Nanostructured Calcium-based Biomaterials and their Application in Drug Delivery

2020 ◽  
Vol 27 (31) ◽  
pp. 5189-5212 ◽  
Author(s):  
Li-Juan Yi ◽  
Jun-Feng Li ◽  
Ming-Guo Ma ◽  
Ying-Jie Zhu
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Bone Repair ◽  
Antibacterial Agents ◽  
Recent Progress ◽  
Review Article ◽  
Future Perspectives ◽  
Comprehensive Review ◽  
The Past ◽  
Biomedical Fields

In the past several decades, various types of nanostructured biomaterials have been developed. These nanostructured biomaterials have promising applications in biomedical fields such as bone repair, tissue engineering, drug delivery, gene delivery, antibacterial agents, and bioimaging. Nanostructured biomaterials with high biocompatibility, including calcium phosphate, hydroxyapatite, and calcium silicate, are ideal candidates for drug delivery. This review article is not intended to offer a comprehensive review of the nanostructured biomaterials and their application in drug delivery but rather presents a brief summary of the recent progress in this field. Our recent endeavors in the research of nanostructured biomaterials for drug delivery are also summarized. Special attention is paid to the synthesis and properties of nanostructured biomaterials and their application in drug delivery with the use of typical examples. Finally, we discuss the problems and future perspectives of nanostructured biomaterials in the drug delivery field.

Self-assembly of Stimuli Responsive Coiled-coil Fibrous Hydrogels

Soft Matter ◽  
2021 ◽  
Author(s):  
Michael Meleties ◽  
Priya Katyal ◽  
Bonnie Lin ◽  
Dustin Britton ◽  
Jin Kim Montclare
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Self Assembly ◽  
Coiled Coil ◽  
Stimuli Responsive ◽  
Tunable Properties ◽  
Stimuli Sensitive ◽  
Biomedical Fields

Owing to their tunable properties, hydrogels comprised of stimuli sensitive polymers are one of the most appealing scaffolds with applications in tissue engineering, drug delivery and other biomedical fields. We...

scholarly journals 3D In Vitro Human Organ Mimicry Devices for Drug Discovery, Development, and Assessment

2020 ◽  
Vol 2020 ◽  
pp. 1-41
Author(s):  
Aida Rodriguez-Garcia ◽  
Jacqueline Oliva-Ramirez ◽  
Claudia Bautista-Flores ◽  
Samira Hosseini
Keyword(s):  
Drug Discovery ◽  
Essential Role ◽  
Future Perspectives ◽  
Human Organ ◽  
Comprehensive Review ◽  
Advantages And Disadvantages ◽  
The Past ◽  
Animal Trials ◽  
On Chip

The past few decades have shown significant advancement as complex in vitro humanized systems have substituted animal trials and 2D in vitro studies. 3D humanized platforms mimic the organs of interest with their stimulations (physical, electrical, chemical, and mechanical). Organ-on-chip devices, including in vitro modelling of 3D organoids, 3D microfabrication, and 3D bioprinted platforms, play an essential role in drug discovery, testing, and assessment. In this article, a thorough review is provided of the latest advancements in the area of organ-on-chip devices targeting liver, kidney, lung, gut, heart, skin, and brain mimicry devices for drug discovery, development, and/or assessment. The current strategies, fabrication methods, and the specific application of each device, as well as the advantages and disadvantages, are presented for each reported platform. This comprehensive review also provides some insights on the challenges and future perspectives for the further advancement of each organ-on-chip device.

scholarly journals Current trends and future perspectives in pelvic reconstructive surgery

2018 ◽  
Vol 14 ◽  
pp. 174550651877649 ◽  
Author(s):  
Mélanie Aubé ◽  
Le Mai Tu
Keyword(s):  
Pelvic Organ Prolapse ◽  
Surgical Repair ◽  
Treatment Options ◽  
Pelvic Organ ◽  
Review Article ◽  
Pelvic Reconstructive Surgery ◽  
Future Perspectives ◽  
Vast Array ◽  
The Past ◽  
Current Trends

Pelvic organ prolapse is a prevalent disorder with a high lifetime incidence of surgical repair. Pelvic organ prolapse surgery has greatly evolved over the past years, and pelvic floor reconstructive surgeons are faced with a vast array of treatment options for their patients. Our review article illustrates the current trends and future perspectives for the surgical treatment of pelvic organ prolapse.

Coupling Hydrophilic Amine-Containing Molecules to the Backbone of Poly(ε-Caprolactone)

2006 ◽  
Vol 59 (8) ◽  
pp. 534 ◽  
Author(s):  
Emma L. Prime ◽  
Justin J. Cooper-White ◽  
Greg G. Qiao
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Functional Groups ◽  
Biodegradable Polymer ◽  
Model Compound ◽  
Side Chains ◽  
Reactive Polymer ◽  
Specific Reactivity ◽  
Biomedical Fields

A poly(ϵ-caprolactone) (PCL) based biodegradable polymer containing robust, amine-reactive side chains has been successfully synthesized. The specific reactivity of the side chains allows for the coupling of unmodified amine-containing molecules such as poly(l-lysine) (PLL) to PCL to occur in the presence of other unprotected functional groups. The reactivity of this polymer has been demonstrated through successful coupling of both benzylamine (a model compound) and PLL. This novel amine-reactive polymer could have numerous applications in biomedical fields such as tissue engineering and drug delivery.

