadly. It can be both physical and mental. The patients describe their sensation of fatigue qualitatively different from that fatigue they experienced before they became sick. Fatigue has a major impact on the quality of life in sarcoidosis. Establishing the extent of fatigue in sarcoidosis provides relevant insight regarding the patient?s quality of life. Unfortunately there is no objective parameter for assessing fatigue in sarcoidosis. Generally, fatigue is detected by means of questionnaires. Regarding the therapy, there is no effective treatment for fatigue in sarcoidosis.

Hyaluronidase-responsive phototheranostic nanoagents for fluorescence imaging and photothermal/photodynamic therapy of methicillin-resistant Staphylococcus aureus infections

2021 ◽  
Author(s):  
Lihui Yuwen ◽  
Qiu Qiu ◽  
Wei-Jun Xiu ◽  
Kaili Yang ◽  
Yuqing Li ◽  
...  
Keyword(s):  
Public Health ◽  
Staphylococcus Aureus ◽  
Photodynamic Therapy ◽  
Infectious Diseases ◽  
Effective Treatment ◽  
Bacterial Infections ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Detection Methods ◽  
Resistant Bacteria ◽  
Antibiotic Resistant

Infectious diseases associated with antibiotic-resistant bacteria are ever-growing threats to public health. Effective treatment and detection methods of bacterial infections are in urgent demand. Herein, novel phototheranostic nanoagents (MoS2@HA-Ce6 nanosheets,...

scholarly journals Molecular mechanisms of drugs recommended in COVID-19 treatment

2020 ◽  
Vol 130 (1) ◽  
pp. 61-64
Author(s):  
Katarzyna Walczak ◽  
Anna Makuch-Kocka ◽  
Justyna Ziemińska
Keyword(s):  
Clinical Trials ◽  
Virus Infection ◽  
Infectious Diseases ◽  
Effective Treatment ◽  
Health Problem ◽  
Molecular Mechanisms ◽  
Supportive Treatment ◽  
The Public ◽  
The World ◽  
Polish Society

Abstract The development of an effective treatment for COVID-19 is now one of the main tasks of scientists and doctors from all over the world. The rapidly spreading SARS-CoV2 virus infection is a serious health problem among the public. Similarity of SARSCoV2 to MERS-CoV and SARS-CoV may suggest the effectiveness of COVID-19 treatment with drugs used to fight infections of previously identified Coronaviridae viruses. On the basis of gained experience and new clinical trials, the Polish Society of Epidemiologists and Infectious Diseases Physicians has created guidelines for the treatment of COVID-19. The recommendations concern primary and supportive treatment at different stages of the disease. This article provides a brief review of the molecular mechanisms of drugs currently used in Poland for the treatment of COVID-19.

Amino-functional polyethers: versatile, stimuli-responsive polymers

2020 ◽  
Vol 11 (24) ◽  
pp. 3940-3950 ◽  
Author(s):  
Patrick Verkoyen ◽  
Holger Frey
Keyword(s):  
Ring Opening ◽  
Review Article ◽  
Stimuli Responsive ◽  
New Class ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers

Amino-functional polyethers have emerged as a new class of “smart”, i.e. pH- and thermoresponsive materials. This review article summarizes the synthesis and applications of these materials, obtained from ring-opening of suitable epoxide monomers.

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