scholarly journals Bidirectional intracellular transport: utility and mechanism

2011 ◽  
Vol 39 (5) ◽  
pp. 1126-1130 ◽  
Author(s):  
Amber L. Jolly ◽  
Vladimir I. Gelfand

Bidirectional transport of intracellular cargo along microtubule tracks is the subject of intense debate in the motility field. In the present review, we provide an overview of the models describing the possible mechanisms driving intracellular saltatory transport, taking into account current experimental results that may at first seem contradictory. We examine the phenomenon of saltatory motion, in an attempt to interpret the mechanistic debate in terms of the utility of saltatory motion.

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6999
Author(s):  
Daniele Malpicci ◽  
Elena Lucenti ◽  
Clelia Giannini ◽  
Alessandra Forni ◽  
Chiara Botta ◽  
...  

Anti-Kasha behavior has been the subject of intense debate in the last few years, as demonstrated by the high number of papers appearing in the literature on this topic, dealing with both mechanistic and applicative aspects of this phenomenon. Examples of anomalous emitters reported in the last 10 years are collected in the present review, which is focused on strictly anti-Kasha organic molecules displaying radiative deactivation from Sn and/or Tn, with n greater than 1.


Author(s):  
Thomas A. Whittle ◽  
Christopher J. Howard ◽  
Siegbert Schmid

The room-temperature structure of the filled tetragonal tungsten bronze, Ba2NaNb5O15 (BNN), has been the subject of a number of studies, and these studies have given an almost corresponding number of different results. From a group theoretical examination of the different possibilities and a review of the published experimental results we conclude that the room-temperature structure is that proposed by Labbé et al. [J. Phys. Condens. Matter (1989), 2, 25–43] in the space group Bbm2 (Ama2 in standard setting) on a 2\sqrt{2}a × \sqrt{2}a × 2c cell. Upon heating, the structure remains ferroelectric but becomes tetragonal (space group P4bm) at 550 K, then paraelectric (space group P4/mbm) at and above 860 K.


Development ◽  
1963 ◽  
Vol 11 (4) ◽  
pp. 683-688
Author(s):  
F. Peetoom ◽  
W. J. A. TH. Kraijenhoff Sloot ◽  
M. W. Woerdeman

The use of specific antisera against different embryonic antigens to detect a correlation between morphological and immunochemical differentiation in ontogenesis has proved to be a valuable technique. In a study of the appearance of lens proteins in chick embryos, using various antisera and agar precipitation methods, we observed the development of precipitation lines which did not correspond to specific lens proteins. These lines were encountered in the Ouchterlony and immunoelectrophoretic pictures obtained with young (up to 120 hr.) embryo or lens extracts when these were tested with antiserum to 24-hr, embryo extract or to adult chick serum. However, this type of precipitation band was never found when antiserum against adult chick lens was used. Some of our experimental results which clarify the nature of these precipitation reactions are summarized below. Full details of these experiments are the subject of another publication.


1896 ◽  
Vol 42 (176) ◽  
pp. 85-102
Author(s):  
A. Wood Renton ◽  
D. Yellowlees

Mr. Wood Renton.Viewed from the Legal Standpoint.Within the last two years no less than three Parliamentary Reports, dealing with the problems presented by the familiar phenomena of inebriety and recidivism, have been published,∗ and a measure † designed, and, to a large extent, calculated to carry the main recommendations embodied in these documents into effect, has been read a second time in the House of Lords, under the pilotage of the then head of English legal administration. These facts show that public opinion has at length been thoroughly aroused as to the necessity for fresh legislation on the subject of habitual drunkenness and crime, and render any preliminary historical sketch of the growth of the movement, which is apparently at last on the eve of attaining its objects, superfluous. If there is any member of the medical or legal profession who is still in ignorance of the process by which the problems in question have been brought to the stage of perfect ripeness for legislative solution, he may be referred with confidence to an admirable summary of the Parliamentary history of legislation affecting inebriates by Mr. Legge, the Secretary to the Inebriates Committee, 1891, which forms the 6th appendix to the minutes of evidence taken by that body, and is reproduced, with some additions and alterations, as Appendix M in the evidence taken by the Scottish Committee of 1894, and to the three Parliamentary Reports which have suggested the present review (see note, sup.).


Author(s):  
Jeremiah Mutuku Muneeni

There has been an intense debate with regards to Chinua Achebe’s (mis)representation of women in his creative works, especially his first four novels. Some scholars have argued that Achebe is a patriarchal writer who has relegated women to the periphery. Nevertheless, a few have read subtle nuances of gender balance in his works. This paper is a continuation of this debate. Specifically, it argues that Achebe has created Mother Archetypes in his novels and if the same is not recognized, he will continue to be demonized as a gender insensitive writer. The unit of analysis is three of the five Achebe’s novels namely: Things Fall Apart, No Longer at Ease, and A Man of the People. The paper interrogates the aforementioned novels within the framework of archetypal criticism, with the aim of unearthing and examining Mother Archetypes inherent in them. The paper identifies religion, education, and justice as the spheres of life in which Achebe has created, empowered and elevated Mother Archetypes to be at par with their male counterparts. However, owing to the breadth of the subject, the paper dwells on education. The paper concludes that creation of empowered Mother Archetypes in Achebe’s novels is a symbolic relay in which women characters hand in the symbolic empowerment baton to the next woman in the next novel until the last one where the creation of a woman major character, Beatrice, wins the race against male dominance.


