scholarly journals Molecular analysis of Homeostatic iron regulator, trans-membrane protease serine-6, and BTB domain-containing protein-9 variants and iron parameters in blood donors

2020 ◽  
Author(s):  
Manal S. Fawzy ◽  
Abeer Fakhr-Eldeen ◽  
Baraah T. Abu AlSel ◽  
Eman A. Toraih
Keyword(s):  
Iron Homeostasis ◽  
Blood Donors ◽  
Middle Eastern ◽  
Blood Parameters ◽  
Genotype Combination ◽  
Blood Indices ◽  
Btb Domain ◽  
Donor Population ◽  
Serum Hepcidin ◽  
Iron Parameters

Genetic variants associated with iron homeostasis have been identified, but their association with iron-related indices and variables among different ethnic populations remains controversial. We aimed to explore the genotype frequency and allelic distribution of three iron-metabolism related variants in homeostatic iron regulator gene (HFE; rs1800562 G/A), Transmembrane Protease, Serine-6 gene (TMPRSS6; rs855791 A/G); and BTB domain-containing protein-9 gene (BTBD9; rs9357271 C/T) among a sample of the Middle Eastern blood donors and to detect the association of these variants on blood indices, and serum hepcidin/ferritin levels. Real-Time TaqMan genotyping assay for the specified variants was applied for 197 unrelated blood donors. Complete blood picture and serum hepcidin/ferritin levels were assessed. All participants were carriers of rs1800562*G/G genotype for HFE. The frequency of A/A and A/G genotypes of TMPRSS6 rs855791 variant was 55% and 45%, and for C/C, C/T, and T/T of BTBD9 rs9357271, were 15%, 43%, and 42%, respectively. Minor allele frequencies of rs855791*G and rs9357271*C were 0.23 and 0.37. The GGC genotype combination (for HFE/TMPRSS6/BTBD9, respectively) was more frequent in male participants. Higher serum hepcidin and hepcidin/ferritin ratio were observed in TMPRSS6 (A/G) carriers. While subjects with BTBD9 C/T and TT genotypes had lower serum ferritin values and higher levels of hepcidin and hepcidin/ferritin ratio compared with C/C genotype. No significant associations were found with any other blood parameters.  In conclusion, TMPRSS6 rs855791 (A/G) and BTBD9 rs9357271 (C/T) variants were prevalent in the present blood donor population and may influence the serum hepcidin and/or ferritin levels.

The Donation Interval of 56 Days Requires Extension to 180 Days for Whole Blood Donors to Recover from Disturbances in Iron Homeostasis

Blood ◽  
2015 ◽  
Vol 126 (23) ◽  
pp. 774-774
Author(s):  
Nienke N.Schotten ◽  
Pieternel C Pasker-de Jong ◽  
Diego Moretti ◽  
Michael Bruce Zimmermann ◽  
Marian G Kraaij ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Whole Blood ◽  
Iron Homeostasis ◽  
Blood Donors ◽  
Iron Absorption ◽  
Blood Donation ◽  
Iron Parameters ◽  
Baseline Levels ◽  
Over Time ◽  
New Donors