scholarly journals Tissue Engineering of the Penis

2011 ◽  
Vol 11 ◽  
pp. 2567-2578 ◽  
Author(s):  
Manish N. Patel ◽  
Anthony Atala
Keyword(s):  
Tissue Engineering ◽  
Recent Progress ◽  
Organ Damage ◽  
Normal Function ◽  
Genitourinary Tract ◽  
Loss Of Function ◽  
New Materials ◽  
Safety And Efficacy ◽  
The Past ◽  
Reconstructive Techniques

Congenital disorders, cancer, trauma, or other conditions of the genitourinary tract can lead to significant organ damage or loss of function, necessitating eventual reconstruction or replacement of the damaged structures. However, current reconstructive techniques are limited by issues of tissue availability and compatibility. Physicians and scientists have begun to explore tissue engineering and regenerative medicine strategies for repair and reconstruction of the genitourinary tract. Tissue engineering allows the development of biological substitutes which could potentially restore normal function. Tissue engineering efforts designed to treat or replace most organs are currently being undertaken. Most of these efforts have occurred within the past decade. However, before these engineering techniques can be applied to humans, further studies are needed to ensure the safety and efficacy of these new materials. Recent progress suggests that engineered urologic tissues and cell therapy may soon have clinical applicability.

scholarly journals UNDERSTANDING NOVEL POLYMER AND LIPID BASED CARRIER SYSTEMS IN CLINICIAN PERSPECTIVE

2020 ◽  
Vol 4 (10) ◽  
Author(s):  
Kallem Sharat Venkat Reddy
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Drug Dosage ◽  
Delivery Systems ◽  
Review Article ◽  
Point Of View ◽  
Smart Polymers ◽  
The Past ◽  
Novel Drug ◽  
Carrier Systems

From the past two decades, technological advancements in science and chemistry made possible many new drug delivery systems that have the potential to completely change the course of routine therapeutic ways.  Lipid and polymer-based drug delivery systems are considered to be the pillars of many drug dosage forms, irrespective of their route of administration. With increasing knowledge on their chemistry, lipids and polymers are being modified and used as potential novel drug delivery systems with smart polymers and lipid nanotechnology paving the way for efficient drug delivery into the patient. This review article covers the swing of these drug delivery systems in the current market and interpreting all this from a health care professional’s point of view. Keywords: Gene delivery, Lipid based drug delivery, Polymer based drug delivery, Target specific drugs, Solid lipid nanoparticles

scholarly journals Development of a modular, biocompatible thiolated gelatin microparticle platform for drug delivery and tissue engineering applications

2021 ◽  
Author(s):  
Hannah A Pearce ◽  
Yu Seon Kim ◽  
Emma Watson ◽  
Kiana Bahrami ◽  
Mollie M Smoak ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Stem Cell ◽  
Cell Attachment ◽  
Control Cell ◽  
Growth Factor Delivery ◽  
Limited Ability ◽  
The Past ◽  
Modular Platform ◽  
Microparticle Formation

Abstract The field of biomaterials has advanced significantly in the past decade. With the growing need for high-throughput manufacturing and screening, the need for modular materials that enable streamlined fabrication and analysis of tissue engineering and drug delivery schema has emerged. Microparticles are a powerful platform that have demonstrated promise in enabling these technologies without the need to modify a bulk scaffold. This building block paradigm of using microparticles within larger scaffolds to control cell ratios, growth factors and drug release holds promise. Gelatin microparticles (GMPs) are a well-established platform for cell, drug and growth factor delivery. One of the challenges in using GMPs though is the limited ability to modify the gelatin post-fabrication. In the present work, we hypothesized that by thiolating gelatin before microparticle formation, a versatile platform would be created that preserves the cytocompatibility of gelatin, while enabling post-fabrication modification. The thiols were not found to significantly impact the physicochemical properties of the microparticles. Moreover, the thiolated GMPs were demonstrated to be a biocompatible and robust platform for mesenchymal stem cell attachment. Additionally, the thiolated particles were able to be covalently modified with a maleimide-bearing fluorescent dye and a peptide, demonstrating their promise as a modular platform for tissue engineering and drug delivery applications.

scholarly journals Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Qi Zhang ◽  
Yanjing Ji ◽  
Weiping Zheng ◽  
Mingzhe Yan ◽  
Danyang Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Repair ◽  
Composite Nanofibers ◽  
Electrospun Nanofibers ◽  
Biological Properties ◽  
Metal Composite ◽  
Future Perspectives ◽  
Polymer Metal

Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.

Liposomes as Anticancer Therapeutic Drug Carrier’s Systems: More than a Tour de Force

2020 ◽  
Vol 10 (2) ◽  
pp. 178-185 ◽  
Author(s):  
Mahfoozur Rahman ◽  
Sarwar Beg ◽  
Amita Verma ◽  
Imran Kazmi ◽  
Farhan Jalees Ahmed ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Real Time ◽  
Clinical Application ◽  
Review Article ◽  
Therapeutic Drug ◽  
Triggered Release ◽  
Extensive Discussion ◽  
Stealth Liposomes ◽  
The Past

A liposome is a spherical vesicle composed of a bilayer of lipid with central aqueous cavity. Liposomes are the first nano vesicular drug delivery carriers, which are successfully translated into real-time clinical application and gained great potential in the past 30 years. The characteristics of liposomes to encapsulate both hydrophilic and hydrophobic drugs, their biocompatibility and biodegradability make it attractive nanocarriers in drug delivery area. Apart from this, great technical advancement has been made to develops second-generation liposomes named as stealth liposomes, cationic liposomes, triggered release liposomes and ligand targeted liposomes. This led to widespread use of liposomes in various areas including anticancer therapeutics, diagnostics and imaging agents. Therefore, the presents review article made an extensive discussion of various liposomes and its applications in cancer treatment.

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