scholarly journals Universal bolometric corrections for active galactic nuclei over seven luminosity decades

2020 ◽  
Vol 636 ◽  
pp. A73 ◽  
Author(s):  
F. Duras ◽  
A. Bongiorno ◽  
F. Ricci ◽  
E. Piconcelli ◽  
F. Shankar ◽  
...  
Keyword(s):  
Galactic Nuclei ◽  
Bolometric Luminosity ◽  
Luminosity Functions ◽  
Wide Range ◽  
Order Of Magnitude ◽  
Independent Variable ◽  
Bolometric Correction ◽  
First Time

Context. The AGN bolometric correction is a key element for understanding black hole (BH) demographics and computing accurate BH accretion histories from AGN luminosities. However, current estimates still differ from each other by up to a factor of two to three, and rely on extrapolations at the lowest and highest luminosities. Aims. Here we revisit this fundamental question by presenting general hard X-ray (KX) and optical (KO) bolometric corrections, computed by combining several AGN samples spanning the widest (about 7 dex) luminosity range ever used for this type of studies. Methods. We analysed a total of ∼1000 type 1 and type 2 AGN for which we performed a dedicated SED-fitting. Results. We provide a bolometric correction separately for type 1 and type 2 AGN; the two bolometric corrections agree in the overlapping luminosity range. Based on this we computed for the first time a universal bolometric correction for the whole AGN sample (both type 1 and type 2). We found that KX is fairly constant at log(LBOL/L⊙) < 11, while it increases up to about one order of magnitude at log(LBOL/L⊙) ∼ 14.5. A similar increasing trend has been observed when its dependence on either the Eddington ratio or the BH mass is considered, while no dependence on redshift up to z ∼ 3.5 has been found. In contrast, the optical bolometric correction appears to be fairly constant (i.e. KO ∼ 5) regardless of the independent variable. We also verified that our bolometric corrections correctly predict the AGN bolometric luminosity functions. According to this analysis, our bolometric corrections can be applied to the whole AGN population in a wide range of luminosity and redshift.

AGN1 vs AGN2 dichotomy as seen from the point of view of ionized outflows

2019 ◽  
Vol 15 (S356) ◽  
pp. 96-96
Author(s):  
Eleonora Sani
Keyword(s):  
Accretion Rate ◽  
Point Of View ◽  
Emission Lines ◽  
Black Hole Mass ◽  
X Ray ◽  
Bolometric Luminosity ◽  
Wide Range ◽  
Strong Contrast

AbstractI present a detailed study of ionized outflows in a large sample of 650 hard X-ray detected AGN. Taking advantage of the legacy value of the BAT AGN Spectroscopic Survey (BASS, DR1), we are able to reveal the faintest wings of the [OIII] emission lines associated with outflows. The sample allows us to derive the incidence of outflows covering a wide range of AGN bolometric luminosity and test how the outflow parameters are related with various AGN power tracers, such as black hole mass, Eddington ratio, luminosity. I’ll show how ionized outflows are more frequently found in type 1.9 and type 1 AGN (50% and 40%) with respect to the low fraction in type 2 AGN (20%). Within such a framework, I’ll demonstrate how type 2 AGN outflows are almost evenly balanced between blue- and red-shifted winds. This, in strong contrast with type 1 and type 1.9 AGN outflows which are almost exclusively blue-shifted. Finally, I’ll prove how the outflow occurrence is driven by the accretion rate, whereas the dependence of outflow properties with respect to the other AGN power tracers happens to be quite mild.

scholarly journals BAT AGN Spectroscopic Survey – XIX. Type 1 versus type 2 AGN dichotomy from the point of view of ionized outflows

2019 ◽  
Vol 491 (4) ◽  
pp. 5867-5880 ◽  
Author(s):  
A F Rojas ◽  
E Sani ◽  
I Gavignaud ◽  
C Ricci ◽  
I Lamperti ◽  
...  
Keyword(s):  
High Redshift ◽  
Maximum Velocity ◽  
Point Of View ◽  
Physical Parameters ◽  
X Ray ◽  
Narrow Component ◽  
Bolometric Luminosity ◽  
First Time