Abstract Background: To protect whole blood donors from developing iron deficiency and anemia, many blood banks require a minimum interval of 56 days between two donations. We aimed to assess whether the donation interval of 56 days is adequate in both new and regular donors to recover from changes in iron homeostasis. Methods: Fifty male whole blood donors (25 new and 25 regular donors), were followed for 180 days after donating 500 mL of blood. Recovery of Hb and iron parameters (Hb, mean corpuscular volume (MCV), mean corpuscular Hb (MCH), MCH concentration (MCHC), red cell distribution width (RDW), reticulocytes, reticulocyte Hb content (CHr), iron, total iron-binding capacity (TIBC), transferrin saturation (TSAT), ferritin, soluble transferrin receptor (sTfR), sTfR-F index (sTfR/log ferritin), erythropoietin (EPO) and hepcidin) was investigated and tested for differences between new and regular donors in blood drawn at baseline (before donation) and at nine time points after blood donation. Differences in iron absorption and erythrocyte iron incorporation between new and regular donors were investigated with stable iron isotopes, administered at day 8 and measured at day 29. Results: At baseline, levels of Hb and iron parameters differed between new and regular donors. In regular donors, Hb, ferritin and hepcidin were lower and EPO was higher compared to new donors. However, patterns of change in parameters over time after whole blood donation were similar for new and regular donors with an increase in EPO and decrease in Hb and hepcidin after day 2 followed by a decrease in ferritin and increase in reticulocytes, sTfR and TIBC after day 4. At day 57, only for TIBC all (100%) regular donors were back at pre-donation level (Figure 1). Percentages for other parameters ranged from 16.0% (regular donors) and 20.8% (new donors) for ferritin to above 80.0% for MCV, reticulocytes, CHr, hepcidin and ZPP (regular donors) and Hb, MCH, MCHC, reticulocytes, CHr, iron, TIBC, hepcidin and ZPP (new donors). At day 85 and 180, >90% of donors were back at their pre-donation levels for all parameters except for i) RDW, EPO, in both donor groups and ii) ferritin at day 85 in new (26.1%), and regular donors (48.0%) and at day 180 in new donors (78.3%). Importantly, for ferritin, when compared to regular donors, the increase in the percentage of new donors that reached pre-donation levels was slower over time and lower at 180 days. Iron absorption (17.0 and 21.9%, respectively) and incorporation into erythrocytes (81.6 and 83.7%, respectively) were not statistically significantly different between new and regular donors, but appeared to be higher in regular donors. Conclusion: For the majority of blood donors the current interval of 56 days is too short to fully recover from a change in Hb and iron parameters after blood donation. Regular donation results in lower ferritin levels at baseline compared to new donors. Our data suggest that ferritin is a promising candidate parameter to personalize donation intervals. Moreover, they imply that prolongation of the donation interval from 56 to 180 days would i) prevent a further decrease of ferritin levels of regular donors, and ii) reduce the risk for iron deficiency associated symptoms upon subsequent donations. Figure 1. Percentage of donors back at baseline levels (before blood donation) at day 57, 85 and 180 after blood donation. Solid lines: regular donors; dashed lines, new donors. Figure 1. Percentage of donors back at baseline levels (before blood donation) at day 57, 85 and 180 after blood donation. Solid lines: regular donors; dashed lines, new donors. Disclosures No relevant conflicts of interest to declare.

scholarly journals A Randomized, Placebo-Controlled, Pilot Clinical Trial to Evaluate the Effect of Supplementation with Prebiotic Synergy 1 on Iron Homeostasis in Children and Adolescents with Celiac Disease Treated with a Gluten-Free Diet

Nutrients ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 1818 ◽  
Author(s):  
Klaudia Feruś ◽  
Natalia Drabińska ◽  
Urszula Krupa-Kozak ◽  
Elżbieta Jarocka-Cyrta
Keyword(s):  
Celiac Disease ◽  
Children And Adolescents ◽  
Iron Homeostasis ◽  
Blood Parameters ◽  
Gluten Free Diet ◽  
Deficiency Anemia ◽  
Gluten Free ◽  
Significant Difference ◽  
Before And After ◽  
Serum Hepcidin

Iron deficiency anemia (IDA) occurs in 15–46% of patients with celiac disease (CD), and in some cases, it may be its only manifestation. Studies in animal models have shown that prebiotics, including inulin, may help to increase intestinal absorption of iron. The aim of this study was to evaluate the effect of a prebiotic, oligofructose-enriched inulin (Synergy 1), on iron homeostasis in non-anemic children and adolescents with celiac disease (CD) in association with a gluten-free diet (GFD). Thirty-four CD patients (4–18 years old) were randomized into two groups receiving Synergy 1 (10 g/day) or a placebo (maltodextrin) for three months. Before and after intervention, blood samples were collected from all patients for assessment of blood morphology, biochemical parameters and serum hepcidin concentration. We found that serum hepcidin concentration after the intervention was significantly decreased by 60.9% (p = 0.046) in the Synergy 1 group, whereas no significant difference was observed in the placebo group. No differences in morphological and biochemical blood parameters (including ferritin, hemoglobin and C-reactive protein (CRP)) were observed after intervention in either group. Given that hepcidin decrease may improve intestinal iron absorption, these results warrant further investigation in a larger cohort and especially in patients with IDA.

scholarly journals Clinical Immunoassay for Human Hepcidin Predicts Iron Deficiency in First-Time Blood Donors