Author(s):  
Marina Minussi Franco

Este artigo trata de descrever os processos de formação profissional de educa-dores sociais no âmbito da educação universitária na Comunidade Autônomada Catalunha, na Espanha. Nos últimos anos, devido ao surgimento de novasformas de exclusão social, ao aumento das desigualdades e à crescente globali-zação, verifica-se um aprofundamento do debate sobre a profissão do educadorsocial, suas competências e funções e, ao mesmo tempo, sobre a necessidade derepensar sua formação. Este trabalho faz parte de um projeto mais amplo sobreo assunto e apresenta uma revisão bibliográfica baseada no contexto acadêmicoespanhol, com uma descrição das propostas formativas dos cursos de graduaçãode Educação Social de duas universidades catalãs de importante reconhecimentointernacional: Universidade de Barcelona e Universidade Autônoma de Barce-lona. Os resultados evidenciam a necessidade de uma maior aproximação entreo processo formativo que os educadores recebem no âmbito universitário e asnecessidades reais presentes nas instituições socioeducativas.Palavras-chave: Educação social. Educador social. Formação profissional.Competências.ResumenEste artículo trata de describir dos procesos de formación profesional de educa-dores sociales en el ámbito de la educación universitaria en la Comunidad Autó-noma de Cataluña, España. En los últimos años, a consecuencia del surgimientode nuevas formas de exclusión social, del aumento de las desigualdades y de lacreciente globalización, se verifica una intensificación del debate sobre la profe-sión del educador social, sus competencias, sus funciones y a la vez sobre la ne-cesidad de repensar su formación. Este trabajo forma parte de un proyecto másamplio acerca del tema y presenta una revisión bibliográfica basada en el contex-to académico español, al lado de una descripción de las propuestas formativas delas carreras de Educación Social de dos universidades catalanas de importante re-conocimiento internacional: Universidad de Barcelona y Universidad Autónomade Barcelona. Los resultados evidencian la importancia de la aproximación entreel proceso formativo que los educadores reciben en el ámbito universitario y lasnecesidades reales presentes en las instituciones socioeducativas.Palabras clave: Educación social. Educador social. Formación profesional.Competencias.AbstractThis article looks at the courses offered at two higher-education institutions fortraining social educators in the autonomous region of Catalonia, Spain. In recentyears, due to new forms of social exclusion, the escalation of inequality andincreasing globalization, there is a more intense debate on the profession of thesocial educator, their competences, roles and, at the same time, on the need torethink their training. This work is part of a larger project on the subject and pre-sents a bibliographical review based on the Spanish academic context, along witha description of the training proposals of the Social Education careers withintwo Catalan universities: University of Barcelona and Autonomous University ofBarcelona. The results show the importance of combining the training processoffered to social educators in the university context with the real needs of thesocio-educational institutions where they will practice their profession.Keywords: Social education. Social educator. Professional training. Competencies.


Author(s):  
Alvaro Clua

Over the last two decades the Slussen in Stockholm designed by Tage William-Olsson in 1935 has been the subject of an intense debate about how to update it to the contemporary needs. Tabula rasa, reconstruction or renovation? This lively discussion, however, has resulted in a final proposal granted by the expertise of an international firm but controversial for its political management, opposed to several social groups and, above all, highly problematic in terms of urban form and sustainability. The strategic location of this place, the indelible presence of its modern shape in the collective imaginary or the overwhelming force of the new paradigms of public space, have ended up provoking a range of more than twenty-five proposals in a short period of time. But while today this process seems to be settled and the demolition works of the original structure has already started, it would be still useful to draw some conclusions relevant to other similar interstitial sites in European compact cities where architecture, infrastructure, public space and landscape meet in such an intense way. Thus, this paper summarizes some of the last arguments of the on-going doctoral thesis about the recent evolution of Slussen according to four different outstanding topics: the form of place and history as an undeniable premise; the strength of tactics versus the power of the image in the process; the importance of time in the sequence of urban decision-making and, finally, the weight of urban culture as a key argument in contemporary urban transformation processes.


2010 ◽  
Vol 63 (2) ◽  
Author(s):  
Aria Adli

AbstractThis work presents experimental results on the position of the subject in


The aim of wound excision is to remove contaminating debris and all devitalised tissue. This should reduce both the bacterial burden and available substrate for microbial colonisation, resulting in fewer deep surgical site infections. In turn, this will lead to improved patient outcomes. The timing of wound excision has been the subject of intense debate. In the past, guidelines have favoured wound excision within 6 hours based on historical animal and human studies. Current data suggest that timing of wound debridement should be determined by the degree of contamination and severity of injury.


Author(s):  
Naohisa Hashimoto ◽  
Simon Thompson ◽  
Shin Kato ◽  
Ali Boyali ◽  
Sadayuki Tsugawa

This study investigated the necessity of automated vehicle control customization for individual drivers via a lane-changing experiment involving 35 subjects and an automated minivan. The experiment consisted of two automated driving conditions: one in which the subject was unable to override vehicle controls, the other with the option to override when the subject felt it was necessary. The automated vehicle drove at a speed of 40 km/h along three kinds of planned paths for lane changing, generated by Bezier curves; the distance required for lane changing was varied to obtain the preferred path of each subject. Various data obtained during driving, including vehicle trajectories and steering angles produced by subjects were logged. After automated driving, a questionnaire was administered to each subject. The experimental data showed that there was a statistically significant difference between comfort when the vehicle drove along the subject’s preferred path, and when it drove along other paths. The results of the questionnaire indicated that 46% of the subjects preferred the planned path that most closely resembled their own. In addition, quantitative analysis of driving data found that approximately 69% of the subjects preferred an automated driving control that resembled their own. However, it was also observed that certain subjects were open to multiple types of automated vehicle control. The experimental results indicate that drivers will not necessarily accept a single type of automated vehicle control, therefore customization will be necessary to improve acceptance of automated driving.


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