scholarly journals Analysis of Tear Fluid for Evaluation on the Concentration of the Generic Anti-Glaucoma Drug Betoptik using Multisensory Stripping Voltammetry and Multivariate Statistics

2021 ◽  
Vol 248 ◽  
pp. 01005
Author(s):  
I. I. Kolesnichenko ◽  
L. M. Balashova
Keyword(s):  
Stripping Voltammetry ◽  
Test System ◽  
Tear Fluid ◽  
Organic Substances ◽  
Interdigitated Electrode ◽  
System Solution ◽  
The Right ◽  
Multidimensional Images ◽  
Multidimensional Statistics

It is important to monitor the concentration of drugs after their instillation: this helps to find the right drug dosages. The proposed method is based on recognizing multidimensional images through the use of multidimensional statistics; the images are produced by multisensory electrochemical systems that provide reliable information about the tested objects. The measurements were carried out using a planar solid-state electrode. The test-system solution was a 0.05 М KCl solution, which contained the Zn2+, Cd2+, Рb2+, Cu2+ Со2+, and Hg2+ metal cations at the concentration of 5 10–5 M. A new electrochemical method for multisensory stripping voltammetry has been used to determine whether it is appropriate for determination of generic forms of the drug Betoptic, that is, Xonef, Betoftan, and Betalink EU in tear fluid. Measurements were carried out on a planar three-electrode interdigitated electrode. It has been shown that this method is effective for determination of the generics. The dynamics of changes in their concentrations over time were examined. After instillation of the generics in glaucoma patients, their concentrations in the Tear fluid remained unchanged within 12 h. The list of organic substances that can be determined by the method of multisensory stripping voltammetry has been extended.

scholarly journals Express Screening of Tear Fluid for Evaluation of the Concentration of Lanomax Using Multisensory Stripping Voltammetry and Multivariate Statistics

2019 ◽  
Vol 224 ◽  
pp. 03002
Author(s):  
I. I. Kolesnichenko ◽  
V. A. Namiot ◽  
L. M. Balashova
Keyword(s):  
Stripping Voltammetry ◽  
Test System ◽  
Test Solution ◽  
Tear Fluid ◽  
Metal Dissolution ◽  
Electrochemical Systems ◽  
Drug Concentrations ◽  
The Right ◽  
Multidimensional Images ◽  
Multidimensional Statistics

The drug concentrations monitoring is very important for finding the right dosage. The developed method is based on the recognition of multidimensional images, which are produced by multisensory electrochemical systems that provide reliable information on objects being tested, using multidimensional statistics. The measurements were carried out using a planar solid-state electrode. The test solution was a 0.05 M KCl solution, which contained the $ {\rm{Z}}{{\rm{n}}_2}^ + ,{\rm{C}}{{\rm{d}}_2}^ + ,{\rm{P}}{{\rm{b}}_2}^ + ,{\rm{C}}{{\rm{o}}_2}^ + $ and $ {\rm{H}}{{\rm{g}}_2}^ + $ metal cations in the concentration of 5 • 10−5 M. The efficiency of this method in determining lanosterol with accounting for changes in its concentration with over time has been demonstrated. In order to determine concentrations of Lanomax in tear fluid, a procedure for multisensory stripping voltammetry has been developed and tested. It has been shown that the effect of lacrimal fluid on metal dissolution currents in the test system lasts 12 hours after the Lanomax instillation.

Application of catalytic adsorptive stripping voltammetry in water analysis

2001 ◽  
Vol 1 (2) ◽  
pp. 1-8 ◽  
Author(s):  
A. Bobrowski ◽  
J. Zarebski
Keyword(s):  
Stripping Voltammetry ◽  
Catalytic Reactions ◽  
Organic Substances ◽  
Considerable Decrease ◽  
Ultratrace Analysis ◽  
Catalytic Systems ◽  
Analytical Response ◽  
Trace Elements In Water ◽  
Electroactive Species

The application of catalytic adsorptive striping voltammetry (CAdSV) for the determination of the trace elements in water is presented. The CAdSV, coupling of very efficient adsorptive accumulation of the electroactive species on the electrode surface with the catalytic reaction, provides a significant amplification of the analytical response, and consequently a considerable decrease of the detection limit, as well as an improvement of the selectivity of the determination. The course of the catalytic reactions occurring in catalytic systems, which is most frequently applied in CAdSV analysis, is given. The features and advantages of the CAdSV method and its exploitation in ultratrace analysis of water samples are discussed. Numerous examples of the CAdSV systems, which have found application in the determination of Co, Cr, U, Fe, Mo, Pt, Rh, Ti, W and V, as well as of some anions and organic substances in various kinds of water, are listed.

