Sustainability in peptide chemistry: current synthesis and purification technologies and future challenges

2022 ◽  
Author(s):  
Lucia Ferrazzano ◽  
Martina Catani ◽  
Alberto Cavazzini ◽  
Giulia Martelli ◽  
Dario Corbisiero ◽  
...  
Keyword(s):  
Pharmaceutical Sector ◽  
Peptide Chemistry ◽  
Industrial Landscape ◽  
Future Challenges

Developing greener synthetic processes is an inescapable necessity to transform the industrial landscape, mainly in the pharmaceutical sector, into a long-term, sustainable reality. In this context, the renaissance of peptides...

Lost Glory

2018 ◽  
Author(s):  
Sumit K. Majumdar
Keyword(s):  
Positive Impact ◽  
Positive Outcomes ◽  
State Sector ◽  
Definitive Evidence ◽  
Industrial Landscape ◽  
Intellectual Origins ◽  
Automobile Manufacturer ◽  
High Output

Lost Glory: India’s Capitalism Story describes India’s industrialization experiences. Questions about long-term industry and productivity evolution, and their impact on economic growth, lie at the heart of discourses of capitalism. The book is based on detailed empirical analyses of India’s industrialization over a period of almost seven decades, and a case study of Maruti Suzuki, India’s largest automobile manufacturer. The deeply nuanced depiction of the historical political economy that has affected India’s industrialization is a unique feature. This history will enlighten everyone interested in India. The presentation takes readers on a definitive evidence-based survey of India’s industrial landscape. It includes a detailed historical description of the intellectual origins of India’s modern industrialization, anchored in a privileged view of economic policymaking. Grounded in historical and political analyses, the facts derived on India’s long-term economic performance are used to set the record straight. It is unsparing in its assessments where the evidence warrants such conclusions. Its findings will transform debate, and set the agenda for thoughtfully assessing the future course of India’s prosperity. The author overturns the assumptions that India’s much-vaunted private sector firms only engender positive outcomes, finding State-sector firms to have become efficient, and the molecular sector to be as effective overall, while also challenging the notion that privatization is necessary for progress. Conversely, it is found that competition policy innovations to have had positive impact. Practical suggestions are provided and three fundamental reforms, one administrative, one structural, and one behavioral, necessary to regenerate high output, are advocated.

scholarly journals Congenital Central Hypoventilation Syndrome: A Comprehensive Review and Future Challenges

2014 ◽  
Vol 2014 ◽  
pp. 1-8
Author(s):  
Karin Ljubič ◽  
Iztok Fister ◽  
Iztok Fister
Keyword(s):  
Ventilatory Support ◽  
Congenital Central Hypoventilation Syndrome ◽  
Phox2b Gene ◽  
Central Controller ◽  
Future Challenges ◽  
The Central Nervous System ◽  
Central Hypoventilation ◽  
Hypoventilation Syndrome ◽  
Cardiovascular Functions

Congenital central hypoventilation syndrome is a disorder predisposed by a paired-like homebox PHOX2B gene. A mutation in the PHOX2B gene is a requisite when diagnosing congenital central hypoventilation syndrome. This mutation is identified in 93–100% of diagnosed patients. The mutation regarding this disorder affects the sensors, the central controller, and the integration of the signals within the central nervous system. This, inter alia, leads to insufficient ventilation and a decrease in PaO2, as well as an increase in PaCO2. Affected children are at risk during and after the neonatal period. They suffer from hypoventilation periods which may be present whilst sleeping only or in more severe cases when both asleep and awake. It is important for clinicians to perform an early diagnosis of congenital central hypoventilation in order to prevent the deleterious effects of hypoxaemia, hypercapnia, and acidosis on the neurocognitive and cardiovascular functions. Patients need long-term management and appropriate ventilatory support for improving the qualities of their lives. This paper provides a detailed review of congenital central hypoventilation syndrome, a congenital disorder that is genetic in origin. We describe the genetic basis, the wider clinical picture, and those challenges during the diagnosis and management of patients with this condition.

scholarly journals Towards the best future for humankind: ZIPAR whitepaper.

2018 ◽  
Author(s):  
Marko Kovic ◽  
Christian Caspar ◽  
Adrian Rauchfleisch
Keyword(s):  
Medium Term ◽  
Short Term ◽  
Profound Impact ◽  
Future Challenges ◽  
The Way

Humankind is facing major challenges in the short-term, medium-term, and long-term future. Those challenges will have a profound impact on humankind’s future progress and wellbeing. In this whitepaper, we outline our understanding of humankind’s future challenges, and we describe the way in which we work towards identifying as well as managing them. In doing so, we pursue the overall goal of ZIPAR: We want to make the best future for humankind (ever so slightly) more probable.

