scholarly journals Man-made load of industrial environment and its impact on human microbiota

2020 ◽  
Vol 161 ◽  
pp. 01109
Author(s):  
Nina Bugero ◽  
Natalya Ilyina ◽  
Yulia Bazarnova ◽  
Yekaterina Aronova ◽  
Svetlana Alexandrova
Keyword(s):  
Pathological Process ◽  
Composition Change ◽  
Industrial Environment ◽  
Functional Changes ◽  
Industrial Sites ◽  
Temperature Thresholds ◽  
Mucous Membranes ◽  
Interferon Activity ◽  
Human Large Intestine ◽  
Intestinal Microbiocenosis

People are exposed to a significant amount of man-made hazards upon contact with technological systems, and foundry engineering industrial sites belong undoubtedly to such systems. Foundry shops are characterized by high noise and temperature thresholds that affect the human body. Unsatisfactory condition of the air is considered to be an acute problem in foundry engineering. In this connection, the state of air and its composition change, which can certainly affect health of workers, and the latter may be seen in the respiratory, cardiovascular, nervous systems, and digestive organs functional changes. However, up to date, the effect of health hazards of foundry engineering on the microbiocenosis of human intestine remains poorly studied. The paper apprizes the microbiota of human large intestine being exposed to integrated effects of foundry engineering factors. A structural change of the intestinal coenotype accompanied by a change of absolute dominants and opportunistic microorganisms appearance is established. Intestinal microbiocenosis disorder is accompanied by a high detectability of parasitic protozoa Blastocystis spp. in the sampling material. The obtained blastocyst isolates have pathogenic properties of varying degree of manifestation, which indicates their unequal etiological significance in the development of the pathological process. The isolated strains of protozoa have a high anti-interferon activity characterizing their persistent properties. This characteristic brings along the displacement of normal symbionts by blastocysts and colonization of the intestinal mucous membranes with these protozoa.

scholarly journals Transformation Directions of Brownfields: The Case of the Górnośląsko-Zagłębiowska Metropolis

2021 ◽  
Vol 13 (4) ◽  
pp. 2075
Author(s):  
Sławomir Pytel ◽  
Sławomir Sitek ◽  
Marta Chmielewska ◽  
Elżbieta Zuzańska-Żyśko ◽  
Anna Runge ◽  
...  
Keyword(s):  
Land Use ◽  
Urban Areas ◽  
Economic Transformation ◽  
Functional Changes ◽  
Industrial Sites ◽  
Mine Dumps ◽  
Post Test ◽  
Post Industrial ◽  
Settling Ponds ◽  
Depth Interviews

Brownfields are remnants of the functional and spatial transformations of urban areas in Poland. They are particularly abundant in old industrial districts, based on coal mining and metallurgy. The aim of this study is to identify the transformation directions and functional changes of brownfields in the former Upper Silesian Industrial Region in southern Poland, which has evolved into the Górnośląsko-Zagłębiowska Metropolis (GZM) through the process of socio-economic transformation. The study makes use of the χ2 test of independence and Cramer’s V as a post-test, and the method of in-depth interviews. The results indicate that the most popular new functions of post-industrial sites are production and services. When we consider large brownfields such as, in particular, disused mine dumps, dumping sites, settling ponds and workings, the most popular new form of land use is green spaces. Moreover, the study shows that the size of brownfields impacts their new forms of land use.

Detection of presymptomatic atherosclerosis: a current perspective

1999 ◽  
Vol 97 (5) ◽  
pp. 615-624 ◽  
Author(s):  
Mark R. ADAMS ◽  
David S. CELERMAJER
Keyword(s):  
Structural Changes ◽  
Surrogate Marker ◽  
Intima Media Thickness ◽  
Serum Markers ◽  
Pathological Process ◽  
Western World ◽  
Functional Changes ◽  
Vascular Ultrasound ◽  
Current Perspective ◽  
Potential Methods

