scholarly journals Role of herbs for elevating immunity against SARS-CoV-2: a concise review

2021 ◽  
Vol 40 (2) ◽  
pp. 176-188
Author(s):  
Aashima Anand ◽  
Juhi Saraswat ◽  
Rajan Patel
Keyword(s):  
The Novel ◽  
Traditional Medicines ◽  
Beneficial Effects ◽  
Synthetic Drugs ◽  
Concise Review ◽  
Number Of Patients ◽  
Novel Coronavirus ◽  
Health Experts ◽  
Better Than

COVID-19 has emerged as a dreadful pandemic caused by the virus SARS-CoV-2. Though the number of patients recovering from infection is encouraging, sturdy cure is still being researched upon and the effective vaccines are yet to be rigidly resolute. COVID-19 has so far instigated a massive loss of lives globally and even the countries with the most advanced healthcare systems have come under its grasp. Health experts suggest in such case “Prevention is better than cure” which includes an appropriate daily lifestyle and a rugged immune system that could help mankind surmount this peril. This review highlights the importance of influential herbs and their medicinal significance. Biomedical articles were explored from PubMed, Google Scholar, Web of Science for the period of 2010-2021. Guidelines from the Ministry of Ayush (India) were also considered. The Ayurveda does not mention any cure for the novel coronavirus; however, it emphasizes the means of boosting one’s immunity. Accordingly, this article highlights some of the role of prevalent Ayurvedic herbs in promoting immunity for combating the novel coronavirus. The herbs in combination with drugs could be utilized for the sake of curtailing the side effects as well as the malefic repercussions of strong synthetic drugs used for treating COVID-19 patients, which would be a paramount leap in the field of Ayurveda as well as western-style medicine. However, the beneficial effects of these traditional medicines and their clinical trials remained to be known. We reviewed the latest updates on traditional medicines proposed for promoting immunity towards COVID-19.

scholarly journals Role of nutrients regulation in the immune system in preventing COVID-19 infection: A brief review

2021 ◽  
Vol 13 (2) ◽  
pp. 760-765
Author(s):  
Anamika Chauhan
Keyword(s):  
Immune System ◽  
Age Groups ◽  
World Health ◽  
The Novel ◽  
Beneficial Effects ◽  
Coronavirus Infection ◽  
The Common ◽  
Novel Coronavirus ◽  
Health Organization

This review aimed to focus on using foods to boost immunity against COVID-19 in all age groups. In human, coronavirus causes the common cold, severe acute respiratory syndrome (SARS), and a major threat to public health. The novel coronavirus was declared a pandemic by the World Health Organization due to its rapid infectivity. COVID-19 infection is most probably reported in people with low immunity response. The nutrients, which show beneficial effects on the immune system, are called immune nutrients and diet is called immune diet. A healthy diet can reduce the risk of infection of COVID-19 and can prevent disease. Nutritional food intake is also necessary for people with chronic illness, obese persons, diabetes, cardiovascular disease, cognitive dysfunction like anxiety and depression. All nutrients are essential for maintaining immunity and providing appropriate amounts of protein, fat, carbohydrate, vitamins, and minerals for the surveillance mode of keeping us from getting sick. The use of plenty of water, minerals such as micronutrients, zinc, copper, selenium, iron, magnesium, food rich in vitamins, and a good lifestyle can promote health and overwhelm this coronavirus infection.

Role of Ashwagandha (Withania Somnifera) as Immunomodulator in Coronavirus in a pandemic – A systemic review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 1649-1654
Author(s):  
Shweta Dadarao Parwe ◽  
Milind Abhimanyu Nisargandha ◽  
Dipak Tryambak Morey
Keyword(s):  
Withania Somnifera ◽  
Systemic Review ◽  
Immunomodulatory Activity ◽  
Clinical Validation ◽  
The Novel ◽  
Defence Mechanism ◽  
Immunomodulatory Action ◽  
Novel Coronavirus ◽  
Better Than

