Biospecific Self-Assembly of a Nanoparticle Coating for Targeted and Stimuli-Responsive Drug Delivery

Stimuli-responsive amphiphilic block copolymers obtained by PISA have emerged as promising nanocarriers for enhancing site-specific and on-demand drug release in response to a range of stimuli such as pH, redox agents, light or temperature.

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Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽

10.1039/d1sm00780g ◽

2021 ◽

Author(s):

Michael Meleties ◽

Priya Katyal ◽

Bonnie Lin ◽

Dustin Britton ◽

Jin Kim Montclare

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Self Assembly ◽

Coiled Coil ◽

Stimuli Responsive ◽

Tunable Properties ◽

Stimuli Sensitive ◽

Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

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Design and self-assembly of albumin nanoclusters as a dynamic-covalent targeting co-delivery and stimuli-responsive controlled release platform

Journal of Materials Chemistry B ◽

10.1039/c8tb01791c ◽

2018 ◽

Vol 6 (42) ◽

pp. 6817-6830 ◽

Cited By ~ 1

Author(s):

Wen Liu ◽

Jian Dai ◽

Wei Xue

Keyword(s):

Drug Delivery ◽

Controlled Release ◽

Tumor Microenvironment ◽

Self Assembly ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Stimuli Responsive ◽

Target Sites

Stimuli-responsive nanomaterial-based drug delivery systems that are able to actively target the tumor microenvironment, enhance intratumoral accumulation and release drugs at target sites are attractive therapeutic platforms at present.

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Morphology-tunable and pH-responsive supramolecular self-assemblies based on AB2-type host–guest-conjugated amphiphilic molecules for controlled drug delivery

Beilstein Journal of Organic Chemistry ◽

10.3762/bjoc.15.188 ◽

2019 ◽

Vol 15 ◽

pp. 1925-1932 ◽

Cited By ~ 3

Author(s):

Yang Bai ◽

Cai-ping Liu ◽

Di Chen ◽

Long-hai Zhuo ◽

Huai-tian Bu ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Controlled Drug Delivery ◽

Transition Process ◽

Hydrodynamic Diameter ◽

Cancer Cell Proliferation ◽

Acidic Ph ◽

Stimuli Responsive ◽

Amphiphilic Molecules ◽

Acidic Conditions

Although stimuli-responsive supramolecular self-assemblies have been constructed, the controlled drug delivery induced by morphology transitions of these supramolecular self-assemblies on the basis of host–guest-conjugated monomers (HGCMs) are few reported. In this paper, the self-assembly behaviors of AB2-type HGCMs, e.g., β-cyclodextrin-benzimidazole2 (β-CD-BM2), were investigated at neutral and acidic pH conditions, respectively. Specifically, β-CD-BM2 first self-assembled into fan-shaped supramolecular self-assemblies with a hydrodynamic diameter of 163 nm at neutral pH, whereas they were further dissociated into spherical supramolecular self-assemblies with a size of 52 nm under acidic conditions. This morphology transition process was utilized to conduct a two-stage DOX delivery under neutral and acidic pH. Basic cell experiments demonstrated that the drug-loaded β-CD-BM2-based supramolecular self-assemblies with varied morphology could inhibit cancer cell proliferation, indicating their potential application in the field of drug delivery.

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Stimuli responsive hydrogels derived from a renewable resource: synthesis, self-assembly in water and application in drug delivery

Journal of Materials Chemistry B ◽

10.1039/c5tb00864f ◽

2015 ◽

Vol 3 (27) ◽

pp. 5560-5568 ◽

Cited By ~ 31

Author(s):

Krishnamoorthy Lalitha ◽

Y. Siva Prasad ◽

C. Uma Maheswari ◽

Vellaisamy Sridharan ◽

George John ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Renewable Resource ◽

Stimuli Responsive ◽

Composite Gel ◽

Drug Delivery Applications ◽

Responsive Hydrogels

We report coumarin-tris based hydrogel and curcumin encapsulated composite gel for stimuli responsive drug delivery applications.

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Poly(N-isopropylacrylamide) derived nanogels demonstrated thermosensitive self-assembly and GSH-triggered drug release for efficient tumor Therapy

Polymer Chemistry ◽

10.1039/c9py00537d ◽

2019 ◽

Vol 10 (29) ◽

pp. 4031-4041 ◽

Cited By ~ 3

Author(s):

Jiaojiao Chen ◽

Ming Wu ◽

Hanitrarimalala Veroniaina ◽

Subhankar Mukhopadhyay ◽

Juequan Li ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Self Assembly ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Delivery Systems ◽

Core Shell ◽

Stimuli Responsive ◽

Triggered Drug Release

Recently, interest in stimuli-responsive core–shell nanogels as drug delivery systems for tumor therapy has increased.