Atherosclerosis, the pathological process underlying myocardial infarction, stroke and other occlusive vascular disease, is the major cause of death in the Western world. The development of techniques to accurately and reproducibly detect and measure the early changes of atherosclerosis and/or to identify subjects at highest cardiovascular risk may aid in the development of prevention strategies and facilitate a decrease in morbidity and mortality from atherosclerosis. Increasing understanding of the pathophysiology of early atherosclerosis has allowed the development of a number of potential methods for the assessment of the early stages of atherosclerosis in humans. These include techniques for assessing early structural changes in the coronary arteries with electron-beam computed tomography and magnetic resonance imaging. External vascular ultrasound has also been used to image other circulations as a surrogate marker for coronary atherosclerosis, e.g. the measurement of carotid artery intima-media thickness. Early functional changes of atherosclerosis have also been described many years before the development of structural changes. A number of techniques have been developed to measure endothelial dysfunction, one of the earliest changes of atherosclerosis, including non-invasive measurement of endothelial function using external vascular ultrasound. A variety of serum markers have also been described, and may be useful markers of atherosclerosis. We discuss some of the more promising techniques for the detection of early, presymptomatic atherosclerosis.

scholarly journals INFLUENCE SIFILITIC IN PREGNANT WOMEN ON THE HEALTH OF NEWBORN CHILDREN

2017 ◽  
Vol 20 (3) ◽  
pp. 188-192
Author(s):  
Natalya Vladimirovna Matyskina ◽  
T. E Taranushenko ◽  
Yu. V Karacheva
Keyword(s):  
Child Health ◽  
Pregnant Women ◽  
Clinical Features ◽  
High Mortality ◽  
Clinical Symptoms ◽  
Congenital Syphilis ◽  
Pathological Process ◽  
Newly Diagnosed ◽  
Syphilis Infection ◽  
Mucous Membranes

A particular challenge for child health represent cases of early and congenital syphilis, which is characterized by a severe multiorgan pathology in children and high mortality in newborns. Purpose. To study the incidence of early congenital syphilis, depending on the time of detection of syphilis infection in women and to present the clinical features of this disease in newborns with the frequency of the detection of the most important specific manifestations of the disease. Material and methods. We observed 114 women with confirmed syphilis infection and newborns from these mothers. Results. The data presented indicate the prevalence of Lues latens praecox in the structure of syphilis infection in pregnant women with newly diagnosed disease. In children from women who were diagnosed with syphilis during this pregnancy early congenital syphilis (PBC) exhibited in 74.3% of cases, while 27 cases in 19 newborns syphilis was accompanied by clinical symptoms. Conclusion. In the pathological process in congenital syphilis, with greatest frequency involved bone, followed - mucous membranes (rhinitis).

Possibility of using of osteopathic methods of correction in the therapy of symphysiopathy in pregnant women

2021 ◽  
pp. 76-85
Author(s):  
E. N. Nenashkina ◽  
V. O. Belash
Keyword(s):  
Russian Literature ◽  
Pubic Symphysis ◽  
Pathological Process ◽  
Sacroiliac Joints ◽  
Functional Changes ◽  
Birth Canal ◽  
Pregnancy And Childbirth ◽  
Natural Birth ◽  
Synovial Membranes ◽  
Clear Description

A number of physiological changes occurring in a woman′s organism during pregnancy includes, among other things, structural and functional changes in the musculoskeletal system, manifested by softening of the ligaments, cartilage, synovial membranes of the pubic and sacroiliac joints, and as a result, there is some discrepancy pubic bones, which contributes to the safe passage of the fetus through the natural birth canal during childbirth. However, these changes can cross physiological boundaries, leading to excessive relaxation of the pelvic joints, the occurrence of pain and the risk of divergence of the pubic symphysis during pregnancy and childbirth. Despite a fairly clear description of this condition, until now there is no unified terminology for pathological changes in the pelvic bones during pregnancy. In the Russian literature the terms such as symphysitis, symphysiopathy, divergence and rupture of the pubic articulation are accepted, but the most foreign authors suggest the term «pubic articulation dysfunction» to be used. However this term also does not fully reflect the essence of the pathological process. Despite the sufficient knowledge of the problem, the management of patients with this nosology still remains a rather serious task for clinicians. The problems of the isolated using and mutual compatibility of various non-drug methods have not yet been sufficiently studied, and the use of drugs is limited by the presence of pregnancy. A case from practice is described, devoted to the isolated use (monotherapy) of osteopathic correction in a pregnant woman in order to prevent rupture of the pubic articulation.

