scholarly journals Aktifitas Kunyit (Curcuma domestica Val.) Sebagai Antiinflamasi Ditinjau Dari Berbagai Literatur

2021 ◽  
Vol 5 (1) ◽  
pp. 102
Author(s):  
Humaira Fadhilah ◽  
Karunia Rachmani ◽  
Nurihardianti Hajaring
Keyword(s):  
Side Effects ◽  
Tissue Injury ◽  
Inflammatory Activity ◽  
Literature Study ◽  
Induction Method ◽  
Protective Response ◽  
Physical Trauma ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Inflammation is a normal protective response to tissue injury caused by physical trauma, damaging chemicals, or microbiological substances. Steroids and nonsteroidal anti-inflammatory drugs have many side effects, so there are many anti-inflammatory developments originating from natural ingredients, especially in plants. Plants that are scientifically proven to have anti-inflammatory properties, namely turmeric (Curcuma domestica Val.) The method used in this literature study is a review of various journals published online, with the keyword turmeric as an anti-inflammatory, reviewed one by one and then the journals obtained are collected and information created by summarizing the content and then comparing the journals to be used as references. The results showed that turmeric tested had anti-inflammatory activity. The strength of the anti-inflammatory effect is shown by the carrageenan induction method which inhibits endema in rat feet and inflammation in the liver using the method of induction by diethylnitrosamine in this plant varies, depending on the dose. Compounds that are considered to provide anti-inflammatory activity are curcumin class compounds because they can inhibit the formation of prostagladin, thromboxan, and prostagycycline by inhibiting the activity of the cyclooxygenase enzyme. Curcumin also inhibits the formation of leuketrien compounds by inhibiting the activity of the lipoxygenase enzyme.Keywords: Anti-inflamatoryTurmericCucurminABSTRAK Inflamasi merupakan perlindungan normal ketika timbul luka jaringan karena zat mikrobiologi, zat kimia atau trauma fisik. Efek samping yang ditimbulkan oleh obat antiinflamasi banyak sehingga dibuat bahan alam untuk pengembangan antiinflamasi salah satunya adalah tanaman. Kunyit (Curcumma domestica Val.) adalah tanaman yang memiliki khasiat antiinflamasi yang terbukti secara ilmiah. Metode yang digunakan adalah studi literatur dengan  kata kunci kunyit sebagai antiinflamasi, diulas satu persatu kemudian jurnal yang didapat dikumpulkan dan informasi dibuat dengan merangkum isi lalu membandingkan jurnal yang akan dijadikan acuan. Hasil membuktikan bahwa kunyit memiliki aktivitas antiinflamasi. Efek antiinflamasi ditunjukkan dengan metode induksi karagenan yg menghambat endema pada  kaki tikus dan peradangan pada hati tikus menggunakan metode induksi oleh dietilnitrosamin tergantung dosisnya pada tanaman berbeda. Senyawa golongan kurkumin merupakan senyawa yang terbukti memberikan aktivitas antiinflamasi karena dapat menghambat pembentukan prostagladin, prostagsiklin dan tromboksan dengan cara menghambat aktifitas enzim siklooksigenase. Aktivitas yang lain dari kurkumin adalah menghambat pembentukan senyawa leuketrien dengan menghambat aktifitas enzim lipoxygenase.Kata Kunci: AntiinflamasiKunyitKukurmin

Anti-nociceptive and anti-inflammatory activity of synthesized novel benzoxazole derivatives

2021 ◽  
Vol 20 ◽  
Author(s):  
Mansi L. Patil ◽  
Swati S. Gaikwad ◽  
Naresh J. Gaikwad
Keyword(s):  
Cytotoxic Activity ◽  
Research Study ◽  
Ex Vivo ◽  
Immunological Response ◽  
Inflammatory Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Introduction: Pain is an immunological response to any infection or inflammation and long term use of pain management therapy includes use of Nonsteroidal anti-inflammatory drugs which is associated with occurrence of toxicity as well as gastrointestinal bleeding. Therefore, the investigation of new analgesic and anti-inflammatory agents remains a major challenge. Aims: The objective of this research study is to undergo the pharmacological evaluation of newly synthesized benzoxazole derivatives. These novel derivatives were evaluated for anti-nociceptive, anti-inflammatory and cytotoxic activity using various in-vivo and ex-vivo methods. Methods: The study was carried out using swiss mice (adult male) weighing between 20gm to 30gm and were divided into groups containing (n=6) six animals in each group for treatment. The anti-nociceptive activity was performed by using 0.1ml of 0.6% v/v acetic acid as nociception inducer and evaluated by the diminished number of abdominal writhes. The anti-inflammatory activity was done using 0.1 ml of 2% w/v Carrageenan induced paw edema method was observed which was evaluated by calculating the percent maximum possible effect. Histopathological evaluation and cytotoxic activity of the compounds was carried out. Results: The results of this research study revealed that synthesized derivatives (a, b, c, d and e) showed promising anti-nociceptive and anti-inflammatory effect along significantly higher cytotoxic activity in MCF-7 cell lines. Conclusion: It can be concluded that synthesized derivatives (a, b, c, d and e) have potential anti-nociceptive and anti-inflammatory effect along with cytotoxic activity and certain modification in structure may result in potent activity.