scholarly journals The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome

2021 ◽  
Vol 118 (6) ◽  
pp. e2010217118
Author(s):  
B. Brett Finlay ◽  
Katherine R. Amato ◽  
Meghan Azad ◽  
Martin J. Blaser ◽  
Thomas C. G. Bosch ◽  
...  
Keyword(s):  
Human Health ◽  
Human Microbiome ◽  
Risk Groups ◽  
Hygiene Hypothesis ◽  
Control Measures ◽  
Prevention Measures ◽  
Long Term Effects ◽  
Substantial Impact ◽  
Future Challenges

The COVID-19 pandemic has the potential to affect the human microbiome in infected and uninfected individuals, having a substantial impact on human health over the long term. This pandemic intersects with a decades-long decline in microbial diversity and ancestral microbes due to hygiene, antibiotics, and urban living (the hygiene hypothesis). High-risk groups succumbing to COVID-19 include those with preexisting conditions, such as diabetes and obesity, which are also associated with microbiome abnormalities. Current pandemic control measures and practices will have broad, uneven, and potentially long-term effects for the human microbiome across the planet, given the implementation of physical separation, extensive hygiene, travel barriers, and other measures that influence overall microbial loss and inability for reinoculation. Although much remains uncertain or unknown about the virus and its consequences, implementing pandemic control practices could significantly affect the microbiome. In this Perspective, we explore many facets of COVID-19−induced societal changes and their possible effects on the microbiome, and discuss current and future challenges regarding the interplay between this pandemic and the microbiome. Recent recognition of the microbiome’s influence on human health makes it critical to consider both how the microbiome, shaped by biosocial processes, affects susceptibility to the coronavirus and, conversely, how COVID-19 disease and prevention measures may affect the microbiome. This knowledge may prove key in prevention and treatment, and long-term biological and social outcomes of this pandemic.

Self-healing organic coatings based on microcapsules – A patent-based review

2021 ◽  
Vol 04 ◽  
Author(s):  
Diego Moreira Schlemper ◽  
Sérgio Henrique Pezzin
Keyword(s):  
Corrosion Protection ◽  
State Of The Art ◽  
Review Article ◽  
The State ◽  
Organic Coatings ◽  
Self Healing ◽  
Future Challenges ◽  
The Matrix ◽  
Healing Agent

: Self-healing coatings are intended to increase long-term durability and reliability and can be enabled by the presence of microcapsules containing a self-healing agent capable of interacting with the matrix and regenerating the system. This review article provides an overview of the state-of-the-art, focusing on the patents published in the field of microcapsule-based self-healing organic coatings, since the early 2000’s. A discussion about coatings for corrosion protection and the different self-healing approaches and mechanisms are also addressed, as well as future challenges and expectations for this kind of coatings.

scholarly journals Out-of-the-box versus in-house tools: how are they affecting data journalism in Australia?

2020 ◽  
pp. 1329878X2096156
Author(s):  
Mathias-Felipe de-Lima-Santos ◽  
Aljosha Karim Schapals ◽  
Axel Bruns
Keyword(s):  
Public Service ◽  
Business Models ◽  
Digital Preservation ◽  
Status Quo ◽  
Third Party ◽  
Future Challenges ◽  
The Status ◽  
Data Journalism ◽  
Depth Interviews

The proliferation of data journalism has enabled newsrooms to deploy technologies for both mundane and more sophisticated workplace tasks. To bypass long-term investment in developing data skills, out-of-the-box software solutions are commonly used. Newsrooms today are partially dependent on third-party platforms to build interactive and visual stories – but the business models of platforms are predisposed to changes, frequently inducing losses of stories. This article combines in-depth interviews and an ancillary survey to study the status quo and identify future challenges in embracing out-of-the-box and in-house tools, and their impact on Australian data journalism. Results indicate a dichotomy between commercial and public service media organisations. Commercial outlets are heavily reliant on out-of-the-box solutions to develop stories, due to a lack of skillsets and a shortage of skilled labour. By contrast, public service media are developing their own in-house solutions, which reflects their desire for the continuous digital preservation of data stories despite the challenges identified.

scholarly journals The FOCAC Process and Sino-African Strategic Partnership

2016 ◽  
Vol 02 (02) ◽  
pp. 259-276
Author(s):  
Garth Shelton
Keyword(s):  
Significant Contribution ◽  
Action Plan ◽  
Strategic Partnership ◽  
Social Aspects ◽  
Successful Implementation ◽  
Positive Outcomes ◽  
Future Challenges ◽  
To Come ◽  
Trade And Investment

Historical records confirm that China’s increasing engagement with Africa through growing trade and investment has been a major boost for African economies. China’s comprehensive commitment to Africa through the Forum on China-Africa Cooperation (FOCAC) has also made significant contribution to Africa’s overall economic development. The constructivist approach underpinning this paper suggests that FOCAC’s evolution can be positively shaped by all active participants toward increased mutual benefit and positive outcomes. With all the consensuses and commitments reached at the Johannesburg FOCAC summit (FOCAC VI) held in December 2015, a stronger Sino-African partnership is expected to take shape as both sides take efforts to enhance their win-win cooperation. The key future challenges for China and Africa are to implement the FOCAC VI Action Plan and develop a long-term FOCAC agenda which will broaden and strengthen win-win outcomes in the years to come. At the same time, Africa should try its best to ensure the successful implementation of FOCAC projects and facilitate China’s engagement, for a business-friendly environment in Africa, whether in policy, legal or social aspects, is the key to promoting the Sino-African strategic partnership and enhancing sustainable development of the African continent.