scholarly journals Direct Determination of Zn, Cd, Pb and Cu in Wine by Differential Pulse Anodic Stripping Voltammetry

Beverages ◽  
2019 ◽  
Vol 5 (1) ◽  
pp. 6 ◽  
Author(s):  
Juliana Maciel ◽  
Michele Souza ◽  
Lisiane Silva ◽  
Daiane Dias
Keyword(s):  
Anodic Stripping Voltammetry ◽  
Direct Determination ◽  
Standard Addition ◽  
Stripping Voltammetry ◽  
Differential Pulse ◽  
Anthropogenic Sources ◽  
Organic Substances ◽  
Addition Method ◽  
Anodic Stripping

Metals in wine can originate from natural and anthropogenic sources and their concentrations have significant effects on wine proprieties as well in its conservation. In this work, direct and simultaneous determinations of Zn, Cd, Pb and Cu in wine samples were carried out by differential pulse anodic stripping voltammetry without any steps of previous pretreatment. The samples analyzed presented concentration levels from 4.64 to 69.3 µg L−1 of Zn, from 1.74 to 5.25 µg L−1 of Cd, from 4.57 to 17.9 µg L−1 of Pb and from 1.0 to 10.3 µg L−1 of Cu. Accuracy was evaluated with the standard addition method and recoveries ranged from 82.5 and 130.8% for Zn, from 85.7 to 107.0% for Cd, from 89.7 to 101.0% for Pb and from 81.4 to 105.9% for Cu. With the application of this method, it was possible to quantify the metals in a simple and easy way not requiring sample preparation or other approaches for the destruction of organic substances.

THE FACTORS OF CAREER SELF-DETERMINATION OF STUDENTS OF HIGHER EDUCATION INSTITUTIONS

2019 ◽  
Vol 7 (1) ◽  
pp. 9-20
Author(s):  
Inna Yeung
Keyword(s):  
Higher Education ◽  
Higher Education Institutions ◽  
Well Being ◽  
Young Person ◽  
Self Determination ◽  
Full Time ◽  
Actual Problem ◽  
The Third ◽  
The Right

Choice of profession is a social phenomenon that every person has to face in life. Numerous studies convince us that not only the well-being of a person depends on the chosen work, but also his attitude to himself and life in general, therefore, the right and timely professional choice is very important. Research about factors of career self-determination of students of higher education institutions in Ukraine shows that self-determination is an important factor in the socialization of young person, and the factors that determine students' career choices become an actual problem of nowadays. The present study involved full-time and part-time students of Institute of Philology and Mass Communications of Open International University of Human Development "Ukraine" in order to examine the factors of career self-determination of students of higher education institutions (N=189). Diagnostic factors of career self-determination of students studying in the third and fourth year were carried out using the author's questionnaire. Processing of obtained data was carried out using the Excel 2010 program; factorial and comparative analysis were applied. Results of the study showed that initial stage of career self-determination falls down on the third and fourth studying year at the university, when an image of future career and career orientations begin to form. At the same time, the content of career self-determination in this period is contradictory and uncertain, therefore, the implementation of pedagogical support of this process among students is effective.

KEBIJAKAN MODERASI PIDANA MATI

2017 ◽  
Vol 10 (2) ◽  
pp. 193
Author(s):  
Mei Susanto ◽  
Ajie Ramdan
Keyword(s):  
Human Rights ◽  
Death Penalty ◽  
Capital Punishment ◽  
Criminal Code ◽  
Right To Life ◽  
Life Imprisonment ◽  
Research Results ◽  
Moderation Model ◽  
The Right

