Protection of menhaden oil from oxidation in Pickering emulsion-based delivery systems with α-lactalbumin-chitosan colloidal nanoparticle

2021 ◽  
Author(s):  
Jiang Yi ◽  
Qingyu He ◽  
Yuting Fan
Keyword(s):  
Electrostatic Interactions ◽  
Hydrophobic Surface ◽  
Pickering Emulsion ◽  
Delivery Systems ◽  
Colloidal Nanoparticles ◽  
Menhaden Oil

In this study, α-lactalbumin-chitosan (ALA-CHI) colloidal nanoparticles were spontaneously formed mainly through electrostatic interactions for stabilizing Pickering emulsion. The film of ALA-CHI colloidal nanoparticles had more hydrophobic surface in nature...

scholarly journals Ion-specific thermodynamical properties of aqueous proteins

2010 ◽  
Vol 82 (1) ◽  
pp. 109-126 ◽  
Author(s):  
Eduardo R.A. Lima ◽  
Evaristo C. Biscaia Jr. ◽  
Mathias Boström ◽  
Frederico W. Tavares
Keyword(s):  
Electrostatic Interactions ◽  
Colloidal Particles ◽  
Effective Interaction ◽  
Virial Coefficients ◽  
Water Structure ◽  
Hydrophobic Surface ◽  
Colloidal Systems ◽  
Salt Solutions ◽  
Monovalent Ions ◽  
Pharmaceutical Industries

Ion-specific interactions between two colloidal particles are calculated using a modified Poisson-Boltzmann (PB)equationandMonteCarlo(MC)simulations. PBequationspresentgoodresultsofionicconcentration profiles around a macroion, especially for salt solutions containing monovalent ions. These equations include not only electrostatic interactions, but also dispersion potentials originated from polarizabilities of ions and proteins. This enables us to predict ion-specific properties of colloidal systems. We compared results obtained from the modified PB equation with those from MC simulations and integral equations. Phase diagrams and osmotic second virial coefficients are also presented for different salt solutions at different pH and ionic strengths, in agreement with the experimental results observed Hofmeister effects. In order to include the water structure and hydration effect, we have used an effective interaction obtained from molecular dynamics of each ion and a hydrophobic surface combined with PB equation. The method has been proved to be efficient and suitable for describing phenomena where the water structure close to the interface plays an essential role. Important thermodynamic properties related to protein aggregation, essential in biotechnology and pharmaceutical industries, can be obtained from the method shown here.

Characterization of Pickering emulsion gels stabilized by zein/gum arabic complex colloidal nanoparticles

2018 ◽  
Vol 74 ◽  
pp. 239-248 ◽  
Author(s):  
Lei Dai ◽  
Cuixia Sun ◽  
Yang Wei ◽  
Like Mao ◽  
Yanxiang Gao
Keyword(s):  
Gum Arabic ◽  
Pickering Emulsion ◽  
Colloidal Nanoparticles

High internal phase Pickering emulsions stabilized by cod protein-chitosan nanocomplex as oral delivery vehicle for astaxanthin

2021 ◽  
Author(s):  
Lijuan Zhang ◽  
Chenfu Zhou ◽  
Xiaokang Na ◽  
Yannan Chen ◽  
Mingqian Tan
Keyword(s):  
Oral Delivery ◽  
Electrostatic Interactions ◽  
Pickering Emulsion ◽  
Food Protein ◽  
Pickering Emulsions ◽  
Delivery Vehicle ◽  
Internal Phase

The high internal phase Pickering emulsion (HIPPEs) stabilized by food protein has attracted widespread attention. In this study, a novel cod protein-chitosan nanocomplex was prepared through electrostatic interactions and used...

scholarly journals Revisiting the Cytotoxicity of Cationic Polyelectrolytes as a Principal Component in Layer-by-Layer Assembly Fabrication

Pharmaceutics ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1230
Author(s):  
Ekaterina Naumenko ◽  
Farida Akhatova ◽  
Elvira Rozhina ◽  
Rawil Fakhrullin
Keyword(s):  
Gene Delivery ◽  
Electrostatic Interactions ◽  
Surface Engineering ◽  
Delivery Systems ◽  
In Vitro Cytotoxicity ◽  
Water Soluble ◽  
Layer By Layer ◽  
Dependent Manner ◽  
Cationic Polyelectrolytes