ABSTRACT We present a detailed study of ionized outflows in a large sample of ∼650 hard X-ray-detected active galactic neuclei (AGNs). Using optical spectroscopy from the BAT AGN Spectroscopic Survey (BASS), we are able to reveal the faint wings of the [O iii] emission lines associated with outflows covering, for the first time, an unexplored range of low AGN bolometric luminosity at low redshift (z ∼0.05). We test if and how the incidence and velocity of ionized outflow is related to AGN physical parameters: black hole mass ($\rm \mathit{ M}_{BH}$), gas column density ($\rm \mathit{ N}_{H}$), Eddington ratio ($\rm \lambda _{Edd}$), [O iii], X-ray, and bolometric luminosities. We find a higher occurrence of ionized outflows in type 1.9 (55 per cent) and type 1 AGNs (46 per cent) with respect to type 2 AGNs (24 per cent). While outflows in type 2 AGNs are evenly balanced between blue and red velocity offsets with respect to the [O iii] narrow component, they are almost exclusively blueshifted in type 1 and type 1.9 AGNs. We observe a significant dependence between the outflow occurrence and accretion rate, which becomes relevant at high Eddington ratios [log($\rm \lambda _{Edd}$) ≳ −1.7]. We interpret such behaviour in the framework of covering factor-Eddington ratio dependence. We do not find strong trends of the outflow maximum velocity with AGN physical parameters, as an increase with bolometric luminosity can be only identified when including samples of AGNs at high luminosity and high redshift taken from literature.

scholarly journals EXPRESS: Pulmonary Hypertension Associated With Neurofibromatosis Type 2

2021 ◽  
pp. 204589402110295
Author(s):  
Hirohisa Taniguchi ◽  
Tomoya Takashima ◽  
Ly Tu ◽  
Raphaël Thuillet ◽  
Asuka Furukawa ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Neurofibromatosis Type ◽  
Pulmonary Vascular Remodeling ◽  
Life Threatening ◽  
History Of ◽  
Pulmonary Arterial ◽  
First Time

Although precapillary pulmonary hypertension (PH) is a rare but severe complication of patients with neurofibromatosis type 1 (NF1), its association with NF2 remains unknown. Herein, we report a case of a 44-year-old woman who was initially diagnosed with idiopathic pulmonary arterial hypertension (IPAH) and treated with PAH-specific combination therapy. However, a careful assessment for a relevant family history of the disease and genetic testing reveal that this patient had a mutation in the NF2 gene. Using immunofluorescence and Western blotting, we demonstrated a decrease in endothelial NF2 protein in lungs from IPAH patients compared to control lungs, suggesting a potential role of NF2 in PAH development. To our knowledge, this is the first time that precapillary PH has been described in a patient with NF2. The altered endothelial NF2 expression pattern in PAH lungs should stimulate work to better understand how NF2 is contributing to the pulmonary vascular remodeling associated to these severe life-threatening conditions.

scholarly journals Cloning, expression and enzyme activity delineation of two novel CANT1 mutations: the disappearance of dimerization may indicate the change of protein conformation and even function

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Hong-Dan Wang ◽  
Liang-Jie Guo ◽  
Zhan-Qi Feng ◽  
Da-Wei Zhang ◽  
Meng-Ting Zhang ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Cloning And Expression ◽  
Expression Vectors ◽  
Extracellular Secretion ◽  
Chinese Origin ◽  
Desbuquois Dysplasia ◽  
Pathogenic Change ◽  
First Time