scholarly journals Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19

2020 ◽  
pp. 000486742096147
Author(s):  
Christos Pantelis ◽  
Mahesh Jayaram ◽  
Anthony J Hannan ◽  
Robb Wesselingh ◽  
Jess Nithianantharajah ◽  
...  
Keyword(s):  
Organ Damage ◽  
Multiple Organ ◽  
Global Pandemic ◽  
Organ Systems ◽  
Future Challenges ◽  
The Central Nervous System ◽  
The Impact ◽  
Collaborative Efforts ◽  
The Brain

Although COVID-19 is predominantly a respiratory disease, it is known to affect multiple organ systems. In this article, we highlight the impact of SARS-CoV-2 (the coronavirus causing COVID-19) on the central nervous system as there is an urgent need to understand the longitudinal impacts of COVID-19 on brain function, behaviour and cognition. Furthermore, we address the possibility of intergenerational impacts of COVID-19 on the brain, potentially via both maternal and paternal routes. Evidence from preclinical models of earlier coronaviruses has shown direct viral infiltration across the blood–brain barrier and indirect secondary effects due to other organ pathology and inflammation. In the most severely ill patients with pneumonia requiring intensive care, there appears to be additional severe inflammatory response and associated thrombophilia with widespread organ damage, including the brain. Maternal viral (and other) infections during pregnancy can affect the offspring, with greater incidence of neurodevelopmental disorders, such as autism, schizophrenia and epilepsy. Available reports suggest possible vertical transmission of SARS-CoV-2, although longitudinal cohort studies of such offspring are needed. The impact of paternal infection on the offspring and intergenerational effects should also be considered. Research targeted at mechanistic insights into all aspects of pathogenesis, including neurological, neuropsychiatric and haematological systems alongside pulmonary pathology, will be critical in informing future therapeutic approaches. With these future challenges in mind, we highlight the importance of national and international collaborative efforts to gather the required clinical and preclinical data to effectively address the possible long-term sequelae of this global pandemic, particularly with respect to the brain and mental health.

scholarly journals Gazing into the crystal ball: future considerations for ensuring sustained growth of the functional food and nutraceutical marketplace

2013 ◽  
Vol 26 (1) ◽  
pp. 12-21 ◽  
Author(s):  
Christopher P. F. Marinangeli ◽  
Peter J. H. Jones
Keyword(s):  
Performance Indicators ◽  
Functional Food ◽  
Food Industry ◽  
Functional Foods ◽  
Academic Community ◽  
Nutrient Requirements ◽  
Future Challenges

Over the last decade the concept of functional foods and nutraceuticals (FFN) has gained support from various stakeholders including the food industry, scientific and academic community, government institutions or regulators, producers and consumers. However, as one begins to evaluate the global FFN industry, several issues emerge including (i) a lack of consensus across jurisdictions for acknowledging safe and efficacious FFN, (ii) challenges regarding the classification of novel food-derived bioactives as FFN or drugs, and (iii) a disconnect between nutrient requirements and dosages of FFN required to facilitate health benefits. The objectives of the present review are to discuss the role of existing stakeholders within the FFN marketplace and identify performance indicators for growth within the FFN sector. In addition, the following report provides feasible resolutions to present and future challenges facing the global FFN industry to ensure sustained long-term growth.

scholarly journals Assessing Corporate Sustainability with Repertory Grid Based Personal Construct Psychology

2019 ◽  
Vol 11 (2) ◽  
Author(s):  
Henning Bundtzen
Keyword(s):  
Corporate Culture ◽  
Corporate Sustainability ◽  
Repertory Grid ◽  
Personal Construct ◽  
Personal Constructs ◽  
Personal Construct Psychology ◽  
Future Challenges ◽  
Corporate Social ◽  
Construct Psychology

Corporate sustainability (CS) is becoming a key feature for preparing an organization for the future challenges of its competitive environment. It has expanded from corporate social responsibility (CSR) by adding the dimensions of ethical, environmental, economic and cultural responsibility whilst asking for a long-term perspective of sustainability for the aforementioned subjects. This paper summarizes the concept of corporate sustainability focusing on the most relevant topics of recent scientific literature. The findings are compared to the results of 61 repertory grid interviews to evaluate how far corporate sustainability is already carried into practical notion. It is tested whether this type of interview technique and the underlying theory of personal constructs allow a visualization of the CS status of an organization. In addition, this article gives a brief outlook on the interconnection of leadership, corporate culture and corporate sustainability.    

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