The novel coronavirus has been transmitted all over the world. Many deaths were occurred due to Coronavirus. The main symptoms are pyrexia, fatigue, and dry cough. Some individual also develops a headache, running nose, congestion, sore throat, shortness of breath. At present, no vaccines or medicines available for the prevention and management of Coronavirus disease. Prevention is better than cure. This verse is famous and all known about it. So now the time has come to used or implement this. Prevention is the only measure to fight against Coronavirus. Ayurveda can offer the best option having preventive as well as curative measures. Many herbs have been mentioned in the Ayurvedic texts, which have immunomodulatory action or works as immunobusting drugs. Ashwagandha is well-known or a far old drug which said in Ayurvedic text as a Rasayan and Immunomodulatory activity. Ashwagandha can be used for the prevention of Coronavirus due to it has property like promoting betterment for health and longevity by an increase defence mechanism. Many kinds of research are conducted on Ashwagandha to prove its immunomodulatory, antioxidant, anti-inflammatory, Neuroprotective. Anti-stress properties. We concluded, in Systemic review to know the role of Ashwagandha in the prevention and curing symptoms of Coronavirus its efficacy and mechanism in Coronavirus. Some more research studies should be on COVID -19 for experimental and clinical validation to needed. 

scholarly journals Cardiac Involvement in COVID-19

Kardiologiia ◽  
2021 ◽  
Vol 61 (4) ◽  
pp. 15-23
Author(s):  
A. B. Sugraliyev
Keyword(s):  
Viral Entry ◽  
Cardiac Involvement ◽  
Viral Disease ◽  
The Novel ◽  
Angiotensin Converting Enzyme 2 ◽  
Number Of Patients ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Inflammatory Syndrome

The novel coronavirus infection, COVID-19, is a highly contagious viral disease associated with acute, severe respiratory syndrome, which is based on the development of pronounced thrombo-inflammatory syndrome. As the number of patients with COVID-19 increased, heart damage has been reported, especially in patients with severe and critical COVID-19. This review describes the role of angiotensin-converting enzyme 2 receptor in the regulation of viral entry, the variety of damages to the heart and coronary arteries, and the importance of arterial hypertension and of the use of renin-angiotensin-aldosterone system inhibitors in the prognosis of patients with COVID-19.

SARS-COV2 virus and Coronavirus disease (COVID-19)

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 977-982
Author(s):  
Mohamed J. Saadh ◽  
Bashar Haj Rashid M ◽  
Roa’a Matar ◽  
Sajeda Riyad Aldibs ◽  
Hala Sbaih ◽  
...  
Keyword(s):  
Close Contact ◽  
Antiviral Agents ◽  
Health Concern ◽  
The Novel ◽  
Global Public Health ◽  
Fatal Disease ◽  
Mild Disease ◽  
Life Threatening ◽  
Novel Coronavirus

SARS-COV2 virus causes Coronavirus disease (COVID-19) and represents the causative agent of a potentially fatal disease that is of great global public health concern. The novel coronavirus (2019) was discovered in 2019 in Wuhan, the market of the wet animal, China with viral pneumonia cases and is life-threatening. Today, WHO announces COVID-19 outbreak as a pandemic. COVID-19 is likely to be zoonotic. It is transmitted from bats as intermediary animals to human. Also, the virus is transmitted from human to human who is in close contact with others. The computerized tomographic chest scan is usually abnormal even in those with no symptoms or mild disease. Treatment is nearly supportive; the role of antiviral agents is yet to be established. The SARS-COV2 virus spreads faster than its two ancestors, the SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), but has lower fatality. In this article, we aimed to summarize the transmission, symptoms, pathogenesis, diagnosis, treatment, and vaccine to control the spread of this fatal disease.

The role and relationship of mindreading and social attunement in HRI – position statements of interdisciplinary researchers. Workshop HRI'20

2020 ◽  
Author(s):  
Agnieszka Wykowska ◽  
Jairo Pérez-Osorio ◽  
Stefan Kopp
Keyword(s):  
Mental States ◽  
Human Robot Interaction ◽  
Human Interaction ◽  
Artificial Agents ◽  
The Novel ◽  
Robot Interaction ◽  
Novel Coronavirus ◽  
Relationship Of ◽  
The Relationship

This booklet is a collection of the position statements accepted for the HRI’20 conference workshop “Social Cognition for HRI: Exploring the relationship between mindreading and social attunement in human-robot interaction” (Wykowska, Perez-Osorio & Kopp, 2020). Unfortunately, due to the rapid unfolding of the novel coronavirus at the beginning of the present year, the conference and consequently our workshop, were canceled. On the light of these events, we decided to put together the positions statements accepted for the workshop. The contributions collected in these pages highlight the role of attribution of mental states to artificial agents in human-robot interaction, and precisely the quality and presence of social attunement mechanisms that are known to make human interaction smooth, efficient, and robust. These papers also accentuate the importance of the multidisciplinary approach to advance the understanding of the factors and the consequences of social interactions with artificial agents.