Abstract Background Desbuquois dysplasia (DBQD) was a rare autosomal recessive skeletal dysplasia. Calcium activated nucleotidase 1 (CANT1) mutation was identified as a common pathogenic change for DBQD type 1 and Kim variant but not for DBQD type 2. To our knowledge, all patients with DBQD type 1 currently found could be explained by mutations in the CANT1 gene, but mutations in the CANT1 gene might not be directly diagnosed as DBQD type 1. Results We have identified two novel CANT1 mutations (mut1: c.594G > A [p.Trp198*], mut2: c.734C > T [p.Pro245Leu]) in three children from a family of Chinese origin for the first time. Two of the three children could be diagnosed as typical DBQD type 1 and one child could not be diagnosed as DBQD type 1 based on the clinical data we had. To further clarify the effect of the two mutations of the CANT1 gene, we studied the CANT1 gene expression and detected the protein secretion and nucleotide enzyme activity through cDNA cloning and expression vectors construction for wild and mutant types. The mut1 was a nonsense mutation which could lead to premature termination and produced the truncated bodies; The CANT1 dimer of mut2 was significantly reduced and even undetectable. The extracellular secretion of mut1 was extremely high while mut2 was significantly reduced compared with the wild type. And mut1 and mut2 also could result in a significant reduction in the activity of CANT1 nucleotidease. From the results we could deduce that the two mutations of the CANT1 gene were the causes of the two cases in this study. Conclusions Regarding the particularity of the cases reported in this study, the pathogenesis of CANT1 might be more complicated. The genetic and phenotype of three children with the same genetic background need to be further studied. Larger cohort of patients was needed to establish genotype–phenotype correlations in DBQD.

Standard complication screening information can be used for risk assessment for first time foot ulcer among patients with type 1 and type 2 diabetes

2019 ◽  
Vol 151 ◽  
pp. 177-186 ◽  
Author(s):  
Sine Hangaard ◽  
Anne Rasmussen ◽  
Thomas Almdal ◽  
Annemette Anker Nielsen ◽  
Kirsten Engelhart Nielsen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Assessment ◽  
Foot Ulcer ◽  
First Time

scholarly journals Examining supernova events in Type 1 active galactic nuclei

2020 ◽  
Vol 495 (4) ◽  
pp. 4419-4429
Author(s):  
Beatriz Villarroel ◽  
Iñigo Imaz ◽  
Elisabeta Lusso ◽  
Sébastien Comerón ◽  
M Almudena Prieto ◽  
...  
Keyword(s):  
Active Galactic Nuclei ◽  
Detection Rate ◽  
Statistical Study ◽  
Galactic Nuclei ◽  
Core Collapse ◽  
Late Type ◽  
Host Galaxies ◽  
Specific Kind

ABSTRACT A statistical study of intermediate Palomar Transient Factory supernovae (SNe) in Type 1 active galactic nuclei (AGNs) has shown a major deficit of supernovae around Type 1 AGN host galaxies, with respect to Type 2 AGN hosts. The aim of this work is to test whether there is any preference for Type 1 AGNs to host SN of a specific kind. Through the analysis of SN occurrence and their type (thermonuclear versus core-collapse), we can directly link the type of stars producing the SN events, thus this is an indirect way to study host galaxies in Type 1 AGNs. We examine the detection fractions of SNe, the host galaxies and compare the sample properties to typical host galaxies in the Open Supernova Catalog (OSC). The majority of the host galaxies in the AGN sample are late type, similar to typical galaxies hosting SN within the OSC. The findings are supportive of a deficiency of SNe near Type 1 AGNs, although we cannot with certainty assess the overall detection fractions of SNe in Type 1 AGNs relative to other SN host galaxies. We can state that Type 1 AGN has equal detection fractions of thermonuclear versus core-collapse SNe. However, we note the possibility of a higher detection rate of core-collapse supernovae in Type 1 AGN with insecure AGN classifications.

scholarly journals Neurofibromatosis: part 2 – clinical management

2015 ◽  
Vol 73 (6) ◽  
pp. 531-543 ◽  
Author(s):  
Pollyanna Barros Batista ◽  
Eny Maria Goloni Bertollo ◽  
Danielle de Souza Costa ◽  
Lucas Eliam ◽  
Karin Soares Gonçalves Cunha ◽  
...  
Keyword(s):  
Clinical Management ◽  
Clinical Manifestations ◽  
Neurofibromatosis Type ◽  
Cutaneous Manifestations ◽  
Wide Range ◽  
Reduced Rate ◽  
Present Text

