scholarly journals Hydrotherapy with using citrate buffer system in treatment of senile xerosis

2020 ◽  
Vol 22 ◽  
pp. 02018
Author(s):  
Marina Ufimtseva ◽  
Kseniya Sorokina ◽  
Nadezhda Belokonova ◽  
Yurii Bochkarev ◽  
Ekaterina Mylnikova
Keyword(s):  
Clinical Symptoms ◽  
Current Knowledge ◽  
Life Quality ◽  
Skin Barrier ◽  
Skin Barrier Function ◽  
Buffer System ◽  
Dry Skin ◽  
Citrate Buffer ◽  
The Subject ◽  
Artesian Water

Senile xerosis is one of the most common pathology in elderly patients. The article presents an overview of current knowledge on the subject of skin barrier function and pathophysiological mechanisms and clinical features of senile xerosis. The corneotherapeutic approach to treatment of senile xerosis is substantiated and the effectiveness of emollients for baths was justified. The pH of water various sources (tap and artesian water) has alkaline values, which leads to an increase in dry skin and worsening clinical symptoms of xerosis. The effectiveness of bath emollients was investigated. The analysis of the adsorption properties of bath emollients was conducted which showed that these properties depend on pH of water. Hydrotherapy with using the citrate buffer system increases the efficiency of treatment. 60 women, aged 75-84 years, diagnosed with senile xerosis were treated with hydrotherapy containing citrate buffer system, bath emollient (shower oil). A clinical assessment was performed at the beginning and end of the study by a dermatologist using the Overall Dry Skin Scale (ODS) and Dermatological Life Quality Index (DLQI). Hydrotherapy with using a citrate buffer system provided a significant softening of the skin, elimination of scaling, remission of pruritus and more rapid clinical effect.

scholarly journals Chamaejasmine Isolated from Wikstroemia dolichantha Diels Suppresses 2,4-Dinitrofluoro-benzene-Induced Atopic Dermatitis in SKH-1 Hairless Mice

Biomolecules ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 697 ◽  
Author(s):  
Tae-Young Kim ◽  
No-June Park ◽  
Jonghwan Jegal ◽  
Sangho Choi ◽  
Sang Woo Lee ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Topical Administration ◽  
Skin Lesions ◽  
Specific Ige ◽  
Transepidermal Water Loss ◽  
Skin Barrier Function ◽  
Enzyme Linked Immunosorbent Assay ◽  
Dermal Thickness

Plants of the genus Wikstroemia have long been used as traditional medicines to treat diseases like pneumonia, rheumatism, and bronchitis. This study was designed to determine the effect of chamaejasmine, a biflavonoid present in W. dolichantha, on atopic dermatitis (AD)-like skin lesions in a 2,4-dinitrochlorobenzene (DNCB)-induced murine model of AD. Initially, we examined the anti-allergic activities of ten flavonoids from W. dolichantha by measuring β-hexosaminidase release from RBL-2H3 cells. Subsequently, an SKH-1 hairless mouse model of AD was developed based on the topical application of DNCB. Chamaejasmine (0.5%) or pimecrolimus (1%, positive control) were applied to dorsal skins of DNCB-sensitized AD mice for two weeks. Serum IL-4 and IgE levels were determined using enzyme-linked immunosorbent assay kits and transepidermal water loss (TEWL) and skin hydration were measured using a Tewameter TM210 and a SKIN-O-MAT, respectively. Of the ten flavonoids isolated from W. dolichantha, chamaejasmine most potently inhibited DNP-specific IgE-induced degranulation in RBL-2H3 cells. Topical administration of chamaejasmine attenuated the clinical symptoms of DNCB-induced dermatitis (i.e., itching, dryness, erythema, and edema). Histological analyses demonstrated that dermal thickness and mast cell infiltration in dermis were significantly reduced by chamaejasmine. In addition, 0.5% chamaejasmine inhibited DNCB-induced increases in total IL-4 and IgE levels in serum, improved skin barrier function, and increased epidermis moisture. Our findings suggest chamaejasmine might be an effective therapeutic agent for the treatment of atopic diseases.

