Sulfated polysaccharide from pacific abalone attenuated DSS-induced acute and chronic ulcerative colitis in mice via regulating intestinal micro-ecology and NF-κB pathway

2021 ◽  
Author(s):  
Jinhui Jia ◽  
Panpan Zhang ◽  
Chenxi Zhang ◽  
Guoping Jiang ◽  
Weiyun Zheng ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Side Effects ◽  
Chronic Ulcerative Colitis ◽  
Sulfated Polysaccharide ◽  
Inflammatory Activity ◽  
Pacific Abalone ◽  
Anti Inflammatory

Due to potential side effects of current drugs in colitis treatment, polysaccharides with anti-inflammatory activity can be considered as an alternative molecule for colitis treatment. Sulfated polysaccharide from pacific abalone...

scholarly journals Periplaneta americana Oligosaccharides Exert Anti-Inflammatory Activity through Immunoregulation and Modulation of Gut Microbiota in Acute Colitis Mice Model

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1718
Author(s):  
Kaimin Lu ◽  
Jing Zhou ◽  
Jie Deng ◽  
Yangjun Li ◽  
Chuanfang Wu ◽  
...  
Keyword(s):  
Side Effects ◽  
Pathogenic Bacteria ◽  
Periplaneta Americana ◽  
Biochemical Characterization ◽  
Antioxidant Activities ◽  
Inflammatory Activity ◽  
Mice Model ◽  
Acute Colitis ◽  
Anti Inflammatory

The incidence and prevalence of inflammatory bowel disorders (IBD) are increasing around the world due to bacterial infection, abnormal immune response, etc. The conventional medicines for IBD treatment possess serious side effects. Periplaneta americana (P. americana), a traditional Chinese medicine, has been used to treat arthritis, fever, aches, inflammation, and other diseases. This study aimed to evaluate the anti-inflammatory effects of oligosaccharides from P. Americana (OPA) and its possible mechanisms in vivo. OPA were purified and biochemical characterization was analyzed by HPGPC, HPLC, FT-IR, and GC–MS. Acute colitis mice model was established, the acute toxicity and anti-inflammatory activity were tested in vivo. The results showed OPA with molecular mass of 1.0 kDa were composed of 83% glucose, 6% galactose, 11% xylose, and the backbone was (1→4)-Glcp. OPA had potent antioxidant activities in vitro and significantly alleviated the clinical symptoms of colitis, relieved colon damage without toxic side effects in vivo. OPA exhibited anti-inflammatory activity by regulating Th1/Th2, reducing oxidative stress, preserving intestinal barrier integrity, and inhibiting TLR4/MAPK/NF-κB pathway. Moreover, OPA protected gut by increasing microbial diversity and beneficial bacteria, and reducing pathogenic bacteria in feces. OPA might be the candidate of complementary and alternative medicines of IBD with low-cost and high safety.

scholarly journals Design, Synthesis and Anti-inflammatory Activity of Structurally Simple Anthranilic Acid Congeners Devoid of Ulcerogenic Side Effects

2012 ◽  
Vol 60 (10) ◽  
pp. 1290-1300 ◽  
Author(s):  
Amal Abdel Haleem Mohamed Eissa ◽  
Gamal Abd El-Hakeem Soliman ◽  
Moayad Hussein Khataibeh
Keyword(s):  
Side Effects ◽  
Anthranilic Acid ◽  
Inflammatory Activity ◽  
Design Synthesis ◽  
Anti Inflammatory

scholarly journals Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

2010 ◽  
Vol 13 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Z. A. Zakaria ◽  
A. S. Mohamad ◽  
M. S. Ahmad ◽  
A. F. Mokhtar ◽  
D. A. Israf ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Preliminary Analysis ◽  
Formalin Test ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Zingiber Zerumbet ◽  
Cotton Pellet ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

scholarly journals Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of 1,4,5,6-Tetrahydropyrimidine-2-Carboxamides