Part 1 of this guideline addressed the differential diagnosis of the neurofibromatoses (NF): neurofibromatosis type 1 (NF1), neurofibromatosis type 2 (NF2) and schwannomatosis (SCH). NF shares some features such as the genetic origin of the neural tumors and cutaneous manifestations, and affects nearly 80 thousand Brazilians. Increasing scientific knowledge on NF has allowed better clinical management and reduced rate of complications and morbidity, resulting in higher quality of life for NF patients. Most medical doctors are able to perform NF diagnosis, but the wide range of clinical manifestations and the inability to predict the onset or severity of new features, consequences, or complications make NF management a real clinical challenge, requiring the support of different specialists for proper treatment and genetic counseling, especially in NF2 and SCH. The present text suggests guidelines for the clinical management of NF, with emphasis on NF1.

scholarly journals HOMOTYPIC COMPLEMENT-FIXING ANTIBODY IN MONKEYS INFECTED WITH TYPE 2 POLIOMYELITIS VIRUS BY THE ORAL ROUTE

1952 ◽  
Vol 96 (1) ◽  
pp. 55-58 ◽  
Author(s):  
Jordi Casals ◽  
Peter K. Olitsky ◽  
Albert B. Sabin
Keyword(s):  
Neutralizing Antibody ◽  
Oral Route ◽  
The Other ◽  
Human Beings ◽  
Serum Dilution ◽  
Cynomolgus Monkeys ◽  
Inapparent Infection ◽  
Order Of Magnitude

CF tests with Type 2 poliomyelitis antigen (MEF1) were performed on the pre- and postinfection sera of 20 cynomolgus monkeys which developed paralytic, non-paralytic, or inapparent infection following oral administration of a Type 2 strain of virus (Y-SK). All the monkeys developed neutralizing antibody, and 17 developed CF antibody in an original serum dilution titer of 1:4 or greater. The 3 monkeys which did not develop this level of CF antibody were in a group of 7 which died within 8 days after onset of paralysis. The CF titers were as high at 2 to 6 days after onset of paralysis in the other 4 moribund or dead monkeys as in the surviving animals tested 4 weeks after the first dose of virus and the CF titers were of the same order of magnitude in the groups with paralytic, non-paralytic, or inapparent infection. The Type 2 poliomyelitis CF titers developed in monkeys as a result of infection with homotypic virus were not greater than those found in human beings infected with heterotypic Type 1 poliomyelitis strains.

scholarly journals Interleukin-18 and CD30 serum levels in patients with moderate-severe depression

2002 ◽  
Vol 11 (4) ◽  
pp. 265-267 ◽  
Author(s):  
Rosaria Alba Merendino ◽  
Antonio Enrico Di Rosa ◽  
Giuseppe Di Pasquale ◽  
Paola Lucia Minciullo ◽  
Carmela Mangraviti ◽  
...  
Keyword(s):  
T Cell ◽  
Severe Depression ◽  
Serum Levels ◽  
Interleukin 18 ◽  
Healthy Donors ◽  
Significant Difference ◽  
First Time ◽  
Helper Type

Interleukin-18 (IL-18), a pro-inflammatory cytokine that plays an important role in the T-cell-helper type 1 response, is a new member of the family of cytokines produced in the brain. CD30 is a marker of T-cell-helper type 2 lymphocytes. We evaluated IL-18 and CD30 serum levels in 10 patients affected by moderate-severe depression (MSD). We demonstrated for the first time that serum IL-18 levels of MSD patients were significantly higher than those of healthy donors. On the contrary, no significant difference was found between serum CD30 levels of MSD patients compared with those of healthy donors. These data strengthen the hypothesis that MSD disease is associated with an inflammatory response, mainly T-cell-helper type 1, and suggest an important role for IL-18 in the pathophysiology of MSD.

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