Dry skin, barrier function, and irritant contact dermatitis in the elderly

2011 ◽  
Vol 29 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Florian Seyfarth ◽  
Sibylle Schliemann ◽  
Dimitar Antonov ◽  
Peter Elsner
Keyword(s):  
Contact Dermatitis ◽  
Barrier Function ◽  
Skin Barrier ◽  
The Elderly ◽  
Skin Barrier Function ◽  
Irritant Contact Dermatitis ◽  
Dry Skin

scholarly journals Pilot Study on the Forehead Skin Microbiome and Short Chain Fatty Acids Depending on the SC Functional Index in Korean Cohorts

2021 ◽  
Vol 9 (11) ◽  
pp. 2216
Author(s):  
Haryung Park ◽  
Karina Arellano ◽  
Yuri Lee ◽  
Subin Yeo ◽  
Yosep Ji ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Skin Barrier ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Skin Barrier Function ◽  
Skin Microbiome ◽  
Dry Skin ◽  
Pathogen Invasion ◽  
The Impact ◽  
Chain Fatty Acids

Dry skin is one of the indicators of a compromised skin barrier. An intact skin barrier is not only important to reserve the hydration within the epidermal tissue but also to protect our skin from environmental stressors and inhibit pathogen invasion; damage to the skin barrier may lead to inflammatory skin diseases. Some microbial metabolites such as short chain fatty acids may inhibit or destroy harmful bacteria and regulate the host immune system. The impact of the skin microbiome and short chain fatty acids on skin barrier function was studied in two groups of 75 participants each. The cohort was equally divided in dry and moist skin types, based on stratum corneum (SC) functionality index (SCFI), reflecting the ratio of transepidermal water loss (TEWL). A dry group represents a low SCFI and a moist group a high SCFI. Compared with the dry skin group, propionate and Cutibacterium levels (previously known as Propionibacterium acnes) were significantly higher (p < 0.001) in the moist group. Levels of Cutibacterium were negatively correlated with those of Staphylococcus (p <0.0001) in both dry and moist groups. The moist group also had a significantly higher propionate concentration (p < 0.001). This study showed that the microbial community and short chain fatty acid concentration may be considered as significant determinants of the SCFI of the skin.

scholarly journals Evaluation of Itch by Using NC/NgaTnd Mice: A Model of Human Atopic Dermatitis

2011 ◽  
Vol 2011 ◽  
pp. 1-5 ◽  
Author(s):  
Akane Tanaka ◽  
Hiroshi Matsuda
Keyword(s):  
Animal Model ◽  
Atopic Dermatitis ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Sensory Nerves ◽  
Laboratory Animals ◽  
Skin Barrier Function ◽  
The Novel ◽  
Suitable Animal Model ◽  
Spontaneous Animal Model

Atopic dermatitis (AD) is the extremely complicated syndrome that various abnormalities develop in a heap. There are various factors in patients for the onset and exacerbation of AD, including genetic cofactors of individuals, environmental factors, the failure of the skin barrier function, unfavorable regulation of the immune system, and the hypersensitivity of sensory nerves. In recent years, there have been many trials of the drug discovery that targets itch, because itch is one of the most serious clinical symptoms of AD. The selection of the suitable animal model that represents the condition of patients, as well as innovative analyzing protocols that can precisely evaluate itch, is indispensable for investigation of an effective drug for AD. In the paper, the unique spontaneous animal model for AD (NC/NgaTnd mice) and the novel quantification system of the laboratory animals that may bring a great progress in the future study of itch are outlined.

Die Rolle des pH-Wertes bei Intertrigo oder zu trockener Haut

2019 ◽  
Vol 7 (3) ◽  
pp. 134-136
Author(s):  
Markus Braun-Falco
Keyword(s):  
Barrier Function ◽  
Good Condition ◽  
Age Groups ◽  
Skin Barrier ◽  
Skin Care ◽  
Skin Barrier Function ◽  
Permeability Barrier ◽  
Buffer System ◽  
Skin Conditions ◽  
Skin Care Products

In order to maintain skin in «good condition» one can use cosmetic products. Importantly, those skin care products should fulfil specific requirements for specific life phases and specific skin conditions. In this review, we focused on 2 different age groups - namely, infants and the elderly - as well as on 2 specific skin conditions occurring in both age groups - very dry skin (Xerosis) and hyperhydrated skin (diaper rash). The goal in both conditions should be to maintain skin surface in its physiological acidic state, which is in turn crucial for the permeability barrier function, stratum corneum integrity/cohesion and antimicrobial defense. Skin care products formulated with an effective buffer system at a more acidic pH, for example 4, may be the best option to improve the acid mantle and skin barrier function and thus keep the skin in «good condition».