2020 ◽  
Vol 5 (5) ◽  
pp. 943-953
Author(s):  
Patrick Gutschow ◽  
Huiling Han ◽  
Gordana Olbina ◽  
Keith Westerman ◽  
Elizabeta Nemeth ◽  
...  
Keyword(s):  
Iron Deficiency ◽  
Iron Homeostasis ◽  
Blood Donors ◽  
Iron Status ◽  
Characteristic Curve ◽  
Serum Markers ◽  
Ferritin Concentration ◽  
Limit Of Quantitation ◽  
Serum Hepcidin ◽  
First Time

Abstract Background Serum markers currently used as indicators of iron status have clinical limitations. Hepcidin, a key regulator of iron homeostasis, is reduced in iron deficiency (ID) and increased in iron overload. We describe the first CLIA-validated immunoassay with excellent accuracy and precision to quantify human serum hepcidin. Its diagnostic utility for detecting ID in first-time blood donors was demonstrated. Methods A monoclonal competitive ELISA (C-ELISA) was developed for the quantitation of human hepcidin and validated according to CLIA guidelines. Sera from nonanemic first-time blood donors (n = 292) were analyzed for hepcidin, ferritin, transferrin, and serum iron. Logistic regression served to determine the utility of hepcidin as a predictor of ID. Results The C-ELISA was specific for human hepcidin and had a low limit of quantitation (4.0 ng/mL). The hepcidin concentration measured with the monoclonal C-ELISA was strongly correlated with a previously established, extensively tested polyclonal C-ELISA (Blood 2008;112:4292–7) (r = 0.95, P < 0.001). The area under the receiver operating characteristic curve for hepcidin as a predictor of ID, defined by 3 ferritin concentration thresholds, was >0.9. For predicting ID defined by ferritin <15 ng/mL, hepcidin <10 ng/mL yielded sensitivity of 93.1% and specificity of 85.5%, whereas the same hepcidin cutoff for ferritin <30 ng/mL yielded sensitivity of 67.6% and specificity of 91.7%. Conclusion The clinical measurement of serum hepcidin concentrations was shown to be a potentially useful tool for diagnosing ID.

Feline blood donation adverse reactions: classification and description of acute and delayed reactions in a donor population

2021 ◽  
pp. 1098612X2110202
Author(s):  
Tiago AM Abreu ◽  
Andreia ST Oliveira ◽  
Rui RF Ferreira ◽  
Sandrina MV Correia ◽  
Mafalda SSQ Morais ◽  
...  
Keyword(s):  
Blood Donors ◽  
Adverse Reactions ◽  
Blood Donation ◽  
Animal Blood ◽  
Veterinary Practitioner ◽  
Donor Programme ◽  
Donor Population ◽  
Delayed Reactions ◽  
Low Incidence ◽  
High Level

Objectives This article aims to analyse the safety of feline blood donation by describing the frequency and nature of any adverse reactions and their causes, as well as propose measures to decrease the incidence of adverse reactions. Methods In this prospective study, any blood donor adverse reactions detected by the clinical staff during and immediately after donation were recorded. The owners of the cats were also surveyed by a veterinary practitioner or veterinary nurse 5 days after donation, using a predefined questionnaire to assess for any clinical or behavioural changes. Data were collected between January 2019 and March 2020 from blood donors enrolled in an animal blood bank programme. Results Of 3690 blood donations from 1792 feline donors assessed, post-donation reactions were reported in 1.14% (n = 42): 0.22% (n = 8) were acute reactions, which included weakness, pallor, tachypnoea and open-mouth breathing; and 0.92% (n = 34) were delayed post-donation reactions, with 0.16% involving cutaneous (haematomas and skin rashes, n = 6), 0.68% involving behavioural (n = 25) and 0.08% involving digestive (emesis and inappetence, n = 3) signs. Conclusions and relevance The low incidence of post-donation reactions in this study is encouraging, suggesting that a well-established protocol and competent staff can help to ensure a high level of safety in a feline donor programme and, in turn, increase the confidence of cat owners.

scholarly journals Correlates of serum hepcidin levels and its association with cardiovascular disease in an elderly general population

2016 ◽  
Vol 54 (1) ◽  
Author(s):  
Raimund Pechlaner ◽  
Stefan Kiechl ◽  
Manuel Mayr ◽  
Peter Santer ◽  
Siegfried Weger ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Alcohol Intake ◽  
Carotid Atherosclerosis ◽  
Blood Parameters ◽  
Population Based ◽  
Dietary Intakes ◽  
Iron Stores ◽  
Serum Hepcidin ◽  
General Community ◽  
Incident Cardiovascular Disease

