Circulating concentrations of C-reactive protein and total sialic acid in tobacco smokers remain unchanged following one year of validated smoking cessation

ABSTRACT Background: This study was undertaken to evaluate and establish the role of total sialic acid (TSA) and highly sensitive C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) and its correlation with complications such as diabetic nephropathy. Materials and Methods: One hundred fifty-seven patients with T2DM with nephropathy (DN) and 162 patients of T2DM without nephropathy (DM) along with 165 unrelated age and sex-matched healthy controls were included in the study. Serum glucose (fasting and postprandial) levels, renal profile, and lipid profile were done as per standard protocol. Serum TSA test levels and hs-CRP level were evaluated using thiobarbituric acid assay and immunoturbidimetric method respectively. Results: We observed a higher concentration of serum TSA (82.67 ± 6.63 mg/dl) and hs-CRP (3.2 ± 1.44 mg/L) in diabetic nephropathy than the diabetes mellitus group (73.83 ± 6.90 mg/dl and 2.07 ± 1.32 mg/L, respectively). Both TSA and hs-CRP levels were found significantly correlated with fasting and postprandial blood sugar, hemoglobin A1c, and urine microalbumin levels in both DM and DN groups. Multinomial logistic regression analysis showed that both TSA and hs-CRP was independently associated with diabetic nephropathy. Conclusion: High serum TSA and hs-CRP levels may increase the microangiopathic (diabetic nephropathy) complications of T2DM.

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Comparison of serum total sialic acid, C-reactive protein, α1-acid glycoprotein and β2-microglobulin in patients with non-malignant bowel diseases

Biomedicine & Pharmacotherapy ◽

10.1016/0753-3322(96)82632-1 ◽

1995 ◽

Vol 49 (5) ◽

pp. 259-262 ◽

Cited By ~ 10

Author(s):

G Ricci ◽

AD' Ambrosi ◽

D Resca ◽

M Masotti ◽

V Alvisi

Keyword(s):

Sialic Acid ◽

C Reactive Protein ◽

Acid Glycoprotein ◽

Β2 Microglobulin ◽

Reactive Protein ◽

Total Sialic Acid ◽

Bowel Diseases

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Serum Total Sialic Acid and Lipid-Associated Sialic Acid in Normal Individuals and Patients with Myocardial Infarction, and Their Relationship to Acute Phase Proteins

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/000456329303000406 ◽

1993 ◽

Vol 30 (4) ◽

pp. 383-386 ◽

Cited By ~ 40

Author(s):

M Haq ◽

S Haq ◽

P Tutt ◽

M Crook

Keyword(s):

Myocardial Infarction ◽

Sialic Acid ◽

Acute Phase ◽

Acute Phase Proteins ◽

C Reactive Protein ◽

Acid Glycoprotein ◽

Reactive Protein ◽

Total Sialic Acid ◽

Normal Individuals ◽

The Mean

Serum total sialic acid (TSA) has gained medical interest, particularly as a cardiovascular risk factor and it has been hypothesized that serum levels relate to serum acute phase proteins, some of which are sialylated. We assayed serum TSA and also lipid associated sialic acid (LASA) in SO normal individuals (24 male) and IS subjects (12 male) who had experienced a myocardial infarct. The mean serum TSA in the normal individuals was 2·05 SD 0·38 mmol/L (range 1·16–2·74) and the mean serum LASA was 0.70 SD 0·19 mmol/L (range 0·23–1·03). We also measured five serum acute phase proteins and found a good correlation between these and serum TSA: C-reactive protein, r = 0.52, P<0.001, α-1-antichymotrypsin, r=0·79, P<0·0001, α-2-macroglobulin, r=0·38, P<0·01 and α-1-acid glycoprotein, r=0·32, P<0·05. A significant correlation between plasma TSA and plasma C-reactive protein ( r = 0·47, P<0·04) and also Fibrinogen ( r=0·53, P<0·04) was noted on day one following the myocardial infarction, whereas a significant correlation between plasma TSA and plasma α-1-antichymotrypsin ( r=0·51, P<0·03) and also plasma α-1-acid glycoprotein ( r=0·64, P<0·05) was found on day two following the infarction. Thus it would seem that serum TSA is at least in part related to some of the acute phase proteins in both healthy individuals and those having had a myocardial infarction.