Anatomical and physiological aspects  of lactostasis

10.12737/5923 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 149-152 ◽  
Author(s):  
Милькевич ◽  
I. Milkevich ◽  
Гусейнов ◽  
A. Guseynov ◽  
Гусейнов ◽  
...  
Keyword(s):  
Breast Disease ◽  
Mammary Glands ◽  
Pathological Process ◽  
Contributing Factors ◽  
Physiological Factors ◽  
Ductal System ◽  
Functional Changes ◽  
The Status ◽  
Lactating Breast ◽  
Clinically Significant

Lactose is a consequence of dysfunction of the mammary glands in women with breastfeeding between production and secretion of milk, resulting in stagnation of milk. The purpose is to study predisposing anatomical and physiological factors in the de-velopment of lactose associated with narrowing of the ducts and hypofunction lobular-ductal system of the breast in women with breastfeeding. The research has included a study of the status of the lactating breast in 42 women with breastfeeding. The 1st group consisted of 27 women with lactose. Control (the 2nd) group consisted of 15 women with breastfeeding without lactose. The study has shown that the development of the stagnation of milk is caused by a range of predisposing and contributing factors, among which the most important are the anatomical and physiological reasons: the restriction and paresis of the milk ducts, dyscoordination of the lobular-ductal system. The leading cause of stagnation of milk is an anatomical narrowing and the tortuous course of the milky threads with physiological dysfunction of the ductal system of the lactating breast. A main factor in the development of the pathological process is fibrocystic breast disease, which is characterized by morphological and functional changes in the mammary glands in the form of diffuse or focal changes of the connective tissue, mainly ductectasia. These changes under effects of other factors on a certain area of the lactating mammary glands lead either to morpho-functional narrowing, the violation of the ducts, either individual or combined physiological hypofunctions of up to paresis. Appeared first sections of the stagnation of milk, swelling of the breast increase the compression duct and obstruct the outflow of milk, leading to clinically significant pathological process of the lactose, the resolution of which requires consideration of all the above clinical and pathogenetic data with a complex of therapeutic measures.

scholarly journals A Remotely-Operated Facility for Evaluation of Post-Combustion CO2 Capture Technologies on Industrial Sites

2016 ◽  
Vol 12 (06) ◽  
pp. 43
Author(s):  
Roger James Watson ◽  
Chih-Wei Lin ◽  
Bill David Buschle ◽  
Jon Gibbins ◽  
Mathieu Serge Lucquiaud
Keyword(s):  
User Interface ◽  
Collaborative Research ◽  
Flue Gases ◽  
Test Facility ◽  
Font Size ◽  
Sample Collection ◽  
Industrial Environment ◽  
Scale Evaluation ◽  
Industrial Sites ◽  
Remote Operation

<p><strong><span style="font-family: Times New Roman;"><em><span style="font-size: small;">Abstract</span></em><span style="font-size: small;">—</span><span style="font-size: small;">ACTTROM (Advanced Capture Testing in a Transportable Remotely-Operated Minilab) is a transportable test facility for bench-scale evaluation of post-combustion CO</span><sub><span style="font-size: xx-small;">2</span></sub><span style="font-size: small;"> capture technologies using real industrial flue gases. It is designed to be remote-operable, requiring visits only once per month for maintenance and sample collection. ACTTROM is the first facility of its kind, owned and operated by academia for collaborative research in an industrial environment, and this has resulted in a number of unique developments to facilitate remote operation at an industrial host site. Specifically, it has been necessary to design the unit to automatically correct or mitigate the effects of fault conditions, and to be remotely-monitored via a user interface at 24 hour intervals. </span></span></strong></p>

scholarly journals Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

2021 ◽  
Vol 22 (14) ◽  
pp. 7373
Author(s):  
Darya V. Telegina ◽  
Oyuna S. Kozhevnikova ◽  
Anna K. Antonenko ◽  
Nataliya G. Kolosova
Keyword(s):  
De Novo ◽  
The Elderly ◽  
Developed Countries ◽  
Pathological Process ◽  
Age Related Macular Degeneration ◽  
Long Term Effects ◽  
Functional Changes ◽  
Age Related ◽  
Functional Features ◽  
Retinal Neurogenesis