AbstractThe expression of the key iron regulatory hormone hepcidin is regulated by iron availability, inflammation, hormones, hypoxia, and anaemia. Increased serum concentrations of hepcidin have recently been linked to atherosclerosis. We studied demographic, haematologic, biochemical, and dietary correlates of serum hepcidin levels and its associations with incident cardiovascular disease and with carotid atherosclerosis.Serum hepcidin concentrations were measured by tandem mass spectrometry in samples taken in 2000 from 675 infection-free participants of the prospective population-based Bruneck study (age, mean±standard deviation, 66.0±10.2; 48.1% male). Blood parameters were measured by standard methods. Dietary intakes of iron and alcohol were surveyed with a food frequency questionnaire. Carotid atherosclerosis (365 cases) was assessed by ultrasound and subjects were observed for incident stroke, myocardial infarction, or sudden cardiac death (91 events) until 2010.Median (interquartile range) hepcidin levels were 2.27 nM (0.86, 4.15). Most hepcidin correlates were in line with hepcidin as an indicator of iron stores. Independently of ferritin, hepcidin was related directly to physical activity (p=0.024) and fibrinogen (p<0.0001), and inversely to alcohol intake (p=0.006), haemoglobin (p=0.027), and γ-glutamyltransferase (p<0.0001). Hepcidin and hepcidin-to-ferritin ratio were not associated with prevalent carotid atherosclerosis (p=0.43 and p=0.79) or with incident cardiovascular disease (p=0.62 and p=0.33).In this random sample of the general community, fibrinogen and γ-glutamyltransferase were the most significant hepcidin correlates independent of iron stores, and hepcidin was related to neither atherosclerosis nor cardiovascular disease.

Safety and persistence of orally administered human Lactobacillus sp. strains in healthy adults

2011 ◽  
Vol 2 (1) ◽  
pp. 79-90 ◽  
Author(s):  
P. Hütt ◽  
P. Kõll ◽  
J. Stsepetova ◽  
B. Alvarez ◽  
R. Mändar ◽  
...  
Keyword(s):  
Denaturing Gradient Gel Electrophoresis ◽  
Blood Parameters ◽  
Second Phase ◽  
Biotechnological Applications ◽  
Gut Health ◽  
Blood Indices ◽  
Day Range ◽  
Gradient Gel Electrophoresis ◽  
Liver And Kidney ◽  
High Doses

The aim of the study was to evaluate the safety and persistence of selected Lactobacillus strains in the gastrointestinal tract (GIT) of healthy adult volunteers after oral consumption of high doses of lactobacilli to identify potential candidates for probiotic and biotechnological applications. In the first phase of the study, nine individuals consumed capsules containing Lactobacillus gasseri 177 and E16B7, Lactobacillus acidophilus 821-3, Lactobacillus paracasei 317 and Lactobacillus fermentum 338-1-1 (each daily dose 1×1010 cfu) for 5 consecutive days. Data on gut health, blood parameters, and liver and kidney function were collected. The persistence of Lactobacillus strains was assessed by culturing combined with arbitrarily primed polymerase chain reaction (AP-PCR) and PCR-denaturing gradient gel electrophoresis (PCR-DGGE) on days 0, 5, 8, 10 and 20 from faecal samples. All strains survived gastrointestinal passage and were detected on the 5th day. L. acidophilus 821-3 was detected in four volunteers on the 8th day (4.3 to 7.0 log10 cfu/g) and in two on the 10th day (8.3 and 3.9 log10 cfu/g, respectively). In the second phase of the study, five additional volunteers consumed L. acidophilus 821-3 (daily 1×1010 cfu) for 5 consecutive days. The strain was subsequently detected in faeces of all individuals using real-time PCR on the 10th day (range 4.6-6.7; median 6.0 log10 cell/g) in both phases of the study for at least 5 days after discontinuation of consumption. The administration of high doses of different Lactobacillus strains did not result in any severe adverse effects in GIT and/or abnormal values of blood indices. Thus, the strain L. acidophilus 821-3 is a promising candidate for probiotic and biotechnological applications. Further studies will be performed to confirm the strain persistence and safety in a larger number of individuals.

scholarly journals Estimation of Serum Ferritin Levels in Blood Donors and its Association with Frequency of Blood Donation and Blood Indices

2021 ◽  
Author(s):  
Amrita S Kumar ◽  
A Geetha ◽  
Jim Joe ◽  
Arun Mathew Chacko
Keyword(s):  
Serum Ferritin ◽  
Blood Donors ◽  
Blood Donation ◽  
Iron Status ◽  
Previous History ◽  
P Value ◽  
Blood Indices ◽  
Iron Stores ◽  
Group I ◽  
History Of