scholarly journals Preliminary Analysis of the Anti-Inflammatory Activity of Essential Oils of Zingiber zerumbet

2010 ◽  
Vol 13 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Z. A. Zakaria ◽  
A. S. Mohamad ◽  
M. S. Ahmad ◽  
A. F. Mokhtar ◽  
D. A. Israf ◽  
...  
Keyword(s):  
Side Effects ◽  
Essential Oil ◽  
Preliminary Analysis ◽  
Formalin Test ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Zingiber Zerumbet ◽  
Cotton Pellet ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Nonsteroidal anti-inflammatory drugs (NSAIDs) have been widely used for the treatment of inflammation. However, despite their effectiveness, most NSAIDs cause various side effects that negatively affect the management of inflammation and, in part, pain. Thus, there is a need to search for new anti-inflammatory agents with few, or no, side effects. Natural products of plant, animal, or microorganism origin have been good sources of new bioactive compounds. The present study was carried out to evaluate the acute and chronic anti-inflammatory activities of the essential oil of the rhizomes of Zingiber zerumbet (Zingiberaceae) using the carrageenan-induced paw edema and cotton pellet-induced granuloma tests, respectively. The effect of the essential oil on inflammatory- and noninflammatory-mediated pain was also assessed using the formalin test. Essential oil of Z. zerumbet, at doses of 30, 100, and 300 mg/kg, was administered intraperitoneally to rats. The substance exhibited significant anti-inflammatory activity both in acute and chronic animal models. The essential oil also inhibited inflammatory- and noninflammatory-mediated pain when assessed using the formalin test. In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments.

scholarly journals Side-Effects of Non-Steroidal Anti-Inflammatory Drugs on the Liver in Dogs and Hepatoprotective Effect of Plant Remedies

2014 ◽  
Vol 58 (3) ◽  
pp. 459-466
Author(s):  
Magdalena Szweda ◽  
Józef Szarek ◽  
Zdzisław Kiełbowicz ◽  
Beata Szynaka
Keyword(s):  
Side Effects ◽  
Adverse Effects ◽  
Tissue Injury ◽  
Histopathological Examination ◽  
Hepatoprotective Effect ◽  
Hepatic Tissue ◽  
Beagle Dogs ◽  
Positive Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Hepatoprotective effect of plant drugs against hepatic tissue injury induced by non-steroidal anti-inflammatory drugs (NSAIDs) was assessed on Beagle dogs. The adverse effects of carprofen and robenacoxib on the hepatic tissue were evaluated on the basis of histopathological examination of liver sections. It was demonstrated that the use of NSAIDs with liquorice and composed plant remedy Pectosol¯ caused a reduction of hepatic adverse effects induced by the administration of NSAIDs. This fact indicates a hepatoprotective effect of the tested plant remedies during the treatment with NSAIDs. However, the results require further studies on a larger group of animals. Liquorice and Pectosol¯ reduce the hepatic side effects, which develop after the treatment with carprofen and, to a lesser extent, robenacoxib in young Beagles. Such studies allow to investigate the negative and positive effects of using robenacoxib and carprofen in dogs and, therefore, help to limit the NSAID-induced side effects on the liver in these animals.

scholarly journals Synthesis, Anti-Inflammatory Activity and Molecular Docking Studies of 1,4,5,6-Tetrahydropyrimidine-2-Carboxamides