Synthetic and semi-synthetic drugs as promising therapeutic option for the treatment of COVID-19

2020 ◽  
Vol 20 ◽  
Author(s):  
Ekta Shirbhate ◽  
Preeti Patel ◽  
Vijay K Patel ◽  
Ravichandran Veerasamy ◽  
Prabodh C Sharma ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Antiviral Treatment ◽  
The Novel ◽  
Clinical Experiences ◽  
Synthetic Compounds ◽  
Synthetic Drugs ◽  
Global Pandemic ◽  
The World ◽  
Novel Coronavirus

: The novel coronavirus disease-19 (COVID-19), a global pandemic that emerged from Wuhan, China has today travelled all around the world, so far 216 countries or territories with 21,732,472 people infected and 770,866 deaths globally (as per WHO COVID-19 update dated August 18, 2020). Continuous efforts are being made to repurpose the existing drugs and develop vaccines for combating this infection. Despite, to date, no certified antiviral treatment or vaccine prevails. Although, few candidates have displayed their efficacy in in vitro studies and are being repurposed for COVID-19 treatment. This article summarizes synthetic and semi-synthetic compounds displaying potent activity in their clinical experiences or studies against COVID-19 and also focuses on mode of action of drugs being repositioned against COVID-19.

scholarly journals Investigation of the genetic variation in ACE2 on the structural recognition by the novel coronavirus (SARS-CoV-2)

2020 ◽  
Author(s):  
Xingyi Guo ◽  
Zhishan Chen ◽  
Yumin Xia ◽  
Weiqiang Lin ◽  
Hongzhi Li
Keyword(s):  
Genetic Variation ◽  
The Novel ◽  
S Protein ◽  
Angiotensin Converting Enzyme 2 ◽  
Missense Variants ◽  
Catalytic Metal ◽  
Using Data ◽  
Novel Coronavirus ◽  
Insight Into

Abstract Background: The outbreak of coronavirus disease (COVID-19) was caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), through its surface spike glycoprotein (S-protein) recognition on the receptor Angiotensin-converting enzyme 2 (ACE2) in humans. However, it remains unclear how genetic variations in ACE2 may affect its function and structure, and consequently alter the recognition by SARS-CoV-2. Methods: We have systemically characterized missense variants in the gene ACE2 using data from the Genome Aggregation Database (gnomAD; N = 141,456). To investigate the putative deleterious role of missense variants, six existing functional prediction tools were applied to evaluate their impact. We further analyzed the structural flexibility of ACE2 and its protein-protein interface with the S-protein of SARS-CoV-2 using our developed Legion Interfaces Analysis (LiAn) program.Results: Here, we characterized a total of 12 ACE2 putative deleterious missense variants. Of those 12 variants, we further showed that p.His378Arg could directly weaken the binding of catalytic metal atom to decrease ACE2 activity and p.Ser19Pro could distort the most important helix to the S-protein. Another seven missense variants may affect secondary structures (i.e. p.Gly211Arg; p.Asp206Gly; p.Arg219Cys; p.Arg219His, p.Lys341Arg, p.Ile468Val, and p.Ser547Cys), whereas p.Ile468Val with AF = 0.01 is only present in Asian.Conclusions: We provide strong evidence of putative deleterious missense variants in ACE2 that are present in specific populations, which could disrupt the function and structure of ACE2. These findings provide novel insight into the genetic variation in ACE2 which may affect the SARS-CoV-2 recognition and infection, and COVID-19 susceptibility and treatment.

scholarly journals The clinical characteristics and treatment approaches of COVID-19: a concise review

2021 ◽  
Author(s):  
Sajjad Eslamkhah ◽  
Nazila Alizadeh ◽  
Khalil Hajiasgharzadeh ◽  
Masoud Eslamkhah ◽  
Ahad Mokhtarzadeh ◽  
...  
Keyword(s):  
Disease Transmission ◽  
Web Of Science ◽  
Close Contact ◽  
Review Article ◽  
Main Concern ◽  
The Novel ◽  
Concise Review ◽  
Potential Benefits ◽  
Characteristic Features ◽  
Novel Coronavirus