Introduction: Blood donation is one of the most significant contributions that a person can make towards the society. A donor generally donates maximum 450 mL of blood at the time of donation. If 450 mL of blood is taken in a donation, men lose 242±17 mg and women lose 217±11 mg of iron. Hence, adequate iron stores are very important in maintenance of the donor’s health. Aim: To assess the influence of frequency of blood donation on iron levels of blood donors by estimating Haemoglobin (Hb) and other blood indices which reflect iron status of blood and serum ferritin which reflects body iron stores. Materials and Methods: The present study was a cross-sectional analytical study, conducted on 150 blood donors, 18-40 years of age presenting to the Blood Bank in Government Medical College, Kottayam, Kerala, India, between December 2016 to December 2017. Total of 150 donors were divided into four groups according to the number of donations per year. Group I were the first time donors with no previous history of blood donation, Group II- included those with history of donation once in the previous year, Group III- those donors with history of donation twice in the previous year and Group IV- those having history of donation thrice in the previous year. Six ml of whole blood collected from each donor, two ml was used for estimating Haemoglobin (Hb), Packed Cell Volume (PCV), Mean Corpuscular Volume (MCV), Mean Corpuscular Hb (MCH), Mean Corpuscular Haemoglobin Concentration (MCHC) in haematology analyser. Serum separated from remaining four mL of blood underwent ferritin analysis by Chemiluminescence Immunoassay (CLIA) method. Iron stores were considered normal at serum ferritin value from 23.9-336ng/mL in males and 11-307ng/mL in females. Statistical analysis was performed in Statistical Package for the Social Sciences (SPSS) version 16.0. Analysis of Variance (ANOVA) test and Pearson correlation test were used to find association between various parameters and collected data. The p-value <0.05 was considered as statistically significant. Results: There was no significant correlation between serum ferritin level and frequency of blood donation. MCH, MCHC showed significant association (p-value 0.039 and 0.007, respectively) with frequency of blood donation. Low positive correlation was seen between Hb and PCV with serum ferritin levels (r=0.381, p-value <0.001 and r=0.354, p-value <0.001, respectively). Conclusion: There is no significant association between frequency of blood donation and serum ferritin levels.

scholarly journals Comparative effect of probiotic (Saccharomyces cerevisiae), prebiotic (Fructooligosaccharide) and their combination on some blood indices in young common carp (Cyprinus carpio L.)

2016 ◽  
Vol 40 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Nasreen M. Abdulrahman
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Blood Cell ◽  
Common Carp ◽  
Red Blood Cell ◽  
Blood Parameters ◽  
Average Weight ◽  
Mean Corpuscular Hemoglobin ◽  
Corpuscular Hemoglobin ◽  
Yeast Saccharomyces Cerevisiae ◽  
Blood Indices

     This study was carried out to examine the effect of Fructooligosaccharide as a source of prebiotic, and commercial dry yeast (Saccharomyces cerevisiae) as a source of probiotic and their combination in different level as a source of synbiotic. The experiment was conducted in the fish laboratory of Animal Production Department, Faculty of Agricultural Sciences of Sulaimani University. The trials lasted for three months after 21 days of adapting period 120 common carp fingerlings with an average weight of 20 ±2 gm, were used  to test the effect of different levels of the Fructooligosaccharide, yeast and their combination. In T1 fish were fed a diet with 2.5 gm/kg Fructooligosaccharide, in T2, fish were fed a diet 2.5 gm/kg yeast, T3 represents the third treatment, in which fish were fed on a diet 5 gm/kg Fructooligosaccharide. While, in T4 fish were fed a diet 5 gm/kg yeast, and T5 2.5 Fructooligosaccharide: 2.5 Yeast (gm/kg), T6 was 5 Fructooligosaccharide: 5 yeast (gm/kg), T7 2.5 Fructooligosaccharide: 5 Yeast gm/kg), while T8 5 Fructooligosaccharide, 2.5 (gm/kg) Yeast. Each treatment in three replicates in which five fingerlings common carp were stocked in plastic tanks, which fed the experimental diets twice daily. Blood parameters of tested fish showed significant differences in Red blood cell count (1012 cells/l) in T5 and T7 by 1.235 and 1.260, respectively. Hemoglobin (g/dl) data were 117.000 in the fifth treatment. The mean corpuscular hemoglobin (pg/cell) was 121.400 in T2, 137.850 in T3, 121.050 in T4, and 135.300 in T6; mean corpuscular hemoglobin concentration (g/l) was 924.000, in the seventh treatment, mean corpuscular volume were (fL) 232.500 and 233.050 in T4 and T8 respectively. There were different effects of the treatment in the studied blood parameters in which the level of 2.5 g/kg in both Fructooligosaccharide and dry yeast affect significantly the Red blood cell, White blood cell and Hemoglobin.