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Recent Advances in Nanomicelles Delivery Systems

Nanomaterials ◽

10.3390/nano11010070 ◽

2020 ◽

Vol 11 (1) ◽

pp. 70

Author(s):

Salah M. Tawfik ◽

Shavkatjon Azizov ◽

Mohamed R. Elmasry ◽

Mirkomil Sharipov ◽

Yong-Ill Lee

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Aqueous Media ◽

New Drugs ◽

Therapeutic Interventions ◽

Stimuli Responsive ◽

Molecular Weights ◽

Therapeutic Drugs ◽

Shape Selective ◽

Selective Delivery

The efficient and selective delivery of therapeutic drugs to the target site remains the main obstacle in the development of new drugs and therapeutic interventions. Up until today, nanomicelles have shown their prospective as nanocarriers for drug delivery owing to their small size, good biocompatibility, and capacity to effectively entrap lipophilic drugs in their core. Nanomicelles are formed via self-assembly in aqueous media of amphiphilic molecules into well-organized supramolecular structures. Molecular weights and structure of the core and corona forming blocks are important properties that will determine the size of nanomicelles and their shape. Selective delivery is achieved via novel design of various stimuli-responsive nanomicelles that release drugs based on endogenous or exogenous stimulations such as pH, temperature, ultrasound, light, redox potential, and others. This review summarizes the emerging micellar nanocarriers developed with various designs, their outstanding properties, and underlying principles that grant targeted and continuous drug delivery. Finally, future perspectives, and challenges for nanomicelles are discussed based on the current achievements and remaining issues.

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Towards Universal Stimuli-Responsive Drug Delivery Systems: Pillar[5]arenes Synthesis and Self-Assembly into Nanocontainers with Tetrazole Polymers

Nanomaterials ◽

10.3390/nano11040947 ◽

2021 ◽

Vol 11 (4) ◽

pp. 947

Author(s):

Dmitriy N. Shurpik ◽

Lyaysan I. Makhmutova ◽

Konstantin S. Usachev ◽

Daut R. Islamov ◽

Olga A. Mostovaya ◽

...

Keyword(s):

Drug Delivery ◽

Self Assembly ◽

Drug Delivery Systems ◽

Polymer System ◽

Delivery Systems ◽

High Yield ◽

Stimuli Responsive ◽

Amino Groups ◽

Tertiary Amino ◽

Decreasing Ph

In this work, we have proposed a novel universal stimulus-sensitive nanosized polymer system based on decasubstituted macrocyclic structures—pillar[5]arenes and tetrazole-containing polymers. Decasubstituted pillar[5]arenes containing a large, good leaving tosylate, and phthalimide groups were first synthesized and characterized. Pillar[5]arenes containing primary and tertiary amino groups, capable of interacting with tetrazole-containing polymers, were obtained with high yield by removing the tosylate and phthalimide protection. According to the fluorescence spectroscopy data, a dramatic fluorescence enhancement in the pillar[5]arene/fluorescein/polymer system was observed with decreasing pH from neutral (pH = 7) to acidic (pH = 5). This indicates the destruction of associates and the release of the dye at a pH close to 5. The presented results open a broad range of opportunities for the development of new universal stimulus-sensitive drug delivery systems containing macrocycles and nontoxic tetrazole-based polymers.

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Hybrid hydrogels derived from renewable resources as a smart stimuli responsive soft material for drug delivery applications

RSC Advances ◽

10.1039/d1ra08447j ◽

2022 ◽

Vol 12 (4) ◽

pp. 2009-2018

Author(s):

Vandana Singh ◽

Yadavali Siva Prasad ◽

Arun Kumar Rachamalla ◽

Vara Prasad Rebaka ◽

Tohira Banoo ◽

...

Keyword(s):

Drug Delivery ◽

Renewable Resources ◽

Self Assembly ◽

Crucial Role ◽

Functional Materials ◽

Soft Material ◽

Stimuli Responsive ◽

Design And Synthesis ◽

Amphiphilic Molecules ◽

Hybrid Hydrogels

The design and synthesis of amphiphilic molecules play a crucial role in fabricating smart functional materials via self-assembly.

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Peptide-Based Drug Delivery Systems

Medicina ◽

10.3390/medicina57111209 ◽

2021 ◽

Vol 57 (11) ◽

pp. 1209

Author(s):

Dmitriy Berillo ◽

Adilkhan Yeskendir ◽

Zharylkasyn Zharkinbekov ◽

Kamila Raziyeva ◽

Arman Saparov

Keyword(s):

Drug Delivery ◽

Side Effects ◽

Self Assembly ◽

Drug Delivery Systems ◽

Molecular Mechanisms ◽

Polymeric Micelles ◽

Solid Phase ◽

Cell Penetrating Peptides ◽

Delivery Systems ◽

Stimuli Responsive

Peptide-based drug delivery systems have many advantages when compared to synthetic systems in that they have better biocompatibility, biochemical and biophysical properties, lack of toxicity, controlled molecular weight via solid phase synthesis and purification. Lysosomes, solid lipid nanoparticles, dendrimers, polymeric micelles can be applied by intravenous administration, however they are of artificial nature and thus may induce side effects and possess lack of ability to penetrate the blood-brain barrier. An analysis of nontoxic drug delivery systems and an establishment of prospective trends in the development of drug delivery systems was needed. This review paper summarizes data, mainly from the past 5 years, devoted to the use of peptide-based carriers for delivery of various toxic drugs, mostly anticancer or drugs with limiting bioavailability. Peptide-based drug delivery platforms are utilized as peptide–drug conjugates, injectable biodegradable particles and depots for delivering small molecule pharmaceutical substances (500 Da) and therapeutic proteins. Controlled drug delivery systems that can effectively deliver anticancer and peptide-based drugs leading to accelerated recovery without significant side effects are discussed. Moreover, cell penetrating peptides and their molecular mechanisms as targeting peptides, as well as stimuli responsive (enzyme-responsive and pH-responsive) peptides and peptide-based self-assembly scaffolds are also reviewed.

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