A series of cases of pneumonia occurred in China in late 2019. For this type of coronavirus, the WHO formally identified the condition as a coronavirus disease 2019 (COVID-19). They announced that this disease is the recent main concern of health problems in the world. Transfer of this novel coronavirus (nCoV) from human to human exists predominantly among family members, who have close contact with each other. This review article is provided based on the recent findings of COVID-19, which were retrieved by searching PubMed, Google Scholar, Scopus, and Web of Science until December 2020. Here, we highlighted the coronaviruses types, COVID-19 symptoms, epidemiology of the disease, transmission ways, and nCoV related pneumonia pathogenesis and continue with characteristic features and treatment methods. While no approved treatments are available for this type of infection therapy but several drugs may have potential benefits. It seems that identifying the detailed characteristics of the novel coronavirus disease offers the foundation for further research into the production of effective anti-COVID-19 drugs and vaccines.

scholarly journals The impact of COVID-19 pandemic on the treatment of acute appendicitis in China

2021 ◽  
Author(s):  
ZhiXue Zheng ◽  
Jing Tao Bi ◽  
Ya Qi Liu ◽  
Xuan Cai
Keyword(s):  
Acute Appendicitis ◽  
White Blood Cells ◽  
Onset Time ◽  
The Novel ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Number Of Patients ◽  
Hospital Visits ◽  
Novel Coronavirus ◽  
The Impact

Abstract Objective This research aims to analyze the impact of the novel coronavirus pandemic on the hospital visits of patients with acute appendicitis. Methods The retrospective analysis was designed to look at the treatment of acute appendicitis in the Department of General Surgery in Beijing Jishuitan Hospital before and during the COVID-19 pandemic (2019–2020). Data was analyzed by the numbers of patients, sex, age, onset time, fever or not, laboratory examination, imaging test, and treatment. And we analyzed the differences between the “pre-COVID group” and “during-COVID group”. Results Compared with the year 2019, the number of acute appendicitis patients has diminished substantially during the COVID-19 pandemic (2020), but the number elevated with the control of the pandemic. Even if we did not find the differences of the treatment before and during the pandemic (P = 0.932), the onset time to emergency was significantly longer (P < 0.001), and more patients had showed fever (P < 0.001) during the COVID-19 pandemic. And the total number of white blood cells and C reactive protein level were significantly higher in 2020 than those in 2019 (P = 0.006, 0.003). And the same result was found in patients with appendiceal fecalith (P = 0.047). Conclusion During the pandemic of the new coronavirus pneumonia, the number of patients with acute appendix treatment dropped significantly, mainly because it took longer than before, and the condition was more severe. It can be seen that the new coronary pneumonia has a great impact on the patients’ medical treatment behavior, and the active prevention and treatment of the new coronavirus pneumonia is currently an important and urgent issue.

scholarly journals The Upsurge and Impact of COVID 19 in India: Health Issues and Remedial Measures

2021 ◽  
pp. 28-34
Author(s):  
Kanchi Isswani
Keyword(s):  
Sudden Increase ◽  
The Novel ◽  
Health Issues ◽  
Public Places ◽  
Frontline Workers ◽  
Time Period ◽  
Essential Services ◽  
Novel Coronavirus ◽  
Major Decision ◽  
Better Than

The novel Coronavirus was something that nobody was prepared for. It was that part of the syllabus which was always neglected. The contagious disease which started in the Wuhan region of China had started to settle in various parts of the World. The outbreak of this disease has reached such a huge number that all the countries witnessed lockdown in some form or the other. Some people have witnessed destruction of mankind while some have even leisured this time to their fullest but as it has been always said “Prevention is better than cure”. Prevention of covid 19 in all the nations was one of the major steps which was taken in the year 2020. In India it all started in the year of 2019 December when the first ever case of covid 19 was reported in the state of Kerala followed by Rajasthan, Maharashtra and Delhi. Following such a situation and then sudden increase in the no of cases all over the country a major decision was taken that was of Complete lockdown excluding the emergency and essential services. Before taking the step of lockdown, as a gesture of respect to the frontline workers, government of India announced Tali Bajao movement. In the period of lockdown Certain norms were even made mandatory that were wearing a mask, maintenance of hand sanitation and following social distancing of 1.5 meters in public places. All the educational institutes and teachings were even suspended during the time period of lockdown as it could have become a hub for the virus to spread. With time, the restrictions which were laid down in lockdown were started to be reduced in the phase wise manner and finally India noticed its very first Unlock period. In all this scenario mankind has dealt with various situations and have emerged to be a better person. All these steps were crucial to control the spread of Novel Coronavirus and prevention from the already spread cases.

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