Hepcidin inhibition improves iron homeostasis in ferrous sulfate and LPS treatment model in mice

Drug Research ◽  
2021 ◽  
Author(s):  
Vishal Patel ◽  
Amit Joharapurkar ◽  
Samadhan Kshirsagar ◽  
Maulik Patel ◽  
Hiren Patel ◽  
...  
Keyword(s):  
Ferrous Sulfate ◽  
Serum Iron ◽  
Iron Homeostasis ◽  
The Body ◽  
Rapid Screening ◽  
Iron Dextran ◽  
Liver Iron ◽  
Hepcidin Expression ◽  
Serum Hepcidin ◽  
Lps Treatment

Abstract Background Hepcidin, a liver-derived peptide, regulates the absorption, distribution, and circulation of iron in the body. Inflammation or iron overload stimulates hepcidin release, which causes the accumulation of iron in tissues. The inadequate levels of iron in circulation impair erythropoiesis. Inhibition of hepcidin may increase iron in circulation and improve efficient erythropoiesis. Activin-like kinase (ALK) inhibitors decrease hepcidin. Methods In this work, we have investigated an ALK inhibitor LDN193189 for its efficacy in iron homeostasis. The effect of LDN193189 treatment was assessed in C57BL6/J mice, in which hepcidin was induced by either ferrous sulfate or lipopolysaccharide (LPS) injection. Results After two hours of treatment, ferrous sulfate increased serum and liver iron, serum hepcidin, and liver hepcidin expression. On the other hand, LPS reduced serum iron in a dose-related manner after six hours of treatment. LDN193189 treatment increased serum iron, decreased spleen and liver iron, decreased serum hepcidin and liver hepcidin expression in ferrous sulfate-treated mice, and increased serum iron in LPS-induced hypoferremia. We observed that ferrous sulfate caused a significantly higher increase in liver iron, serum hepcidin, and liver hepcidin than turpentine oil or LPS in mice. Iron dextran (intraperitoneal or intravenous) increased serum iron, but LDN193189 did not show hyperferremia with iron dextran stimulus. Conclusion Ferrous sulfate-induced hyperferremia can be a valuable and rapid screening model for assessing the efficacy of hepcidin inhibitors.

Organ Donation Registration and Decision-Making Among Current Blood Donors in the Netherlands

2017 ◽  
Vol 27 (3) ◽  
pp. 266-272 ◽  
Author(s):  
Eva-Maria Merz ◽  
Katja van den Hurk ◽  
Wim L.A.M. de Kort
Keyword(s):  
The Netherlands ◽  
Organ Donation ◽  
Cultural Context ◽  
Blood Donors ◽  
Research Question ◽  
Organ Donor ◽  
Information Provision ◽  
Personal Factors ◽  
Organ Donations ◽  
Donor Population

Introduction: In the Netherlands, there is a constant shortage in donor organs, resulting in long waiting lists. The decision to register as organ donor is associated with several demographic, cultural, and personal factors. Previous research on attitudes and motivations toward blood and organ donations provided similar results. Research Question: The current study investigated demographic, cultural, and personal determinants of organ donation registration among current Dutch blood donors. Design: We used data from Donor InSight (2012; N = 20 063), a cohort study among Dutch blood donors, to test whether age, gender, religious and political preferences, donor attitude, and altruism predicted organ donor registration among current blood donors. Results: Organ donors were more often represented in the blood donor population compared to the general Dutch population. Women showed a higher propensity to be registered as organ donor. Higher education as well as higher prosocial value orientation, prosocial behavior, that is, doing volunteer work, and awareness of need significantly associated with being registered as organ donor. Religious denomination negatively predicted organ donation registration across all faiths. Discussion: Results are discussed in light of cultural context, and possible implications for improving information provision and recruitment are mentioned.

Sign in / Sign up

Export Citation Format

Share Document