ABSTRAKPutusan Nomor 2-3/PUU-V/2007 selain menjadi dasar konstitusionalitas pidana mati, juga memberikan jalan tengah (moderasi) terhadap perdebatan antara kelompok yang ingin mempertahankan (retensionis) dan yang ingin menghapus (abolisionis) pidana mati. Permasalahan dalam penelitian ini adalah bagaimana kebijakan moderasi pidana mati dalam putusan a quo dikaitkan dengan teori pemidanaan dan hak asasi manusia dan bagaimana kebijakan moderasi pidana mati dalam RKUHP tahun 2015 dikaitkan dengan putusan a quo. Penelitian ini merupakan penelitian doktrinal, dengan menggunakan bahan hukum primer dan sekunder, berupa peraturan perundang-undangan, literatur, dan hasil-hasil penelitian yang relevan dengan objek penelitian. Penelitian menyimpulkan, pertama, putusan a quo yang memuat kebijakan moderasi pidana mati telah sesuai dengan teori pemidanaan khususnya teori integratif dan teori hak asasi manusia di Indonesia di mana hak hidup tetap dibatasi oleh kewajiban asasi yang diatur dengan undang-undang. Kedua, model kebijakan moderasi pidana mati dalam RKUHP tahun 2015 beberapa di antaranya telah mengakomodasi amanat putusan a quo, seperti penentuan pidana mati di luar pidana pokok, penundaan pidana mati, kemungkinan pengubahan pidana mati menjadi pidana seumur hidup atau penjara paling lama 20 tahun. Selain itu masih menimbulkan persoalan berkaitan dengan lembaga yang memberikan pengubahan pidana mati, persoalan grasi, lamanya penundaan pelaksanaan pidana mati, dan jenis pidana apa saja yang dapat diancamkan pidana mati.Kata kunci: kebijakan, KUHP, moderasi, pidana mati. ABSTRACTConstitutional Court’s Decision Number 2-3/PUU-V/2007, in addition to being the basis of the constitutionality of capital punishment, also provides a moderate way of arguing between retentionist groups and those wishing to abolish the death penalty (abolitionist). The problem in this research is how the moderation policy of capital punishment in aquo decision is associated with the theory of punishment and human rights and how the moderation policy of capital punishment in the draft Criminal Code of 2015 (RKUHP) is related with the a quo decision. This study is doctrinal, using primary and secondary legal materials, in the form of legislation, literature and research results that are relevant to the object of analysis. This study concludes, firstly, the aquo decision containing the moderation policy of capital punishment has been in accordance with the theory of punishment, specificallyy the integrative theory and the theory of human rights in Indonesia, in which the right to life remains limited by the fundamental obligations set forth in the law. Secondly, some of the modes of moderation model of capital punishment in RKUHP of 2015 have accommodated the mandate of aquo decision, such as the determination of capital punishment outside the main punishment, postponement of capital punishment, the possibility of converting capital punishment to life imprisonment or imprisonment of 20 years. In addition, it still raises issues regarding the institutions that provide for conversion of capital punishment, pardon matters, length of delay in the execution of capital punishment, and any types of crime punishable by capital punishment. Keywords: policy, criminal code, moderation, capital punishment.

Adolescent athletes and nutrition – analysis of two groups of children

2020 ◽  
pp. 1-6
Author(s):  
Tatyana Dzimbova
Keyword(s):  
Energy Expenditure ◽  
Energy Intake ◽  
Eating Habits ◽  
Energy Deficit ◽  
Young Athletes ◽  
Adolescent Athletes ◽  
Basketball Players ◽  
Calcium Magnesium ◽  
The Right

Introduction. Proper nutrition is crucial for child and adolescent athletes to maintain growth and development and to achieveoptimal results in sports. It is very important to balance the energy expenditure with the energy intake in order to prevent the energy deficit or excess.Materials and methods. Subjects involved in two different sports participated in the study: 13 gymnasts (age 13.8 ± 4.1 years, height 153.4 ± 11.3 cm, weight 47.1 ± 10.5 kg) and 15 basketball players (age 15.5 ± 1.1 years, height 176.7 ± 7.9 cm, weight 65.2 ± 10.7 kg). Determination of total energy expenditure was made by prediction equations. The subjects maintained a food records for 5 consecutive days, which were processed in the ASA24 system of the NCI. Results and discussion. Energy intake in both groups is sufficient to meet the daily needs, development of young athletes andprovide the energy needed in training. The intake of three minerals (calcium, magnesium and potassium) and three vitamins (D, E and A) was lower than recommended values in both groups.Conclusion. As a result of the busy schedule of adolescent athletes, their main meals are out of home, and the proportion of highly processed foods containing small amounts of important vitamins and minerals is high. The main recommendations include dairy products, fruits, vegetables and whole grains. The idea behind the changes is to give young athletes the right diet and the right eating habits.

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