2020 ◽  
Vol 27 (3) ◽  
pp. 353-365
Author(s):  
Volodymyr Ya. Horishny ◽  
Pavlo V. Zadorozhnii ◽  
Ivanna V. Horishnia ◽  
Vasyl S. Matiychuk
Keyword(s):  
Molecular Docking ◽  
Side Effects ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Cox Inhibitors ◽  
White Rats ◽  
Urgent Task ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. The widespread use of NSAIDs is associated with a number of serious side effects and complications observed for both selective and non-selective COX inhibitors. Therefore, the search for new COX inhibitors, which along with their effectiveness will have minimal side effects, is a very important and urgent task. Methods: This work studied the synthesis of new 1,4,5,6-tetrahydropyrimidine-2-carboxamides based on the reaction of 2-morpholin-4-yl-N-(het)aryl-2-thioxoacetamides with 1,3-diaminopropane. All obtained compounds were tested for anti-inflammatory activity in vitro and in silico conditions. All synthesized 1,4,5,6-tetrahydropyrimidine-2-carboxamides were tested for influence on the course of the exudative phase of the inflammatory process based on the carrageenan model of paw edema of laboratory nonlinear heterosexual white rats weighing 220-250 g, using Diclofenac as a reference. Optimization of the geometry of the studied structures and molecular docking was carried out using the ArgusLab 4.0.1 software package. Results: The target products were obtained with yields of 71-98% and easily isolated from the reaction mixture. The best anti-inflammatory activity was found in N-(4-chlorophenyl)-1,4,5,6-tetrahydropyrimidine-2-carboxamide and in N-[4-chloro-3-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydropyrimidine-2-carboxamide, suppression of the inflammatory response was 46.7 and 46.4%, respectively. The results of molecular docking with COX-1 and COX-2 enzymes were in good agreement with the experimental data, R2 ˃ 0.92 and R2 ˃ 0.83, respectively. Conclusion: The compounds under study were shown to be promising as potential anti-inflammatory agents.

ANTI-INFLAMMATORY ACTIVITY OF A ZINC-CONTAINING COMPOSITE IN THE PRESENCE OF SIMULATED ULCERATIVE COLITIS

2018 ◽  
Vol 67 (4) ◽  
Author(s):  
K.A. Apartsin ◽  
A.D. Kim ◽  
S.A. Lepekhova ◽  
Ya.A. Kostyro ◽  
E.Yu. Chashkova ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Inflammatory Activity ◽  
Anti Inflammatory

scholarly journals Aktifitas Kunyit (Curcuma domestica Val.) Sebagai Antiinflamasi Ditinjau Dari Berbagai Literatur

2021 ◽  
Vol 5 (1) ◽  
pp. 102
Author(s):  
Humaira Fadhilah ◽  
Karunia Rachmani ◽  
Nurihardianti Hajaring
Keyword(s):  
Side Effects ◽  
Tissue Injury ◽  
Inflammatory Activity ◽  
Literature Study ◽  
Induction Method ◽  
Protective Response ◽  
Physical Trauma ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Inflammation is a normal protective response to tissue injury caused by physical trauma, damaging chemicals, or microbiological substances. Steroids and nonsteroidal anti-inflammatory drugs have many side effects, so there are many anti-inflammatory developments originating from natural ingredients, especially in plants. Plants that are scientifically proven to have anti-inflammatory properties, namely turmeric (Curcuma domestica Val.) The method used in this literature study is a review of various journals published online, with the keyword turmeric as an anti-inflammatory, reviewed one by one and then the journals obtained are collected and information created by summarizing the content and then comparing the journals to be used as references. The results showed that turmeric tested had anti-inflammatory activity. The strength of the anti-inflammatory effect is shown by the carrageenan induction method which inhibits endema in rat feet and inflammation in the liver using the method of induction by diethylnitrosamine in this plant varies, depending on the dose. Compounds that are considered to provide anti-inflammatory activity are curcumin class compounds because they can inhibit the formation of prostagladin, thromboxan, and prostagycycline by inhibiting the activity of the cyclooxygenase enzyme. Curcumin also inhibits the formation of leuketrien compounds by inhibiting the activity of the lipoxygenase enzyme.Keywords: Anti-inflamatoryTurmericCucurminABSTRAK Inflamasi merupakan perlindungan normal ketika timbul luka jaringan karena zat mikrobiologi, zat kimia atau trauma fisik. Efek samping yang ditimbulkan oleh obat antiinflamasi banyak sehingga dibuat bahan alam untuk pengembangan antiinflamasi salah satunya adalah tanaman. Kunyit (Curcumma domestica Val.) adalah tanaman yang memiliki khasiat antiinflamasi yang terbukti secara ilmiah. Metode yang digunakan adalah studi literatur dengan  kata kunci kunyit sebagai antiinflamasi, diulas satu persatu kemudian jurnal yang didapat dikumpulkan dan informasi dibuat dengan merangkum isi lalu membandingkan jurnal yang akan dijadikan acuan. Hasil membuktikan bahwa kunyit memiliki aktivitas antiinflamasi. Efek antiinflamasi ditunjukkan dengan metode induksi karagenan yg menghambat endema pada  kaki tikus dan peradangan pada hati tikus menggunakan metode induksi oleh dietilnitrosamin tergantung dosisnya pada tanaman berbeda. Senyawa golongan kurkumin merupakan senyawa yang terbukti memberikan aktivitas antiinflamasi karena dapat menghambat pembentukan prostagladin, prostagsiklin dan tromboksan dengan cara menghambat aktifitas enzim siklooksigenase. Aktivitas yang lain dari kurkumin adalah menghambat pembentukan senyawa leuketrien dengan menghambat aktifitas enzim lipoxygenase.Kata Kunci: AntiinflamasiKunyitKukurmin

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