2020 ◽  
Vol 27 (3) ◽  
pp. 353-365
Author(s):  
Volodymyr Ya. Horishny ◽  
Pavlo V. Zadorozhnii ◽  
Ivanna V. Horishnia ◽  
Vasyl S. Matiychuk
Keyword(s):  
Molecular Docking ◽  
Side Effects ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Cox Inhibitors ◽  
White Rats ◽  
Urgent Task ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in the world. The widespread use of NSAIDs is associated with a number of serious side effects and complications observed for both selective and non-selective COX inhibitors. Therefore, the search for new COX inhibitors, which along with their effectiveness will have minimal side effects, is a very important and urgent task. Methods: This work studied the synthesis of new 1,4,5,6-tetrahydropyrimidine-2-carboxamides based on the reaction of 2-morpholin-4-yl-N-(het)aryl-2-thioxoacetamides with 1,3-diaminopropane. All obtained compounds were tested for anti-inflammatory activity in vitro and in silico conditions. All synthesized 1,4,5,6-tetrahydropyrimidine-2-carboxamides were tested for influence on the course of the exudative phase of the inflammatory process based on the carrageenan model of paw edema of laboratory nonlinear heterosexual white rats weighing 220-250 g, using Diclofenac as a reference. Optimization of the geometry of the studied structures and molecular docking was carried out using the ArgusLab 4.0.1 software package. Results: The target products were obtained with yields of 71-98% and easily isolated from the reaction mixture. The best anti-inflammatory activity was found in N-(4-chlorophenyl)-1,4,5,6-tetrahydropyrimidine-2-carboxamide and in N-[4-chloro-3-(trifluoromethyl)phenyl]-1,4,5,6-tetrahydropyrimidine-2-carboxamide, suppression of the inflammatory response was 46.7 and 46.4%, respectively. The results of molecular docking with COX-1 and COX-2 enzymes were in good agreement with the experimental data, R2 ˃ 0.92 and R2 ˃ 0.83, respectively. Conclusion: The compounds under study were shown to be promising as potential anti-inflammatory agents.

scholarly journals Anti-Inflammatory Effects of Berchemia floribunda in LPS-Stimulated RAW264.7 Cells through Regulation of NF-κB and MAPKs Signaling Pathway

Plants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 586
Author(s):  
Hyun Ji Eo ◽  
Jun Hyuk Jang ◽  
Gwang Hun Park
Keyword(s):  
Signaling Pathway ◽  
Inflammatory Activity ◽  
Nuclear Accumulation ◽  
Raw264.7 Cells ◽  
No Production ◽  
Tnf Α ◽  
Inflammatory Drugs ◽  
Cox 2 ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Berchemia floribunda (Wall.) Brongn. (BF), which belongs to Rhamnaceae, is a special plant of Anmyeon Island in Korea. BF has been reported to have antioxidant and whitening effects. However, the anti-inflammatory activity of BR has not been elucidated. In this study, we evaluated the anti-inflammatory effect of leaves (BR-L), branches (BR-B) and fruit (BR-F) extracted with 70% ethanol of BR and elucidated the potential signaling pathway in LPS-induced RAW264.7 cells. BR-L showed a strong anti-inflammatory activity through the inhibition of NO production. BR-L significantly suppressed the production of the pro-inflammatory mediators such as iNOS, COX-2, IL-1β, IL-6 and TNF-α in LPS-stimulated RAW264.7 cells. BR-L suppressed the degradation and phosphorylation of IκB-α, which contributed to the inhibition of p65 nuclear accumulation and NF-κB activation. BR-L obstructed the phosphorylation of MAPKs (ERK1/2, p38 and JNK) in LPS-stimulated RAW264.7 cells. Consequently, these results suggest that BR-L may have great potential for the development of anti-inflammatory drugs to treat acute and chronic inflammatory disorders.

scholarly journals The use of hyaluronic acid preparations for the treatment of osteoarthritis of the major joints

2021 ◽  
Vol 4 (2) ◽  
pp. 11-16
Author(s):  
O Kalashnikov ◽  
O Sulyma ◽  
T Osadchuk ◽  
V Zayets ◽  
T Nizalov ◽  
...  
Keyword(s):  
Side Effects ◽  
Adverse Side Effects ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
High Level ◽  
Time Of Administration ◽  
Inflammatory Effect ◽  
The Ideal