The Role of Host Defense Peptide Human β-defensins in the Maintenance of Skin Barriers

2018 ◽  
Vol 24 (10) ◽  
pp. 1092-1099 ◽  
Author(s):  
Chanisa Kiatsurayanon ◽  
Hideoki Ogawa ◽  
Francois Niyonsaba
Keyword(s):  
Host Defense ◽  
Current Knowledge ◽  
Skin Barrier ◽  
Skin Inflammation ◽  
The Body ◽  
Skin Barrier Function ◽  
Host Defense Peptides ◽  
Host Defense Peptide ◽  
Novel Therapeutic Strategies

The epidermis functions as a first-line defense barrier that protects the body from the external environment. As a chemical hindrance, the epidermis possesses acidic pH, highly organized lipids and various host defense peptides, also known as antimicrobial peptides. Human β-defensins (hBDs), one of the most important host defense peptide families found in our skin, are well-known for their broad-spectrum microbicidal activities. However, there is a growing body of evidence indicating that hBDs also orchestrate several immunomodulatory functions and are the cornerstone that bridges the innate and adaptive immune responses during skin inflammation and infection. Moreover, recent work identified the potential role of hBDs in the regulation and maintenance of the skin barrier function. In this review, we describe the current knowledge concerning the role of hBDs in skin barriers and discuss the potential clinical implications of these peptides in cutaneous biology. Understanding the roles of hBDs in the regulation and maintenance of skin barriers may aid in the development of novel therapeutic strategies for skin conditions where the skin barrier is impaired, such as atopic dermatitis and psoriasis.

scholarly journals Lithospermum erythrorhizon Alleviates Atopic Dermatitis-like Skin Lesions by Restoring Immune Balance and Skin Barrier Function in 2.4-Dintrochlorobenzene-Induced NC/Nga Mice

Nutrients ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 3209
Author(s):  
Jin-Su Oh ◽  
Sang-Jun Lee ◽  
Se-Young Choung
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Clinical Symptoms ◽  
Skin Barrier ◽  
Developed Countries ◽  
Skin Barrier Function ◽  
Lithospermum Erythrorhizon ◽  
Th22 Cells ◽  
Cytokines And Chemokines ◽  
Immune Balance

The incidence of atopic dermatitis (AD), a disease characterized by an abnormal immune balance and skin barrier function, has increased rapidly in developed countries. This study investigated the anti-atopic effect of Lithospermum erythrorhizon (LE) using NC/Nga mice induced by 2,4-dinitrochlorobenzene. LE reduced AD clinical symptoms, including inflammatory cell infiltration, epidermal thickness, ear thickness, and scratching behavior, in the mice. Additionally, LE reduced serum IgE and histamine levels, and restored the T helper (Th) 1/Th2 immune balance through regulation of the IgG1/IgG2a ratio. LE also reduced the levels of AD-related cytokines and chemokines, including interleukin (IL)-1β, IL-4, IL-6, tumor necrosis factor-α (TNF-α), thymic stromal lymphopoietin, thymus and activation-regulated chemokine, macrophage-derived chemokine, regulated on activation, normal T cell expressed and secreted, and monocyte chemoattractant protein-1 in the serum. Moreover, LE modulated AD-related cytokines and chemokines expressed and secreted by Th1, Th2, Th17, and Th22 cells in the dorsal skin and splenocytes. Furthermore, LE restored skin barrier function by increasing pro-filaggrin gene expression and levels of skin barrier-related proteins filaggrin, involucrin, loricrin, occludin, and zonula occludens-1. These results suggest that LE is a potential therapeutic agent that can alleviate AD by modulating Th1/Th2 immune balance and restoring skin barrier function.

Sign in / Sign up

Export Citation Format

Share Document