Age-related macular degeneration (AMD) is a complex multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in the developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily of its “dry” type which is by far the most common (90% of all AMD cases). In the recent years, AMD has become “younger”: late stages of the disease are now detected in relatively young people. It is known that AMD pathogenesis—according to the age-related structural and functional changes in the retina—is linked with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, and an impairment of neurotrophic support, but the mechanisms that trigger the conversion of normal age-related changes to the pathological process as well as the reason for early AMD development remain unclear. In the adult mammalian retina, de novo neurogenesis is very limited. Therefore, the structural and functional features that arise during its maturation and formation can exert long-term effects on further ontogenesis of this tissue. The aim of this review was to discuss possible contributions of the changes/disturbances in retinal neurogenesis to the early development of AMD.

scholarly journals Features of Retinal Neurogenesis as a Key Factor of Age-Related Neurodegeneration: Myth or Reality?

2021 ◽  
Author(s):  
Darya Telegina ◽  
Oyuna Kozhevnikova ◽  
Anna Antonenko ◽  
Nataliya Kolosova
Keyword(s):  
De Novo ◽  
The Elderly ◽  
Developed Countries ◽  
Pathological Process ◽  
Age Related Macular Degeneration ◽  
Long Term Effects ◽  
Functional Changes ◽  
Age Related ◽  
Functional Features ◽  
Retinal Neurogenesis

Age-related macular degeneration (AMD) is a complex, multifactorial neurodegenerative disease that constitutes the most common cause of irreversible blindness in the elderly in developed countries. Incomplete knowledge about its pathogenesis prevents the search for effective methods of prevention and treatment of AMD, primarily its &ldquo;dry&rdquo; type, which is by far the most common (90% of all AMD cases). In recent years, AMD became younger: late stages of the disease are now detected in relatively young people. It is known that AMD pathogenesis&mdash;according to the age-related structural and functional changes in the retina&mdash;is linked with inflammation, hypoxia, oxidative stress, mitochondrial dysfunction, and an impairment of neurotrophic support, but the mechanisms that trigger the conversion of normal age-related changes to the pathological process as well as the reason for early AMD development remain unclear. In the adult mammalian retina, de novo neurogenesis is very limited. Therefore, the structural and functional features that arise during its maturation and formation can exert long-term effects on further ontogenesis of this tissue. The aim of this review is to discuss possible contributions of the changes/disturbances in retinal neurogenesis to the early development of AMD.

scholarly journals RAMAN-FLUORESCENT DIAGNOSTICS OF A CONDITION OF TISSUES OF THE PERSON IS NORMAL ALSO AT PATHOLOGY AND ITS HARDWARE-SOFTWARE SOLUTION

2017 ◽  
Vol 21 (5) ◽  
pp. 228-232
Author(s):  
M. T Alexandrov ◽  
V. I Kukushkin ◽  
Edita Garnikovna Margaryan
Keyword(s):  
Laser Radiation ◽  
Biological Object ◽  
Pathological Process ◽  
Clinical Effects ◽  
Secondary Effects ◽  
Negative Effects ◽  
Functional Changes ◽  
Medical Diagnostic ◽  
Primary And Secondary Effects ◽  
High Degree

Use of laser radiation is especially important in modern clinical practice when it is required to carry out treatment and assessment of its efficiency on the modern principles of «diagnostics at the place of treatment» that objectively has to provide both medical, and diagnostic use of the laser radiation influencing to a biological object. It's necessary for the purpose of identification of positive (negative) physiological and clinical effects, ensuring timely correction of negative effects of laser radiation on a live organism or lack of those. It determines the need and validity of consideration of the all-biological concept of interaction of laser radiation with a biological object as medical-diagnostic. Both primary and secondary effects, and the functional changes induced by them and pathological process can be registered with modern technical means and used for the porpose of optometry of the flow and evaluation of the effectiveness of treatment using laser radiation and laser medical equipment and medical technology. The offered hardware programm complex raman-fluorescent diagnostics will technically and technologically allow high degree ofsensitivity, objectively and authentically provide the most important stage of inspection - diagnosis of a disease, monitoring of his current and process of rehabilitation in general.

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