The authors of the article analyzed the experience of domestic and foreign experts in the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major joints. Background  and  Objective. To analyze the literature sources in order to determine the effectiveness of the use of HA preparations in the treatment of osteoarthritis of major ligaments. Materials and methods. Articles in specialized scientific journals and collections, Internet resource.Results. The analysis of literature sources determined the important role of HA preparations in the supplying and functioning of the articular cartilage. Researchers are inclined to believe that the ideal HA preparation should be as close as possible to the physiological HA of the synovial fluid of the joint. The developed domestic drug Artro-Patch fully corresponds to these parameters. Conclusions. The use of modern injectable HA preparations is advisable at stages 1–3 of OA. Anti-inflammatory effect of HA preparations makes it possible to reduce the dose and time of administration of non-steroidal anti-inflammatory drugs and, as a consequence, reduce the risk of developing many adverse side effects of NSAIDs. The high level of safety of HA preparations, the absence of serious side effects during their long-term use determine their widespread use in the clinical practice of modern orthopedists.

scholarly journals Nimesulide Mechanism of Action: Focus on Histamine

Doctor Ru ◽  
2021 ◽  
Vol 20 (4) ◽  
pp. 67-70
Author(s):  
G.Yu. Knorring ◽  
◽  
Keyword(s):  
Side Effects ◽  
Mechanism Of Action ◽  
Low Risk ◽  
Histamine Secretion ◽  
Interesting Effect ◽  
Key Points ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Available Information ◽  
Inflammatory Effect

Objective of the Review: To analyse available information on the nimesulide mechanism of action, namely of recent studies of COXindependent effects of nimesulide, affecting primarily histamine-mediated reactions. Key Points. Fast and lasting anti-inflammatory and analgetic effects of nimesulide are a result of a number of actions not associated with cyclooxygenase 2 inhibition. Of utmost interest are effects associated with suppression of immune and non-immune histamine secretion. Conclusion. An interesting effect of nimesulide is an impact on histamine secretion; it explains more pronounced analgetic and anti-inflammatory effect of nimesulide and a low risk of respiratory and GIT side effects. Keywords: nonsteroidal anti-inflammatory drugs, cyclooxygenase, histamine, nimesulide.

scholarly journals Phytochemical research and anti-inflammatory activity of the dry extracts from northern highbush blueberry leaves

2021 ◽  
pp. 40-48
Author(s):  
Oleksandr Stremoukhov ◽  
Oleh Koshovyi ◽  
Mykola Komisarenko ◽  
Igor Kireyev ◽  
Andriy Gudzenko ◽  
...  
Keyword(s):  
Amino Acids ◽  
Phenolic Compounds ◽  
Side Effects ◽  
New Drugs ◽  
Inflammatory Activity ◽  
Highbush Blueberry ◽  
Northern Highbush Blueberry ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Blueberry Leaves

All over the world, non-steroidal anti-inflammatory drugs (NSAIDs) are taken annually by about three hundred million people and this figure is constantly increasing. At the same time, NSAIDs are also one of the most common causes of side effects of drug therapy. The development and implementation of new anti-inflammatory drugs, including those of plant origin, with minimal side effects is an urgent task of modern pharmaceutical science. Vaccinium corymbosum L. (family Ericaceae), which is gaining more and more popularity among berry crops and is successfully cultivated in Ukraine, is promising in this direction for research. The aim: phytochemical analysis of dry extracts from blueberry leaves to establish the possibility of creating new drugs with anti-inflammatory activity. Materials and methods. The objects of the study were dry extracts of northern highbush blueberry leaves. The content of amino acids and phenolic compounds was determined by HPLC and spectrophotometry. The prototypal activity was studied in vivo and in vitro. Research results. 4 dry extracts were obtained from northern highbush blueberry leaves. In the extracts obtained by HPLC, 7 amino acids were identified, including 3 essential ones: arginine, histidine, and phenylalanine. As a result of the HPLC study, 7 phenolic compounds were identified in extracts from the leaves of northern highbush blueberry: 5 flavonoids - rutin, quercetin-3-O-glucoside, kaempferol-3-O-glucoside, quercetin and kaempferol and 2 hydroxycinnamic acids, chlorogenic and caffeic acid. For the first time, the anti-inflammatory effect of extracts from blueberry leaves was investigated. It was revealed that extract 1 at a dose of 50 mg/kg and extract 4 modified with arginine at a dose of 25 mg/kg have the highest anti-inflammatory activity. Conclusions. The results of the conducted studies indicate that extracts from the leaves of northern highbush blueberry in terms of the content of biologically active substances are promising sources for the creation of new drugs and dietary supplements with anti-inflammatory activity

scholarly journals Migración de neutrófilos en larvas de pez cebra expuestos a extractos de sofrito de tomate