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Serum Sialic Acid and Acute-Phase Proteins in Hypertriglyceridaemic Patients Showing the Frederickson's Type IIB Phenotype

Clinical Science ◽

10.1042/cs0850219 ◽

1993 ◽

Vol 85 (2) ◽

pp. 219-222 ◽

Cited By ~ 8

Author(s):

S. Haq ◽

P. Tutt ◽

M. Haq ◽

M. Crook

Keyword(s):

Sialic Acid ◽

Acute Phase Proteins ◽

Correlation Coefficients ◽

Normal Subjects ◽

Spearman Correlation ◽

C Reactive Protein ◽

Acid Glycoprotein ◽

Reactive Protein ◽

Total Sialic Acid ◽

Α2 Macroglobulin

1. We have shown that serum total sialic acid is elevated in hypertriglyceridaemic patients showing the Frederickson's type IIB phenotype in comparison with normal subjects (2.30 ±0.34 versus 1.92 ± 0.32 mmol/l, P <0.02). Lipid-associated sialic acid was also elevated in the hypertriglyceridaemic group in comparison with the normal subjects (0.60 ±0.09 versus 0.35 ±0.04 mmol/l, P <0.001). 2. We measured five serum acute-phase proteins in the hypertriglyceridaemic patients and the normal subjects, namely α1-antichymotrypsin, α1-acid glycoprotein, α2-macroglobulin, C-reactive protein and haptoglobin. Serum α2-macroglobulin was significantly elevated in the hypertriglyceridaemic patients compared with the normal subjects (2.1 ±1.0 versus 1.5 ± 0.55 g/l, P <0.05) as was serum C-reactive protein (5.9 ±3.5 versus 3.5±1.9mg/l, P <0.05). There were, however, no significant differences in the serum concentrations of α1-antichymotrypsin, α1-acid glycoprotein or haptoglobin between the two groups. 3. There was a significant correlation between serum total sialic acid and serum α1-antichymotrypsin, α1-acid glycoprotein and haptoglobin (Spearman correlation coefficients 0.74, 0.50 and 0.76, respectively) in the normal subjects, and there was a significant correlation between serum total sialic acid and serum α1-antichymotrypsin and α1-acid glycoprotein (Spearman correlation coefficients 0.72 and 0.84, respectively) in the hypertriglyceridaemic patients.

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The repeatability of interleukin-6, tumor necrosis factor-α, and C-reactive protein in COPD patients over one year

International Journal of Chronic Obstructive Pulmonary Disease ◽

10.2147/copd.s5018 ◽

2009 ◽

pp. 149 ◽

Cited By ~ 25

Author(s):

U Kolsum

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis Factor Alpha ◽

Tumor Necrosis ◽

C Reactive Protein ◽

Necrosis Factor Alpha ◽

Reactive Protein ◽

Copd Patients ◽

Factor Alpha ◽

One Year ◽

Necrosis Factor

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Usefulness of Early C-Reactive Protein Kinetics in Response and Prognostic Assessment in Infected Critically Ill Patients: An Observational Retrospective Study

Acta Médica Portuguesa ◽

10.20344/amp.12143 ◽

2019 ◽

Vol 32 (12) ◽

pp. 737

Author(s):

Marta Ayres Pereira ◽

Ana Lídia Rouxinol-Dias ◽

Tatiana Vieira ◽

José Artur Paiva

Keyword(s):

Intensive Care Unit ◽

Intensive Care ◽

Antibiotic Therapy ◽

Critically Ill ◽

Fast Response ◽

C Reactive Protein ◽

Protein Kinetics ◽

Reactive Protein ◽

Prognostic Assessment ◽

One Year

Introduction: The ideal biomarker to assess response and prognostic assessment in the infected critically ill patient is still not available. The aims of our study were to analyze the association between early C-reactive protein kinetics and duration and appropriateness of antibiotic therapy and its usefulness in predicting mortality in infected critically ill patients.Material and Methods: We have carried out an observational retrospective study in a cohort of 60 patients with community-acquired pneumonia, aspiration pneumonia and bacteremia at an intensive care unit. We have collected C-reactive protein consecutive serum levels for eight days as well as duration and appropriateness of initial antibiotic therapy. C-reactive protein kinetic groups were defined based on the levels at days 0, 4 and 7. With a follow-up of one year, we have evaluated mortality at different time-points.Results: We have obtained three different C-reactive protein kinetic groups from the sample: fast response, delayed but fast response and delayed and slow response. We did not find statistically significant associations between C-reactive protein kinetics and early (intensive care unit, hospital and 28-days) or late (six months and one year) mortality and antibiotic therapy duration (p > 0.05). Although there were no statistically significant differences between the appropriateness of antibiotic therapy and the defined groups (p = 0.265), no patient with inappropriate antibiotic therapy presented a fast response pattern.Discussion: Several studies suggest the importance of this protein in infection.Conclusion: Early C-reactive protein kinetics is not associated with response and prognostic assessment in infected critically ill patients. Nevertheless, a fast response pattern tends to exclude initial inappropriate antibiotic therapy.

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