Polycations are an essential part of layer-by-layer (LbL)-assembled drug delivery systems, especially for gene delivery. In addition, they are used for other related applications, such as cell surface engineering. As a result, an assessment of the cytotoxicity of polycations and elucidation of the mechanisms of polycation toxicity is of paramount importance. In this study, we examined in detail the effects of a variety of water-soluble, positively charged synthetic polyelectrolytes on in vitro cytotoxicity, cell and nucleus morphology, and monolayer expansion changes. We have ranked the most popular cationic polyelectrolytes from the safest to the most toxic in relation to cell cultures. 3D cellular cluster formation was disturbed by addition of polyelectrolytes in most cases in a dose-dependent manner. Atomic force microscopy allowed us to visualize in detail the structures of the polyelectrolyte–DNA complexes formed due to electrostatic interactions. Our results indicate a relationship between the structure of the polyelectrolytes and their toxicity, which is necessary for optimization of drug and gene delivery systems.

Oxygen-Generating Gel Systems Induced by Visible Light and Application to Artificial Photosynthesis

2012 ◽  
Vol 1418 ◽  
Author(s):  
Kosuke Okeyoshi ◽  
Ryo Yoshida
Keyword(s):  
Visible Light ◽  
Functional Groups ◽  
Electrostatic Interactions ◽  
Artificial Photosynthesis ◽  
Polymer Network ◽  
Steric Effects ◽  
Colloidal Nanoparticles ◽  
Graft Polymer ◽  
Hierarchical Network ◽  
Novel Strategy

ABSTRACTToward complete artificial photosynthesis systems to generate hydrogen and oxygen using visible light and water, we firstly design and fabricate oxygen-generating gel systems using the electrostatic interactions of ionic functional groups and steric effects of a polymer network. By using a graft polymer chain with Ru(bpy)32+ units as sensitizers to closely arrange RuO2 nanoparticles as catalyst, the functional groups transmit multiple electrons cooperatively to generate oxygen. In this study, a novel strategy is shown to design a hierarchical network structure using colloidal nanoparticles and macromonomers.

Effect of chemical composition and sulfated modification of alginate in the development of delivery systems based on electrostatic interactions for small molecule drugs

2020 ◽  
Vol 263 ◽  
pp. 127235 ◽  
Author(s):  
Zahra Nazemi ◽  
Mohammad Sadegh Nourbakhsh ◽  
Sahar Kiani ◽  
Hamed Daemi ◽  
Mohammad Kazemi Ashtiani ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Small Molecule ◽  
Electrostatic Interactions ◽  
Delivery Systems ◽  
Small Molecule Drugs

scholarly journals Use of Protamine in Nanopharmaceuticals—A Review

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1508
Author(s):  
Ivana Ruseska ◽  
Katja Fresacher ◽  
Christina Petschacher ◽  
Andreas Zimmer
Keyword(s):  
Electrostatic Interactions ◽  
Delivery Systems ◽  
Biologically Active ◽  
Active Components ◽  
New Class ◽  
Self Assembling ◽  
Current State ◽  
Phosphate Backbone ◽  
Small Molecule Therapeutics ◽  
Positively Charged

Macromolecular biomolecules are currently dethroning classical small molecule therapeutics because of their improved targeting and delivery properties. Protamine-a small polycationic peptides represent a promising candidate. In nature, it binds and protects DNA against degradation during spermatogenesis due to electrostatic interactions between the negatively charged DNA-phosphate backbone and the positively charged protamine. Researchers are mimicking this technique to develop innovative nanopharmaceutical drug delivery systems, incorporating protamine as a carrier for biologically active components such as DNA or RNA. The first part of this review highlights ongoing investigations in the field of protamine-associated nanotechnology, discussing the self-assembling manufacturing process and nanoparticle engineering. Immune-modulating properties of protamine are those that lead to the second key part, which is protamine in novel vaccine technologies. Protamine-based RNA delivery systems in vaccines (some belong to the new class of mRNA-vaccines) against infectious disease and their use in cancer treatment are reviewed, and we provide an update on the current state of latest developments with protamine as pharmaceutical excipient for vaccines.

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