2021 ◽  
Vol 70 (3) ◽  
pp. 216-224
Author(s):  
Cristina Arteaga ◽  
Alberto Bustillos ◽  
Jesús Gómez
Keyword(s):  
Neutrophil Migration ◽  
Inflammatory Activity ◽  
Control Group ◽  
Percentage Decrease ◽  
Zebrafish Larvae ◽  
Tomato Extract ◽  
Inflammatory Drugs ◽  
Food Matrices ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Este trabajo se fundamenta en la evaluación de la actividad antiinflamatoria de extractos de sofrito de tomate, así como de compuestos estándares de la dieta mediterránea, usando un modelo experimental optimizado basado en larvas de pez cebra. La migración de neutrófilos en larvas de pez cebra de 96 horas post fertilización se indujo mediante una lesión y se potenció añadiéndole lipopolisacárido, dicha migración se visualizó y cuantificó mediante análisis de imagen. El efecto antiinflamatorio del extracto de tomate y de los compuestos utilizados fue correlacionado porcentualmente por la disminución de la migración de los neutrófilos. Los resultados muestran que el extracto de tomate presentó una reducción en la migración de neutrófilos de 40 % respecto al grupo control. Por otra parte, el ácido clorogénico y la cianidina presentes en el sofrito de tomate utilizados como estándares presentaron una disminución de la migración de neutrófilos de un 66,7 % y 62,5 % respectivamente. Estos porcentajes son comparables a los resultados observados en ensayos con drogas antiinflamatorias como la indometacina y piroxicam. Los resultados muestran que el extracto de sofrito de tomate presenta posible actividad antinflamatoria demostrada por la reducción de la migración de neutrófilos, además el modelo se mostró sensible y válido para ser aplicado en matrices alimentarias complejas. The main of this study was to evaluate the anti-inflammatory activity of tomato sofrito extracts, as well as standard compounds present in the Mediterranean diet, using an optimized experimental model based on zebrafish larvae. Neutrophil migration in zebrafish larvae 96 hours post fertilization was induced by a cut in the caudal fin and enhanced by adding lipopolysaccharide and was visualized and quantified by image analysis. The anti-inflammatory effect of tomato extract and the compounds used was correlated by the percentage decrease in the migration of neutrophils. The results showed that, tomato extract showed a reduction in neutrophil migration of 40% compared to the control group. Moreover, chlorogenic acid and cyanidin present in tomato sofrito sauce showed a decrease in neutrophil migration of 66.7% and 62.5% respectively. These percentages are comparable to the results observed in trials with anti-inflammatory drugs such as indomethacin and piroxicam. The results show that tomato sofrito extract has possible anti-inflammatory activity demonstrated by the reduction of neutrophil migration, furthermore the model was sensitive and valid to be applied in complex food matrices.

scholarly journals Evaluation of in- vitro Anti-inflammatory Potential of Grevillea robusta A. Cunn, EX R.BR. Leaves

2021 ◽  
Vol 68 (1) ◽  
Author(s):  
Samanta Jhuma ◽  
Kumar Vineet
Keyword(s):  
Side Effects ◽  
Chemical Constituents ◽  
Fibre Length ◽  
Ethanol Extract ◽  
Inflammatory Activity ◽  
Grevillea Robusta ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Microscopic Measurement

Synthetic Non-steroidal anti-inflammatory drugs (NASAIDs) are the choice of drug for inflammation. NASAIDs caused severe side effects like hyperacidity, gastric ulcer and so on. To avoid the side effects of NASAIDs, there is an urgent need for searching new molecule from natural origin. Present study is therefore aimed to explore Grevillea robusta A. Cunn, ex R.Br. Family proteaceae leaves for anti-inflammatory activity. Microscopic measurement (fibre length and width), Ash values and extractive values of Grevillea robusta leaves were determined to set the pharmacognostic standards. Chemical constituents were evaluated through chemical tests. The Ethanol extract of Grevillea robusta leaves (GRLE)) were subjected to evaluate in-vitro anti-inflammatory activity through HRBC method and Heat induced haemolytic method. The leaves of Grevillea robusta showed significant anti-inflammatory activity. The Ethanol extract (GRLE) showed significant anti-inflammatory activities. GRLE was found to contain polyphenols as chemical constituents which was the basis of anti-inflammatory activity. On the basis of result we can conclude that Ethanol extract of leaves of Grevillea robusta has good anti-inflammatory activity. GRLE could be used for treatment of inflammation.

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